• MYOCARDIUM
  • As opposed to reducing the exposure of cardiomyocytes to injurious stimuli, apoptosis of these cells is attenuated through modulation of the caspase-related proapoptotic process, and this may allow ischemic myocardium to survive even after receiving significant injury. (ahajournals.org)
  • After MI, the myocardium suffers from reperfusion injury which leads to death of cardiomyocytes and detrimental remodelling of the heart, consequently reducing proper cardiac function. (wikipedia.org)
  • superoxide
  • These results provide a basic molecular framework for understanding one apoptotic pathway that is induced by reperfusion (Figure 1 ⇓ ), but multiple questions remain to be answered by future studies: (1) Which ROS (superoxide, hydrogen peroxide, hydroxyl radical, peroxynitrite, or others) generated by reperfusion are responsible for the induction of neutral sphingomyelinase activity? (ahajournals.org)
  • acute kidney
  • Serum creatinine and BUN may be elevated in the setting of Acute Kidney Injury. (wikipedia.org)
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
  • Patients undergoing long-lasting, abdominal, and urogenital surgeries with risk factors such as advanced age, peripheral artery disease, diabetes mellitus, renovascular disease, and congestive heart failure are candidates for acute kidney injury (AKI) due to impaired renal perfusion and decreased functional renal reserve. (dovepress.com)
  • apoptotic
  • The results of this study indicate that the occurrence of inflammation and the subsequent cell death by apoptosis are the most important changes in the early stage of hepatic reperfusion injury and the presence of apoptotic bodies were augmented as the time of reperfusion was increased. (medindia.net)
  • inflammation
  • Continuous pressure limits blood supply and causes ischemia, and the inflammation occurs during reperfusion. (wikipedia.org)
  • We therefore hypothesize that administration of human AM/AMBP-1, even after reperfusion, improves cardiovascular function, attenuates organ injury and inflammation responses, and reduces mortality following gut I/R injury. (sbir.gov)
  • However, during reperfusion not only some changes including bleb formation was reduced, but some other alterations including portal hepatitis, inflammation and the induction of apoptosis, were occurred. (medindia.net)
  • PPIB localizes to the endoplasmic reticulum (ER) and participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer. (wikipedia.org)
  • Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leighs disease, and Melas disease, and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. (wikipedia.org)
  • inflammatory
  • Some theorize that this delayed reaction derives from the various inflammatory immune responses that occur during reperfusion. (wikipedia.org)
  • These inflammatory responses cause intracranial pressure, pressure which leads to cell injury and in some situations cell death. (wikipedia.org)
  • organ
  • As such, the development of effective strategies for preventing and treating circulatory collapse and organ injury after gut I/R is critical for the improvement of patient outcome under such conditions. (sbir.gov)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • reduces
  • Although we have shown that administration of rat AM plus human AMBP-1 at the beginning of reperfusion is protective, it remains unknown whether a combination of human AM and human AMBP-1 is also beneficial and, if so, whether delayed administration of AM/AMBP-1 (which is more clinically relevant) reduces gut I/R-induced mortality. (sbir.gov)
  • Transfection of cardiac myocytes with human HGF reduces ischemic reperfusion injury after MI. (wikipedia.org)
  • cardiac
  • Until the 1980s, the enzymes SGOT and LDH were used to assess cardiac injury. (wikipedia.org)
  • Transfection with HGF plasmids in damaged cardiac tissue also promotes angiogenesis (increased capillary density compared to control subjects), as well as decreasing detrimental remodelling of the tissue at the site of injury (decreased fibrotic deposition). (wikipedia.org)
  • surgical
  • Blood samples were drawn from all animals to evaluate plasma neutrophil gelatinase-associated lipocalin (NGAL) at the beginning, 15 minutes after ischemia, 15 minutes after reperfusion, and 6 hours after the surgical procedure (T0, T1, T2, and T3, respectively). (dovepress.com)
  • therapeutic
  • Taken together, naringin could be a potential therapeutic agent to prevent the brain from I/R injury via attenuating ONOO − -mediated excessive mitophagy. (springer.com)
  • cellular
  • Systemic effects of IR injury During periods of ischemia, cellular break down products accumulate in the local tissue. (wikipedia.org)
  • It is produced and proteolytically cleaved to its active state in response to cellular injury or during apoptosis. (wikipedia.org)
  • Therapy
  • The 12 lead ECG is used to classify patients into one of three groups: those with ST segment elevation or new bundle branch block (suspicious for acute injury and a possible candidate for acute reperfusion therapy with thrombolytics or primary PCI), those with ST segment depression or T wave inversion (suspicious for ischemia), and those with a so-called non-diagnostic or normal ECG. (wikipedia.org)
  • mechanisms
  • However, the detailed mechanisms of cell death and the structural alterations induced during different stages of reperfusion injury i.e. the early stage, are not completely determined yet. (medindia.net)
  • hours
  • 7. The method of claim 4 , wherein the PS-binding agent is administered to the patient up to about 6 hours prior to reperfusion. (google.com)
  • regeneration
  • Stem cells have been implicated in the regeneration of skeletal muscle after traumatic and blast injuries, and have been shown to hone to muscle damaged after exercise. (wikipedia.org)
  • protective effect
  • In addition, the protective effect of hypothermia on IR injury was investigated using a new method for in situ hypothermic perfusion (IHP). (uva.nl)
  • treatment
  • and 3) the pharmacokinetics of AM and AMBP-1 in normal animals and after gut I/R. Our ultimate goal (SBIR Phase II and beyond) is to obtain commercial utilization of human AM/AMBP-1 as a safe and effective treatment for patients with gut I/R injury. (sbir.gov)
  • cardiomyocytes
  • The increased production of HGF by transfected cardiomyocytes during injury has also shown to be a powerful chemo-attractant of adult mesenchymal stem cells via HGF/c-Met binding. (wikipedia.org)
  • vascular
  • Recognizing this, surgeons frequently prophylacticly release (i.e., incise) fascia of arm and leg fascial compartments after repair of a proximal vascular injury. (wikipedia.org)
  • results
  • Professor Dan Atar, the Coordinating Investigator of the F.I.R.E. (FX06 In ischemia and REperfusion) trial, a Phase II clinical study of FX06, will present the results of the trial at: 12-noon on September 2nd in the Hot Line III Session at the European Society of Cardiology Congress in Munich, Germany. (innovations-report.com)