• The studies were conducted in zebrafish at Princeton and in African clawed frogs (Xenopus laevis) at Northwestern. (princeton.edu)
  • The two best-known species of this genus are Xenopus laevis and Xenopus tropicalis, which are commonly studied as model organisms for developmental biology, cell biology, toxicology, neuroscience and for modelling human disease and birth defects. (wikipedia.org)
  • Xenopus laevis is a rather inactive creature. (wikipedia.org)
  • At times the ponds that Xenopus laevis is found in dry up, compelling it, in the dry season, to burrow into the mud, leaving a tunnel for air. (wikipedia.org)
  • If the pond dries up in the rainy season, Xenopus laevis may migrate long distances to another pond, maintaining hydration by the rains. (wikipedia.org)
  • The females of many species produce a release call, and Xenopus laevis females produce an additional call when sexually receptive and soon to lay eggs. (wikipedia.org)
  • In 1931, Lancelot Hogben noted that Xenopus laevis females ovulated when injected with the urine of pregnant women. (wikipedia.org)
  • We examined the bioelectric properties (resting potential gradients in the epidermis) of Xenopus laevis froglets undergoing hindlimb amputation and observed that the contralateral (undamaged) limb exhibits apparent depolarization signals immediately after the opposite hindlimb is amputated. (biologists.com)
  • Membrane proteins in Xenopus laevis embryos were analysed on 1- and 2-dimensional gels. (warwick.ac.uk)
  • Microinjection of 30 S-methionine into Xenopus laevis embryos was used to investigate membrane protein synthesis. (warwick.ac.uk)
  • Dramatic changes in the composition of proteins synthesised during Xenopus laevis early development were noted, with most significant changes observed at the gastrula stage following the mid-blastula transition. (warwick.ac.uk)
  • Cell membrane variation in Xenopus laevis embryos was studied using cell surface labelling with 125 Iodine. (warwick.ac.uk)
  • Cell surface labelling with 125 Iodine was also used to characterise overall changes in the cell membrane during Xenopus laevis early development. (warwick.ac.uk)
  • Histo- autoradiography of 125 Iodine surface labelled embryos was used to confirm the origin of cleavage furrow membrane in the dividing embryo, and the source of ciliated cells from the double layered epidermis in Xenopus laevis neurulae. (warwick.ac.uk)
  • 2B12, a monoclonal antibody raised against adult Xenopus laevis brain tissue, was characterised on embryo and tissue sections using indirect immunofluoresence. (warwick.ac.uk)
  • Uma técnica para o transplante 'Extreme Anterior Domain' tecido facial entre embriões de Xenopus laevis foi desenvolvido. (jove.com)
  • TOF-SIMS 3D Biomolecular Imaging of Xenopus laevis Oocytes Using Buckminsterfullerene (C60) Primary Ions. (manchester.ac.uk)
  • And of all the amphibians available for study, the most valuable is Xenopus laevis, which is easy to keep and ovulates at any time of year in response to simple hormone injections. (cshlpress.com)
  • E ) Western blot on Hek293T cells extract transfected with the various Xenopus laevis protocadherin. (elifesciences.org)
  • For the first time, these nanoparticles were evaluated in an in vivo Xenopus laevis model to study whole organism toxicity and their impact on iron and zinc metabolic pathways. (uea.ac.uk)
  • This testing approach based on a battery of cellular systems and the use of the Xenopus laevis model could be a viable strategy for studying the toxicity, degradability and ultimately the long-term fate of zinc ferrites in the organism. (uea.ac.uk)
  • Nucleotide sequence analysis of TEF-1 delta cDNA revealed an open reading frame encoding the predicted protein of 281 amino acids and exhibited significant conservation with the corresponding protein of human, Xenopus laevis and Artemia. (cdc.gov)
  • Early Pleistocene Olduvai Formation, Tanzania Like many other frogs, they are often used in laboratory as research subjects.Xenopus embryos and eggs are a popular model system for a wide variety of biological studies. (wikipedia.org)
  • For a reverse experiment, DNA methylation in early Xenopus embryos was assessed by MBD affinity capture. (biomedcentral.com)
  • Embryos of zebrafish and Xenopus frogs are abundant, small and free-living. (nih.gov)
  • The advantages of Xenopus embryos as in vivo models to study human inherited diseases will be presented and their utility for drug discovery screening will be discussed. (nih.gov)
  • Xenopus embryos have been studied for years but this is a particularly exciting time for the field. (cshlpress.com)
  • This manual contains a comprehensive collection of protocols for the study of early development in Xenopus embryos. (cshlpress.com)
  • In this paper we address this problem by taking advantage of the observation that the transcription activator Brachyury is essential for gastrulation movements in Xenopus and mouse embryos. (elsevierpure.com)
  • 1. A cDNA library was constructed with mRNA isolated from stage 8 Xenopus embryos. (mun.ca)
  • Szl can dorsalize Xenopus embryos if expressed after the midblastula transition, strengthening the idea that zygotic expression of wnts and in particular of Xwnt8 plays a role in antagonizing dorsal signals. (wustl.edu)
  • We have cloned 17 fgf genes from Xenopus tropicalis and have analysed their temporal expression by RT-PCR and spatial expression by whole mount in situ hybridisation at key developmental stages. (manchester.ac.uk)
  • Xenopus tropicalis DnaJ heat shock protein family (Hsp40) member B11 (dnajb11), mRNA. (genscript.com)
  • Proteins showing temporal variation in their expression in the membrane during Xenopus development were detected. (warwick.ac.uk)
  • Here, we show that Claspin associates with several core replication fork proteins in Xenopus egg extracts. (caltech.edu)
  • Furthermore, Xenopus oocytes are a leading system for studies of ion transport and channel physiology. (wikipedia.org)
  • Here we show that the activation kinetics of I sK expressed in Xenopus oocytes depend upon the amount of its mRNA injected, with larger amounts resulting in slower activation kinetics with a longer initial delay during activation. (wustl.edu)
  • Here, we tested modulations of human KCNQ1 channels by an activator ML277 in Xenopus oocytes. (elifesciences.org)
  • Xenopus has long been an important tool for in vivo studies in molecular, cell, and developmental biology of vertebrate animals. (wikipedia.org)
  • Thus, Xenopus is a vertebrate model system that allows for high-throughput in vivo analyses of gene function and high-throughput biochemistry. (wikipedia.org)
  • However, the wide breadth of Xenopus research stems from the additional fact that cell-free extracts made from Xenopus are a premier in vitro system for studies of fundamental aspects of cell and molecular biology. (wikipedia.org)
  • Endogenous MeCP2 and MBD3 were precipitated from Xenopus oocyte extracts and conditions for methylation-specific binding were optimized. (biomedcentral.com)
  • We analyzed genome-wide changes in DNA methylation and their relationship to gene regulation in the brain of Xenopus tadpoles during metamorphosis, a thyroid hormone-dependent developmental process. (nih.gov)
  • For over a century amphibians from the genus Xenopus have been the organisms of choice to study developmental processes. (biomedcentral.com)
  • Xenopus is also a unique system for analyses of genome evolution and whole genome duplication in vertebrates, as different Xenopus species form a ploidy series formed by interspecific hybridization. (wikipedia.org)
  • This volume is essential reading for all investigators interested in the developmental and cell biology of Xenopus and vertebrates generally. (cshlpress.com)
  • Being a tetrapod, Xenopus complements zebrafish as an indispensable non-mammalian animal model for the study of human disease pathologies and the discovery of novel therapeutics for inherited diseases. (nih.gov)
  • As a result, a sophisticated new understanding of Xenopus development has emerged, which ensures the species continued prominent position among the organisms favored for biological investigation. (cshlpress.com)
  • Like the wild type XFGFR-1, XFGFR-A3 is also uniformly expressed throughout Xenopus development. (mun.ca)
  • Here, we will review the rapid progress made in adapting these novel genome editing tools to Xenopus. (nih.gov)
  • The open session of the National Advisory Council for Human Genome Research was convened for its thirty-eighth meeting at 8:40 a.m. on September 13, 2004 at the Natcher Conference Center, National Institutes of Health, Bethesda, MD. Francis Collins, Director of the National Human Genome Research Institute, called the meeting to order. (genome.gov)
  • Genome Research. (dtu.dk)
  • Several online books for comprehensive coverage of a particular research field, biological question, or technology. (bioconductor.org)
  • All species of Xenopus have flattened, somewhat egg-shaped and streamlined bodies, and very slippery skin (because of a protective mucus covering). (wikipedia.org)
  • Xenopus species are entirely aquatic, though they have been observed migrating on land to nearby bodies of water during times of drought or in heavy rain. (wikipedia.org)
  • The Xenopus species are also active during the twilight (or crepuscular) hours. (wikipedia.org)
  • and in terms of careers that our graduates go on to, loads of different options are available to them, whether that's more academics so perhaps following a PhD, postgraduate research pathway or in an industrial lab, or we have students who've gone into teaching. (port.ac.uk)
  • This research evaluates the economic sustainability of rabbit farms using different housing systems-bicellular (BI), conventional dual-purpose (DP) and enriched cages designed according to the World Rabbit Science Association guidelines (WRSA)-through a field-based study involving six. (awionline.org)
  • Alternatively, use the search form below to search the faculty research interest pages for keywords. (berkeley.edu)
  • We're researching how microbes can cause infectious diseases and benefit human health, and tackling antibiotic resistance by identifying new molecules in pathogenic microbes. (port.ac.uk)
  • While non-human primate studies have long been conducted in laboratories, and more recently at zoological parks, sanctuaries are increasingly considered a viable setting for research. (awionline.org)
  • Advances in Cancer Research, Vol. 159). (dtu.dk)
  • Proceedings of the 93rd American Association for Cancer Research Annual Meeting, April 6-10, 2002, San Francisco, California. (cdc.gov)
  • During neurogenesis in Xenopus, apicobasally polarised superficial and non-polar deep cells take up different fates: deep cells become primary neurons while superficial cells stay as progenitors. (bath.ac.uk)
  • Between 2013 and 2020, we secured research income of £14.7 million, averaging around £2 million per year. (port.ac.uk)