• JCVI projects focus on elucidating gene pathways, understanding host responses and ultimately developing new anti-fungal treatments. (jcvi.org)
  • Since the incidence of fungal systemic infections drastically increased over the last years, it is a major goal to investigate the pathobiology of A. fumigatus and in particular the interactions of A. fumigatus conidia with immune cells. (ilrs.de)
  • The hematogenous is by far the most frequent route for systemic infections of various bacterial and fungal pathogens, in the most severe cases leading to blood stream infections ( 2 ). (frontiersin.org)
  • Therefore, we previously established an ex vivo human whole-blood infection model that allowed us to define which immune cells interact with the human fungal pathogen Candida albicans ( 4 ), to identify cross-talk between different components of the host response ( 5 ), and to detect substantial differences between related fungal pathogens ( 6 ). (frontiersin.org)
  • To date, 24 different ToxA haplotypes have been identified from four cereal leaf spot causing fungal pathogens. (usda.gov)
  • A summary of the identified ToxA haplotypes, and the proposed new nomenclature, is presented here from four fungal pathogens: Pyrenophora tritici-repentis, Parastagonospora nodorum, Parastagonospora pseudonodorum (formerly Parastagonospora avenaria f. sp. (usda.gov)
  • In response to the rising threat of fungal infections, combined with existing and emerging resistance and treatability issues, we prioritize research of emergent fungal pathogens, considering their unmet research and development needs and perceived public health importance. (amc.edu)
  • Standard methods for fungal brood disease research. (usda.gov)
  • This international collaborative unit Fungal Extracellular Vesicles will bring together three scientific teams specializing in the study of extracellular vesicles produced by fungal pathogens. (pasteur.fr)
  • This unit will be coordinated by three internationally renowned scientists: Guilhem Janbon, Head of the ARN Biology of Fungal Pathogens Unit at the Institut Pasteur in Paris, Marcio L. Rodrigues, Head of the Fungal Pathogens Group at the Carlos Chagas Institute, Fiocruz, Brazil and Robin C. May, Professor of Infectious Diseases & Gresham Professor of Physic, Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, UK. (pasteur.fr)
  • The main objectives of the Pasteur International Joint Research Unit Fungal Extracellular Vesicles is to support the present common high quality research, to expand the fields of cooperation beyond those existing, especially in the study of the Extracellular Vesicles (EVs), combining unique tools and expertise in the three contributing centers in order to make major inroads into EV biology. (pasteur.fr)
  • The Fungal Pathogens Group at the Carlos Chagas Institute of Fiocruz headed by Marcio L. Rodrigues. (pasteur.fr)
  • National Centre for Biotechnology Information, the CAB ferences between the major pathogen groups--viruses, International Bioscience database of fungal names, and bacteria, fungi, protozoa, and helminths. (cdc.gov)
  • Host-directed therapies (HDTs) can improve immune mechanisms by augmenting the ability of host cells to kill M. tuberculosis (Mtb) or by modulating the immune response to prevent excessive inflammation, cell death and tissue damage. (europa.eu)
  • This novel approach will dissect crucial mechanisms of host-pathogen interaction during Mtb infection and will point to new targets for HDTs of TB. (europa.eu)
  • Accordingly, the mechanisms by which bats tolerate virulent pathogens (and whether such patterns hold across both bat and pathogen taxa) remain poorly understood.The gaps in our understanding of bat-pathogen interactions have been exacerbated by limited integration among field studies of the bat immune response to infection, in vitro and in vivo experimental tests, and modeling frameworks that cross scales of biological organization. (frontiersin.org)
  • Years of studies have unraveled myriad macrophage pathways that combat pathogens and demonstrated how pathogen effectors subvert these mechanisms. (amc.edu)
  • Although plants have evolved a myriad of immune mechanisms, successful pathogens overcome the defence system and cause disease. (cam.ac.uk)
  • A deep understanding of the molecular mechanisms that underlie host-pathogen interactions is essential for developing durable disease resistance. (cam.ac.uk)
  • Our research involves using a range of biochemical approaches to address underlying mechanisms and processes in a range of biological and health related areas including innate immunity, rheumatoid arthritis, cancer, virology (including COVID19) and parasitology. (keele.ac.uk)
  • Current research interests including heme uptake, degradation and tolerance in GAS, and molecular mechanisms for heme and hemoglobin use in Streptococcus pneumoniae. (gsu.edu)
  • Her goal in this research is to uncover the neurophysiological mechanisms of short- and long-term drug use and its relation to negative affective behaviors. (vanderbilt.edu)
  • His research focus is to develop and apply proteomics based techniques to characterize the molecular mechanisms behind invasive bacterial infection. (lu.se)
  • During sepsis, these host defence systems become pathologically augmented and deregulated and we develop experimental models to delineate cellular and molecular mechanisms involved. (lu.se)
  • His research aims to elucidate molecular mechanisms underlying bacterial interactions with human cells and to use that information to identify targets for treatment and diagnostics of bacterial infections. (lu.se)
  • To the best of our knowledge, this is the first study that reports on platelet interactions of SBSEC-isolates other than Streptococcus gallolyticus subspecies gallolyticus as well as the first study to report of mechanisms of platelet interaction of SBSEC-isolates. (lu.se)
  • The course covers innate and acquired immunity, infection biology and host-pathogen interactions, mechanisms behind autoimmunity and allergy, vaccination, and evolution of animal immune systems. (lu.se)
  • Global analysis of Mtb transposon mutant fitness (TnSeq) across the CC panel revealed that many virulence pathways are only required in specific host microenvironments, identifying a large fraction of the pathogen's genome that has been maintained to ensure fitness in a diverse population. (elifesciences.org)
  • The project will seek to elucidate the role of quorum sensing pathways in host-pathogen and pathogen-commensal interactions. (fems-microbiology.org)
  • The Streptococcus bovis/Streptococcus equinus complex (SBSEC) contains known IE-pathogens, but there is limited research on the different subspecies ability to interact with platelets and what signaling pathways are involved. (lu.se)
  • Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. (ucsd.edu)
  • Both immunological and bacterial traits can be associated with genetic variants distributed across the mouse genome, making the CC a unique population for identifying specific host-pathogen genetic interactions that influence pathogenesis. (elifesciences.org)
  • Research projects include studies of viral molecular genetics and host cell genes and proteins involved in the pathogenesis of disease. (hopkinsmedicine.org)
  • To prevent clearance by the host immune system, they remodel their host cells by secreting proteins that co-opt, or interfere with host cell functions. (gulbenkian.pt)
  • In the lab we use a combination of unbiased genetic screens and reverse genetics to uncover the function of the secreted proteins in host-pathogen interaction. (gulbenkian.pt)
  • We also found Phytophthora virulence proteins, called effectors, that suppress host sRNAs as a counter-defence mechanism. (cam.ac.uk)
  • Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)
  • The dynamic interplay between virulence factors of a pathogen and the innate immunity of a host determines whether disease will occur. (cam.ac.uk)
  • Bats have been increasingly identified as hosts for zoonotic pathogens, including but not limited to viruses, bacteria, and protozoa. (frontiersin.org)
  • Zoonotic pathogens are twice as likely to be in species) rather than on the effects of disease that they this category as are nonzoonotic pathogens. (cdc.gov)
  • ToxA is a protein, a virulence factor, and one of the most studied necrotrophic effectors produced by plant pathogens. (usda.gov)
  • Aspergillus fumigatus is a ubiquitous airborne fungus and opportunistic human pathogen. (ilrs.de)
  • An updated literature survey identified 1,407 recog- these differ between the major pathogen groups or between nized species of human pathogen, 58% of which are zoonotic and nonzoonotic pathogens. (cdc.gov)
  • Aspergillus fumigatus is an opportunistic pathogen of humans. (jove.com)
  • Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus . (ilrs.de)
  • Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus . (ilrs.de)
  • Our research is focused but not limited to Aspergillus fumigatus ( Af ) related diseases. (amc.edu)
  • Two NIH-funded postdoctoral fellow positions are available in the group of Muthiah Kumaraswami in the Department of Infectious Diseases at Houston Methodist Research Institute . (fems-microbiology.org)
  • Promising areas of investigation such as the increasingly recognized relevance for the infectious process, of RNA-mediated regulations in the bacterium, and the role of bacterially controlled posttranslational and epigenetic modifications in the host will also be discussed. (pasteur.fr)
  • Our investigators study all aspects of infectious disease ranging from the fundamental science of microbial pathogens to the clinical outcomes of the infections they cause. (imperial.ac.uk)
  • Dr Teresa Thurston, Advanced Research Fellow in the Department of Infectious Disease, discusses her journey to obtaining a Fellowship. (imperial.ac.uk)
  • Emerging human genomics research will continue to provide insights into host-pathogen interactions and enhance the effectiveness of the public health response to infectious disease threats. (cdc.gov)
  • The models highlighted areas where pathogens of infectious disease were dispersed locally by examining the interactions between vectors, reservoirs and susceptible people (hosts) in a spatially explicit environment. (lu.se)
  • and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious and immune-mediated diseases. (cdc.gov)
  • Whole-blood models can help to elucidate host-pathogens interactions and have been used for several Candida species in human blood. (frontiersin.org)
  • An automated explainable bioinformatics and deep learning workflow to elucidate microbiome-metabolite relationships during a host-pathogen interaction. (ibm.com)
  • Many pathogenic bacteria, such as food-borne Staphylococcus aureus and Clostridium botulinum, secrete toxins into the host to cause symptoms. (wikipedia.org)
  • This causes an immune response, resulting in common symptoms as phagocytes break down the bacteria within the host. (wikipedia.org)
  • Many of the bacteria aid in the breaking down of nutrients for the host and, in return, our bodies act as their ecosystem. (wikipedia.org)
  • Jost Enninga's research relates to host-pathogenic bacteria interactions at cellular and molecular level. (pasteur.fr)
  • His team's work identified molecular cascades used by certain types of intracellular bacteria such as Shigella flexneri , Salmonella enterica , and Mycobacterium tuberculosis, enabling them to access the host cell cytosol. (pasteur.fr)
  • In this research, a novel microbial agent containing two thermotolerant nitrifying bacteria was identified and its impacts on nitrogen conversion, bacterial structure and functional genes during cattle manure composting were investigated. (bvsalud.org)
  • Oonagh Shannon is Associate Professor in Experimental Infection Medicine and she has a long-standing research interest in understanding the host response to bacteria that breach the bloodstream. (lu.se)
  • Current research targets ultrasonic separation and enrichment of cells, bacteria, virus and extracellular vesicles aimed at providing new technology for faster sepsis diagnostics. (lu.se)
  • Anders Håkansson is Professor in Experimental Infection Medicine at the Department of Translational Medicine and his group is focused on better understanding how bacteria interact with the host during severe infections such as pneumonia and sepsis. (lu.se)
  • We examined 3 aspects of host range, both for all pathogens combined and separately for each of the virus- es, bacteria, fungi, protozoa, and helminths. (cdc.gov)
  • While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this respect. (lu.se)
  • We offer you to join our dynamic team and contribute to the research of pathogenic bacteria. (lu.se)
  • European - American Journals are run by the European Centre for Research, Training and Development (ECRTD), UK . (eajournals.org)
  • Around 900 employees in research, administration and infrastructure, and about 220 visiting scientists from 40 different countries are employed at the Helmholtz Centre for Infection Research. (helmholtz-hzi.de)
  • From 1 July 2023, Prof Josef Penninger takes over the Scientific Management of the Helmholtz Centre for Infection Research (HZI). (helmholtz-hzi.de)
  • A directory of all members of the Research School of Biology. (edu.au)
  • The Cell Biology of Host - Pathogen Interaction Lab wants to find out how these parasites manage to infect human cells, how they evade the immune system, how they move through the body, and how they emerge to infect other people. (gulbenkian.pt)
  • While in her postdoctoral fellowship, she will be mentored by Dr. Danny Winder, director of the Vanderbilt Center for Addiction Research and Bixler-Johnson-Mayes Professor and professor of molecular physiology and biophysics at Vanderbilt, and Dr. Brian Nelms, dean of the School of Natural Sciences and Mathematics and associate professor of biology at Fisk. (vanderbilt.edu)
  • A recent large collaborative host genomics study provides valuable insight into the interplay of biology and epidemiology on COVID-19. (cdc.gov)
  • We obtained taxonomic classifications online from mation on the biology and epidemiology of recognized the International Committee on Taxonomy of Viruses, the human pathogens. (cdc.gov)
  • There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)
  • We leveraged the genetically diverse Collaborative Cross (CC) mouse panel in conjunction with a library of Mtb mutants to create a resource for associating bacterial genetic requirements with host genetics and immunity. (elifesciences.org)
  • Bacterial and viral pathogens are masters of exploiting weak points to establish infection and cause devastating diseases. (whiterose.ac.uk)
  • HIV and hepatitis B are viral infections caused by blood-borne pathogens. (wikipedia.org)
  • The lysogenic cycle, however, is when the viral DNA is incorporated into the host genome, allowing it to go unnoticed by the immune system. (wikipedia.org)
  • These studies are being extended to viral RNPs (the physiological RNA synthesis units) to understand the behaviour of the viral nucleoprotein during replication and transcription and to include host factors important for viral replication. (embl.org)
  • More than 30 bacterial, viral and parasitic pathogens are transmissible sexually. (who.int)
  • Yet such findings remain largely restricted to a small set of bat-pathogen interactions representing a minor pool of global bat diversity (>1400 species). (frontiersin.org)
  • In this Research Topic, we invite manuscripts to explore the diversity of bat-pathogen interactions and encourage opportunities to link different approaches and perspectives to bat immune systems. (frontiersin.org)
  • Endosymbionts in cranberries: diversity and effect on plant growth and pathogen biocontrol. (umontreal.ca)
  • That this is effective is demonstrated by the diversity of pathogens from distinct kingdoms capable of manipulating the same gene regulatory networks, such as the RNA silencing machinery. (nih.gov)
  • We focus mainly on pathogen diversity (as numbers of reemerging. (cdc.gov)
  • Pathogen species were categorized as emerging or emergence or reemergence, considering both the type and reemerging based on previously published reviews of the diversity of nonhuman hosts. (cdc.gov)
  • The host-pathogen interaction is defined as how microbes or viruses sustain themselves within host organisms on a molecular, cellular, organismal or population level. (wikipedia.org)
  • Viruses can also infect the host with virulent DNA, which can affect normal cell processes (transcription, translation, etc.), protein folding, or evading the immune response. (wikipedia.org)
  • this is when the virus inserts its DNA or RNA into the host cell, replicates, and eventually causes the cell to lyse, releasing more viruses into the environment. (wikipedia.org)
  • The coronaviruses are a family of viruses that includes a series of very different pathogens. (helmholtz-hzi.de)
  • It was during this time that my curiosity evolved into a passionate drive to understand the world of microbiology and host-pathogen interactions. (drexel.edu)
  • Bo Nilson combines clinical work and research at Clinical Microbiology, Lund University Hospital, Lund. (lu.se)
  • We are currently seeking highly motivated and dedicated Master's student to contribute to research in our well-established group of Clinical Microbiology situated on the Malmö hospital campus. (lu.se)
  • Although host genomics studies in COVID-19 are still a work in progress, this type of research has the potential for both a direct public health benefit resulting from genetic knowledge itself and an indirect benefit resulting from the use of genetics to identify modifiable environmental factors. (cdc.gov)
  • This study also provides insights into other benefits of host genomics research in COVID-19 through Mendelian randomization , a study design that uses human genetics as a proxy for modifiable exposures. (cdc.gov)
  • So, if you are a Master's student looking for a challenging but also rewarding research project, who is interested in bacterial genetics, we encourage you to apply to our project. (lu.se)
  • Bacterial genetics and evolution are discussed in relation to infection and interaction with the host. (lu.se)
  • The two laureats: Sigolène Meilhac, head of the Heart Morphogenesis 5-year group at the Institut Pasteur and Jost Enninga, head of the Institut Pasteur's Dynamics of Host-Pathogen Interactions Unit. (pasteur.fr)
  • In 2012, she was selected for the "jeunes chercheuses, jeunes chercheurs" young researchers program run by the French National Research Agency (ANR), and has directed the Heart Morphogenesis laboratory at the Institut Imagine and Institut Pasteur since 2015. (pasteur.fr)
  • Jost Enninga is a director of research at the Institut Pasteur where he manages the Dynamics of Host-Pathogen Interactions unit. (pasteur.fr)
  • In addition to his research, Jost Enniga is involved in scientific teaching as the joint organizer of a series of practical imaging courses at the Institut Pasteur and around the world. (pasteur.fr)
  • The Institut Pasteur has created the Pasteur International Joint Research Units in order to strengthen the partnership between the Institut Pasteur and its international partners and develop scientific collaborations that implement the Institut Pasteur international strategy. (pasteur.fr)
  • Matched large-scale culturing and whole-genome sequencing of over 800 bacterial strains from these babies identified virulence factors and clinically relevant antimicrobial resistance in opportunistic pathogens that may predispose individuals to opportunistic infections. (nature.com)
  • 2022 ) Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. (lu.se)
  • 2022 ) Protein domain-dependent vesiculation of Lipoprotein A, a protein that is important in cell wall synthesis and fitness of the human respiratory pathogen Haemophilus influenzae . (lu.se)
  • Host Range and Emerging and Reemerging Pathogens (including microsporidia), protozoa, and helminths. (cdc.gov)
  • The McCormick Lab has historically studied epithelial barrier function in the intestine and mucosal inflammation during enteric bacterial pathogen infection and inflammatory bowel diseases. (umassmed.edu)
  • Here, we will for the first time use the groundbreaking CRISPR technology to screen the human genome in macrophages infected with Mtb and discover genes that are critically involved in host-pathogen interactions. (europa.eu)
  • We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. (hopkinsmedicine.org)
  • Research in the Nicola Heller Lab focuses on the immunobiology of macrophages . (hopkinsmedicine.org)
  • We show sequences that spawn these antimicrobial sRNAs exhibiting a high level of diversification, consistent with their engagement in antagonistic interactions with pathogens. (cam.ac.uk)
  • Our findings highlight the critical role of the local environment in establishing the gut microbiota in very early life, and identify colonization with antimicrobial-resistance-containing opportunistic pathogens as a previously underappreciated risk factor in hospital births. (nature.com)
  • His research interest lies in epidemiology, early diagnostics, treatment and long-term outcomes of sepsis. (lu.se)
  • Toxoplasma and Plasmodium falciparum are two distantly related eukaryotic, single cell parasites of humans and animals that live and replicate in cells of their eukaryotic host. (gulbenkian.pt)
  • We identified a specific family of plant sRNAs that, instead of regulating endogenous gene expression, guide target gene silencing in the invading eukaryotic filamentous pathogen Phytophthora. (cam.ac.uk)
  • You will also employ functional assays investigating host-pathogen interactions in vitro, such as serum bactericidal assay or adherence to eukaryotic cells. (lu.se)
  • On the molecular and cellular level, microbes can infect the host and divide rapidly, causing disease by being there and causing a homeostatic imbalance in the body, or by secreting toxins which cause symptoms to appear. (wikipedia.org)
  • However, our understanding of how pathogens interact with cellular and humoral host factors in blood is limited, mainly due to technical issues: While it is relatively easy to study the interaction of pathogens with isolated blood cells, or their survival in serum or plasma, such approaches lack the complexity of interactions between different types of immune cells and additional factors, e.g., complement, present in blood. (frontiersin.org)
  • In immunocompromised hosts, the fungus can cause life-threatening diseases like invasive pulmonary aspergillosis. (ilrs.de)
  • My lab is interested in translational research with a focus on pulmonary diseases in immunocompromised persons. (amc.edu)
  • Hearing firsthand accounts of their battles with rampant pathogens and dysregulated immune functions opened my eyes to the world of immunology. (drexel.edu)
  • Immunology is one of the largest and most active areas for basic research in life science. (lu.se)
  • Moreover, knowledge in immunology and immunological laboratory techniques are key for applied research in many disciplines, for example drug development. (lu.se)
  • By doing so we hope to learn i) basic principles of pathogen evolution, ii) what makes one parasite strain more lethal than another, iii) how pathogens achieve tolerance in a host which is ultimately required for success, iv) learn about the immune response and v) identify therapeutic entry points that may allow development of intervention strategies. (gulbenkian.pt)
  • Within the host, pathogens can do a variety of things to cause disease and trigger the immune response. (wikipedia.org)
  • Here we report the disrupted transmission of maternal Bacteroides strains, and high-level colonization by opportunistic pathogens associated with the hospital environment (including Enterococcus , Enterobacter and Klebsiella species), in babies delivered by caesarean section. (nature.com)
  • against intestinal infections, Bacteroides -derived metabolites can also be utilized by pathogens," Westermann explains. (helmholtz-hzi.de)
  • Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. (ucsd.edu)
  • A recent rise in the identification and naming of ToxA haplotypes from species of the Pleosporales order by different research groups requires a standardization of this nomenclature. (usda.gov)
  • Emerging and impose, noting that many diseases, e.g., infant diarrhea, reemerging pathogens are not strongly associated with particular types of nonhuman hosts, but they are most like- can be caused by more than one species of pathogen. (cdc.gov)
  • tious disease, only a small minority have proved capable of We obtained counts of pathogen species from an updat- causing major epidemics in the human population. (cdc.gov)
  • We included pathogens than half known to be zoonotic, i.e., able to infect other that have only been reported as causing a single case of host species (1,2). (cdc.gov)
  • A imate factors or drivers that have been linked with species was regarded as emerging or reemerging if any pathogen emergence and reemergence and ask whether recognized variant fell into this category (e.g. (cdc.gov)
  • First, we dis- tinguished pathogen species according to whether they were known to be zoonotic, using the WHO definition "diseases or infections which are naturally transmitted between vertebrate animals and humans" (16). (cdc.gov)
  • Twenty-six isolates of the four most common species and subspecies of SBSEC identified in bacteremia were collected, and interactions with platelets were investigated in platelet rich plasma (PRP) from three donors. (lu.se)
  • Our group is interested in the research of clinically relevant bacterial species that mainly cause upper and lower airway infections and their interactions with the host. (lu.se)
  • There has been a slew of research over the past decade on biomarkers in respiratory infections , and we hope that we can summarize some of that data here today. (medscape.com)
  • The presence of these genes provides insights into the interactions of this pathogen with its gramineous host. (nih.gov)
  • Because of the impact of respiratory exposure on human health and disease, there has been considerable interest in developing reliable and predictive in vitro model systems for respiratory toxicology and basic research. (cdc.gov)
  • Exposures can be conducted using particulates, aerosols, gases, vapors generated from volatile and semi-volatile substances, and respiratory pathogens. (cdc.gov)
  • Although toxicity evaluations using human airway ALI models require further standardization and validation, this approach shows promise in supplementing or replacing in vivo animal models for conducting research on respiratory toxicants and pathogens. (cdc.gov)
  • The looming challenge of feeding the rapidly growing population is threatened by crop losses from plant diseases with an average of 10-15% of the yield being lost to pathogens and pests each year. (cam.ac.uk)
  • Some of the commonest sexually transmitted pathogens and the diseases they cause are shown in Table 1. (who.int)
  • This review highlights the dichotomous role of senescence in infection: an innate defence that is exploited by pathogens to cause disease. (whiterose.ac.uk)
  • Due to its extensive interface with the environment, the gill plays a key role as a primary mucosal defense tissue against pathogens, as manifested by the presence of the gill-associated lymphoid tissue (GIALT). (frontiersin.org)
  • Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
  • Dr Jamaspishvili conducts multi-disciplinary collaborative translational research projects with the goal to develop innovative strategies to advance biomarker assessment using quantitative digital pathology, computer vision and artificial intelligence (AI). (upstate.edu)
  • Given the large surface area and extensive ventilation of the lung, it is prone to exposure to airborne substances, such as pathogens, allergens, chemicals, and particulate matter. (cdc.gov)
  • We also focus research on a family of genes--the EPA genes--that allow the organism to bind to host cells. (hopkinsmedicine.org)
  • The Contributions of Host Genomics Research to the COVID-19 Response: It's Not Just About Genes! (cdc.gov)
  • For human blood, opsonization was shown to decrease platelet interaction suggesting that complement factors interfere with fungus-to-platelet binding. (frontiersin.org)
  • Note that this definition includes pathogens for which humans are the main host and other vertebrates are only occasional might be through an indirect route (e.g., a vector or an hosts, as well as the opposite, but excludes purely human intermediate host), from those for which humans can only pathogens that recently evolved from nonhuman acquire infection (directly or indirectly) from a nonhuman pathogens, e.g. (cdc.gov)