ImpairmentCorticosteroidsImpaired renal functionEosinophilia and systemic symptomsHydroxychloroquineNSAIDsAssess renal functionGout flaresSecretionFamilial MeditMyopathySymptomsRhabdomyolysisHypothyroidismAcute gouty arTherapiesInsufficiencyReactionsGlucocorticoidsDiseaseImmunosuppressiveExposureTubularInhibitsAmyloidPrecipitatePancreasNSAIDSclerosisAmyloidosisDosageHypertensionInhibitorsPulmonaryAllopurinolComplicationsAdequateOccursInflammatorySclerodermaTreatmentSyndromePregnancy
Impairment6
- concurrent use contraindicated in patients with renal or hepatic impairment. (drugguide.com)
- In patients with mild renal impairment (CrCl 50-80 ml/min), no dose adjustment is required (see sections 4.4 and 5.2), although close monitoring for possible adverse effects is recommended. (lab-seid.com)
- In patients with moderate renal impairment (CrCl 30-50 ml/min), it may be necessary to halve the dose and/or increase the intervals between doses. (lab-seid.com)
- In cases of severe renal impairment (CrCl (lab-seid.com)
- In elderly patients or those with renal or hepatic impairment, alternative therapies should be used. (lab-seid.com)
- Severe renal impairment and haemodialysis patients. (lab-seid.com)
Corticosteroids2
- Patients with constitutional symptoms, visceral involvement, a more severe course of the disease, or high acute phase reactants, were treated mainly with systemic corticosteroids and/or cytotoxic agents for varying durations. (biomedcentral.com)
- Results: Based on the available evidence at the time of guideline development (20 February, 2021), the panel makes a strong recommendation in favour of the use of systemic corticosteroids in patients requiring supplementary oxygen or ventilatory support, and for the use of anticoagulation in hospitalised patients. (bvsalud.org)
Impaired renal function2
- It is necessary to reduce the dose for patients with impaired renal function or the eighth pair of impaired brain nerve function. (ballyabio.com)
- In patients with impaired renal function, monitor renal function test values. (medicscientist.com)
Eosinophilia and systemic symptoms2
- Cases of Stevens-Johnson syndrome, erythema multiforme, and toxic skin eruptions, including drug rash, eosinophilia and systemic symptoms (DRESS) syndrome, have been reported in patients receiving atazanavir. (evotazhcp.com)
- It is known as the leading cause of severe cutaneous adverse drug reactions (SCARs) comprising Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) and HyperSensitivity Syndrome (HSS)/Drug-Rash with Eosinophilia and Systemic Symptoms (DRESS) (Halevy et al. (confex.com)
Hydroxychloroquine1
- Conditional recommendations are made against the use of azithromycin, hydroxychloroquine combined with azithromycin, colchicine, and remdesivir, in the latter case specifically in patients requiring invasive mechanical ventilation. (bvsalud.org)
NSAIDs1
- Recommended drugs for acute attacks were oral non-steroidal anti-inflammatory drugs (NSAIDs), oral colchicine (ES = 0.87 (95% confidence interval, 0.25 to 1.50)), or joint aspiration and injection of corticosteroid. (bmj.com)
Assess renal function1
- Periodically assess renal function. (medicscientist.com)
Gout flares3
- Colchicine capsules are indicated for prophylaxis of gout flares in adults. (rxlist.com)
- The safety and effectiveness of colchicine capsules for acute treatment of gout flares during prophylaxis has not been studied. (rxlist.com)
- For prophylaxis of gout flares, the recommended dosage of colchicine capsules is 0.6 mg once or twice daily. (rxlist.com)
Secretion1
- Ethanol increases purine catabolism in the liver and increases the formation of lactic acid, which blocks urate secretion by the renal tubules, and ethanol may also stimulate liver urate synthesis. (msdmanuals.com)
Familial Medit1
- Early Predictors of Colchicine Resistance in Familial Mediterranean Fever. (cdc.gov)
Myopathy2
- Common adverse reactions include rhabdomyolysis with myoglobinuria , acute renal failure , myopathy (including myositis ) and liver enzyme abnormalities. (wikidoc.org)
- Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported. (nih.gov)
Symptoms1
- Systemic symptoms of leprosy are also possible. (medscape.com)
Rhabdomyolysis1
- Colchicine: Increased risk of rhabdomyolysis with this combination. (pediatriconcall.com)
Hypothyroidism1
- autoimmune diseases (such as hypothyroidism, inflammatory bowel disease, systemic lupus erythematosus, and rheumatoid arthritis). (myamericannurse.com)
Acute gouty ar2
- To treat acute gouty arthritis the usual dose of colchicine to relieve or abort an attack is 1 to 1.2 mg (two 0.5 mg granules or two 0.6 mg tablets). (rxlist.com)
- Sulfinpyrazone use may precipitate acute gouty arthritis, urolithiasis and renal colic. (medicscientist.com)
Therapies1
- No therapies have been shown in blinded placebo-controlled trails to improve the overall course of systemic sclerosis. (skintherapyletter.com)
Insufficiency1
- The uricosuric benzbromarone is more effective than allopurinol (ES = 1.50 (0.76 to 2.24)) and can be used in patients with mild to moderate renal insufficiency but may be hepatotoxic. (bmj.com)
Reactions1
- Gastrointestinal disorders are the most common adverse reactions with colchicine. (rxlist.com)
Glucocorticoids1
- Though steroids (glucocorticoids) both topical and systemic are very important for acute control of active uveitis, long-term use of steroids can cause various side effects. (aao.org)
Disease6
- Cite this: Managing Gout as a Systemic Disease - Medscape - Nov 15, 2018. (medscape.com)
- Liver disease has adverse effect on pharmacokinetic profile, and causes increased systemic exposure of the drug. (pediatriconcall.com)
- The clinical manifestations are renal disease, idiopathic pulmonary fibrosis (IPF), heart failure, end-stage liver diseases, and so on ( Bataller and Brenner, 2005 ). (frontiersin.org)
- In children, localized scleroderma is three times more common than the systemic form of the disease. (mountsinai.org)
- People with scleroderma may develop either a localized or a systemic (body-wide) form of the disease. (mountsinai.org)
- Mortality has been estimated to be up to nearly one quarter of AHS cases, with multiorgan system disease including hepatocellular changes and renal failure being a serious concern. (astrazenecaclinicaltrials.com)
Immunosuppressive1
- Subject that requires or may require systemic immunosuppressive or immunomodulatory treatment. (astrazenecaclinicaltrials.com)
Exposure3
- Avoid coadministration with strong CYP3A4 inhibitors with (increases cobimetinib systemic exposure by 6.7-fold). (medscape.com)
- Strong CYP3A4 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. (medscape.com)
- Systemic effects of ricin poisoning depend upon route of exposure and dose. (cdc.gov)
Tubular1
- Lead poisoning and cyclosporine, usually in the higher doses given to transplant patients, alter renal tubular function leading to urate retention. (msdmanuals.com)
Inhibits1
- this, in turn, inhibits sodium and chloride reabsorption in the ascending loop of Henle and distal renal tubule. (medscape.com)
Amyloid1
- Amorphous eosinophilic interstitial amyloid observed on a renal biopsy. (medscape.com)
Precipitate1
- These proteins either arise from proteins expressed by cells at the deposition site (localized), or they precipitate systemically after production at a local site (systemic). (medscape.com)
Pancreas2
- This as flares or phototoxicity should be restrictive, par- as the pancreas, renal cortex. (thehasse.org)
- To explore the common genes and pathogenic pathways among different fibrotic diseases, we collected all the reported genes of the eight fibrotic diseases: eye fibrosis, heart fibrosis, hepatic fibrosis, intestinal fibrosis, lung fibrosis, pancreas fibrosis, renal fibrosis, and skin fibrosis. (frontiersin.org)
NSAID2
- In case of acute exacerbations, administer concomitant treatment with indomethacin (or another NSAID) or colchicine. (medicscientist.com)
- Subject must be able to take gout flare prophylaxis with colchicine or NSAID (including Cox-2 selective NSAID) ± PPI. (astrazenecaclinicaltrials.com)
Sclerosis4
- Systemic sclerosis is a multisystem disorder with vascular instability as a clinical hallmark. (skintherapyletter.com)
- Systemic sclerosis (SSc) differs from localized scleroderma in prognosis as well as clinical expression. (skintherapyletter.com)
- 1 Systemic sclerosis is commonly divided into the limited form (formerly termed CREST) or the diffuse form. (skintherapyletter.com)
- Systemic scleroderma is also called systemic sclerosis . (mountsinai.org)
Amyloidosis2
- The development of systemic reactive amyloidosis is a potential complication of all the autoinflammatory diseases. (drjwv.com)
- Amyloidosis develops in the presence of chronic inflammatory diseases such as heartworm, tuberculosis, systemic fungal diseases, chronic bacterial infections and cancer. (drjwv.com)
Dosage1
- The recommended dosage of colchicine depends on the use of coadministered drugs [see DRUG INTERACTIONS ]. (rxlist.com)
Hypertension1
- Systemic hypertension is high buy Zestoretic Online How To pressure in the arteries that carry blood from your heart to your bodys. (institutoa.com.br)
Inhibitors1
- Prevent- inhibitors of p-gp [212] colchicine clarithromycin colchicine intoxication during clarithromycin administration. (thehasse.org)
Pulmonary1
- Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. (medscape.com)
Allopurinol1
- Allopurinol, a xanthine oxidase inhibitor, has been used since the 1960s for gout, hyperuricaemia associated with treatment for malignancy and renal calculi due to hyperuricosuria. (confex.com)
Complications3
- potential for renal complications. (medicscientist.com)
- Its progression is very slow, and it rarely, if ever, spreads throughout the body (becomes systemic) or causes serious complications. (mountsinai.org)
- Nous avons exa- miné les dossiers de 56 patients ayant eu un diagnostic de fièvre méditerranéenne familiale et suivis au Centre médical Roi Hussein en Jordanie sur une période de 4 ans afin d'étudier leur profil clinique, l'évolution de la maladie, le génotype, le traitement et les complications. (who.int)
Adequate1
- The dose of 25-30 mmoles is adequate, for systemic therapy. (riversideortho.com)
Occurs1
- Systemic capillary leak syndrome occurs due to the disruption of endothelial cells, which leads to increased vascular permeability, causing intravascular fluid to leak into the extravascular space and albumin to be retained in the interstitial space. (substack.com)
Inflammatory2
- Colchicine decreases leukocyte motility and phagocytosis in inflammatory responses. (medscape.com)
- IL-6 is also involved in the Systemic Inflammatory Response Syndrome (SIRS). (drjwv.com)
Scleroderma3
- Systemic scleroderma is a serious condition, while localized scleroderma carries a good prognosis and normal lifespan. (mountsinai.org)
- Bosentan is currently under study in the US for systemic scleroderma. (mountsinai.org)
- There is less than a 1% chance that this disorder will progress to systemic scleroderma. (mountsinai.org)
Treatment4
- Neomicina is not suitable for the treatment of systemic infections. (ballyabio.com)
- Follow-up examination: patients with audiogram, renal function measurement, original renal function damage or 8th brain nerve damage or long-term treatment should be checked before and during medication. (ballyabio.com)
- The recommended dose as preventive treatment of gout attacks is 0.5 mg of colchicine once or twice a day, which is equivalent to 1 tablet once or twice a day. (lab-seid.com)
- Treatment with colchicine has greatly ali on the criteria of Livneh et al. (who.int)
Syndrome1
- The Presence of Systemic Capillary Leak Syndrome (SCLS): Is This How the Spike Mimics FIP? (substack.com)
Pregnancy1
- During pregnancy, colchicine should be used only when prescribed. (rxlist.com)