• However, the level in which these B[a]P regulated genes are expressed differs between Wt and Xpc-/- mice (p = 0.000000141), and were predominantly involved in the regulation of cell cycle, translation, chromatin structure and spermatogenesis, indicating a general stress response. (maastrichtuniversity.nl)
  • Exposure to benzo(a)pyrene affected the expression of genes that are involved in cell cycle regulation in both genotypes, indicating that the presence of unrepaired DNA damage in testis blocks cell proliferation to protect DNA integrity in both DNA repair proficient and deficient animals. (maastrichtuniversity.nl)
  • repair, regulation, and genomic analysis. (cdc.gov)
  • Our study provides first evidence for a compensatory regulation of DNA-repair mechanisms in PTSD. (uni-konstanz.de)
  • Similarly, while your genes are "fixed", the expression of those genes - the amount of proteins they cause to be made, whether or not they are even switched on or off at all - depends on the "environment," the circumstances surrounding those genes . (marksdailyapple.com)
  • Her interests are directed towards understanding the fidelity of human DNA polymerases in addition to studying proteins involved in mismatch repair processes. (nih.gov)
  • In prokaryotes, the NER complex consists of the three Uvr proteins, but in eukaryotes, more than a dozen proteins operate to regulate DNA repair. (jove.com)
  • They destroy the RNA before it can make proteins - say, in a matter of a few hours - and, in doing so, destroy the gene editing attempt. (eurekalert.org)
  • The protein produced from this gene is part of a group of proteins (a complex) that helps regulate several critical functions within cells. (medlineplus.gov)
  • The course comprises molecular biology of genes, proteins, multicomponent protein complexes, and other biomolecules that provide structure and perform the organism's functions. (lu.se)
  • Users can either search the database for a particular gene of interest and check its expression across a number of experimental conditions, or set statistical thresholds and obtain lists of differentially-expressed transcripts, which can then be compared across datasets and annotated. (hdinhd.org)
  • RESULTS: Two-Way ANOVA revealed only 4 genes differentially expressed between wild type and Xpc-/- mice, and 984 genes between testes of B[a]P treated and untreated mice irrespective of the mouse genotype. (maastrichtuniversity.nl)
  • CONCLUSIONS: Gene expression in testis of untreated Xpc-/- and wild type mice were very similar, with only 4 genes differentially expressed. (maastrichtuniversity.nl)
  • The expression of the following genes was salient: (a) Cd163, an anti-inflammatory stroke-associated gene, was the most differentially expressed gene by NPD1+RvD1, displaying more than a 123-fold upregulation in the ipsilesional penumbra (Lisi et al. (springer.com)
  • Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
  • Examples include inherited mutations in BRCA1/2 in breast and ovarian cancer, and mutations in mismatch repair genes (Lynch syndrome) in colorectal and endometrial cancer. (cdc.gov)
  • Other processes that were expected to have changed by exposure, like apoptosis and DNA repair, were not found to be modulated at the level of gene expression. (maastrichtuniversity.nl)
  • Study published in BMC Cancer found genes associated with metabolism, membrane drug pumps, DNA repair, and apoptosis. (genengnews.com)
  • The genes identified in this study," Cree explains, "fall into several categories linked with much studied mechanisms such as metabolism within the cell, membrane drug pumps, and DNA repair but also with apoptosis, suggesting that the general susceptibility of the cell to undergo this process may be an important determinant of tumor chemosensitivity, outweighing more specific mechanisms. (genengnews.com)
  • It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. (cdc.gov)
  • The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. (cdc.gov)
  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
  • The TP53 gene plays an important role in regulating the cell cycle, apoptosis and DNA damage repair ( 8 , 9 ). (spandidos-publications.com)
  • Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
  • We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
  • Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among overexpressed genes. (nature.com)
  • We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
  • SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. (medlineplus.gov)
  • ABSTRACT: BACKGROUND: Benzo[a]pyrene (B[a]P) exposure induces DNA adducts at all stages of spermatogenesis and in testis, and removal of these lesions is less efficient in nucleotide excision repair deficient Xpc-/- mice than in wild type mice. (maastrichtuniversity.nl)
  • This type of damage can be fixed by a process called nucleotide excision repair. (jove.com)
  • Damaged DNA can be detected and repaired in a process called nucleotide excision repair (NER). (jove.com)
  • Nucleotide excision repair relies on specific protein complexes to recognize damaged regions of DNA and flag them for removal and repair. (jove.com)
  • Gene Ontology Domain-centric Gene Ontology (GO) automatically annotated. (wikipedia.org)
  • Superfamily Annotation InterPro abstracts for over 1,000 superfamilies, and Gene Ontology (GO) annotation for over 700 superfamilies. (wikipedia.org)
  • correlation of expression to DNA Repair was analyzed using Gene Ontology enrichment. (biu.ac.il)
  • DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)
  • In this study, we investigated by using microarray technology whether compromised DNA repair in Xpc-/- mice may lead to a transcriptional reaction of the testis to cope with increased levels of B[a]P induced DNA damage. (maastrichtuniversity.nl)
  • The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. (aacrjournals.org)
  • A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
  • When fasted, your cells initiate cellular repair processes. (healthline.com)
  • Our ongoing project aims to elucidate how cells recognize temperature or cellular events caused by the temperature changes and control the expression of DESAT1 to adapt the cellular processes and behaviors," Umeda said. (asbmb.org)
  • Disturbance of this process alters the activity of many genes and disrupts several cellular processes, which could explain the diverse signs and symptoms of Coffin-Siris syndrome. (medlineplus.gov)
  • The process of bone repair is an event finely regulated and characterized by different phases with predominance of specific cellular types, aiming at the formation of tissue in the affected area. (bvsalud.org)
  • Among the different study models of bone repair, the model of bone repair in tooth socket has been very adequate because it enables a chronological evaluation of the repair process, detailing the main cellular events at each stage 31 . (bvsalud.org)
  • Materials and Methods: Digital RNA quantification (Nanostring) of previously curated 188 B-cell lymphoma specimens across four subtypes, follicular lymphoma (FL), diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), primary testicular lymphoma (PTL), and plasmablastic lymphoma (PBL), was reanalyzed with focus on TBL1XR1 and NCOR1 expression, juxtaposing them with 730 ontogenically linked genes. (iiarjournals.org)
  • The median TBL1XR1 expression was remarkably diminished in FL, yet, intriguingly, GCB-subtypes of DLBCL-NOS exhibited significantly enhanced expression compared to FL (p=0.001). (iiarjournals.org)
  • Expression patterns of a selected panel of 67 genes including both immune stimulatory and inhibitory genes, showed significant associations with subtypes, and DDR gene mutation status. (bmj.com)
  • These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
  • We sorted excitatory neurons and key inhibitory neuron subtypes from mouse brains and assessed differential mRNA expression. (jneurosci.org)
  • For example, the 2015 annual report showed breast cancer incidence by molecular subtypes using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. (cdc.gov)
  • Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is caused by a point mutation in the LMNA gene, resulting in production of a truncated farnesylated-prelamin A protein (progerin). (nih.gov)
  • n = 408) from The Cancer Genome Atlas, to determine subtype specific immune cell abundance, expression of 67 immune regulatory genes, and association with DDR gene inactivation (via mutation, copy number alteration) profiles. (bmj.com)
  • Our findings also emphasize the urgent need for biomarker discovery approaches that combine molecular subtype, DDR gene mutation status, tumor immune landscape classification, and immune checkpoint gene expression to increase the number of patients responding to immunotherapies. (bmj.com)
  • The ones that fix themselves can pass the repair, or "mutation," to their progeny. (eurekalert.org)
  • The TP53 gene mutation is the most common gene alteration in many tumors, including esophageal cancer. (spandidos-publications.com)
  • Although the biological significance of TP53 gene mutation is well characterized, its clinical significance in esophageal cancer remains controversial, especially as a prognostic biomarker. (spandidos-publications.com)
  • Therefore, the overexpression of p53 does not always indicate a mutation in the TP53 gene. (spandidos-publications.com)
  • In young adults, mutation in the Werner syndrome (WS) gene is believed to be associated with clinical symptoms typically found in elderly individuals. (medscape.com)
  • However, a child may have characteristics of WS but with no identifiable mutation in the WRN gene. (medscape.com)
  • LMNA (lamin A/C) gene mutation has been described with atypical Werner syndrome, with the severe metabolic complications, the extent of the lipodystrophy being linked with A133L mutation in the LMNA gene. (medscape.com)
  • The SMARCE1 gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. (medlineplus.gov)
  • Importantly, TBL1XR1's pronounced association with several DNA Damage repair (DDR) genes was noted suggesting influence on DNA repair. (iiarjournals.org)
  • DNA damage caused by UV light or other carcinogens must be repaired to maintain genome integrity. (isbscience.org)
  • We previously reported that XPA mislocalized to the progerin-induced DNA double-strand break (DSB) sites, blocking DSB repair, which led to DSB accumulation, DNA damage responses, and early replication arrest in HGPS. (nih.gov)
  • In alignment with these concepts, recent immune checkpoint blockade (ICB) therapies in UC have demonstrated the predictive potential of mutations in the DNA damage repair (DDR) genes. (bmj.com)
  • Higher XRCC1 (F = 2.39, p = 0.010, η2p = 0.10) and PARP1 (F = 2.15, p = 0.022, η2p = 0.09) expression accounted for slower repair of experimentally X-ray irradiation-induced DNA damage, highlighting the possible physiological relevance of altered DNA-repair gene expression in PTSD. (uni-konstanz.de)
  • We discuss the implications of increased DNA damage and altered DNA-repair mechanisms in immune senescence, premature aging, and increased physical morbidity in PTSD. (uni-konstanz.de)
  • RESULTS: Our results showed that astragaloside IV significantly improved AOM/DSS-induced CAC mice by inhibiting colonic shortening, preventing intestinal mucosal damage, reducing the number of tumors and, the expression of Ki67 protein. (bvsalud.org)
  • We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
  • Eat a diet that is high in sugar, and gene expression moves in a direction that produces more insulin, that shuts off insulin receptors, that down-regulates lipase and other enzymes involved in fat-burning, that increases pro-inflammatory cytokines, etc. (marksdailyapple.com)
  • When you change to a diet low in sugars and rich in healthy fats, those or other genes are directed to reduce inflammatory expression, down-regulate insulin-producing metabolic machinery, up-regulate insulin receptors and rebuild cell membranes to reflect the presence of better building materials (omega 3 fatty acids, etc. (marksdailyapple.com)
  • 2021 ). They exert multiple biological functions, including limiting excessive inflammatory responses, regulating metabolism and immune cell functions, decreasing the production of pro-inflammatory factors, increasing anti-inflammatory mediators, and promoting tissue repair and homeostasis (Miao et al. (springer.com)
  • They antagonize pro-inflammatory signaling on macrophage/neutrophil infiltration, enhance macrophage phagocytosis towards apoptotic cells, and accelerate tissue repair (Cheng and Rong 2019 ). (springer.com)
  • METHODS: We searched for drinks that reactivate the functions of tumor-suppressor retinoblastoma gene (RB) products and exert anti-inflammatory and antioxidant effects. (bvsalud.org)
  • Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy). (unime.it)
  • Objective: To measure oxidative-stress, DNA repair and detoxification genes in school children living near the industrial area and in age-matched controls. (unime.it)
  • This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
  • TBL1XR1 over-expression has been linked to poor prognosis in several solid organ cancers, impacting various oncogenic signaling pathways ( 6 ). (iiarjournals.org)
  • The TBL1XR1-DDR genes connection offers insights into potential DNA repair roles, paving avenues for innovative therapies in B-cell lymphomas. (iiarjournals.org)
  • The general transcription factor TFIIH plays central roles in both processes and is also important to couple gene transcription with DNA repair. (isbscience.org)
  • Samples were analyzed for urinary 8-hydroxydeoxyguanosine (8OHdG) levels, and gene expression of OGG1 (DNA repair gene), NQO1, ST13, and MT1A (detoxifying genes). (unime.it)
  • Conclusion: Our exploratory findings unravel the expression patterns of TBL1XR1/NCOR1 in B-cell lymphoma variants. (iiarjournals.org)
  • At least five variants (also known as mutations) in the SMARCE1 gene cause Coffin-Siris syndrome, which is characterized by delayed development, abnormalities of the fifth (pinky) fingers or toes, and characteristic facial features that are described as coarse. (medlineplus.gov)
  • Most SMARCE1 gene variants involved in Coffin-Siris syndrome change single protein building blocks (amino acids) in the SMARCE1 protein. (medlineplus.gov)
  • Polymorphic variants at regulatory elements can cause differential allelic expression (DAE), thus using DAE as a quantitative trait could help identify such variation. (springer.com)
  • Gene testing can be salient to confirm autosomal recessive inheritance. (medscape.com)
  • Conclusions: The DNA Repair score, previously shown to be a lung cancer risk factor in the Israeli population, was validated in this independent study as a mechanism-based cancer risk biomarker and can substantially improve current lung cancer risk prediction, assisting prevention and early detection by computed tomography scanning. (biu.ac.il)
  • Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)
  • In addition, analysis of cell cycle phase dependent gene expression revealed that expression of genes involved in G1-S and G2-M phase arrest was increased after B[a]P exposure in both genotypes. (maastrichtuniversity.nl)
  • Diet, exercise, exposure to toxic chemicals (or fresh air), medicines, even the thoughts you think (which generate actual chemical signals) all influence gene expression - positively and/or negatively, depending on the choice. (marksdailyapple.com)
  • Progeria can also refer to Hutchinson-Gilford syndrome , which is described as a lamin A gene defect and has onset early in life. (medscape.com)
  • In her current position as a biologist, her focus on human DNA polymerases continues and expands towards studying genome-wide gene expression changes in yeast strains. (nih.gov)
  • To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
  • There was considerable heterogeneity between tumors, and while this showed no direct correlation with individual gene expression, there was strong correlation of multigene signatures for many of the single chemotherapy agents and combinations tested," says Ian Cree, who led the study. (genengnews.com)
  • When these results were compared to gene expression in the tumors, there was a strong correlation of multigene signatures for many of the single agents and combinations tested. (genengnews.com)
  • Conclusion Findings from our study provide compelling evidence for co-expression of multiple immune checkpoint genes including, PD-1 , PD-L1, IDO1, TIGIT, TIM-3, TGFB1, LAG3, and others, that potentially contribute to compensatory immune evasion in bladder tumors. (bmj.com)
  • Genes associated with the classical complement pathway were downregulated in non-muscle invasive cancer. (urotoday.com)
  • Researchers at Queen Alexandra Hospital in the U.K. say that they found a good correlation between genes previously linked to drug sensitivity and resistance with in vitro chemosensitivity when taken together. (genengnews.com)
  • The details are published August 27 in BMC Cancer in a paper called "Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC). (genengnews.com)
  • By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
  • A slightly higher induction of average gene expression was observed at the G2-M checkpoint in Xpc-/- mice, but this did not reach statistical significance (P=0.086). (maastrichtuniversity.nl)
  • We therefore examined the utility for lung cancer risk assessment of a DNA Repair score obtained from OGG1, MPG, and APE1 blood tests. (biu.ac.il)
  • The doublet combinations of cisplatin with gemcitabine and cisplatin with docetaxel showed gene-expression signatures incorporating resistance mechanisms for both agents. (genengnews.com)
  • Results: DNA Repair score was lower in case patients than in control individuals, regardless of the case's disease stage. (biu.ac.il)
  • This characteristic of the TP53 gene limits the use of IHC in TP53 gene research, which may be the cause of the conflicting results in the study of TP53 in esophageal cancer. (spandidos-publications.com)
  • Grange syndrome results from mutations in the YY1AP1 gene. (medlineplus.gov)
  • Ours results suggest an effect of fluoride on the activity of MMPs 2 and 9 at the initial period of alveolar repair which could be associated to the process of blood clot remission and delay in bone repair. (bvsalud.org)
  • A comprehensive understanding of DDR gene inactivation associated expression of immune regulatory genes could thus aid in expansion of current immunotherapies and predictive biomarkers for the design of patient-tailored combination treatments. (bmj.com)
  • The technique provides a less toxic alternative to standard gene transfer techniques by using an array of carbon nanotubes to deliver DNA into primary neurons, immune cells, and stem cells. (rochester.edu)
  • When modRNA Cas9 is successfully delivered to the target gene, it creates a double-stranded break in the genome, which some cells will try to fix. (eurekalert.org)
  • Your cells also initiate important repair processes and change the expression of genes. (healthline.com)
  • Regulatory polymorphisms in cis-acting elements result in the unequal expression of alleles. (springer.com)
  • Differential allelic expression (DAE) in heterozygote individuals could be used to develop a new approach to discover regulatory breast cancer susceptibility loci. (springer.com)
  • We aimed to perform a more extensive evaluation of differential allelic expression between blood and breast in order to assess the potential usefulness of LCL and fresh blood in association studies, to identify regulatory polymorphisms related to susceptibility to breast cancer. (springer.com)
  • It has an essential role in B-cell development, influencing the transition of memory B-cells to plasma cells, while mutations in the TBL1XR1 gene have been observed to inhibit this progression and promote lymphomagenesis ( 7 , 8 ). (iiarjournals.org)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • DNA Repair activity was measured in peripheral blood mononuclear cells, and the transcriptome of nasal and bronchial cells was determined by RNA sequencing. (biu.ac.il)
  • Retaining vital levels of DNA integrity requires cells to mobilize compensatory efforts in elevating their DNA-repair capacity. (uni-konstanz.de)
  • Only 20% to 30% of the targeted cells will receive gene-editing DNA when using CRISPR. (eurekalert.org)
  • The issue, Lian said, is that most cells with this break identify it as a major problem with the genome and will self-destruct instead of trying to repair themselves. (eurekalert.org)
  • Many new cell-based therapies depend on changing the gene expression of primary cells. (rochester.edu)
  • These approaches range from stem cells for production of patient-specific repair tissues, to CAR T-cells used for focused cancer therapy. (rochester.edu)
  • We compared the distribution of allelic ratios of gene expression in fresh blood (B cells and total mononuclear cells), transformed lymphoblasts, and breast tissue from unmatched healthy individuals. (springer.com)
  • Mutations in the YY1AP1 gene likely disrupt the function of the complex, which leads to reduced proliferation and differentiation of smooth muscle cells. (medlineplus.gov)
  • In addition, astragaloside IV could activate PPARγ signaling, which not only promoted the expression of Nrf2 and HO-1, restored the level of SOD, CAT and GSH, but also inhibited the expression of iNOS and reduced the production of NO in the intestine and IEC-6 cells. (bvsalud.org)
  • Our special focus is on pericytes as key players in inflammation and neurodegeneration and potential target cells for brain repair. (lu.se)
  • Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
  • The positive rate of p53 protein expression was 54.5% (201/369) in the multi‑ethnic group, and was significantly different between sex (P=0.026) and between tumor differentiation groups (P=0.032). (spandidos-publications.com)
  • These include gene activity (expression), repair of damaged DNA, cell specialization (differentiation), and cell growth and division (proliferation). (medlineplus.gov)
  • Normal gene expression variation is thought to play a central role in inter-individual variation and susceptibility to disease. (springer.com)
  • While CRISPR-Cas9 is faster, less expensive and more accurate than other gene-editing methods, according to project leader Xiaojun "Lance" Lian, associate professor of biomedical engineering and biology at Penn State, the technology has limitations - especially in applications to improve human health. (eurekalert.org)
  • Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were performed to detect the expression of p53 protein and gene deletion in ESCC tissue samples from different ethnic groups in Xinjiang, in order to analyze their association with clinicopathological characteristics and patient prognosis, as well as the sensitivity and specificity of the two methods. (spandidos-publications.com)
  • CRISPR uses a disc of genetic material, known as plasmid DNA, to deliver guided ribonucleic acid (RNA) that positions the Cas9 enzyme at the precise location of the target gene. (eurekalert.org)
  • Our findings support the use of differential allelic expression in blood as a surrogate for breast tissue in future studies on predisposition to breast cancer. (springer.com)
  • This paper reclaims the term "mechanotherapy" and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and bone. (bmj.com)
  • 1 - 4 But what happens at the tissue level to promote repair and remodelling of tendon, muscle, articular cartilage and bone? (bmj.com)
  • also these molecules may be important markers of tissue repair, especially MMPs known as gelatinases (MMP-2 e MMP-9) 39 . (bvsalud.org)
  • AceView: gene:dpy-21, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
  • The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
  • Other tumor-related genome markers are rapidly maturing providing prognostic indicators for survival and response to therapy (e.g. gene expression profiling in prostate cancer ). (cdc.gov)
  • REPAIR contains microarray- and RNA-sequencing-based gene expression studies of HD patient biosamples and animal and cell models of HD. (hdinhd.org)
  • The human genome is enormous, and CRISPR-Cas9 makes it possible for scientists to find and target a mutated gene for the purpose of studying it," Lian said. (eurekalert.org)
  • The human body has more than 20,000 genes, yet we study the functions of only about 10% of them," Lian said. (eurekalert.org)
  • However, there are many new biomarkers that have been incorporated into the AJCC 8th Edition as a component of prognostic stage and will be collected starting in January 2018, if they are not already part of routine surveillance (such as breast cancer gene expression profiling and human papilloma virus). (cdc.gov)
  • pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
  • Human progeroid syndromes are linked with mutations in single genes accelerating some, but not all, features of normal aging. (medscape.com)
  • According to AceView, this gene is expressed at high level , 2.6 times the average gene in this release, at all stages of development [Kohara cDNAs]. (nih.gov)
  • ASXL1 MT are further associated with de novo accessibility of distal enhancers binding ETS transcription factors, targeting important leukemogenic driver genes. (nature.com)