• tetracycline repressor protein
  • Inducers and Induction of the Tetracycline Repressor Protein: Computational Studies Den Naturwissenschaftlichen Fakultäten der Friedrich-Alexander-Universität Erlangen-Nürnberg zur Erlangung des Doktorgrades vorgelegt von Olaf G. Othersen aus Bamberg Als Dissertation genehmigt von den Naturwissenschaftlichen Fakultäten der Universität Erlangen-Nürnberg Tag der mündlichen Prüfung: 19.12.2006 Vorsitzender der Promotionskommission: Professor Dr. E. Bänsch Erstberichterstatter: Professor Dr. T. Clark Zweitberichterstatter: Professor DrA. (youscribe.com)
  • Amino Acids
  • Δ324 found at low levels in human and mouse cells - an alternative splice variant encoding an 88kDa protein lacking zinc fingers 6 and 7 Δ105 variant is unique to mice, and results in a protein truncated by 105 amino acids at the acidic C-terminus. (wikipedia.org)
  • Homeodomain
  • The Proline-Rich Homeodomain protein (PRH/Hex) is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haematopoiesis. (bham.ac.uk)
  • interaction
  • Cooperativity between KorB and either KorA or TrbA repressor proteins is a key element of these circuits and deletion analysis has implicated the conserved C-terminal domain of KorAand TrbAin this interaction. (bham.ac.uk)
  • Studies on mutants showed that tyrosine 84 (or phenylalanine, in some alleles) is dispensable for repressor activity but critical for the specific interaction with KorB in both in vivo reporter gene assays and in vitro electrophoretic mobility shift and co-purification assays. (bham.ac.uk)
  • This study aims to study the significance of the FIR-SAP155 interaction for the coordination of c-myc transcription, pre-mRNA splicing, and c-Myc protein modification, as well as to interrogate FIRΔexon2 for other functions relating to altered FIR pre-mRNA splicing. (aacrjournals.org)
  • Bunker, C. A. and Kingston, R. E. (1995) Identification of a cDNA for SSRP1, an HMG-box protein, by interaction with the c-Myc oncoprotein in a novel bacterial expression screen. (springer.com)
  • SAP30 proteins provide the first example in which the DNA and PIs seem to stand in a mutually antagonizing interrelationship in regard to their interaction with zinc finger proteins and thus exemplifies the molecular mechanism how these lipids can contribute for gene regulation. (wikipedia.org)
  • operator
  • and protein production is induced by addition of tetracycline.The addition of an extra nucleotide destabilizes the repressor-operator roadblock. (1004682.gq)
  • More specifically, TetR represses the expression of TetA, a membrane protein that pumps out substances toxic to the bacteria, by binding the TetA operator. (wikipedia.org)
  • isoforms
  • Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus. (wikipedia.org)
  • A large number of transcript variations exist, encoding different isoforms or chimeric proteins. (wikipedia.org)
  • dimeric
  • B) Active repressor fusions can be reconstituted when a dimeric peptide/protein is placed at the C terminus. (springer.com)
  • In this example the fusion is dimeric but a higher order oligomer can also reconstitute the activity of the repressor. (springer.com)
  • In animals, as well as some fungi such as yeast, these same reactions occur on fatty acid synthase I (FASI), a large dimeric protein that has all of the enzymatic activities required to create a fatty acid. (wikipedia.org)
  • 1992
  • Within each A/P domain, a different HOX protein assigns positional identities which are eventually realized in diverse morphological structures on the segmented A/P axis of the Drosophila embryo ( McGinnis and Krumlauf, 1992 ). (embopress.org)
  • molecules
  • Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus.Thomas Simonson's Research Group. (1004682.gq)
  • They are usually constantly expressed so the cell always has a supply of repressor molecules on hand. (wikipedia.org)
  • kinase
  • Phosphorylation of Thr at position 148 is detected in response to various stress conditions such as UV irradiation, oxidative stress, and anisomycin treatment or JDP2 is also regulated by other kinases such as p38 MAPK and doublecortin like protein kinase. (wikipedia.org)
  • Peptides
  • One of the library encoded peptides (C 2 ) is able to form a heterodimer with the target peptide reconstituting the activity of λ repressor. (springer.com)
  • mutations
  • for tetracycline-inducible bacteriophage-T7-based expression in the LEXSY host T7.Two mutations in the tetracycline repressor. (1004682.gq)
  • Mutations that change the affinity of a small autoactivation element for EXD protein result in corresponding changes in the element's embryonic activity. (embopress.org)
  • family
  • TetR is one of many proteins in the TetR protein family, which is so named because TetR is the most well characterized member. (wikipedia.org)
  • These domains mainly consist of a helix-turn-helix (HTH) motif that is common in TetR protein family members (see below). (wikipedia.org)
  • As of December 2004, this family of proteins has about 2,353 members that are transcriptional regulators. (wikipedia.org)
  • In the majority of the family members, this motif is on the N-terminal end of the protein and is highly conserved. (wikipedia.org)
  • TGF-β, along with other TGF-β family ligands such as bone morphogenic protein (BMP) and activin are involved in regulating important cellular functions such as proliferation, differentiation, apoptosis, and matrix production. (wikipedia.org)
  • SAP30 and SAP30L together constitute a well-conserved SAP30 protein family. (wikipedia.org)