• genes
  • In non-recombining regions of the Y chromosome repetitive DNA sequences are accumulated, representing a dominant and early process forming the Y chromosome, probably before genes start to degenerate. (biomedsearch.com)
  • The clones containing 5S rDNA genes, 18S-25S rDNA sequences and the 180 bp paracentromeric repeated element account for 3.6%, 8.9% and 5.8%, respectively. (harvard.edu)
  • Previous studies of repetitive elements (REs) have implicated a mechanistic role in generating new chimerical genes. (nih.gov)
  • Examination of their flanking sequences revealed an excess of repetitive sequences, with the majority belonging to the transposable element DNAREP1 family, associated with the new genes. (nih.gov)
  • With his move to the University of Cologne he started projects in comparative genomics, with a special focus on the evolution of new genes, which resulted in the discovery of de novo evolution of genes from non-coding sequences. (wikipedia.org)
  • citation needed] Yeast SRP RNA genes have a TATA box and additional intragenic promoter sequences (referred to as A- and B-blocks) which play a role in regulating transcription of the SRP gene by Pol III. (wikipedia.org)
  • Although the repetitive nature of MAEB stem-loops supports this kind of a role, the association of MAEB with metabolic genes is inconsistent with known repetitive elements, which are typically the result of selfish replication or errors in replication. (wikipedia.org)
  • Some types of interspersed repetitive DNA elements allow new genes to evolve by uncoupling similar DNA sequences from gene conversion during meiosis. (wikipedia.org)
  • Repetitive sequences play the role of uncoupling the gene conversion network, thereby allowing new genes to evolve. (wikipedia.org)
  • By breaking the links that would otherwise overwrite novel DNA sequence variations, interspersed repeats catalyse evolution, allowing the new genes and new species to develop. (wikipedia.org)
  • genomic
  • Several allelic variants of this tandemly repeated sequence can be resolved by genomic blotting. (biomedsearch.com)
  • Reference-free SNP calling: improved accuracy by preventing incorrect calls from repetitive genomic regions. (nih.gov)
  • The advent of next-generation sequencing (NGS) technologies has made it possible to efficiently genotype a large number of SNPs in the non-model organisms with no or limited genomic resources. (nih.gov)
  • The iML algorithm incorporates the mixed Poisson/normal model to detect composite read clusters and can efficiently prevent incorrect SNP calls resulting from repetitive genomic regions. (nih.gov)
  • The iML algorithm can efficiently prevent incorrect SNP calls resulting from repetitive genomic regions, and thus outperforms the original ML algorithm by achieving much higher genotyping accuracy. (nih.gov)
  • The results highlight the promise of next generation sequencing for development of genomic resources for any organism. (nih.gov)
  • In many organisms, a significant fraction of the genomic DNA is highly repetitive, with over two-thirds of the sequence consisting of repetitive elements in humans. (wikipedia.org)
  • JDotter - Java version of Dotter Dotplot, easy (educational) HTML5 tool to generate dot plots from RNA sequences lastz and laj, programs to prepare and visualize genomic alignments. (wikipedia.org)
  • gene
  • We determined the DNA sequence of a gonococcal H.8 gene, and confirmed the relationship between the cloned gene and the H.8 OMP by constructing a gonococcal mutant lacking H.8. (biomedsearch.com)
  • The common SINE family Alu probably originated from a 7SL RNA gene after deletion of a central sequence. (wikipedia.org)
  • Gene conversion acts on DNA sequence homology as its substrate. (wikipedia.org)
  • The shorter Alu or SINE repetitive DNA are specialized for uncoupling intrachromosomal gene conversion while the longer LINE repetitive DNA are specialized for uncoupling interchromosomal gene conversion. (wikipedia.org)
  • DNA sequences are linked together in a gene pool by gene conversion events. (wikipedia.org)
  • LTR retrotransposons are further sub-classified into the Ty1-copia-like (Pseudoviridae), Ty3-gypsy-like (Metaviridae), and BEL-Pao-like groups based on both their degree of sequence similarity and the order of encoded gene products. (wikipedia.org)
  • Evolution
  • Here we review the occurrence and role of repetitive DNA in Y chromosome evolution in various species with a focus on dioecious plants. (biomedsearch.com)
  • Controversial references to 'junk' or 'selfish' DNA were put forward early on, implying that repetitive DNA segments are remainders from past evolution or autonomous self-replicating sequences hacking the cell machinery to proliferate. (wikipedia.org)
  • probe
  • Commonly cDNA is created with labelled primers for the RNA sequence of interest to act as the probe in the northern blot. (wikipedia.org)
  • Biological
  • In bioinformatics a dot plot is a graphical method that allows the comparison of two biological sequences and identify regions of close similarity between them. (wikipedia.org)
  • sugars
  • The role of RNA in the origin of life is best supported by the ease of forming RNA from basic chemical building blocks (such as amino acids, sugars, and hydroxyl acids) that were likely present 4 billion years ago. (wikipedia.org)
  • One of the main constrains in the glycoinformatics is the difficulty of representing sugars in the sequence form especially due to their branching nature. (wikipedia.org)
  • similarity
  • For a simple visual representation of the similarity between two sequences, individual cells in the matrix can be shaded black if residues are identical, so that matching sequence segments appear as runs of diagonal lines across the matrix. (wikipedia.org)
  • Some idea of the similarity of the two sequences can be gleaned from the number and length of matching segments shown in the matrix. (wikipedia.org)
  • The closeness of the sequences in similarity will determine how close the diagonal line is to what a graph showing a curve demonstrating a direct relationship is. (wikipedia.org)
  • RNAs
  • For example, the RNA interference (RNAi) mechanism of small interfering RNAs derived from L1 sequences can cause suppression of L1 retrotransposition. (wikipedia.org)
  • whereas
  • For A. thaliana, iML always generated lower FPRs than the threshold approach or ML with 12 ~ 19%, 6 ~ 11% and 2 ~ 4% FPR reductions corresponding to the read lengths of 35, 50 and 100 bp, respectively, at a 40x sequencing depth, whereas iML generated only slightly higher FNRs (~1%) in comparison with ML (Figure 3A, Additional file 3: Table S3). (nih.gov)
  • Activation was achieved by transmembrane sequences such as [VVVEVVA]n or [VVVEVVV]n, whereas activation was not achieved by a transmembrane domain consisting only of Val residues. (nih.gov)
  • insertion
  • Furthermore, retrotransposon-induced mutations are relatively stable, because the sequence at the insertion site is retained as they transpose via the replication mechanism. (wikipedia.org)
  • repeat
  • Accordingly, a repetitive unit of a particular microsatellite locus is commonly referred to as a mono-, di-, tri-, tetra- or pentanucleotide repeat locus, as applicable. (google.com)