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  • cardioprotection
  • We have reported that NFkB activation is increased in the heart following I/R. We have also observed that modulation of TLR signaling pathways was induce cardioprotection in I/R. Our long-term goals are to elucidate the immunoregulatory and pro-inflammatory signaling mechanisms associated with myocardial I/R injury. (etsu.edu)
  • infarct
  • By contrast a competing strategy using nicorandil, a nicotinamide nitrate that activates potassium channels, did not reduce infarct size or reduce reperfusion injury. (medpagetoday.com)
  • The J-WIND trial was actually two parallel trials of different strategies to reduce infarct size, improve ejection fraction, and reduce revascularization injury. (medpagetoday.com)
  • Dr. Harrington, who served as discussant for the J-WIND trial, noted that about a dozen drugs that were tested for reduction of infarct size and reperfusion injury "all reported early, positive results. (medpagetoday.com)
  • organ
  • As such, the development of effective strategies for preventing and treating circulatory collapse and organ injury after gut I/R is critical for the improvement of patient outcome under such conditions. (sbir.gov)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • NECROSIS
  • The Phase II clinical trial of FX06 (F.I.R.E. study) was completed in March 2008, with data indicating a statistically significant reduction in myocardial necrosis following intravenous application of FX06 concurrent with reperfusion. (innovations-report.com)
  • cardiac
  • Until the 1980s, the enzymes SGOT and LDH were used to assess cardiac injury. (wikipedia.org)
  • Now, the markers most widely used in detection of MI are MB subtype of the enzyme creatine kinase and cardiac troponins T and I as they are more specific for myocardial injury. (wikipedia.org)
  • Transfection of cardiac myocytes with human HGF reduces ischemic reperfusion injury after MI. (wikipedia.org)
  • Transfection with HGF plasmids in damaged cardiac tissue also promotes angiogenesis (increased capillary density compared to control subjects), as well as decreasing detrimental remodelling of the tissue at the site of injury (decreased fibrotic deposition). (wikipedia.org)
  • reduces
  • Although we have shown that administration of rat AM plus human AMBP-1 at the beginning of reperfusion is protective, it remains unknown whether a combination of human AM and human AMBP-1 is also beneficial and, if so, whether delayed administration of AM/AMBP-1 (which is more clinically relevant) reduces gut I/R-induced mortality. (sbir.gov)
  • species
  • J. D. Stoner, T. L. Clanton, S. E. Aune, and M. G. Angelos, "O 2 delivery and redox state are determinants of compartment-specific reactive O 2 species in myocardial reperfusion," American Journal of Physiology-Heart and Circulatory Physiology , vol. 292, no. 1, pp. (hindawi.com)
  • Therapy
  • Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm. (curehunter.com)
  • The 12 lead ECG is used to classify patients into one of three groups: those with ST segment elevation or new bundle branch block (suspicious for acute injury and a possible candidate for acute reperfusion therapy with thrombolytics or primary PCI), those with ST segment depression or T wave inversion (suspicious for ischemia), and those with a so-called non-diagnostic or normal ECG. (wikipedia.org)
  • Regeneration
  • R. Couteaux, J.-C. Mira, and A. d'Albis, "Regeneration of muscles after cardiotoxin injury. (hindawi.com)
  • Stem cells have been implicated in the regeneration of skeletal muscle after traumatic and blast injuries, and have been shown to hone to muscle damaged after exercise. (wikipedia.org)
  • skeletal muscle
  • Functional, cellular and molecular aspects of skeletal muscle recovery after injury induced by snake venom from Notechis scutatus scutatus," Toxicon , vol. 45, no. 6, pp. 789-801, 2005. (hindawi.com)
  • patients
  • and 3) the pharmacokinetics of AM and AMBP-1 in normal animals and after gut I/R. Our ultimate goal (SBIR Phase II and beyond) is to obtain commercial utilization of human AM/AMBP-1 as a safe and effective treatment for patients with gut I/R injury. (sbir.gov)
  • The F.I.R.E. (FX06 In Ischemia and REperfusion) trial was conducted between October 2006 and March 2008 as a randomized, double-blind, placebo-controlled study involving 234 patients from 26 leading centres of interventional cardiology in Europe. (innovations-report.com)
  • illnesses and injuries
  • Due to the unplanned nature of patient attendance, the department must provide initial treatment for a broad spectrum of illnesses and injuries, some of which may be life-threatening and require immediate attention. (wikipedia.org)
  • The most seriously ill or injured patients will be dealt with in this area, as it contains the equipment and staff required for dealing with immediately life-threatening illnesses and injuries. (wikipedia.org)
  • Emergency medical services, also known as ambulance services or paramedic services (abbreviated to the initialism EMS, EMAS, EMARS or SAMU in some countries), are a type of emergency service dedicated to providing out-of-hospital acute medical care, transport to definitive care, and other medical transport to patients with illnesses and injuries which prevent the patient from transporting themselves. (wikipedia.org)
  • lung
  • Blood and bronchoalveolar lavage (BAL) fluid were collected from 35 patients with acute lung injury (ALI)/ARDS, 14 patients at risk from ARDS and 7 ventilated controls at baseline and after 4 days' treatment with placebo or salbutamol (ALI/ARDS group). (bmj.com)
  • Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are major causes of respiratory failure in the critically ill patient. (bmj.com)
  • 4, 5 The number of neutrophils in BAL fluid relates to the severity of lung injury, 6 and the persistence of neutrophils is associated with increased mortality. (bmj.com)
  • 7 Animal studies have shown that neutrophil-mediated lung injury reduces alveolar fluid clearance, preventing the resolution of non-cardiogenic pulmonary oedema. (bmj.com)
  • 8 Neutrophil elastase inhibitors in animal models limit the degree of lung injury caused by ischaemia reperfusion 9 and lipopolysaccharide (LPS), 10 although a recent multicentre clinical trial of the elastase inhibitor Sivelestat failed to improve outcome in a heterogeneous group of patients with ARDS. (bmj.com)
  • Buckberg introduced the concept of "unintended reoxygenation injury" when blue babies (cyanotic) are placed on cardiopulmonary bypass (heart-lung machine) to correct the congenital defect causing cyanosis. (wikipedia.org)
  • damage
  • This study called attention to the role of active interventions, including antioxidants, to limit this injury, and provided the first evidence of a new biochemical pathway that causes this damage. (wikipedia.org)
  • heart
  • The diagnostic potential of the biomarker H-FABP for heart injury was discovered in 1988 by Professor Jan Glatz (Maastricht, Netherlands). (wikipedia.org)
  • role
  • It has been demonstrated that high concentrations of oxygen lead to generation of oxygen free radicals, which have a role in reperfusion injury after asphyxia. (wikipedia.org)
  • human
  • Hepatitis is caused by many factors including alcohol, viruses, drugs, immune injury, and idiopathic factors and has remained a serious human health problem throughout the world [ 1 , 2 ]. (hindawi.com)