Relapse gastric cancer patients cancer patient selection. Medical search. Frequent questions

Fine-needle aspiration cytology of the nodule revealed it to be metastasis from gastric adenocarcinoma. (lww.com)
Cutaneous metastasis may be the first presentation of internal malignancies even with a short history of disease in young patients. (lww.com)
This case is reported due to the rarity of cutaneous metastasis at multiple sites from a highly aggressive adenocarcinoma in a young patient, to emphasize the importance of cutaneous metastasis as a poor prognostic sign in patients with a history of cancer. (lww.com)
Targeted proteomics analysis of the prioritized proteins in saliva, combined with machine-learning methods, highlights a peptide-based signature as the most powerful predictor to distinguish patients with and without lymph node metastasis. (nature.com)
Deep Learning for Prediction of N2 Metastasis and Survival for Clinical Stage I Non-Small Cell Lung Cancer. (cdc.gov)
Gastric Extent of Tumor Predicts Peritoneal Metastasis in Siewert II Adenocarcinoma. (viictr.org)
We collected data for 180 patients (71 OG and 109 LG patients) who satisfied the following inclusion criteria: gastrectomy with curative intent, pathologically confirmed gastric adenocarcinoma with T2, T3, or T4 invasion, an R0 resection, and no evidence of distant metastasis. (kjco.org)
Cancer stem cells (CSCs) are considered to be critically involved in the recurrence and metastasis of NB and are isolated as NB spheres. (oncotarget.com)
Due to their self-renewal property and strong tumorigenic ability, CSCs are regarded as the starting point for tumors and are considered to be critically involved in relapse and metastasis [ 2 ]. (oncotarget.com)
Metastasis-associated in colon cancer-1 (MACC1) was first identified as a transcriptional activator for proto-oncogene c-MET expression, and its overexpression is frequently associated with metastatic progression for multiply tumor types. (biomedcentral.com)
In the present study, we analyzed for the first time the expression of MACC1 in breast cancer and its correlation with clinicopathologic features, including metastasis and patient survival. (biomedcentral.com)
Statistical analysis showed a significant correlation of MACC1 expression with the primary tumor, lymph node metastasis, distant metastasis classifications as well as the clinical staging in breast cancer patients. (biomedcentral.com)
Metastasis-associated in colon cancer-1 (MACC1) was first identified to be overexpressed in primary and metastatic tumor specimens of colon cancer as compared to normal colon mucosa and was found to be indicative of metastasis as well as poor survival of the patients. (biomedcentral.com)
These studies revealed that MACC1 might play a role in the recurrence, metastasis and patient survival in various types of human cancers. (biomedcentral.com)
The poor outcome of metastatic breast cancer patients underscores the importance of defining molecular factors responsible for cancer metastasis. (biomedcentral.com)
Therefore, identifying risk markers to elucidate pathways responsible for breast cancer metastasis is important for the improvement of the risk classification in patients as well as discovery of therapeutic targets. (biomedcentral.com)
This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)

Immatics expects to enroll up to 20 patients with relapsed and/or refractory solid cancers that have no current treatment options, according to the release. (pharmacytimes.com)
This activity will explore the management of patients with newly diagnosed, relapsed/refractory, and secondary acute myeloid leukemia (AML). (medlearninggroup.com)

In addition, the recurrence of symptoms that require intensive treatment is often encountered in clinical practice and poses a considerable concern for physicians and patients. (springer.com)
To further explore this topic, we retrospectively analyzed the impact of adjuvant chemotherapy on the clinical outcomes of 77 stage II and 117 stage III patients diagnosed between January 2008 and December 2012. (springeropen.com)
Immatics recently announced patient enrollment into a phase 1 clinical trial of its adoptive cellular therapy (ACT) IMA101, which uses its ACTolog approach. (pharmacytimes.com)
A nomogram containing clinical characteristics and the prognostic model was established to predict the prognosis of Asian GC patients. (e-crt.org)
5-fluorouracil (5-FU) remains the main chemotherapeutic agent for the treatment of gastric cancer, and combination chemotherapy with 5-FU has shown an improved clinical outcomes [ 1 ]. (biomedcentral.com)
Our belief-and the core of our strategy-is that innovative, highly differentiated medicines that provide large clinical benefits in addressing serious diseases are medicines that will not only help patients, but also will help reduce the social and economic burden of disease in society today. (instrumentl.com)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. (mdanderson.org)
The results of these studies, which will be presented at the virtual 2021 American Society of Clinical Oncology (ASCO) Annual Meeting , highlight new advances in drug therapy research to improve patient outcomes. (mdanderson.org)
In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)
Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. (nature.com)
Histopathological-based models may be used to stratify patients into low- and high-risk classes 9 and further identify patients at risk of aggressive early-stage OSCC, thus contributing to disease predictability in terms of clinical progression and treatment outcomes. (nature.com)
The clinical and pre-clinical data discussed has potentially significant clinical implications in the management of treatment-relapsed HGSOC. (almacgroup.com)
This clinical and pre-clinical data supports the use of anti-angiogenic agents in the first and second line setting in patients with innate and acquired resistance to platinum therapy, respectively. (almacgroup.com)
The monitoring of postoperative recurrence in patients with NSCLC is of critical clinical importance. (researchsquare.com)
Early diagnosis and treatment of tumor recurrence may prolong the survival time of patients and improve clinical efficacy. (researchsquare.com)
Deep Learning for Lung Cancer Nodal Staging and Real-World Clinical Practice. (cdc.gov)
Predicting future amyloid biomarkers in dementia patients with machine learning to improve clinical trial patient selection. (cdc.gov)
The objectives of combining sentinel lymph node biopsy with or without selective lymphadenectomy in clinical practice include both decreasing the extent of the operation for selected patients and increasing the identification rate of occult lymph node metastases, thereby increasing the accuracy of staging by providing the pathologist with the lymph node (or nodes) most likely to contain metastatic disease. (medscape.com)
Several clinical studies are currently underway in CRC patients. (medicaltrend.org)
Among 14 evaluable patients, 3 (21.4%) had stable disease, with only one patient achieving long-term clinical benefit. (medicaltrend.org)
Phase 1 data from an early clinical trial (NCT02699515) in 30 pretreated biliary tract cancer patients showed an objective response rate of 20% (6/30), with median progression-free and overall survival of 2.5 and 12.7 months, respectively. (medicaltrend.org)
Dr. Haesun Choi joined MD Anderson Cancer Center in 1999 as a clinical radiologist. (mdanderson.org)
Her clinical experience is focused on male and female pelvic MRI, including the prostate, uterus, cervix and rectum, liver imaging, functional MRI including dynamic contrast enhanced (DCE) - MRI, DWI and spectroscopy (MRS). She has extensive clinical experience on prostate MRI parallels with building up a highly successful prostate imaging program at MD Anderson Cancer Center. (mdanderson.org)
Methods Demographic, clinical and pharmacological variables, including tacrolimus whole blood concentrations obtained from therapeutic drug monitoring and data from dense-sampling pharmacokinetic profiles, were recorded in 26 paediatric patients with biliary atresia who underwent liver transplantation between 2016 and 2021. (unav.edu)
Clinical data of 180 patients (109 LG and 71 OG) who underwent radical D2 gastrectomy for AGC at Gyeongsang National University Hospital between 2007 and 2009 were included. (kjco.org)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
This survey, addressed to breast cancer surgeons in Spain, has the objective of assessing current clinical trends on axillary staging of cN + patients treated with NAC. (unav.edu)
Breast cancer is a heterogeneous disease with a variety of different molecular subtypes and varied clinical outcomes. (biomedcentral.com)
To date, molecular classification of breast cancer based on the estrogen receptor (ER), progesterone receptor (PR) and HER2 expression status in clinical setting to differentiate a prognosis and guide treatment. (biomedcentral.com)
The objectives of combining sentinel lymph node biopsy with selective lymphadenectomy in clinical practice include both decreasing the extent of the operation for selected patients (decreasing the number of nontherapeutic lymphadenectomies) and increasing the identification rate of occult lymph node metastases (increasing the accuracy of staging) by providing the pathologist with the lymph node (or nodes) most likely to contain metastatic disease. (medscape.com)
The World Health Organization, through its International Clinical Trials Registry Platform, has developed the ICTRP database to provide patients, family members and members of the public current information about clinical research studies. (who.int)
The risk of distant recurrence in breast cancer patients is difficult to prognostic indices, such as the Nottingham Prognostic Index (6, 7), assess with current clinical and histopathological parameters, and have proven valuable in identifying patients with poor prognosis. (lu.se)
The National Cancer Institute's Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J. (medscape.com)

The primary objective of the new study is to assess the safety and tolerability of the ACTolog therapy in patients with target-positive solid tumors, according to the release. (pharmacytimes.com)
A recent phase 2 study in patients with heavily pretreated microsatellite instability-high (MSI-H) metastatic solid tumors, including 12 CRC patients, reported early results. (medicaltrend.org)
Genomic amplification of FLT3 has been reported in solid tumors including colorectal cancer, breast cancer, and gastric cancer [ 9 ]. (hindawi.com)

Using Targeted Treatment Options for the Management of BRAF-mutant Metastatic Colorectal Cancer: How Does Your Approach Compare with the Experts? (medlearninggroup.com)
Gastric cancer and colorectal cancer are also connected to alterations in gut microbiota. (deepdyve.com)
Combining TGF-β and PD-1/PD-L1 signal inhibition has shown promising anti-tumor activity in preclinical mouse models of colorectal cancer. (medicaltrend.org)
Hence, caution may be needed when advancing Bintrafusp alfa and similar targets without guiding biomarkers, partly due to the inherent anti-tumor effects of TGF-β signaling in colorectal cancer. (medicaltrend.org)

The influence of adjuvant chemotherapy on the survival of gastric adenocarcinoma patients in a stage-specific manner is controversial. (springeropen.com)
Highly aggressive gastric adenocarcinoma with multiple skin. (lww.com)
Although gastric adenocarcinoma is common in middle- and old-aged population, it is rare in young people. (lww.com)
We report the case of a 19-year young man with gastric adenocarcinoma who had multiple skin nodules over the trunk during presentation. (lww.com)
Gastric adenocarcinoma is one of the common causes of cancer death in the world. (lww.com)
Contrast-enhanced computed tomography radiomics and multilayer perceptron network classifier: an approach for predicting CD20 B cells in patients with pancreatic ductal adenocarcinoma. (cdc.gov)
A decade's experience of managing suspected pancreatic adenocarcinoma at a tertiary cancer center. (viictr.org)

Dr. Curtis has been the recipient of numerous awards, including the National Institutes of Health (NIH) Director's Pioneer Award (2018) and the American Association for Cancer Research (AACR) Award for Outstanding Achievement in Basic Science (2022). (stanford.edu)
A comprehensive systematic literature research was performed for studies exploring the value of ctDNA in predicting postoperative recurrence in NSCLC patients up to February 2022. (researchsquare.com)
Ten researches comprising 799 patients, published between 2017 and February 2022, were finally enrolled into our meta-analysis. (researchsquare.com)

Tailoring therapy based on different characteristics for patients with stage II gastric cancer may produce better outcomes. (springeropen.com)
Amaria and other researchers are continuing to follow patient outcomes and will be conducting further translational studies to discern the mechanisms of response and resistance to this combination. (mdanderson.org)
Salvage Esophagectomy Definition Influences Comparative Outcomes in Esophageal Squamous Cell Cancers. (viictr.org)
We investigated the long-term oncologic outcomes of laparoscopic gastrectomy (LG) and open gastrectomy (OG) for advanced gastric cancer (AGC) with a 5-year follow-up period. (kjco.org)
In addition, several publications have described the short-term and long-term outcomes of LG with D2 lymphadenectomy in advanced gastric cancer (AGC) as equivalent to those of open gastrectomy (OG) [ 5 - 10 ]. (kjco.org)
The aim of the current study was to investigate the oncologic outcomes, including disease-free survival (DFS) rate, overall survival (OS) rate, and prognostic factors of survival, of patients undergoing LG vs. OG. (kjco.org)

NGS has led to improved cancer classification and the more precise and earlier diagnosis of cancers, potentially improving the patient's prognosis. (partnerre.com)
We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients. (e-crt.org)
However, most patients with GC will eventually metastasize or relapse and the prognosis is still unsatisfactory [ 3 ]. (e-crt.org)
Therefore, there is an urgent need to explore novel prognostic biomarkers to increase the accuracy of prognosis prediction and seize therapeutic opportunities for GC patients. (e-crt.org)
Although the majority of patients present with non-muscle invasive disease, approximately 30-40% of patients have muscle invasive disease at diagnosis with a worse prognosis. (biomedcentral.com)
For NSCLC patients, ctDNA is a promising biomarker for predicting postoperative recurrence, which can be used as a supplement to the current monitoring of radiation and blood biomarkers to better guide the treatment selection and prognosis of patients after surgery. (researchsquare.com)
Applied machine learning in cancer research: A systematic review for patient diagnosis, classification and prognosis. (cdc.gov)
The need to achieve no residual disease after surgery in order to optimize the prognosis of advanced-stage ovarian cancer introduced the idea of neoadjuvant chemotherapy followed by interval debulking surgery in an effort to reduce tumoural size in the case of non-operable advanced-staged ovarian cancer patients. (termedia.pl)
CFC1, which functions in the development of embryos and decides the left-right axis, was strongly expressed in sphere-forming cells only and was related to the unfavorable prognosis of NB patients. (oncotarget.com)
Therefore, CSCs have become promising target cancer cells for preventing cancer relapse and improving the prognosis of tumor patients [ 3 ]. (oncotarget.com)
MACC1 may represent a potentially useful biomarker for the prognosis of breast cancer patients and might be involved in progression of breast cancer. (biomedcentral.com)
In this context, biomarkers that can identify individuals with a favorable prognosis among ER- negative breast cancer patients, for whom the toxic chemotherapy might be avoidable, are of value in choosing appropriate adjuvant therapy. (biomedcentral.com)

epstein-barr virus (ebv) is a human γ-herpesvirus associated with cancer, including burkitt lymphoma, nasopharyngeal, and gastric carcinoma. (liverpool.ac.uk)

The ACTolog approach targets tumor-specific antigens to fight cancer. (pharmacytimes.com)
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
Lung cancer is the most common malignant tumor worldwide, and non-small cell lung cancer(NSCLC) accounts for approximately 85% of all lung carcinoma cases. (researchsquare.com)
Lung cancer is one of the most frequent malignant tumor worldwide, as well as the leading cause of cancer-related death, posing a serious threat to human health [ 1 ] . (researchsquare.com)
Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies. (viictr.org)
Accumulating evidence has shown that cancer stem cells (CSCs) are a small subpopulation of tumor cells that exhibit the properties of self-renewal, differentiation into various tumor cell types, tumorigenicity, and chemo/irradiation resistance [ 1 ]. (oncotarget.com)
The primary cause of tumor-related death in breast cancer (BC) is still represented by distant metastasization. (amegroups.org)
The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)

2018. Chemotherapy Use, End-of-Life Care, and Costs of Care Among Patients Diagnosed With Stage IV Pancreatic Cancer. . (cornell.edu)
The rate of depression is highest in those closest to the end of life and in patients with certain types of cancer, including pancreatic cancer, lung cancer, gastric cancer, and oropharyngeal cancer. (cancernetwork.com)

Secondary objectives include, feasibility, persistence of T-cells in vivo , and assessment of anti-cancer activity, and biomarkers. (pharmacytimes.com)
Despite these multiple approvals, the development of clinically useful biomarkers to determine the optimal treatment for patients remains somewhat elusive. (biomedcentral.com)
Therefore the identification of new biomarkers and treatments for highly invasive/metastatic prostate cancers is of a high priority. (almacgroup.com)
There is much interest in the utility of molecular biomarkers in BO, both to predict which patients may develop cancer (and therefore offer therapy) and to aid prognostication by guiding surveillance intervals following therapy. (nature.com)

IMA101 is a personalized investigational immunotherapy being evaluated for the treatment of multiple cancers, including ovarian, gastric, esophageal, non-small cell lung cancers, and head and neck squamous cell carcinoma. (pharmacytimes.com)
Non-Small Cell Lung Cancer (NSCLC) is the most common pathological subtype, accounting for approximately 85% of all lung cancers [ 2 ] . (researchsquare.com)

The use of serum prostate-specific antigen (PSA) levels has been recognised as a huge step forward in the diagnosis and treatment of prostate cancer, however since its implementation as a biomarker it has become apparent that the numbers of deaths from prostate cancer has only decreased slightly. (almacgroup.com)
Machine learning-based rapid diagnosis of human borderline ovarian cancer on second-harmonic generation images. (cdc.gov)
Phenotype Discovery and Geographic Disparities of Late-Stage Breast Cancer Diagnosis across U.S. Counties: A Machine Learning Approach. (cdc.gov)
Dysplasia is a marker of cancer risk in Barrett's oesophagus (BO), but this risk is variable and diagnosis is subject to inter-observer variability. (nature.com)
In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)
The National Comprehensive Cancer Network (NCCN) guidelines for NHL provide general recommendations on classification, differential diagnosis and supportive care, as well as specific guidance for the management of the most common subtypes. (medscape.com)

Validation of the prognostic model was conducted using The Cancer Genome Atlas (TCGA) database. (e-crt.org)
The four-gene-related prognostic model and the nomogram based on it are reliable tools for predicting the overall survival of Asian GC patients. (e-crt.org)
Thus, the identification of complementary biological signatures that assist in the prognostic prediction of patients with OSCC is needed. (nature.com)
For survival, TMN cancer stage was statistically independent prognostic factors. (kjco.org)
Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
While the prognostic value of each individual S100 in ovarian cancer is still elusive. (cancerindex.org)
In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)
Stratification of breast cancer patients according to the estrogen receptor (ER) status revealed that MACC1 was prognostic for both ER-negative and ER-positive patients. (biomedcentral.com)
The risk of developing distant strated enough prognostic accuracy in breast cancer (10). (lu.se)

Patients with stage II gastric cancer accounted only for 24 and 23 %, and patients with stage III for 22 and 22 % in the D1 and D2 groups, respectively [staging according to American Joint Committee on Cancer (AJCC), 5th edition] (Fleming et al. (springeropen.com)
One indicator of the degree to which sentinel lymph node biopsy with selective lymph node dissection has been accepted in the staging and treatment of melanoma is the evolution of the American Joint Commission on Cancer (AJCC) staging guidelines for melanoma, which, beginning in 2004, incorporate nodal microstaging and discriminate between microscopic and macroscopic nodal disease. (medscape.com)
We performed LG in patients diagnosed as having clinically T1N0 (defined according to the American Joint Committee on Cancer [AJCC], 6th edition) gastric cancer before January 2005 [ 11 ]. (kjco.org)
The indication for undergoing LG with D2 lymphadenectomy was then extended to include clinically T3N1 gastric cancer (AJCC, 6th edition). (kjco.org)

Although patient survival for breast cancer has been improved in recent decades[ 9 ], the outcome of patients with metastatic breast cancer remains poor with a median overall survival time of 2 to 3 years[ 10 ]. (biomedcentral.com)

All 194 patients underwent radical operation plus D2 dissection, and were followed a median time of 23.3 (range 0.4-80.2) months. (springeropen.com)
Between January 2007 and December 2009, 398 consecutive patients underwent radical gastrectomy for gastric cancer at Gyeongsang National University Hospital. (kjco.org)

Her research has redefined the molecular map of breast cancer and led to new paradigms in understanding the origins of human cancers, as well as how they evolve and metastasize. (stanford.edu)

Surgical resection remains the most effective treatment for early and some advanced forms of GC, and over the last decade, chemotherapy has been considered a standard therapeutic regimen for patients with advanced or metastatic GC [ 2 ]. (e-crt.org)
This may provide a therapeutic rationale for immune-checkpoint targeted therapies in the context of DNA damage response deficiency in cancer. (almacgroup.com)
The WHO truncal melanoma trial (No. 14) found a significant improvement in 5-year survival rates (48% vs 26%, P = .04) for patients with clinically occult metastatic lymph nodes who underwent elective lymph node dissection at the time of wide local excision versus patients who underwent therapeutic lymph node dissection after developing clinically detectable lymphadenopathy. (medscape.com)
Cancer treatment is a significant challenge for the global health system, although various pharmacological and therapeutic discoveries have been made. (frontiersin.org)
These factors should be considered and mentioned during preoperative counseling in order to allow the patient to participate in the therapeutic choice. (actaitalica.it)

Higher overall survival from adjuvant chemotherapy in stage II patients with node involvement did not reach the level of statistical significance ( P = 0.102). (springeropen.com)
75 years were included in a subgroup analysis in which the benefit of adjuvant chemotherapy on relapse-free survival and overall survival were demonstrated for patients with stage III disease. (springeropen.com)
Adjuvant chemotherapy prolongs relapse-free and overall survival for patients with stage III gastric cancer in a real-world situation. (springeropen.com)
The 5-year overall survival (OS) rate was 52.8% for all patients, 40.8% in the OG group, and 60.6% in the LG group. (kjco.org)
Moreover, overexpression of MACC1 was associated with both a reduced recurrence-free survival (RFS) and poorer patients' overall survival (OS). (biomedcentral.com)

whole-body (18)f-fdg pet/ct for m staging in the patient with newly diagnosed nasopharyngeal carcinoma: who needs? (liverpool.ac.uk)
although whole-body fluorine-18 fluorodeoxyglucose ((18)f-fdg) positron emission tomography (pet)/computed tomography (ct) ((18)f-fdg pet/ct) is commonly used for m staging of newly diagnosed nasopharyngeal carcinoma (npc), some patients may not benefit from this procedure. (liverpool.ac.uk)

The five immunotherapy agents that are FDA approved for the treatment of metastatic urothelial carcinoma all have similar objective response rates (ORR) - between 15 and 23% in unselected patients in the second line setting (Table 1 ). (biomedcentral.com)

Although the precise cause remains unknown, profiling studies of the gut microbiome associate the pathogenesis of IBD, a chronic and relapsing inflammatory disorder of the gut, with the under-representation of certain species in the faecal microbiota [16-19]. (deepdyve.com)
In one limited study in patients with confirmed C. burnetti infection and chronic endocarditis, a regimen of doxycycline and hydroxychloroquine was associated with a lower relapse rate than a regimen of doxycycline and ofloxacin. (antiinfectivemeds.com)
Association networks in a matched case-control design - Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls. (cornell.edu)
The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). (hindawi.com)
Here, to our best knowledge, we present the first case of amplification encompassing the FLT3 gene acting as dmin in a patient with chronic myelomonocytic leukemia (CMML). (hindawi.com)

Usually, cancer cell genomes have countless mutations differing them from the host cell genome, though only a few will be clinically material. (partnerre.com)
Thus, sentinel lymph node biopsy with selective lymph node dissection has been embraced as an alternative to elective lymphadenectomy or observation for patients with clinically negative regional lymph nodes who are at risk for nodal metastases. (medscape.com)

and having multiple, primary cancers. (partnerre.com)
Despite surgical operation is still the primary method for treating early NSCLC, there are still a considerable postoperative recurrence patients even after complete resection. (researchsquare.com)
According to NCCN guidelines, surgical resection remains the primary treatment for patients with early stage NSCLC. (researchsquare.com)
The last decade has been characterized by the breakthrough scientific evidence that neoadjuvant chemotherapy followed by interval debulking surgery for advanced-stage ovarian cancer may be comparable to primary debulking surgery. (termedia.pl)
They observed that largest residual tumour was 1 cm or less in diameter in 80.6% of patients after interval debulking vs. 41.6% in primary debulking. (termedia.pl)
Patients with pathologic T1 invasion, other primary malignancies, or recurrent or remnant gastric cancers, were excluded from this analysis. (kjco.org)
However, a simple way to screened 240 sera from 64 patients with primary breast cancer. (lu.se)

From 2015 to 2017, 119 patients underwent OPHL for glottic LSCC at the Otolaryngology Service of Vittorio Veneto Hospital, and the Otolaryngology Service of San Luigi Gonzaga University Hospital in Turin (Italy). (actaitalica.it)

Tracheal involvement, pre-treatment C-reactive protein level, and initial prednisolone monotherapy were risk factors for recurrence in patients with RP. (springer.com)
The selection and creation of the ACTolog cell therapy drug is tailored for each patient, making the treatment precise. (pharmacytimes.com)
We believe that attacking multiple cancer targets simultaneously using our tailored approach may lead to promising new treatment options for cancer patients with significant unmet medical need. (pharmacytimes.com)
The heterogeneity of cancer cells introduces significant challenges in designing effective treatment strategies. (wikipedia.org)
Some of these agents are approved in the first line setting as well - based on single-arm phase II studies atezolizumab and pembrolizumab received accelerated approval for first-line treatment of cisplatin ineligible patients. (biomedcentral.com)
Within the last 18 months five new immunotherapies have been approved for second-line treatment of metastatic urothelial cancer (mUC) (Fig. 1 ). (biomedcentral.com)
During adjuvant treatment, 26% of patients experienced a Grade 3 or 4 adverse event. (mdanderson.org)
Hopefully, our research will lead to a new treatment paradigm for metastatic melanoma patients. (mdanderson.org)
[ 12 ] Additionally, the National Comprehensive Cancer Network (NCCN) guidelines for the treatment of melanoma include sentinel lymph node biopsy with selective lymph node dissection in their treatment algorithms, and this technique has been endorsed by the World Health Organization (WHO) as well as multiple other national and international cancer treatment organizations. (medscape.com)
For example, some dietary factors may alter gut microbiota interactions and affect cancer development and response to cancer treatment [22]. (deepdyve.com)
Standard methods of treatment for advanced-stage ovarian cancer enrol both cytoreduction surgery, also called optimal debulking, as well as platinum-based chemotherapy [ 2 ]. (termedia.pl)
Overall, the treatment was well-tolerated, with five patients (15.6%) experiencing grade 3/4 treatment-related adverse events. (medicaltrend.org)
Because of its low renal clearance, doxycycline may not be as effective as other currently available tetracyclines for the treatment of urinary tract infections in patients with normal or impaired renal function. (antiinfectivemeds.com)
As the solubility of lapatinib is pH dependent, concomitant treatment that increases gastric pH have to be prevented, in any other case lapatinib absorption could possibly be lowered. (ehd.org)
Open partial horizontal laryngectomies (OPHLs) nowadays represent the first line surgical choice for the conservative treatment of locally intermediate and selected advanced stage laryngeal cancers. (actaitalica.it)
The excision of the clipped node (92.0%), use of dual tracer (73.2%), and axillary US (65.9%) after treatment were the most important variables considered by respondents, to increase the accuracy of SLNB in cN + patients. (unav.edu)
In this article, we discuss the importance of screening for depression in cancer patients, as well as the available treatment options and their pros and cons. (cancernetwork.com)
When pharmacotherapy is warranted, selection of treatment agent(s) should be made based on the patient's medical history, cancer type, and disease severity. (cancernetwork.com)
Increased awareness about the risk of depression along with knowledge of how to identify symptoms and initiate treatment are essential to improve the overall quality of life for patients with cancer. (cancernetwork.com)
The implementation of molecular and genomic characterization of CTCs could contribute to improve the treatment selection and thus, to move toward more personalized treatments. (amegroups.org)

It is now evident that the strategy of neoadjuvant chemotherapy for stage IIIC and more has led to a significant positive impact among ovarian cancer patients. (termedia.pl)

The old standard of care was that stage III melanoma patients get surgery first, but we've shown they can really benefit from a neoadjuvant approach," said Rodabe Amaria, M.D. , associate professor of Melanoma Medical Oncology , who will present the findings. (mdanderson.org)

Cohort 2 of IMvigor enrolled patients who had disease progression during or following platinum-based chemotherapy or within 12 months of neoadjuvant or adjuvant therapy. (biomedcentral.com)
Genomic instability seems to be a fundamental property of neoplastic progression that develops before the onset of cancer, and a large body of evidence now suggests that most oesophageal adenocarcinomas arise in association with a process of gain or loss of whole chromosomes or large portions of chromosomes ( Reid et al, 2010 ). (nature.com)
The remaining 11 patients (78.6%) experienced disease progression. (medicaltrend.org)
Only one MSI-H, locally advanced PDAC patient showed a partial response lasting 10.5 months before disease progression. (medicaltrend.org)

People receiving operation for gastric cancer without adjuvant chemotherapy are at risk for disease recurrence. (springeropen.com)
Data from a recent randomized trial enrolling only patients with II-IIIB gastric cancer revealed a 36 % recurrence rate in 5 years for patients without adjuvant chemotherapy after D2 dissection (Noh et al. (springeropen.com)
Before 2000, there was no large-scaled randomized phase III trial to evaluate the benefit of adjuvant chemotherapy on the survival of patients with gastric cancer after operation. (springeropen.com)
Information on adjuvant chemotherapy in gastric cancer is largely derived from meta-analyses. (springeropen.com)
Although some meta-analyses suggested a positive effect of adjuvant chemotherapy on survival of patients with gastric cancer (Hejna et al. (springeropen.com)
Some studies suggested that adjuvant chemotherapy only be recommended for patients with positive lymph node (Earle and Maroun 1999 ), or not recommended because the benefit was small (Janunger et al. (springeropen.com)
The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as first-line palliative combination chemotherapy. (biomedcentral.com)
Modified FOLFOX-6 chemotherapy appears to be active and well tolerated as first line chemotherapy in AGC patients. (biomedcentral.com)
Despite improvements in the early detection of gastric cancer, a significant proportion of patients present with inoperable stages where chemotherapy is required. (biomedcentral.com)
Thus, we conducted a phase II trial of 5-FU, folinic acid and oxaliplatin (a modified FOLFOX-6 regimen) in advanced gastric cancer (AGC) patients as a first line palliative chemotherapy. (biomedcentral.com)
Another problem in chemotherapy of AGC is the selection of patients who might benefit from specific chemotherapy. (biomedcentral.com)
The novel identification of chemotherapy-mediated selection for an angiogenic phenotype in EOC, through upregulation of the PDGFR-VEGF-A signalling pathway. (almacgroup.com)
The laparoscopic approach for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (L-CRS + HIPEC) in highly selected patients was previously reported from the PSOGI registry with a demonstrable reduction in length of stay and post-operative morbidity. (unav.edu)
pediatric bl patients received standardized chemotherapy and supportive care. (liverpool.ac.uk)

In this work, we describe a mammalian adaptation to dietary chitin that is coordinated by gastric innate immune activation and acidic mammalian chitinase (AMCase). (bvsalud.org)
Chitin consumption causes gastric distension and cytokine production by stomach tuft cells and group 2 innate lymphoid cells (ILC2s) in mice, which drives the expansion of AMCase-expressing zymogenic chief cells that facilitate chitin digestion. (bvsalud.org)

Conclusions: Minimally invasive CRS + HIPEC is a safe procedure for selected patients with peritoneal carcinomatosis in specialized centers. (unav.edu)

However, even undergoing radical surgery and adjuvant therapy, patients with early stage NSCLC have a substantial chance of recurrence [ 3 ] . (researchsquare.com)
Although the improvements in BC detection and adjuvant treatments led to a significant decrease in BC-related deaths in the last two decades, about 30% of women initially diagnosed with early-stage cancer eventually develop metastatic disease. (amegroups.org)
analyzing the velocity (i.e., the change over time) of the markers, malignancy we could stipulate for each patient the risk of developing metas- tasis after the end of adjuvant systemic therapy. (lu.se)

Although both regimens require long-term therapy, the mean duration of therapy for cured patients was 55 months for those who received the doxycycline/quinolone regimen compared with 31 months for those who received the doxycycline/hydroxychloroquine regimen. (antiinfectivemeds.com)
Prolonged therapy (at least 18 months) with the doxycycline and hydroxychloroquine regimen is necessary to prevent relapse. (antiinfectivemeds.com)
Erythromycin is less effective than either azithromycin or doxycycline and GI effects associated with the drug may discourage patient compliance with the regimen. (antiinfectivemeds.com)

Methods An online survey was conducted among breast surgeons from the Spanish Society of Surgery (AEC), Spanish Surgical Oncology Society (SEOQ), Spanish Breast Cancer Surgeons Society (AECIMA) and Spanish Gynecology and Obstetrics Society (SEGO). (unav.edu)

Evidence of the cancer stem cell model has been demonstrated in multiple tumour types including leukemias, glioblastoma, breast cancer, and prostate cancer. (wikipedia.org)
Christina Curtis, PhD, MSc is the RZ Cao Professor of Medicine, Genetics and Biomedical Data Science at Stanford University where she also serves as the Director of Artificial Intelligence and Cancer Genomics and of Breast Cancer Translational Research. (stanford.edu)
In a nonrandomized, open-label Phase II study, MD Anderson researchers demonstrated that talazoparib, a PARP inhibitor, showed activity in patients with germline BRCA1/2 mutation-positive, early HER2-negative breast cancer. (mdanderson.org)
The study enrolled 61 patients with stage I-III breast cancer and a germline BRCA mutation who were treated with talazoparib for 24 weeks prior to surgery. (mdanderson.org)
DNA damage response deficient human breast cancers are associated with CD8+ and CD4+ lymphocytic infiltration. (almacgroup.com)
Conclusion This survey confirms a trend toward a less invasive approach for axillary staging in cN + patients treated with NAC among breast cancer surgeons in Spain. (unav.edu)
MACC1 protein expression was analyzed in two cohorts of clinicopathologically characterized breast cancer using immunohistochemistry. (biomedcentral.com)
Worldwide, breast cancer is by far the most common cancer in women, and the second most common type of cancer for the general population[ 7 ]. (biomedcentral.com)
Because of the strong predictive importance of ER to endocrine therapy, breast cancer is generally classified into ER+ and ER- subtypes. (biomedcentral.com)
Breast cancer (BC) remains the most common type of cancer diagnosed among women and is responsible for 15% of all cancer-related deaths with 40,000 estimated deaths in 2014 ( 1 ). (amegroups.org)
The samples were collected from breast cancer patients rent procedures. (lu.se)
Survival from breast cancer has improved during the past dec- markerserumlevelshavebeenusedpreviously,e.g.,incalculating ades in the Western world. (lu.se)

NGS is invaluable because many cancer therapies are based on actionable genomic alterations/target molecules which pave the way towards personalized medicine (precision oncology). (partnerre.com)

the present study investigated which patients require this modality for m staging. (liverpool.ac.uk)

Application of convolutional neural networks for evaluating the depth of invasion of early gastric cancer based on endoscopic images. (cdc.gov)
The present study retrospectively reviewed a cohort of 72 patients who underwent OPHL for glottic LSCC, in order to identify preoperative (endoscopic and radiological) parameters that are able to predict modulation surgery. (actaitalica.it)

There are over 200 known inherited cancer susceptibility syndromes . (partnerre.com)
Although many of these are rare syndromes, they account for at least 5 - 10% of all cancer incidences. (partnerre.com)
In comparison to inherited cancer susceptibility syndromes, familial cancers aren't linked to a single inherited cancer gene, but to the interaction of low-penetrance genes and the gene environment, and/or to environmental/lifestyle factors. (partnerre.com)

Although the survival rates of patients with relapsing polychondritis (RP) have increased remarkably, the high recurrence rate remains a significant concern for physicians and patients. (springer.com)
Background: Despite the use of aggressive therapy, survival rates among high-risk neuroblastoma (NB) patients remain poor. (oncotarget.com)

What's the difference between genomic sequencing and the traditional genetic testing of cancer? (partnerre.com)
Thanks to a significant reduction in genomic sequencing costs, digital technology and bioinformatic tools that can analyze complex and large-scale data, understanding of the underlying biology of many types of cancers is set to fundamentally advance over coming years. (partnerre.com)
Genomic DNA from the patients' peripheral blood mononuclear cells was extracted. (biomedcentral.com)
17% of the patients show greater genomic instability and present with targetable immune biology -that can be identified with the combination of the DDRD and PCM assays. (almacgroup.com)
Abnormalities in DNA ploidy are a consequence of genomic instability that has been shown to predict future cancer risk in non-dysplastic BO when measured by flow cytometry, with a relative risk of 5.0 for aneuploidy ( Reid et al, 2000b ). (nature.com)
In brief, the patient genomic DNA and gender-matched reference genomic DNA were labeled with cyanine 5 (Cy5) and cyanine 3 (Cy3), respectively. (hindawi.com)

Historical evidence of a survival benefit for elective lymph node dissection in selected melanoma patients, as well as immunohistochemical- and molecular-based detection of metastatic melanoma in lymph nodes deemed negative by standard histopathology, implies that some patients are understaged by conventional techniques. (medscape.com)

The median time before the initial recurrence was significantly longer in patients who received combination therapy with prednisolone and immunosuppressants or biologics (400 vs. 70 days, p =0.0015). (springer.com)
Median patient age was 67.7 (range 33.9-97.5) years. (springeropen.com)
Malignant melanoma typically affects young patients (median age 48 y). (medscape.com)
The median peritoneal cancer index (PCI) was 3 (3-5). (unav.edu)

Previous studies combining ipilimumab and nivolumab in the neoadjuvant setting for stage III melanoma have shown high pCR rates, which indicates the absence of actively growing cancer cells in tissue removed during surgery but led to high-grade toxicity in 30-40% of patients in the neoadjuvant setting. (mdanderson.org)

For underwriting, added together, inherited and familial cancer represents a significant proportion of all cancer incidences. (partnerre.com)

A minimal level of intra-tumour heterogeneity is a simple consequence of the imperfection of DNA replication: whenever a cell (normal or cancerous) divides, a few mutations are acquired-leading to a diverse population of cancer cells. (wikipedia.org)
The cancer stem cell model asserts that within a population of tumour cells, there is only a small subset of cells that are tumourigenic (able to form tumours). (wikipedia.org)
To further these goals we developed a specific array platform, this array was based upon extensive sequencing of prostate tumour samples and contains approximately 90,000 probesets, many of which are specific to prostate cancer. (almacgroup.com)

The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of gastric adenoma and cancer to significant extent. (bvsalud.org)

Basically, each cancer is a genetic disease-that is, cancer is caused by a buildup of mutations in specific genes. (partnerre.com)

Ovarian cancer represents the fifth cause of cancer death among women, carrying one of the worst prognoses among gynaecological malignancies [ 1 ]. (termedia.pl)

Immune checkpoint blockade using PD-1 inhibition is an effective approach for treating a wide variety of cancer subtypes. (bvsalud.org)

Anatomy12

Organisms3

Diseases50

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment85

Psychiatry and Psychology1

Phenomena and Processes42

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science8

Named Groups2

Health Care40

Geographicals5

Metastasis17

Refractory2

Clinical35

Tumors3

Colorectal4

Adenocarcinoma7

20223

Outcomes6

Prognosis12

Lymphoma1

Tumor9

Pancreatic Cancer2

Biomarkers4

Lung cancers2

Diagnosis6

Prognostic11

AJCC4

Metastatic breast1

Underwent radical2

Human cancers1

Therapeutic5

Overall survival5

Newly diagnosed2

Carcinoma1

Chronic5

Clinically2

Primary7

20171

Treatment20

Ovarian cancer patients1

Stage III melanoma patients1

Progression4

Chemotherapy14

Innate2

Centers1

Adjuvant3

Regimen3

Surgical1

Breast12

Oncology1

Modality1

Endoscopic2

Syndromes3

Survival rates2

Genomic6

Lymph node disse1

Median4

Neoadjuvant1

Significant proportion1

Tumour3

Extent1

Genes1

Represents1

Immune1