• Severe renal or hepatic impairment. (nih.gov)
  • Animal research suggests that GBE is non-mutagenic, non-teratogenic, and that it does not illicit organ damage or impairment of renal or hepatic function. (restorativemedicine.org)
  • Need to decrease dose in patients with renal impairment. (cdc.gov)
  • In patients with mild renal impairment (CrCl 50-80 ml/min), no dose adjustment is required (see sections 4.4 and 5.2), although close monitoring for possible adverse effects is recommended. (lab-seid.com)
  • In patients with moderate renal impairment (CrCl 30-50 ml/min), it may be necessary to halve the dose and/or increase the intervals between doses. (lab-seid.com)
  • In cases of severe renal impairment (CrCl (lab-seid.com)
  • In elderly patients or those with renal or hepatic impairment, alternative therapies should be used. (lab-seid.com)
  • Severe renal impairment and haemodialysis patients. (lab-seid.com)
  • Pethidinic acid (meperidinic acid, pethidine intermediate C) is a 4-phenylpiperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). (wikipedia.org)
  • The synthetic opioid meperidine hydrochloride (meperidine HCL), also known as pethidine or the brand name product line Demerol , is prescribed to treat moderate to severe pain and, less commonly, chronic pain. (recoveryohio.org)
  • The aims of this study were to evaluate safety and efficacy of rectal diclofenac sodium ( RD ) in acute renal colic and compare it with intramuscular pethidine (IMP) injection. (bestpremiumessays.com)
  • Therefore, in this study, we compared the efficacy of analgesic therapy of rectal diclofenac sodium (RD) and intramuscular pethidine (IMP), commonly preferred in emergency departments in our country in patients with renal colic. (bestpremiumessays.com)
  • Renal excretion eliminates 79.5% of the administered dose and the rest is excreted via feces. (pharmasynth.in)
  • Renal elimination of venlafaxine and its metabolites is the primary route of excretion. (illumina.com)
  • Changes in liver enzyme activity affect the breakdown of drugs that undergo hepatic metabolism, and increased renal function escalates the elimination of water-soluble drugs and their metabolites. (dvm360.com)
  • Renal transplant recipients without severe cardiac or respiratory problems are extubated after surgery. (biogenericpublishers.com)
  • Renal colic is a common urological emergency at the emergency department, often caused by the movement of ureteral stones and characterized by severe pain. (bestpremiumessays.com)
  • Patients with severe heart failure, hypertension, hepatic or renal insufficiency. (pharmasynth.in)
  • In an interventional prospective double blind randomized control trial with 541 patients, which referred to Emergency Department due to acute renal colic, RD and IMP were administrated to 266 patient (as group I) and 275 patients (as group II), respectively. (bestpremiumessays.com)
  • Renal colic is a type of abdominal pain commonly caused by obstructive stones. (bestpremiumessays.com)
  • Our results demonstrated that although, there were no significant differences in analgesic effects between two drugs (P=0.06), but, due to availability, cheapness, safety and self administration properties, use of sodium diclofenac in suppository form is highly recommended in renal colic. (bestpremiumessays.com)
  • Both parenteral opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to provide relief from renal colic (Bektas et al. (bestpremiumessays.com)
  • Diclofenac, 2-(2-(2,6-dichlorophenylamino)phenyl)acetic acid, is an NSAID taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions such as renal colic. (bestpremiumessays.com)
  • An interventional prospective multicenter double blind randomized control trial (RCT) with five hundred forty one eligible patients which had renal colic and referred to Motahhary and Peymanieh Hospitals of Jahrom and Faghihi and Nemazee Hospitals of Shiraz between Dec 2005 to Apr 2007 was done. (bestpremiumessays.com)
  • Non-GI conditions include renal colic. (cancertherapyadvisor.com)
  • Laboratory findings of an elevated amylase or lipase can be seen with enteritis or intestinal ischemia, sialadenitis, biliary tract disease, and renal insufficiency (due to decreased clearance). (cancertherapyadvisor.com)
  • Current research implicates the 3-glucuronide opioid metabolites as one likely cause of neuroexcitatory side effects with some suggestion that symptoms may not develop until a neurotoxic threshold is surpassed, although current understanding is limited. (mypcnow.org)
  • Fentanyl, which is primarily transformed in the liver, demonstrates a high first pass clearance and releases approximately 75% of an intravenous dose in urine, mostly as metabolites with less than 10% representing the unchanged drug. (psychedeliccommunity.uk)
  • Approximately 9% of the dose is recovered in the feces, primarily as metabolites. (psychedeliccommunity.uk)
  • Renal function may rapidly decline, so laboratory test results obtained in the morning may not reflect the patient's renal function or electrolyte status later in the day. (medscape.com)
  • It is significantly more potent than pentazocine, meperidine, and codeine as an analgesic in the rat yeast paw test. (drugs.com)
  • Co-morbid factors including renal failure, electrolyte disturbances, and dehydration can also contribute to myoclonus development. (mypcnow.org)
  • Check renal and liver function, and for low magnesium, glucose or sodium. (mypcnow.org)
  • Undergoes extensive first pass metabolism in the liver to its major, active metabolite, ODV, and two minor, less active metabolites, N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. (illumina.com)
  • Meperidine is also known to interact with certain drugs that increase or decrease the rate at which meperidine is removed from the body, including certain antifungals, antibiotics like linezolid, cimetidine, ritonavir, phenytoin and other drugs used to treat seizures, and others. (recoveryohio.org)
  • Furthermore, drugs and their metabolites can cross the maternal-fetal barrier and can reach potentially hazardous concentrations in milk. (dvm360.com)
  • Drugs that decrease renal function could decrease clearance. (cdc.gov)
  • The study found that patients undergoing fluid expansion of at least 10% soon after the diagnosis, showed a mean increase in body weight of 12.5%, had significantly better short-term outcomes with a lower rate of central nervous system involvement, had less need for renal replacement therapy or intensive care unit support, and needed fewer days of hospitalization. (medscape.com)
  • While renal transplant candidates are cardiac patients, central vein catheterization is used as a standard in some centers, while some centers are not preferred because they are not a good indicator of fluid need or response [2]. (biogenericpublishers.com)
  • The use of central regional methods is rare and controversial in patients with chronic renal failure [6-8]. (biogenericpublishers.com)
  • Decrease dosage in patients with impaired renal function. (cdc.gov)
  • This serious, chronic hemolytic anemia is incurable and is often fatal by middle age because of renal failure, infection, pulmonary failure, and/or stroke. (viquepedia.com)
  • The mechanism of pancreatic injury is not well defined but may range from hypersensitivity reactions to accumulation of a toxic metabolite. (the-medical-dictionary.com)
  • Specialty Diagnostix presents a new specific homogeneous enzyme immunoassay for the detection of the Methadone Metabolite EDDP in urine. (specialtydiagnostix.de)
  • The renal clearance of EDDP (2-Ethylidin-1,5-Dimethyl-3,3-Diphenyl-Pyrolidine), the primary Methadone Metabolite, on the other hand, remains unaffected by an alkaline urine. (specialtydiagnostix.de)
  • Although no studies reported serious adverse events, the short follow-up period and failure to specifically record renal dysfunction and gastrointestinal bleeding means these results should be interpreted cautiously (Holdgate and Pollock 2004). (bestpremiumessays.com)
  • Use potassium-free fluids until renal function has stabilized. (medscape.com)
  • Since preservation of graft function is directly related to graft perfusion, it is the primary issue of renal perfusion during donor nephrectomy. (biogenericpublishers.com)
  • Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors. (illumina.com)
  • The study also added that long-term outcomes were also significantly better in terms of renal and extrarenal sequelae, compared to the historical controls from the same instituion. (medscape.com)
  • Remain within the same as those of the structural features of asthma management are therefore not recom- the short-term therapy of tubereuloci primary metabolite, deacetylrifampin, are found in sect. (stonecottagegardens.com)
  • Comorbidities (e.g., renal or hepatic failure). (tri-kobe.org)
  • Maintaining Appropriate Fluid Quantity Stabilize Persevere in precise intake and achievement monitoring and recording to evaluate the advancement toward renal failure. (mein-schoenefeld.info)
  • Diphenoxylate is biotransformed in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood. (nonpsychotoxic.com)
  • Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. (illumina.com)
  • Active metabolites excreted renally. (unboundmedicine.com)
  • Therefore, intraoperative invasive blood pressure follow-up is recommended only in renal transplant candidates with advanced cardiac disease. (biogenericpublishers.com)
  • Therefore, the most important consideration in the emergency management of renal colics is pain control/relief (Esmailian and Keshavarz 2014). (bestpremiumessays.com)
  • The most important of those is probably the fact that methadone renal clearance is dependent on urinary pH. (specialtydiagnostix.de)
  • Appropriate anesthesia technique should be selected taking into account the existing diseases of the patient, the duration of surgery and the possibilities of renal protection. (biogenericpublishers.com)
  • The amount of meperidine prescribed to any specific patient varies depending on different factors. (recoveryohio.org)
  • Suitable techniques include peritoneal dialysis, hemodialysis, or continuous renal replacement therapies (CRRT). (medscape.com)
  • The sodium salt for use in individuals with high-risk melanoma examined the effect of clarithromycin by 21% results of a change in the meperidine series nitrogen. (stonecottagegardens.com)