This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases. (justia.com)
The present invention relates to the field of bioconjugate preparation, and more particularly, to a class of bifunctional boronic compound complexing reagents useful for the conjugation of biological macromolecules, and the method of making and using such reagents. (justia.com)
This invention relates to a process for making 1,2-Benzisothiazolin-3-ones (hereinafter BIT) by cyclising a bisamide precursor under alkaline conditions using oxygen or an oxygen-release compound in the presence of a nitrogen, suphur or phosphorus nucleophile. (allindianpatents.com)
The present invention relates to novel alkoxy propionic acid and their pharmaceutical accetable salts having use as antidiabetic,hypolipidemic,antiobesity and hypocholesterolemic compounds. (allindianpatents.com)
The invention also relates to a process for the preparation of above said novel compounds and phamaceutically acceptable salts. (allindianpatents.com)
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. (allindianpatents.com)
Compounds7
There are compounds in which an acidic hydrogen of acids mentioned in this article are not replaced by an organyl, but by some other group. (wikipedia.org)
This method allows the synthesis of high-value compounds including medicinally relevant scaffolds and a monodecarboxylation of differently substituted dicarboxylic acids. (organic-chemistry.org)
A copper-catalyzed aerobic oxidative decarboxylation of phenylacetic acids and α-hydroxyphenylacetic acids enables the synthesis of aromatic carbonyl compounds via decarboxylation, dioxygen activation, and C-H bond oxidation steps in a one-pot protocol with molecular oxygen as the sole terminal oxidant. (organic-chemistry.org)
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. (lookformedical.com)
We are engaged in offering Chemical Compounds which includes hydroxy flavone, gossypin, vanillinacetate, chlorogenic acid, bromovanillin and harmine pure.All these chemical compounds can exist as solids, at low enough temperatures & may also exist as liquids, gases, and even plasmas. (pcchem.net)
Esters can be formed from oxoacids (e.g. esters of acetic acid, carbonic acid, sulfuric acid, phosphoric acid, nitric acid, xanthic acid), but also from acids that do not contain oxygen (e.g. esters of thiocyanic acid and trithiocarbonic acid). (wikipedia.org)
for example, according to them, trimethylstannyl acetate (or trimethyltin acetate) CH3COOSn(CH3)3 is a trimethylstannyl ester of acetic acid, and dibutyltin dilaurate (CH3(CH2)10COO)2Sn((CH2)3CH3)2 is a dibutylstannylene ester of lauric acid. (wikipedia.org)
For example, butyl acetate (systematically butyl ethanoate), derived from butanol and acetic acid (systematically ethanoic acid) would be written CH3CO2(CH2)3CH3. (wikipedia.org)
Many amides can be reduced to amines by triacetoxyborohydride formed in situ from sodium borohydride and glacial acetic acid. (thevespiary.org)
WO 2006/135881 describes quaternized ammonium salts prepared by condensation of a hydrocarbyl-substituted acylating agent and of an oxygen- or nitrogen-containing compound with a tertiary amino group, and subsequent quaternization by means of hydrocarbyl epoxide in the presence of stoichiometric amounts of an acid, especially acetic acid. (trea.com)
5- and 6-Alkynoylsilanes are converted to α -alkylidenecycloalkanones by treatment with [RhCl(CO) 2 ] 2 in the presence of acetic acid via transmetallation between the acylsilane moiety and a rhodium(I) complex. (go.jp)
The use of radical-based methodology in the synthesis of highly substituted amines and amino acids. (exeter.ac.uk)
Synthesis3
For example, triethyl orthoformate (HC(OCH2CH3)3) is derived, in terms of its name (but not its synthesis) from esterification of orthoformic acid (HC(OH)3) with ethanol. (wikipedia.org)
Recent studies have focused on asymmetric synthesis of structurally complex amino acids, using what has proved to be a very versatile radical-based methodology and also the use of structurally unusual heterocycles for masking the reactivity of synthetically valuable functional groups. (exeter.ac.uk)
The transcriptome data showed 1015 (459 up-regulated and 556 down-regulated) differentially expressed genes with functional gene annotation related to nitrogen source metabolism, glycolysis, tricarboxylic acid cycle, extracellular polysaccharide synthesis, energy conversion and transmembrane transport, revealing the metabolic process of ammonium nitrogen conversion to biological nitrogen in P. stutzeri F2 through assimilation. (bvsalud.org)
Dicarboxylic acids1
This methodology enables also a selective monoprotodecarboxylation of several aromatic dicarboxylic acids. (organic-chemistry.org)
Tertiary1
A Fukuzumi acridinium photooxidant with phenyldisulfide as a redox-active cocatalyst enable a direct, catalytic hydrodecarboxylation of primary, secondary, and tertiary carboxylic acids as well as a double decarboxylation of malonic acid derivatives. (organic-chemistry.org)
Derivatives4
According to some authors, organyl derivatives of acidic hydrogen of other acids are esters as well (e.g. amides), but not according to the IUPAC. (wikipedia.org)
9~ yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread®) and (2R, 5S, cis)-4-amino-5- fluoro-l-(2~ hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, EmtrivaTM, (-)-cis FTC) and their physiologically functional derivatives. (gc.ca)
The aim of these studies has been to develop a much-needed general synthetic route to amino acids (and other amine derivatives) possessing a quaternary chiral centre alpha -to the nitrogen atom and in particular, alpha , alpha -disubstituted alpha -amino acids. (exeter.ac.uk)
The central theme of this methodology is the formation of alpha -aminoalkyl radicals from existing amino acid and alpha -amino alcohol derivatives by 1,5-hydrogen atom transfer and the subsequent trapping of these radicals with appropriate radicalphiles, thus generating quaternary centres with high efficiency and excellent stereocontrol. (exeter.ac.uk)
Aqueous1
A base-catalyzed Michael-type addition of sodium diethyl malonate to N -Boc-α-amidoalkyl- p -tolyl sulfones in tetrahydrofuran followed by hydrolysis of the adducts in refluxing 6 M aqueous hydrochloric acid affords β 3 -amino acid hydrochlorides in high yield and excellent purity. (organic-chemistry.org)
Organic7
In chemistry, an ester is a compound derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group (−OH) of that acid is replaced by an organyl group (−R). Analogues derived from oxygen replaced by other chalcogens belong to the ester category as well. (wikipedia.org)
The names of esters that are formed from an alcohol and an acid, are derived from the parent alcohol and the parent acid, where the latter may be organic or inorganic. (wikipedia.org)
The chemical formulas of organic esters formed from carboxylic acids and alcohols usually take the form RCO2R' or RCOOR', where R and R' are the organyl parts of the carboxylic acid and the alcohol, respectively, and R can be a hydrogen in the case of esters of formic acid. (wikipedia.org)
Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. (wikipedia.org)
Similarly, an organic compound with multiple amino groups is called a diamine , triamine , tetraamine and so forth. (newworldencyclopedia.org)
The salts of BIT of formula 1 may be those of an inorganic or organic acid such as acetic, propionic, sulphuric, phosphoric or hydrochloric acid. (allindianpatents.com)
These nitrogen, sulphur and phosphorus nucleophiles include hard, borderline and soft Lewis Acids and Bases as set forth in "Mechanism and Theory in Organic Chemistry" (3rd Edition) by T.H. Lowry and K.S. Schueller, Harper and Row, New York, 1987 on pages 318 to 322, particularly the bases and especially those detailed in Table 3.21. (allindianpatents.com)
Phosphoric1
Esters of phosphoric acid form the backbone of DNA molecules. (wikipedia.org)
A non-essential amino acid that is synthesized from GLUTAMIC ACID. (lookformedical.com)
N -terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. (pcchem.net)
Nitrogen2
Since oxygen is more electronegative than nitrogen, RO- H is typically more acidic than the related R 2 N- H compound. (newworldencyclopedia.org)
R8 and R9 when present on nitrogen atom together may form a 5 or 6 membered cyclic structure containing carbon atoms and one or more heteroatoms selected from oxygen, sulfur or nitrogen. (allindianpatents.com)
Mixture1
When the acid has been added the mixture is allowed to stir for one hour with or without heating. (thevespiary.org)
Naturally1
A mild decarboxylative reduction of naturally abundant carboxylic acids such as α-amino acids and α-hydroxy acids has been achieved via visible-light photoredox catalysis using an organocatalytic photoredox system. (organic-chemistry.org)
Hydrogen2
An example of an ester formation is the substitution reaction between a carboxylic acid (R−C(=O)−OH) and an alcohol (R'−OH), forming an ester (R−C(=O)−O−R'), where R stands for any group (typically hydrogen or organyl) and R′ stands for organyl group. (wikipedia.org)
It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (lookformedical.com)
Amides1
Especially preferred amides are the Ci^-alkyl amides of C1-4-fatty acids such as dimethylformamide and dimethylacetamide. (allindianpatents.com)
Esters8
Esters of nitric acid, such as nitroglycerin, are known for their explosive properties. (wikipedia.org)
Esters derived from the simplest carboxylic acids are commonly named according to the more traditional, so-called "trivial names" e.g. as formate, acetate, propionate, and butyrate, as opposed to the IUPAC nomenclature methanoate, ethanoate, propanoate, and butanoate. (wikipedia.org)
Esters derived from more complex carboxylic acids are, on the other hand, more frequently named using the systematic IUPAC name, based on the name for the acid followed by the suffix -oate. (wikipedia.org)
Phosphorous acid forms two kinds of esters: phosphite esters, e.g. triethyl phosphite (P(OCH2CH3)3), and phosphonate esters, e.g. diethyl phosphonate (HP(=O)(−OCH2CH3)2) Thiosulfuric acid forms two kinds of thiosulfate esters, e.g. (wikipedia.org)
O,O-dimethyl thiosulfate ((CH3−O−)2C=S) and O,S-dimethyl thiosulfate (CH3−O−C(=O)−S−CH3) Some inorganic acids that are unstable or elusive form stable esters. (wikipedia.org)
Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
Formulations1
0004] While there are attempts in the state of the art aiming at related objectives, there remains a demand for surfactant mixtures capable of providing softening formulations meeting the above requirements even at relatively low EQ concentrations, and which do not necessitate the excessive use of solvents or further additives. (epo.org)
Hormones1
One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by attaching glucuronic acid to them in the liver and then excreting the complex in the bile. (medindex.am)
Aromatic2
An effective protocol allows the smooth protodecarboxylation of diversely functionalized aromatic carboxylic acids within 5-15 min under microwave irradiation. (organic-chemistry.org)
This is one of several forms of blocked N -terminals which present a problem for N -terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. (pcchem.net)
Yields1
A palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids provides the desired polyenes in good yields under mild conditions using either a Pd(0) or Pd(II) catalyst. (organic-chemistry.org)
Acidity1
These studies have also revealed intriguing and unexpected physical properties associated with the parent imide heterocycle (particularly in terms of its acidity) and as a result, studies involving related heterocycles are proposed. (exeter.ac.uk)
Chemistry1
To foster acquisition of knowledge and understanding of terms, concepts, facts, processes, techniques and principles relating to the subject of Chemistry. (oswalpublishers.com)
Pyridine nucleophiles include pyridine itself and substituted pyridines, especially those substituted by amino or C1-4-substituted amino groups such as 4-dimethylaminopyridine. (allindianpatents.com)
Sodium1
The sodium salt of pyroglutamic acid - known either as sodium pyroglutamate, sodium PCA, or sodium pidolate - is used for dry skinand hair products, as it is a humectant. (pcchem.net)
High1
The use of FeCl 3 as catalyst enables a rapid decarboxylation of methylene tethered cyclic 1,3-diesters in the presence of water to yield α,β-unsaturated acids with high E -stereoselectivity under both microwave and conventional heating conditions. (organic-chemistry.org)
Form1
The calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property. (medindex.am)
Liver1
It is conjugated to GLYCINE in the liver and excreted as hippuric acid. (lookformedical.com)
Highly1
A simple and highly efficient protodecarboxylation of various heteroaromatic carboxylic acids is catalyzed by Ag 2 CO 3 and AcOH in DMSO. (organic-chemistry.org)
Field1
Publishing on IntechOpen allows authors to earn citations and find new collaborators, meaning more people see your work not only from your own field of study, but from other related fields too. (intechopen.com)
Products1
The X-ray crystallographic analysis of the products indicates that the cis-addition of the acids to the Si-Si bond is preferable. (go.jp)
Capable1
EC3.4.141), is a lysosomal cysteine protease capable of removing dipeptides from the amino terminus of protein substrates. (justia.com)