Researchers drug combinations. Medical search. Frequent questions

Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. (mdanderson.org)
Pleural tumors were discovered more than two centuries ago, but researchers only made clear connections between asbestos and mesothelioma in recent decades. (mesothelioma.com)
A team of researchers from the School of Cancer & Pharmaceutical Sciences, led by Dr. Alan Ramsay , reveal that the drug Avadomide can convert non responsive immunologically 'cold' CLL tumors into T-cell rich 'hot' ones, that can then effectively respond to immunotherapy antibodies. (kcl.ac.uk)
By combining two drugs, researchers shrank tumors in some patients with treatment-resistant Ewing's sarcoma, a cancer that primarily affects the bones and most often occurs in teens and young adults. (mdanderson.org)
Researchers will screen 400 compounds on 1,000 lines of cancer cells derived from a variety of types of tumors. (technologyreview.com)
The researchers were able to classify HGSC tumors into three groups on the basis of genomic changes. (medicalxpress.com)
The researchers analyzed genomics data on cancer tumors collected in the DECIDER project from 148 patients with HGSC treated and recruited in Turku University Hospital. (medicalxpress.com)
The researchers identified signaling pathways characteristic of each tumor group, which make these tumors biologically distinct. (medicalxpress.com)
The researchers observed a similar pattern in both women and men, as well as in people who either had or hadn't been previously treated with a targeted therapy against a gene that is commonly mutated in melanoma tumors. (cancer.gov)
The findings suggest that cytotoxic T cell activity is suppressed by regulatory T cells in melanoma tumors of younger patients, the researchers wrote, limiting the effectiveness of immune checkpoint inhibitors. (cancer.gov)

As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Children in Uganda recover from malaria faster when taking an herb-based combination therapy than when given standard drugs, solidifying the herbal drugs as frontline treatments for malaria in Africa. (sciencenews.org)
The goal is to develop personalized prescriptions that are more effective than single drugs and that can potentially replace more invasive treatments such as bariatric surgery, especially for children. (eurekalert.org)
What About New PNH Treatments or Combinations? (webmd.com)
New treatments or combination treatments also might cost more. (webmd.com)
In a small study, the combination of two targeted therapies led to long-lasting remission s for the majority of patients with hairy cell leukemia that had come back after previous treatments. (cancer.gov)
Researchers are also exploring similar drug combinations as treatments for hairy cell leukemia, Dr. Kreitman noted. (cancer.gov)
Researchers look to drug combinations, vaccines, and gene therapy for the next generation of Alzheimer's treatments. (medpagetoday.com)
Lead researcher Aung Naing, M.D., assistant professor in MD Anderson's Department of Investigational Cancer Therapeutics, says that prior to the Phase I clinical trial, patients were heavily treated and resisted most other treatments. (mdanderson.org)
Researchers used a network meta-analysis, which combines direct and indirect information across a network of randomized clinical trials to estimate the comparative effectiveness of multiple treatments. (medscape.com)

a chemotherapy drug that mimics DNA. (mesothelioma.com)
More than 60 years ago, British physician Denis Parsons Burkitt and his associates achieved one of the signal successes in cancer medicine when they cured children in sub-Saharan Africa with a form of lymphoma by treating them with high doses of the chemotherapy drug cyclophosphamide. (medindia.net)
The course of treatment will also be influenced if these drugs are being implemented individually, as part of a multimodal treatment with either surgery or radiation therapy, or if they are being used in tandem with another chemotherapy drug. (maacenter.org)
Alimta is the first and only chemotherapy drug to be approved by the U.S. Food and Drug Administration (FDA) to treat malignant pleural mesothelioma. (maacenter.org)
Carboplatin is a chemotherapy drug that has been on the market since the 1980s, and has been popular for treating a variety of cancers, including lung and ovarian cancer. (maacenter.org)
If your relapse occurs within 6 months of your treatment, it's generally recommended to try a different regimen with a single chemotherapy drug. (healthline.com)

Five University of Toronto researchers - working on artificial intelligence, anti-cancer therapies, pandemic prevention and international learning - were awarded RBC Post-Doctoral & Graduate Fellowships at this week's virtual Entrepreneurship Week . (utoronto.ca)
An international collaboration between anticancer researchers from across the world, the ReDO project is dedicated to promoting the cause of common medicines which may represent an untapped source of novel therapies for cancer. (sciencedaily.com)
Identifying the biological and immunological reasons for this lack of activity is therefore a priority area, alongside identifying more powerful combination therapies. (kcl.ac.uk)
In contrast to daily therapies, sustained release approaches to drug delivery have special appeal for use in the developing world: they are less expensive on a per-patient, per-day basis, they require less infrastructure to provide to the community, and they can be more effective," adds Dr. Baum. (scienceblog.com)
All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
2. Launch of pregnancy registries in three African countries to capture safety and exposure data on the real- life use of artemisinin-combination therapies during all stages of pregnancy, to support policy change through robust data, thereby improving treatment options for pregnant women suffering from malaria. (who.int)

The results of these studies, which will be presented at the virtual 2021 American Society of Clinical Oncology (ASCO) Annual Meeting , highlight new advances in drug therapy research to improve patient outcomes. (mdanderson.org)

Further studies should also focus on how differences in biological sex affect drug efficacy and safety. (eurekalert.org)
SMART researchers combine rifaximin and clarithromycin to effectively restore the latter drug's efficacy. (mit.edu)
Cimetidine is one of the most interesting examples of repurposed drugs in oncology -- a drug with an extensive history of pre-clinical and clinical evidence of efficacy in a range of different cancers and with multiple mechanisms of action at work," says Pantziarka. (sciencedaily.com)
The early results from this clinical trial are very promising and show that the efficacy of the combination is even better than chemotherapy given to healthier patients with similar stages of bladder cancer. (moffitt.org)
Clinical trials are ongoing for many to determine the most effective treatment combinations, as the response rates or efficacy of these drugs still varies widely among patients. (maacenter.org)
Initial results of the study, released last week, identified some previously known cancer mutations, such as a gene called BRAF, that affect drug efficacy, confirming that the approach works. (technologyreview.com)
Through its AHEAD 3-45 Study , researchers will test the safety and efficacy of lecanemab on participants who have varying amounts of amyloid pathology, but do not yet have levels of cognitive decline to warrant a dementia diagnosis. (nih.gov)
4. In support of efforts to repurpose malaria medicines against COVID-19 and meet the needs of low- resource settings, a partnership with the University of the Witwatersrand, South Africa, to initiate a Phase II exploratory study to assess the safety and efficacy of four different anti-infective drugs compared to standard of care in adults with mild COVID-19 infection. (who.int)

Improved access to viral load and drug resistance testing is not enough to improve viral suppression in children with HIV, researchers from Kenya and the United States reported at the Conference on Retroviruses and Opportunistic Infections (CROI 2022) this week. (aidsmap.com)
In 2022, researchers at Biogen/Eisai published the results of a phase 3 clinical trial called Clarity-AD in The New England Journal of Medicine . (nih.gov)

It is an experimental drug in early-stage clinical trials for various cancers including chronic lymphocytic leukemia (CLL). (wikipedia.org)
It matches drugs that target specific cancer mutations to people whose cancers have those mutations, regardless of where their cancers appear or what type of cancer they have. (unm.edu)
Tawfik explains that changing the combinations helps to capture information about mutations that occur infrequently in some cancers. (unm.edu)
In 1943, researcher H.W. Wedler reported a connection between asbestosis and pleural cancers. (mesothelioma.com)
Researchers discovered, for example, that while high doses are much more effective against certain cancers than low doses, they inflict about the same amount of DNA damage, suggesting that something else comes into play at high doses. (medindia.net)
Understanding the ways in which the individual genomes of cancers are broken is key to effective treatment, particularly with molecularly targeted agents," says Andy Futreal , codirector of the Cancer Genome Project at the Wellcome Trust Sanger Institute, in Hinxton, U.K. Futreal is overseeing the largest study yet to correlate genetics with response to cancer drugs, in collaboration with scientists at Massachusetts General Hospital. (technologyreview.com)

Another way researchers are trying to make PNH treatment better is by looking at new medicines and combinations of medicines. (webmd.com)
Researchers are also looking at medicines that work against other players in the complement system. (webmd.com)
The hope is that different medicines or combinations of medicines could control PNH in people when existing medicines aren't enough. (webmd.com)
Clinical trials are now testing new PNH medicines and combinations. (webmd.com)
Prescription drugs are medicines that a health care provider prescribes for you. (mayoclinic.org)
You can't buy them off the shelf in a drug store like you can buy nonprescription medicines. (mayoclinic.org)
95% CI, −34.6 to −14.7), and 14 other medicines compared with placebo, the researchers report. (medscape.com)

The prevalence of drug resistance is high among children with HIV, making it critical that children receive regimens that are active against drug-resistant virus and that clinicians have timely viral load information to enable a switch in treatment before high-level drug resistance emerges. (aidsmap.com)
The hypothesis of Opt4Kids was that point-of-care viral load testing and early referral for drug resistance testing would speed up clinical decision-making resulting in improved treatment outcomes among children with HIV. (aidsmap.com)
Causes of viral rebound can include drug resistance, poor adherence to an HIV treatment regimen or interrupting treatment. (aidsmap.com)
Study participants were randomised to receive point-of-care viral load testing every three months and drug resistance testing if they had a viral load above 1000, or to receive the standard of care, which consists of viral load testing every six months and resistance testing only in the case of second-line regimen failure. (aidsmap.com)
Amaria and other researchers are continuing to follow patient outcomes and will be conducting further translational studies to discern the mechanisms of response and resistance to this combination. (mdanderson.org)
Researchers have continued to develop new types of antibiotics to combat MRSA infections, but resistance to many of these have already been reported. (nih.gov)
The researchers next tested the ability of the drug trio to suppress the development of resistance in MRSA. (nih.gov)
In contrast, the bacteria developed resistance to all the drugs used alone or in pairs within 1-8 days. (nih.gov)
Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA. (nih.gov)
The two drugs address molecular pathways that cause cell growth and survival, abnormal blood vessel growth, and resistance to chemotherapy and radiation. (mdanderson.org)
Researchers theorized that combining the drugs would help stave off onset of drug resistance, a common occurrence and major obstacle in cancer treatment. (mdanderson.org)
By combining drugs in a scientifically rational way, we may be able to overcome resistance to single agents and provide benefit to patients with advanced Ewing's sarcoma," says study senior author Razelle Kurzrock, M.D., professor and chair of the Department of Investigational Cancer Therapeutics. (mdanderson.org)
The objective is to generate diagnostic tests that are comprehensive, consolidating information on particular genetic alterations now associated with drug response and resistance into a single test, so you don't have to do dozens of tests," says Garraway, one of the company's cofounders. (technologyreview.com)

Immunotherapy drugs are classified by how they utilize the immune system. (mesothelioma.com)
Extensive stage SCLC is most commonly treated with a combination of chemotherapy and immunotherapy . (healthline.com)
Another combination of this new regimen pairs the immunotherapy avelumab with axitinib . (medscape.com)
In addition to immunotherapy treatment work like that by Dr. Annunziata, cancer researchers are exploring new chemotherapy drugs and drug combinations that could result in more effective treatment for ovarian cancer patients. (medlineplus.gov)

In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)
An expert shares her take on emerging strategies for combination treatment for NAFLD and NASH with GLP-1 receptor agonists plus SGLT2 inhibitors. (clinicaloptions.com)
Researchers think that giving an extra treatment of high dose chemotherapy with 2 stem cell transplants might be better. (cancerresearchuk.org)
Researchers are also looking at adding an extra treatment of radiotherapy to the standard treatment. (cancerresearchuk.org)
In a previous paper published in ecancermedicalscience , the ReDO researchers examined the anti-cancer properties of the drug mebendazole, an over-the-counter treatment currently used for threadworm. (sciencedaily.com)
The ASCO-TAPUR study has defined more than 50 combination baskets of cancer types and FDA-approved drugs, so that people with rare mutations may get access to a potentially life-saving treatment. (unm.edu)
Today, doctors and researchers are working to improve diagnosis and treatment for mesothelioma patients. (mesothelioma.com)
The combination treatment also appeared to be very safe, causing mostly mild side effects that went away on their own. (cancer.gov)
However, this treatment combination is still far from perfect. (moffitt.org)
When the two drugs, cixutumumab and temsirolimus, were used as single agents, treatment results were mixed. (mdanderson.org)
Treatment with combinations of AIDS drugs can keep people with HIV from getting AIDS. (health.am)
In clinical studies, where everybody gets state-of-the art treatment and very regular medical exams, the drugs work for the vast majority of people. (health.am)
In every trial, combination treatment worked better than just the drug. (psychologytoday.com)
According to Dr. Baum, the choice of drugs available for HIV PrEP has expanded greatly in recent years, and many ARVs that were historically used exclusively for HIV treatment have now been added to the PrEP pipeline. (scienceblog.com)
Below are some of the most commonly studied and used drugs in the treatment of mesothelioma . (maacenter.org)
Side effects may vary from person to person and may also depend on the drug or treatment combinations. (maacenter.org)
Based on our findings, we are better able to identify the subset of patients likely to benefit from such treatment," says Postdoctoral Researcher Jaana Oikkonen from the University of Helsinki. (medicalxpress.com)
Typically treatment involves a wide variety of chemotherapeutic agents given in specific doses and combinations for the specific lymphoma. (rxwiki.com)
Prescription weight-loss drugs that you can use for more than 12 weeks, called long-term use, lead to major weight loss compared with an inactive treatment that doesn't use medicine, called a placebo. (mayoclinic.org)
If you haven't lost at least 5% of your body weight after taking the full dose of a drug for 3 to 6 months, your health care provider will probably change your treatment. (mayoclinic.org)
In an analysis of more than 500 patients, researchers found that older people with melanoma appeared to respond better to checkpoint inhibitor treatment than younger people. (cancer.gov)
This combination treatment approach "might have great benefit in young patients," the investigators wrote June 13 in Clinical Cancer Research . (cancer.gov)
For every decade of age, the probability that a patient was resistant to pembrolizumab treatment dropped by 13%, the researchers observed. (cancer.gov)
This page was updated to include the U.S. Food and Drug Administration's July 6, 2023, announcement about approval of lecanemab for the treatment of Alzheimer's disease. (nih.gov)
The U.S. Food and Drug Administration (FDA) today granted traditional approval for Leqembi (lecanemab-irmb) for the treatment of Alzheimer's . (nih.gov)
This page was updated to include the U.S. Food and Drug Administration's Jan. 6, 2023, announcement about accelerated approval of lecanemab for the treatment of Alzheimer's disease. (nih.gov)
To fill this knowledge gap, the researchers conducted a systematic review and analysis of controlled trials comparing analgesics with another analgesic, placebo, or no treatment in patients with acute, nonspecific low back pain. (medscape.com)
Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
sertraline should be the drug of choice for the pharmacological treatment of puerperal depression. (bvsalud.org)
Since the launch of the WHO Global Technical Strategy, several successes in the antimalarial drug space have helped transform the prevention and treatment of malaria and saved millions of lives. (who.int)

A clinical trial testing the combination of Gemcitabine and Carboplatin saw overall positive results among the 50 patients tested. (maacenter.org)
3.6) in analyzing drug synergy by studying combinations involving non-steroidal analgesics (celecoxib and indomethacin) and antitumor drugs (carboplatin, gemcitabine, and vinorelbine) on two canine mammary tumor cell lines. (bvsalud.org)

Other antibiotics might also be repurposed in similarly designed synergistic combinations. (nih.gov)
Celecoxib-based combinations showed the most consistent synergistic effect among software and reference models. (bvsalud.org)
When the average values of the combination matrices were compared, some combinations shifted from synergistic to antagonistic due to differences in the curve fitting. (bvsalud.org)
We also used a simulated dataset to normalize each software's synergy scores, finding that Combenefit tends to increase the distance between synergistic and antagonistic combinations. (bvsalud.org)
We conclude that concentration-response data fitting biases the direction of the combination (synergistic or antagonistic). (bvsalud.org)
In contrast, the scoring from each software increases the differences among synergistic or antagonistic combinations in Combenefit when compared to SynergyFinder. (bvsalud.org)

A drug-resistant HIV strain is one which is less susceptible to the effects of one or more anti-HIV drugs because of an accumulation of HIV mutations in its genotype. (aidsmap.com)
Targeted drugs interfere with the effects of specific mutations to stop cancer cells from growing and reproducing. (unm.edu)
Basket" clinical trials offer a more efficient way to test several drugs against several mutations and cancer types at the same time. (unm.edu)
Now this genetic knowledge is being used to direct drug development by testing specific compounds on 1,000 cancer cell lines that incorporate many of these mutations. (technologyreview.com)
Oftentimes, there may be multiple mutations that you need to read together to determine if a drug is effective or not," says Levi Garraway , a researcher at the Broad Institute, in Cambridge, MA. (technologyreview.com)
Earlier work showed that mutations in this gene affect how well melanoma patients respond to certain drugs. (technologyreview.com)
But we have much more complex analysis going on that shows combinations of mutations that appear to drive response," says Benes. (technologyreview.com)
In the first study of more than 31,000 women with BRCA1/2 mutations from 55 centers in 33 countries on 6 continents, researchers estimated the magnitude of risk for breast and ovarian cancer based on mutation type, function, and position. (cdc.gov)
In the second study of more than 33,000 breast cancer cases and 33,000 control women, researchers assessed the value of using 77 breast cancer-associated common variants for breast cancer risk stratification (rare variants such as BRCA1/2 mutations were not included in this study). (cdc.gov)

In a nonrandomized, open-label Phase II study, MD Anderson researchers demonstrated that talazoparib, a PARP inhibitor, showed activity in patients with germline BRCA1/2 mutation-positive, early HER2-negative breast cancer. (mdanderson.org)
The typical regimen consists of three drugs: tacrolimus, a cell cycle inhibitor, and steroids (prednisone)," said Dr. Wijesinha. (sciencedaily.com)
Researchers are at work now to develop an inhibitor drug for it. (webmd.com)
Giving young mice a drug that eliminates one type of immune cell before treating them with a checkpoint inhibitor substantially improved their responses. (cancer.gov)
New findings suggest that first-line therapy with a combination of a tyrosine kinase inhibitor (TKI) and an immune checkpoint inhibitor improved outcomes in patients with metastatic renal cell carcinoma (mRCC) when compared with the current standard of care. (medscape.com)
Because of these results, researchers are suggesting that this combination of a TKI and an immune checkpoint inhibitor may well represent the new standard of care and is likely to be incorporated into guidelines in the near future. (medscape.com)

The only potential cure is a bone marrow transplant, a procedure in which radiation or drug therapy is used to destroy your existing marrow and replace it with marrow from a donor. (webmd.com)
A combination of chemotherapy drugs is often administered together with radiation therapy in people with limited stage SCLC to try to cure the cancer. (healthline.com)

To see what might help lung transplant recipients live longer, researchers at the University of Maryland School of Medicine (UMSOM) developed a novel epidemiological analysis of lung transplant data in the United States focused on regimens that prevent the body's immune system from attacking the transplanted lung. (sciencedaily.com)
Further, the U.S. Food and Drug Administration has not approved any immunosuppressive drugs or drug regimens specifically for use in patients with a lung transplant. (sciencedaily.com)
The most notable changes in these guidelines reflect both the findings of clinical trials that evaluated new drug regimens for treating and preventing TB among HIV-infected persons and recent advances in the use of antiretroviral therapy. (cdc.gov)

Using a database of over 9,000 lung transplant patients maintained by the United Network for Organ Sharing (UNOS), the researchers categorized patients by their immunosuppression regimen and compared survival rates. (sciencedaily.com)
The drug regimen, tested so far in mouse models and on human colon cancer tissue in the laboratory, appears to address a problem with chemopreventive drugs--they must be taken continuously long term to be effective, exposing patients to possible side effects, said senior author Dr. Xiangwei Wu, associate professor in M.D. Anderson's Department of Head and Neck Surgery. (bioquicknews.com)

The researchers conclude that combining the drugs has several advantages, including higher effectiveness in at least some patients and fewer side-effects. (eurekalert.org)
In addition to drug combinations, the researchers are looking for non-pharmacological solutions, such as how adding fibre to a person's diet can slow weight gain and improve the effectiveness of existing diabetes medications. (eurekalert.org)
Over the years, clues emerged that there's more to the drugs' effectiveness than damaging DNA. (medindia.net)
Manufacturers have exaggerated the drugs' effectiveness. (psychologytoday.com)
While a number of molecularly targeted cancer drugs, such as gleevec and herceptin, are already on the market, the effectiveness of most of these drugs depends on a single genetic mutation or molecular marker in the tumor. (technologyreview.com)
Reimburse · The drug under review demonstrates comparable or added clinical benefit and acceptable cost/cost- effectiveness relative to one or more appropriate comparators to recommend reimbursement in accordance with the defined patient population under review, which is typically the patient population defined in the Health Canada-approved indication (as applicable). (bvsalud.org)
with · The drug under review demonstrates comparable or added clinical benefit and acceptable cost/cost- clinical effectiveness relative to one or more appropriate comparators in a subgroup of patients within the criteria approved indication. (bvsalud.org)
The drug under review demonstrates comparable or added clinical benefit, but the cost/cost- effectiveness relative to one or more appropriate comparators is unacceptable. (bvsalud.org)

Studying the effect of novel cancer drugs on 1,000 lines of genetically diverse cancer cells will drive the development of personalized medicine. (technologyreview.com)
Depending on the group, the cancer populations grew up in combinations of either genetically different or clonal cells. (medicalxpress.com)
Through the NIA Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) , researchers will use lecanemab in combination with another drug, E2814 in participants who are genetically susceptible to early-onset Alzheimer's, a rare form of the disease that typically occurs in a person's 30s to mid-60s. (nih.gov)

So, researchers and doctors will need to weigh these risks and benefits carefully. (webmd.com)
Others will look to see if a new drug works better than ones doctors already have. (webmd.com)
In the 1960s, doctors and researchers began looking into the causes of mesothelioma . (mesothelioma.com)
In the real world, some AIDS doctors say, the drugs fail in about half of their patients. (health.am)
Doctors use a variety of chemotherapy drugs individually and in multimodal approaches to treat mesothelioma patients. (maacenter.org)
Doctors usually treat SCLC with a combination of chemotherapy drugs. (healthline.com)
Now, doctors use drugs, called granulocyte-colony stimulating factors (GCSFs), which are far easier to tolerate. (popsci.com)

Cimetidine is an interesting drug as it's very safe, very well-known, and has clinical results in cancer that have been confirmed in a number of trials," says Pan Pantziarka, lead author of the paper and member of the Repurposing Drugs in Oncology (ReDO) project. (sciencedaily.com)
Dr. Roger Li , a genitourinary oncology surgeon and researcher at Moffitt Cancer Center, received a grant from the Department of Defense to study the immunogenic actions of the oncolytic virus and immune checkpoint blockade. (moffitt.org)

These drugs interfere with the synthesis of cell walls to prevent bacteria from growing and reproducing. (nih.gov)

Findings published last week in the journal PLOS ONE confirm that researchers from the Oak Crest Institute of Science, located in Monrovia, CA, have demonstrated for the first time that two powerful antiretroviral (AVR) drugs can provide complete protection against HIV when delivered topically by a sustained release intravaginal ring (IVR) device. (scienceblog.com)

Mathematical models, such as Loewe, Bliss, and HSA, are used to interpret drug combinations, while informatics tools help cancer researchers identify the most effective combinations. (bvsalud.org)

Thirty patients were enrolled in the study and received two doses of nivolumab with relatlimab before surgery, followed by up to 10 additional doses of the combination therapy after surgery. (mdanderson.org)
In mouse models implanted with human lymphoma tissue, the researchers showed that high doses of the drug, but not normal doses, damaged tumor cells in a way that severely stressed the lymphoma cells. (medindia.net)
Although high doses of cyclophosphamide and other alkylating agents may be too toxic for patients with diseases other than Burkitt lymphoma, researchers are investigating agents that mimic their ability to stress cancer cells, but with milder side effects. (medindia.net)

Immune checkpoint inhibitors -drugs that unleash an immune response against cancer-work astonishingly well for some people with advanced melanoma but do not work at all for many others. (cancer.gov)
Now researchers believe they have found a simple characteristic that may be associated with how well somebody with melanoma will respond to checkpoint inhibitors: age. (cancer.gov)

Because we saw the same epigenetic changes in people with type 2 diabetes and individuals at risk for the disease, we conclude that these changes may contribute to the development of type 2 diabetes," says Tina Rönn, lead author and researcher at LUDC. (lu.se)

Combining a gene-targeted drug, a cancer-bursting virus and a drug that removes the immune system's brake pedal can tackle thyroid cancer with newfound gusto, research has found. (znan.org)
The team found that a combination of Vitamin A acetate (RAc) and TRAIL, (tumor necrosis factor-related apoptosis-inducing ligand), kills precancerous polyps and inhibits tumor growth in mice that have deficiencies in a tumor-suppressor gene. (bioquicknews.com)
The researchers found that the gene RHOT1 showed epigenetic changes in people with type 2 diabetes and that it also played a key role in insulin secretion in insulin-producing cells. (lu.se)
Researchers have developed mathematical models that help estimate how many years of life an average woman with a BRCA, or BReast CAncer gene mutation, might gain if she has her ovaries and fallopian tubes removed. (medlineplus.gov)

Weakened immune system: The risk of developing lymphoma may be increased by having a weakened immune system (such as from an inherited condition or certain drugs used after an organ transplant). (rxwiki.com)

They found that the structural properties of the anti-inflammatory drug Indomethacin changed in the presence of common biomolecules. (lu.se)

The findings will help pharmaceutical companies design clinical trials so that they include only those patients most likely to respond to a drug. (technologyreview.com)
The researchers behind the new findings published in Nature Communications now aim to develop methods for disease prevention. (lu.se)

In comparison with a placebo, the drug slowed the rate of cognitive decline over 18 months and reduced the levels of brain amyloid. (nih.gov)

Ultimately, physicians hope to be able to screen a patient's tumor and choose the most effective drug based on its specific genetic profile. (technologyreview.com)

Geographical epidemiology, which is part of descriptive epidemiological studies, is the description of spatial patterns in health-related phenomena, such as diseases, injuries and disasters, and health-related behaviours, such as drug abuse [5]. (who.int)

Researchers estimate that the condition affects 1 in 50,000 to 1 in 500,000 newborns. (medlineplus.gov)

Repurposed anticancer drugs such as aspirin and antacids may represent the future of cancer drug research, according to leaders of the ReDO project. (sciencedaily.com)
Drug combinations are increasingly studied in the field of anticancer agents. (bvsalud.org)

These combinations either continued to evolve in metastases or remained unchanged. (medicalxpress.com)
Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)

Clinicians and researchers are eagerly searching for factors that can help identify patients that are most likely to have good responses . (cancer.gov)

Although more testing is needed, the results suggest that combinations of already-approved antibiotics might add to our options to combat MRSA infections. (nih.gov)
All mice treated with ME/PI/TZ survived for 6 days after infection, which was comparable to those treated with linezolid, a more expensive drug currently used to treat resistant infections. (nih.gov)

The study has identified a drug combination that appears to significantly extend patient survival. (sciencedaily.com)
The study also considered induction therapy, an optional addition to maintenance therapy used in over half of transplant centers in the U.S. In induction therapy, patients are given a high dose of immunosuppression at the time of transplantation for a short duration -- three to 14 days, with drugs such as basiliximab, daclizumab, alemtuzumab, or antithymocyte globulin. (sciencedaily.com)
Results of the study, Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protect Macaques from Multiple SHIV Exposures, confirm that the combination of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) delivered at independently controlled rates via the pod-IVR were successful at preventing SHIV162p3 infection in a rigorous, repeat low-dose vaginal exposure model using normally cycling female pigtailed macaques. (scienceblog.com)
This study has shown that the drug combination and the versatile drug delivery system that we have designed can indeed remain protective for over four and a half months. (scienceblog.com)
The compounds to be screened in the Mass General/Wellcome study include both traditional chemotherapies, which can affect both healthy and cancerous tissue, and molecularly targeted drugs, designed to attack a particular genetic flaw specific to cancer cells. (technologyreview.com)
In a study in mice, the drug pull stem cells out of the bone marrow quickly and efficiently. (popsci.com)
However, Forsberg says she's heard from other researchers who would be interested in running that type of study. (popsci.com)
A new study by researchers at Lund University provides increased support for the idea that epigenetic changes can cause type 2 diabetes. (lu.se)

It's been nearly two years since Biogen announced it would seek federal approval for its drug, aducanumab, to treat some people in the early stages of Alzheimer's disease. (aarp.org)

Scientists are testing new ways to screen women for ovarian cancer with imaging techniques like functional MRIs and PET/CT scans, as well as how drug and lifestyle changes may alter the risk of ovarian cancer. (medlineplus.gov)

Innovation is a critical component of RBC's tech strategy, and we're thrilled to partner with the University of Toronto to support these researchers," added Bruce Ross, RBC's group head, technology and operations . (utoronto.ca)
Researchers at the University of Maryland School of Medicine (UMSOM) have developed two rapid diagnostic tests for COVID-19 that are nearly as accurate as the gold-standard test currently used in laboratories. (umaryland.edu)
At the University of Sao Paulo in Brazil, researchers analyzed 11 studies comparing the benefits of Viagra by itself versus the drug plus sex/martital therapy . (psychologytoday.com)
Further research is being carried out on, for instance, what would be the easiest way to classify patients into the three groups identified," says Postdoctoral Researcher Alexandra Lahtinen from the University of Helsinki. (medicalxpress.com)
A two-drug combination destroys precancerous colon polyps with no effect on normal tissue, opening a new potential avenue for chemoprevention of colon cancer, according to a team of scientists at The University of Texas M.D. Anderson Cancer Center and INCELL Corporation. (bioquicknews.com)

image: Andrea Haqq (right) is bringing her clinical experience working with patients to an international collaboration aimed at identifying personalized drug combinations to better treat people with obesity and Type 2 diabetes. (eurekalert.org)
Even a five per cent weight loss is considered clinically meaningful, and patients in some of the combination drug trials are achieving 10 or 15 per cent, said Haqq, who is a member of the Alberta Diabetes Institute and the Women and Children's Health Research Institute . (eurekalert.org)
To prevent chronic rejection, the most common cause of death after a lung transplant, patients must take immunosuppressive drugs for the rest of their lives. (sciencedaily.com)
They singled out an immunosuppressive drug called sirolimus, in a class of drugs called cell cycle inhibitors, based on a few small, long-term studies that found dramatically improved survival, reduced incidence of chronic rejection, and improved lung function in lung transplant patients who took sirolimus. (sciencedaily.com)
The majority of patients in the database, nearly 5,800, were given MMF plus tacrolimus, a combination that has become the de facto standard immunosuppression after lung transplant. (sciencedaily.com)
Dr. Kreitman has seen that trend in his own studies involving patients with hairy cell leukemia, including an ongoing clinical trial of rituximab in combination with moxetumomab pasudotox-tdfk (Lumoxiti) (see box). (cancer.gov)
Furthermore, the drug combination is safe and very well tolerated by patients. (moffitt.org)
Most often, Alimta is used in combination with cisplatin as a first-line therapy after a clinical trial showed pemetrexed plus Cisplatin extended the patients' survival to about 12 months, compared to 9 months when treated with cisplatin on its own. (maacenter.org)
Another clinical trial conducted between 2008 and 2014, found a median survival of 16 months for 225 patients treated with a combination of pemetrexed + Cisplatin. (maacenter.org)
In clinical trials, however, Avastin in combination with other chemotherapy drugs has shown improvement in overall survival and quality of life among mesothelioma patients. (maacenter.org)
In a clinical trial held from 2008 to 2014, 223 patients received a combination of Avastin, Alimta and Cisplatin. (maacenter.org)
This "triplet" therapy showed promising results, with patients' experiencing a median survival of 19 months versus 16 months with the combination of just Alimta and Cisplatin. (maacenter.org)
Pharmaceutical companies can use the results to define the genetic profile of patients most likely to respond to the drug. (technologyreview.com)
The drugs also can't be used in patients with sickle cell disease. (popsci.com)
The combination of pembrolizumab and axitinib increased both overall and progression-free survival in patients with previously untreated mRCC, compared with similar patients who were treated with sunitinib. (medscape.com)

The NAMCS and NHAMCS no longer use the NCHS-developed 5-digit code to classify drugs according to their generic components (the second coding described above), nor do they use the National Drug Code Directory to code therapeutic class. (cdc.gov)

Our hypothesis has been that controlled, sustained release of ARV drug combinations could overcome these low adherence rates if the product itself could remain protective for extended periods of time. (scienceblog.com)

A drug combination designed to enhance the immune system's ability to zero in and attack cancer cells has shown a pronounced therapeutic effect against cancer. (medindia.net)

The researchers also identified a potential strategy to improve responses to checkpoint inhibitors in younger people. (cancer.gov)
The researchers wondered if altering the ratio of regulatory to cytotoxic T cells in mice would change the response to checkpoint inhibitors. (cancer.gov)

Cyclophosphamide was just the eighth anti-cancer drug to enter standard therapy when it was approved by the U.S. Food and Drug Administration in 1954. (medindia.net)
In one trial, researchers at the Center for Sexual Health in San Jose, California, gave 53 couples either Viagra or the drug plus eight sessions of weekly sex therapy. (psychologytoday.com)

The researchers analyzed thousands of these macrophages to determine which genes were active, or expressed, in each of them. (medindia.net)
Researchers are working to identify and describe specific genes related to this condition. (medlineplus.gov)

The U.S. Food and Drug Administration (FDA) registered the laboratory of Dr. Pan as an approved laboratory development site for the Antisense test in June. (umaryland.edu)
Forsberg and Smith-Berdan work in pre-clinical basic science, so they won't try and test their drug combination in people themselves. (popsci.com)
The drugs would likely be fairly easy to test, and test safely, in people, because the drugs used are already FDA-approved. (popsci.com)

The ME/PI/TZ trio was more effective against the strain than any of the drugs alone or in pairs. (nih.gov)
The triple combination also proved effective in the lab against a panel of strains taken from 72 other clinical cases of MRSA. (nih.gov)
Effective drug discovery relies on having a robust and reliable workflow. (t-systems.com)

Now, working in partnership with ecancer, the ReDO project is publishing a series of papers on drugs with enough evidence to be taken to clinical trials. (sciencedaily.com)
Focusing clinical trials in this manner should speed up the process, and may even allow the approval of drugs that would have failed in the broader population. (technologyreview.com)

Canadian and German researchers work together to identify personalized prescriptions for weight loss and blood glucose control, especially for kids. (eurekalert.org)
Canadian and German researchers are teaming up to identify new drug combinations to treat people with obesity and Type 2 diabetes. (eurekalert.org)
Haqq and Tan recommend further research to identify why some individuals respond differently to the drugs. (eurekalert.org)
Only by going to a separate ingredient file (which includes therapeutic classes for each ingredient of a drug), would a researcher be able to identify that the product contained an antihistamine, antitussive, and a decongestant. (cdc.gov)

Moderate to low confidence was also noted for secondary outcomes and secondary analysis of medicine classes," the researchers note. (medscape.com)
The drug under review demonstrates inferior clinical outcomes or significant clinical harm relative to one or more appropriate comparators. (bvsalud.org)

And the number of combinations varies: some are removed and others are added weekly. (unm.edu)

Around half of men over 50 report at least some degree of erectile dysfunction (ED). How many have used erection drugs? (psychologytoday.com)
Before Viagra made its money as a blockbuster erectile dysfunction drug, the medication was originally researched for its ability to dilate blood vessels. (popsci.com)

Reversed-Phase Liquid Chromatography (RPLC) is a common liquid chromatographic mode used for the control of pharmaceutical compounds during their drug life cycle. (researchgate.net)

But conducting a clinical trial for every possible combination of mutation and cancer type is not feasible. (unm.edu)
For example, an ongoing clinical trial is testing vemurafenib plus obinutuzumab (Gazyva) , a drug that works in a similar way as rituximab. (cancer.gov)

The researchers also found that the average age of overdose death among women increased by 2.8 years, from 43.5 years in 1999 to 46.3 years in 2017. (livescience.com)
This finding is further supported by previous studies that have found a recent increase in overdose deaths and drug-related emergency department visits for women ages 45 to 64, the researchers wrote. (livescience.com)
The team found that a combination of Viagra and a stem cell mobilizer called Plerixafor were able to pull stem cells out of the bone marrow and into the bloodstream (like GCSF's do), where they could be easily harvested. (popsci.com)
RAc, researchers found, sensitizes polyp cells to TRAIL. (bioquicknews.com)
The researchers studied epigenetics in insulin-producing human cells and found 5584 sites in the genome with changes that differed between 25 individuals with type 2 diabetes and 75 individuals without the disease. (lu.se)

Anatomy3

Organisms6

Diseases17

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology9

Phenomena and Processes21

Disciplines and Occupations20

Anthropology, Education, Sociology and Social Phenomena10

Technology, Industry, Agriculture2

Humanities4

Information Science28

Named Groups3

Health Care37

Geographicals1

Tumors10

Treatments10

Chemotherapy drug6

Therapies6

20211

Efficacy8

20222

Cancers6

Medicines7

Resistance13

Immunotherapy4

Treatment30

Carboplatin2

Synergistic6

Mutations9

Inhibitor6

Radiation2

Regimens3

Regimen2

Effectiveness8

Genetically3

Doctors7

Oncology2

Synthesis1

Antiretroviral1

Cancer researchers1

Doses3

Melanoma2

Conclude1

Gene4

Lymphoma1

Indomethacin1

Findings2

Placebo1

Tumor1

Diseases1

50,0001

Anticancer2

Metastases2

Clinicians1

Infections2

Study8

Biogen1

Ovarian cancer1

University5

Patients15

Classify1

Overcome1

Immune1

Inhibitors2

Therapy2

Genes2

Test3

Effective3

Trials2

Identify4

Outcomes2

Varies1

Erectile dysfunction2

Compounds1

Clinical trial2

Found5