Regulator transcription proteins genes bacterial. Medical search. Frequent questions

Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)
Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
These results suggest that Esr41 plays important roles in the inverse regulation of LEE and flagellar gene expression. (nih.gov)
In this study, we investigated the regulation of the competence genes qstR and comEA as an example of the complex process that controls competence gene activation in V. cholerae . (biomedcentral.com)
Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)
The ProQ/FinO family of RNA binding proteins mediate sRNA-directed gene regulation throughout gram-negative bacteria. (nature.com)
Notably, the benzoic acid inducer readily and passively moves across bacterial membranes, allowing regulation of the level of expression by simply adding more or less of the inducer. (pharmasalmanac.com)
2023. Comparative genomics sheds light on transcription factor-mediated regulation in the extreme acidophilic Acidithiobacillia representatives. (openwetware.org)
A landscape of gene regulation in the parasitic amoebozoa Entamoeba spp. (openwetware.org)
MicroRNAs (miRNAs) are small endogenous RNAs with an approximate length of 18-22 nucleotides and involved in the regulation of gene expression in transcriptional or post-transcriptional levels. (springeropen.com)
Although genomic and transcriptomic studies of S. pneumoniae have provided detailed perspectives on gene content and expression programs, they have lacked information pertaining to the translational landscape, particularly at a resolution that identifies commonly overlooked small open reading frames (sORFs), whose importance is increasingly realized in metabolism, regulation, and virulence. (biomed.news)
The biological roles of four sORF examples are characterized: two control the regulation of a cell-cell communication (quorum sensing) system, one contributes to the ability of S. pneumoniae to colonize the upper respiratory tract of mice, and a fourth governs the translation of PrfB, a protein enabling ribosome release at stop codons. (biomed.news)
We mathematically modeled transcriptional regulation of the genes encoding interleukin 6 and C/EBPδ and experimentally confirmed the prediction that the combination of an initiator (NF-κB), an amplifier (C/EBPδ) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. (nature.com)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)

The locus of enterocyte effacement (LEE) in EHEC encodes a type three secretion system and effector proteins, all of which are essential for bacterial adherence to host cells. (nih.gov)
Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. (frontiersin.org)
Despite its small genome and limited number of effector proteins, Ehrlichia efficiently establishes an intracellular infection and avoids immune defenses in vertebrate and invertebrate hosts through complex molecular and cellular reprogramming strategies. (frontiersin.org)
However virulent pathogens, escape PTI-based surveillance by transporting small effector proteins in the plant cells, which in turn cause effector triggered plant susceptibility. (austinpublishinggroup.com)
Quorum sensing is mediated by the accessory gene regulator agr , and RNAIII is the effector ( 9 ). (cdc.gov)
Various types of ILCs can be discriminated based on the expression of distinct transcription factors controlling the expression of a distinct set of cytokine genes endowing the various ILC subsets with a specific range of effector functions. (iisymposium.nl)

DDR increased the expression level of pathogenesis-related ( PR ) genes and the total salicylic acid (SA) content and promoted mitogen-activated protein kinase signaling cascades, including the WRKY signaling pathway in Arabidopsis. (ppjonline.org)
The real-time PCR method was used to analyse the L. rhamnosus supernatant effect on the expression of Wnt signaling pathway genes. (hindawi.com)
The supernatant of this bacterium significantly reduced the expression of Wnt signaling pathway genes. (hindawi.com)
This study is the first report that assessed the potential impact of L. rhamnosus , especially its supernatant on esophageal cancer and Wnt signaling pathway genes. (hindawi.com)
Present study reviews rice defense signaling pathway in disease resistance against blast, bacterial blight, BPH and Asian rice gall midge. (austinpublishinggroup.com)
The evolutionarily conserved immune deficiency (IMD) signaling pathway shields against bacterial infections. (cnrs.fr)

The pneumococcal R6 genome harbours several gene clusters that are not present in all strains of the species. (bvsalud.org)
In addition, we show that PclR has common features with the MgaSpn transcriptional regulator (493 amino acids), which is also encoded by the R6 genome. (bvsalud.org)
These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. (bvsalud.org)
We reported previously that the MafR protein of E. faecalis causes genome-wide changes in the transcriptome. (bvsalud.org)
Protein MafR from Enterococcus faecalis was shown to activate the transcription of many genes on a genome-wide scale. (bvsalud.org)
The genome atlases allowed for distinguishing distinct DNA structures and highlighted suspicious high transcription zones. (mdpi.com)
Natural competence is a mode of horizontal gene transfer, which is based on the ability of a bacterium to take up free DNA from the environment and recombine it with the bacterial genome resulting in natural transformation. (biomedcentral.com)
Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
Sub-objective 4.1: Analysis of ExPEC isolated from chickens and humans: biofilm assays, virulence gene profiles, antimicrobial resistance profiles, whole genome comparison of ExPEC strains isolated from chicken and human infections. (usda.gov)

We will use omic technologies to analyze a large variety of strains of each of the pathogens to identify genes and proteins necessary for pathogens to survive stresses encountered in food environments and cause human illness. (usda.gov)
We investigated differences in sRNA gene content and expression levels in S. aureus strains isolated from patients with bloodstream infections and from asymptomatic carriers. (cdc.gov)
Over time, OspC genes were transferred between strains through recombinations involving the whole or parts of the gene and one or both flanks. (cdc.gov)

Consequently, bacteria have developed different systems to sense changes in environmental conditions such as temperature and induce an adaptation of metabolism and gene expression. (springer.com)

In addition, pyrD inactivation reduced flagellar motility and strongly affected biofilm formation by downregulating transcription of both type 1 fimbriae and curli subunit genes. (rossimicrolab.com)
2023. The gene regulatory network of Staphylococcus aureus ST239-SCCmecIII strain Bmb9393 and assessment of genes associated with the biofilm in diverse backgrounds. (openwetware.org)
Related to this, in biofilm the diffusion of nutrients, vitamins, or cofactors is slower resulting in a bacterial community in which some of cells are metabolically inactive. (igem.org)
2). Bacillus subtilis forms biofilm whose constituent cells are held together by the extracellular matrix and one of the main matrix competent is the protein TasA which is a form of amyloid fibers and binds cells together in the biofilm (3). (igem.org)
The matrix, which is composed of polysaccharides, proteins, nucleic acids and water, enables the biofilm to attach to the surfaces. (igem.org)

To establish synthetic gene circuits capable of predictably regulating gene expression in plants, scientists adapted a large collection of bacterial gene regulators for use as synthetic activators or repressors of gene expression in plants, also known as transcription factors. (energy.gov)

It stimulates transcription of the pclA gene by binding to a specific DNA site upstream of the core promoter. (bvsalud.org)
For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)
Para isso, as regiões upstream dos genes gacA, gacS, ladS, retS, rsmA, rsmZ e PA1611 foram clonadas separadamente em um vetor repórter miniTn7 e inseridas no cromossomo de PAO1. (usp.br)
We identified previously unrecognized putative CRP-S sites upstream of both genes. (biomedcentral.com)
in an operon with an upstream PurR/LacI-type transcriptional regulator gene, named amlR ( ACSP50_2475 ), and a gene downstream ( ACSP50_2473 ) encoding a GGDEF-EAL-domain-containing protein putatively involved in c-di-GMP signaling. (frontiersin.org)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
Herein, we found that DNA damage provoked the association of ribosomes with IRES region in lncRNA CTBP1-DT, which overcame the negative effect of upstream open reading frames (uORFs), and elicited the novel microprotein DNA damage-upregulated protein (DDUP) translation via a cap-independent translation mechanism. (biomed.news)
The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)

One of these clusters contains two divergent genes, pclA, which encodes a putative surface-exposed protein that contains large regions of collagen-like repeats, and spr1404 (here named pclR). (bvsalud.org)
Esr41-mediated ler and pch repression was not observed in cells lacking hfq, which encodes an RNA-binding protein essential for most sRNA functions, indicating that Esr41 acts in an Hfq-dependent manner. (nih.gov)
In addition, Esr41 activated the expression of flagellar Class 3 genes by indirectly inducing the transcription of fliA, which encodes the sigma factor for flagellar synthesis. (nih.gov)
This gene encodes a protein that is the master regulator of transformation and a homolog of Sxy, which was first described in Haemophilus influenzae [ 7 ],[ 8 ]. (biomedcentral.com)
The Bph14 gene against brown-plant hopper also encodes CC-NB-LRRprotein of the NB-LRR family [2]. (austinpublishinggroup.com)
agr P2 drives the synthesis of RNA II, which encodes Agr ABCD, the structural components of the QS system, while agr P3 leads to the synthesis of RNA III which encodes delta-hemolysin 20 but also acts as a regulatory RNA that controls the expression of a series of virulence genes transcriptionally or translationally 21 . (ijpsr.com)

We also discuss the strategies that can be used to tackle bacterial infections and propose an entente cordiale with the bacterial world so that instead of war and destruction of the 'fierce enemy' we can achieve a peaceful coexistence (the One Earth concept) between the human and the bacterial worlds. (bvsalud.org)
In contrast, flies overexpressing this phosphatase are highly sensitive to bacterial infections. (cnrs.fr)
Wiskott-Aldrich syndrome (see the image below) is an X-linked recessive immunodeficiency disorder characterized in one third of patients by the triad of recurrent bacterial sinopulmonary infections, eczema (atopiclike dermatitis), and a bleeding diathesis caused by thrombocytopenia and platelet dysfunction. (medscape.com)
Figure 5: The function of C/EBPδ in the restriction of transient and persistent bacterial infections. (nature.com)
Fighting bacterial infections by interfering with their command language and disrupting virulence expression could serve as a viable alternative. (ijpsr.com)
Fighting bacterial infections by interfering with their command language or QS and disrupting virulence expression could serve as an alternative way to inhibit growth 15-18 . (ijpsr.com)
ILC3s are believed to be involved in the protection against intestinal bacterial infections and, if inappropriately stimulated, can be important drivers of inflammatory disorders. (iisymposium.nl)

We demonstrate by using purified bacterial components that the protein kinases that regulate chemotaxis and transcription of nitrogen-regulated genes, CheA and NRII, respectively, have cross-specificities: CheA can phosphorylate the Ntr transcription factor NRI and thereby activate transcription from the nitrogen-regulated glnA promoter, and NRII can phosphorylate CheY. (princeton.edu)
Protein-based thermosensors are a very diverse group including transcriptional regulators, sensor kinases, chaperones or proteases (reviewed in Klinkert and Narberhaus 2009 ). (springer.com)

In vitro analysis revealed that a putative switch-protein kinase regulator, RsbW, is capable of interacting directly with σ 66 , as well as phosphorylating its own antagonist, RsbV1, rendering it inactive. (plos.org)

MreB, a major component of the bacterial cytoskeleton, exhibits high structural homology to its eukaryotic counterpart actin. (hasenchat.info)
Homology-based reconstruction of regulatory networks for bacterial and archaeal genomes. (openwetware.org)
In order to derive structures of these AgrA proteins, homology modeling approach was employed. (ijpsr.com)
The structural homology with the RecA recombination protein covers the five contiguous parallel beta strands and the tandem alpha helices. (embl.de)

Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. (princeton.edu)
Due to the inherent diversity in the underlying mechanisms, protein-based thermosensors affect different cellular processes such as transcription, translation, protein stability, signal transduction as well as proteolytic processes. (springer.com)

Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin. (nih.gov)
Translational gene-reporter fusion experiments revealed that Esr41 regulates ler expression at a post-transcriptional level, and pch transcription, probably via an unknown target of Esr41. (nih.gov)
22 ]. The transcriptional regulator QstR, which might require a cofactor for its full activity (indicated by the triangle), positively regulates the comEA gene potentially by binding to a QstR-specific binding motif (indicated by the dashed box and so far unidentified). (biomedcentral.com)
It regulates the expression of antimicrobial peptides encoding genes through the activation of the NF-κB transcription factor Relish. (cnrs.fr)

To determine whether DDRs induce plant resistance to pathogens, Arabidopsis plants were treated with bleomycin, a DNA damage-inducing agent, and the replication levels of viral pathogens and growth of bacterial pathogens were determined. (ppjonline.org)
A virulent pathogen, successfully recognized by the action of disease resistance (R) gene products in plant, elicit a biphasic ROS accumulation that act as direct reactive substrates to kill pathogens, and to strengthen plant cell walls by via cross-linking of glycoproteins to obstruct further extension of the pathogen [20]. (austinpublishinggroup.com)

Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
Aggregatibacter actinomycetemcomitans, a periodontal pathogen, synthesizes leukotoxin (LtxA), a protein that helps the bacterium evade the host immune response. (usda.gov)
Disruption of plant plasma membrane by Nep1-like proteins in pathogen/plant interactions. (ki.si)
Borrelia burgdorferi , an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. (cdc.gov)
By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)

Further it has been suggested that members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion. (hasenchat.info)
Towards in silico CLIP-seq : predicting protein-RNA interaction via sequence-to-signal learning. (ki.si)
Here we use systems-biology approaches to predict and confirm the existence of a gene-regulatory network involving dynamic interaction among the transcription factors NF-κB, C/EBPδ and ATF3 that controls inflammatory responses. (nature.com)
One of the current strategies is to attenuate virulence gene expression of agr quorum sensing system of some Gram-positive bacteria through inhibition of AgrA_ P2/P3 interaction. (ijpsr.com)

The accessory gene regulator ( agr ), a well-studied QS system, controls the expression of a series of virulence-associated protein genes in some Gram-positive bacteria 19, 20 . (ijpsr.com)

An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)
Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
Our results were surprising and significant since in another bacteria associated with human health, E. coli, the protein Mlc has the opposite function. (usda.gov)
VB Secretion technology, originally developed by Professor Kelly Hughes at the University of Utah and commercialized through the company T3S Technologies, is based on truncated versions of bacterial flagella, organelles in bacteria that help in locomotion. (pharmasalmanac.com)
Our findings emphasize the importance of sORFs present in the genomes of pathogenic bacteria and underscore the utility of ribosome profiling for identifying the bacterial translatome. (biomed.news)
Tertiary structures of AgrA proteins of some pathogenic bacteria like Listeria monocytogenes, Chlamydia trachomatis, Enterococcus faecalis, Streptococcus pyogenes and Macrococcus canis showing antimicrobial resistance are not yet available in structural databases like PDB. (ijpsr.com)
The compositional and structural differences of the LytTR domain of AgrA proteins between the pathogenic and non-pathogenic bacteria were analyzed in our study. (ijpsr.com)
Many different principles of thermoregulation have been identified in bacteria, which can be assigned to the class of protein-, DNA- or RNA-thermosensors. (springer.com)
Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis Natalia Comella and Alan D. Grossman* Department of Biology, Building 68-530, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. (igem.org)

RNA interference-mediated gene silencing of , , and which encode the catalytic and regulatory subunits of the phosphatase complex, respectively, caused a marked upregulation of bacterial-induced antimicrobial peptide gene expression in both S2 cells and adult flies. (cnrs.fr)

The zinc uptake regulator (Zur) gene is a bacterial gene that codes for a transcription factor protein involved in zinc homeostasis. (wikipedia.org)
The protein is a member of the ferric uptake regulator family and binds zinc with high affinity. (wikipedia.org)
It typically functions as a repressor of zinc uptake proteins via binding to characteristic promoter DNA sequences in a dimer-of-dimers arrangement that creates strong cooperativity. (wikipedia.org)
Under conditions of zinc deficiency, the protein undergoes a conformational change that prevents DNA binding, thereby lifting the repression and causing zinc uptake genes such as ZinT and the ZnuABC zinc transporter to be expressed. (wikipedia.org)
This altered gene expression also correlated directly with protein levels, bacterial capacity for DNA uptake, and natural transformability. (biomedcentral.com)
In our current working model, the components of a type IV pilus combined with a few other competence proteins (such as ComEA, ComEC, and ComF) make up the majority of the DNA-uptake machinery. (biomedcentral.com)
Here, we investigate the structural basis for RNA recognition by ProQ/FinO proteins, through the crystal structure of the ProQ/FinO domain of the Legionella pneumophila DNA uptake regulator, RocC, bound to the transcriptional terminator of its primary partner, the sRNA RocR. (nature.com)

In vivo, MafR increased the activity of the P12294 and P11486 promoters and also the transcription levels of the two genes controlled by those promoters. (bvsalud.org)
Using a transient expression system, the researchers demonstrated that the synthetic transcription factors and their target DNA sequences (promoters) are able to direct specific and tunable control of gene expression. (energy.gov)
They designed synthetic promoters that responded to one synthetic transcription factor to work as simple logic gates that responded to one input, while more complex gates required synthetic promoters that responded to multiple inputs. (energy.gov)
To implement synthetic gene circuits in a multicellular context, the researchers used Arabidopsis roots as a model system where endogenous promoters drove tissue-specific expression of the synthetic transcription factors. (energy.gov)
At the agr locus, there are two divergent transcription units driven by promoters agr P2 and agrP3 . (ijpsr.com)

The eponymous FinO protein was discovered as a regulator of F plasmid conjugation nearly 50 years ago, and acts to bind a single partner sRNA called FinP to stabilize FinP and facilitate its interactions with its antisense partner, the mRNA encoding the major F plasmid transcription factor, TraJ 5 . (nature.com)
For pharmaceutical manufacturing, Vectron Biosolutions is focused on improving the performance of Escherichia coli systems by using expression vectors based on the xylS/Pm regulator/promoter system from Pseudomonas putida (xylS is the transcription regulator gene) on an RK2 plasmid modified to greatly reduce its size. (pharmasalmanac.com)
One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)

These thermosensors are part of a regulatory network, such as the production of heat shock proteins mediated by sigma factor 32 (RpoH) in Escherichia coli or the transcriptional repressor of heat-shock genes HrcA in Bacillus subtilis (Hecker et al. (springer.com)

When LEE expression is activated, flagellar gene expression is down-regulated because bacterial flagella induce the immune responses of host cells at the infection stage. (nih.gov)
Furthermore, p53 as a transcription factor in DDRs is involved in innate and adaptive responses through recognizing immune receptors and activating immune cells such as T cells, B cells, NK cells, and macrophages. (ppjonline.org)
The autoantibodies are produced as an immune response to undegraded fragments of proteins in gluten. (texasorganicresearchcenter.org)
Previous studies have suggested that ACOD1, also known as immune-responsive gene 1, is an immunometabolic regulator that favors itaconate production to inhibit bacterial lipopolysaccharide-induced innate immunity. (usuhs.edu)
Bacterial translocation from the gut and subsequent immune activation are hallmarks of HIV infection and are thought to determine disease progression. (prelekara.sk)
We examined humanized mice infected with HIV to determine if disruption of the intestinal barrier alone is responsible for elevated levels of LPS and if bacterial translocation increases immune activation. (prelekara.sk)
Acquisitions of OspC genes that are novel for the region confer to recipients unique identities to host immune systems and, presumably, selective advantage when immunity to existing types is widespread among hosts. (cdc.gov)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)

In Bacillus subtilis, a quorum response is mediated by a secreted 10-amino-acid modified peptide (ComX pheromone) that activates a receptor histidine kinase (ComP) that activates a response regulator transcription factor (ComA). (igem.org)

DDR cascades are activated by ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) proteins, which are DNA damage sensors and members of the phosphatidylinositol-3 kinase-like family that amplify and transmit signals to downstream components ( Meek, 2009 ). (ppjonline.org)
In the absence of Wnt signals, the cytoplasmic catenin beta-1 ( β-catenin ) is associated with a complex including auxin, glycogen synthase kinase 3 ( GSK-3 ), and adenomatous polyposis coli ( APC ) (the APC protein acts as the primary regulator of β-catenin function). (hindawi.com)
This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
Majority of R genes cloned so far belong to the Nucleotide-Binding Site Leucine-Rich Repeat (NBS-LRR) or LRR Kinase super-families [7]. (austinpublishinggroup.com)
After recognition, plant's constitutive basal defense mechanisms [12] initiates a diverse set of downstream signaling events, leading to an activation of complex signaling cascades such as rapid microbursts of Reactive Oxygen Species (ROS), callose deposition to strengthen the cell wall, ion channels and MAP kinase cascades, phytohormones like Salicylic Acid (SA), Jasmonic Acid (JA), Ethylene (ET) and transcriptional induction of defense related genes [18,19]. (austinpublishinggroup.com)
We further revealed that the phosphorylation of cyclin-dependent kinase 2 (CDK2) on threonine-160 mediates the activation of mitogen-activated protein kinase 8 through receptor for activated C kinase 1, leading to JUN-dependent transcription of ACOD1 in human and mouse macrophages or monocytes. (usuhs.edu)

Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
In the presence of Wnt signals, the Wnt proteins bind to (frizzled) frizzled receptors ( FZDs ) and low-density lipoprotein receptor-related protein ( LRP ) receptors, leading to the stabilization of β-catenin , its transfer to the nucleus, and the activation of target genes. (hindawi.com)
Similarly, a minimal ProQ/FinO domain protein, NMB1681, has been shown to bind a range of structured RNAs in Neisseria meningitidis 15 . (nature.com)
The Pm promoter does not operate via a repressor mechanism but rather requires a benzoic acid external inducer to bind to the transcription regulator to turn it on. (pharmasalmanac.com)
These small non-coding RNAs derived from their precursor sequences, bind to their target mRNAs and negatively mediate the gene expressions in pre-transcriptional or post-transcriptional stages by impeding mRNA translation [ 12 , 13 ]. (springeropen.com)
All of the proteins bind ATP and, consequently, all of them carry the classical Walker A (phosphate-binding loop or P-loop) and Walker B (Mg2+-binding aspartic acid) motifs. (embl.de)

ETI, also known as R-gene-mediated resistance, or specific resistance, represents a more amplified form of resistance [10]. (austinpublishinggroup.com)
Specific recognition is generally mediated via resistance (R) gene products carrying Leucine-Rich Repeats (LRRs), and is typically distinguished from PTI by elicitation of Hypersensitive Response (HR)-associated localized program cell death. (austinpublishinggroup.com)
Examples of known NBS-LRR R genes include the Xanthomonas resistance gene Xa1 in rice [12]. (austinpublishinggroup.com)
Most of the R genes mapped against gall midge resistance in rice are also from NBS-LRR gene family [15-17]. (austinpublishinggroup.com)
An attractive pathway to resolve this problem of resistance may be achieved by targeting the bacterial quorum sensing (QS) process. (ijpsr.com)
It is estimated that bacterial resistance can increase mortality and morbidity by two-fold 6 . (ijpsr.com)
An attractive pathway to resolve the problem of bacterial resistance to current antibacterial agents is targeting bacterial QS 10-14 . (ijpsr.com)
Innate and induced resistance mechanisms of bacterial biofilms. (igem.org)

RGA and GAI belong to the DELLA subfamily within the GRAS family of plant regulatory proteins. (nih.gov)

ROS commonly triggers and precedes programmed cell death and also functions as signal molecules for production of Pathogenesis-Related (PR) protein. (austinpublishinggroup.com)

Integration with 456 mass-spectrometry datasets confirms the presence of 603 small peptides at the protein level in humans and provides insights into the subcellular localization of these small proteins. (biomed.news)
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. (cipsm.de)

Altogether, our results suggest that the crucial role played by the pyrD gene in AIEC virulence, and the presence of structural differences between E. coli and human DHOD allowing for the design of specific inhibitors, make E. coli DHOD a promising target for therapeutical strategies aiming at counteracting chronic inflammation in CD by acting selectively on its bacterial triggers. (rossimicrolab.com)
We explain a variety of bacterial swarming and social foraging behaviors and discuss the control system on the E. coli that dictates how foraging should proceed. (typeset.io)
Final improvements to the technology in E. coli are being made to increase the secretion rate and ensure that the technology is applicable to many different proteins. (pharmasalmanac.com)
In the case of the lac operon of E. coli, a well-studied system for whether a gene is regulated. (lu.se)

The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)

It has been discovered that a large number of bacterial species produce many virulence factors and form biofilms, which are regulated by the cell to cell communication process called quorum sensing (QS) 7-9 . (ijpsr.com)
in Bacterial Biofilms (ed. (igem.org)

β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)
Target genes activated by hypoxia inducible factor (HIF) decrease the dependence of the cell on oxygen, whereas Ras, Myc, and Akt can also upregulate glucose consumption and glycolysis. (pharmaceuticalintelligence.com)
Many of the target genes by the newly identified miRNAs were associated with plant growth and development, stress response, defense and hormone signaling, and oil synthesis pathways. (springeropen.com)

Although the number of AgrA protein sequences has increased exponentially, the number of experimentally determined protein structures lags far behind. (ijpsr.com)

The mechanisms that control modulation in transcription and associated phenotypic changes are poorly understood. (plos.org)

A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
We have evaluated the orthologous distribution of these elements in other sequenced bacterial genomes using the repertoire of TFs identified in USA300, and identified a core set of regulators for both the Firmicutes phylum, and the Staphylococacceae group. (biomedcentral.com)

The expression of the CDK2-ACOD1 axis also correlated with severity of illness in a cohort of 40 patients with bacterial sepsis. (usuhs.edu)
ABSTRACT This study aimed to evaluate the association of plasma MIF level and -173 G/C single nucleotide polymorphism of the MIF gene with the occurrence, severity and mortality of sepsis patients. (who.int)
High MIF levels and MIF -173G/C gene polymorphism are powerful predictors of the severity of sepsis and its outcome. (who.int)
Sepsis is defined as a host's response to been a candidate gene for investigation into blood culture bottles (Egyptian infection resulting from an imbalance in inflammatory disease, and studies Diagnostic Media) then incubated at between systemic pro-inflammatory focusing on elucidation of MIF gene 37 °C for 7-14 days. (who.int)
Up to now there gle nucleotide polymorphism (SNP) late and MacConkey agar (Oxoid) have been no published data about the was identified in the untranslated 5´ plates both aerobically and anaerobi- incidence of sepsis in developing coun- region of the MIF gene at position -173 cally using BD GasPack EZ anaerobic tries. (who.int)

This screen identifies new regulators of myofiber atrophy and hypertrophy, including the transcription factor Deaf1 . (sdbonline.org)
A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
As the early tumor expands, it outgrows the diffusion limits of its local blood supply, leading to hypoxia and stabilization of the hypoxia-inducible transcription factor, HIF. (pharmaceuticalintelligence.com)
Figure 1: Prediction and confirmation of the existence of an LPS-induced transcription factor network involving NF-κB, C/EBPδ and ATF3. (nature.com)
Barnes, P.J. & Karin, M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. (nature.com)
It is believed that the ILC1 fate decision is controlled by the T-box transcription factor T-bet endowing ILC1s with the capability to produce large amounts of IFN-g. (iisymposium.nl)
Group 3 ILCs developmentally depend on the transcription factor RORgt and produce the cytokines IL-22, IL-17A and IL-17F. (iisymposium.nl)
The prototype of DEAD-box proteins is the translation initiation factor eIF4A. (embl.de)
Eukaryotic TFIIH basal transcription factor complex helicase XPB subunit. (embl.de)
An ATP-dependent 3'-5' DNA helicase which is a component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. (embl.de)
Transcription factor binding motifs help to elucidate regulatory mechanism. (systemsbiology.net)
The TCF7L2 transcription factor is a critical regulator of Wnt pathway-dependent gene expression in the intestinal epithelia. (cam.ac.uk)

These genes are predicted to encode a calcium-transporting P-type ATPase and a QueT transporter family protein, respectively. (bvsalud.org)
Multiple copies of esr41 abolished LEE expression by down-regulating the expression of ler and pch, which encode positive regulators of LEE. (nih.gov)

Mice homozygous for a knock-out allele exhibit impaired selective autophagy and abnormal response to bacterial infection in MEFs. (jax.org)

Current research on viral proteins that interact with fibrillarin. (nih.gov)

RGA (repressor of ga1-3) and GAI (gibberellin insensitive) are negative regulators of plant hormone gibberellin (GA) signaling in Arabidopsis. (nih.gov)

Targeted gene deletion mutants of amlE and amlR were constructed by use of the CRISPR/Cas9 technology. (frontiersin.org)
Transcription of the aml operon is significantly repressed in the wild type when growing on glucose and repression is absent in an Δ amlR deletion mutant. (frontiersin.org)

We show that, in the AIEC strain LF82, inactivation of the pyrD gene, encoding dihydroorotate dehydrogenase (DHOD), an enzyme of the de novo pyrimidine biosynthetic pathway, completely abolished its ability of to grow in a macrophage environment-mimicking culture medium. (rossimicrolab.com)
Neither a gene encoding a maltose phosphorylase (MalP) nor MalP enzyme activity were detected in the wild type. (frontiersin.org)
Temperature has a direct effect on fundamental biological systems, including enzyme activity and correct folding of proteins. (springer.com)

DEAF-1 recognizes several TTCG motifs within the portion of the Dfd autoregulatory region termed 'module E.' In addition, DEAF-1 binds several similar motifs within a Dfd response element ( DRE ) from the 1.28 gene that enhances maxillary gene expression during embryogenesis (Pederson, 2000). (sdbonline.org)
The cyclic adenosine monophosphate (cAMP) receptor protein CRP, which is the global regulator of CCR, binds to regulatory DNA elements called CRP sites when in complex with cAMP. (biomedcentral.com)
Previous studies in Haemophilus influenzae suggested that the CRP protein binds competence-specific CRP-S sites under competence-inducing conditions, most likely in concert with the master regulator of transformation Sxy/TfoX. (biomedcentral.com)

Although AmlR apparently is a local transcriptional regulator of the aml operon, the Δ amlR strain shows severe growth inhibitions on glucose and - concomitantly - differential transcription of several genes of various functional classes. (frontiersin.org)
Transcription of the ltxA operon is induced during anaerobic growth. (usda.gov)

The top category of Deaf1-regulated genes consists of glycolytic enzymes, which are suppressed by Deaf1 and Gsk3 but are upregulated by Deaf1 RNAi. (sdbonline.org)
In addition, the results tend to be better for bacterial proteins and enzymes. (pharmasalmanac.com)

Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. (sdbonline.org)
It is proposed that DEAF-1 is a regulator of Drosophila immunity (Reed, 2008). (sdbonline.org)
By acquisition of the complete part or a large part of a novel ospC gene, an otherwise adapted strain would assume a new serotypic identity, thereby being comparatively fitter in an area with a high prevalence of immunity to existing OspC types. (cdc.gov)

NBS-LRR gene family organized in large clusters of orthologous genes and comprised about 1500 genes in rice [11]. (austinpublishinggroup.com)

We determined the ribosome locations across six primary human cell types and five tissues and detected 7,767 smORFs with translational profiles matching those of known proteins. (biomed.news)
To identify protein-coding sORFs in S. pneumoniae, antibiotic-enhanced ribosome profiling was conducted. (biomed.news)

The biosynthesis genes are encoded by the acb gene cluster, which was identified in 1999 by Stratmann et al. (frontiersin.org)

Our goals were to identify other proteins that affect bacterial toxin production and to elucidate how these proteins work together. (usda.gov)

First, analyses of ltxA RNA expression from defined leukotoxin promoter mutations in the chromosome identify -69 to -35 as the key control region and indicate that an activator protein modulates leukotoxin transcription. (usda.gov)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
the mutations lead to the expression of a truncated version of TCF7L2 that is functionally identical to the processed, short form of the protein. (cam.ac.uk)
Bioinformatics analyses have identified unique, molecular biomarkers and clinical characteristics of TCF7L2 mutant colorectal cancers that include microsatellite instability, exclusivity of BRAFV600E mutations, better prognosis and differential gene expression. (cam.ac.uk)
I further showed the outcome of TCF7L2 mutations and the altered ratio of long and short versions of the TCF7L2 protein - alteration of the Wnt pathway gene expression program with specific consequences on cell proliferation, clonogenic growth, cell cycle progression and survival. (cam.ac.uk)
SCID results from mutations in any of more than 15 known genes. (medscape.com)

The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. (nih.gov)
Small RNAs (sRNAs) control a variety of physiological responses across bacterial species 1 . (nature.com)

Insight into how these proteins recognize their cognate RNAs initiated with FinO. (nature.com)

Regulated in parallel to CT are pilus genes, which allow effective colonization of the digestive tract. (kenyon.edu)

The protein is highly conserved, and forms a huge variety of structure in cells in concert with a huge numbers of actin binding proteins. (hasenchat.info)
Here, we identify the highly conserved protein phosphatase 4 (PP4) complex as a bona fide negative regulator of the IMD pathway. (cnrs.fr)

The expression of retS over time was also evaluated by western blot when co-cultivated with Staphylococcus aureus and Candida albicans in artificial sputum media and we noticed that there was no change in the expression of this gene when compared to the axenically cultured PAO1. (usp.br)

Here we demonstrate that MafR functions as a transcription activator. (bvsalud.org)
However, full expression of those genes requires a QS-dependent secondary activator (HapR and QstR, respectively). (biomedcentral.com)

To investigate the response of LuxS01 and wild type strain to exogenously added AI-2, cells from Venetoclax in vitro experiments A and B were harvested in late exponential phase for RNA extraction and microarray gene expression analysis. (hsdpathway.com)

Based on the data provided in this study we suggest that the identified sites are important for the expression of the competence genes qstR and comEA and therefore for natural transformability of V. cholerae even though the motifs might not reflect bona fide CRP-S sites. (biomedcentral.com)

The cAMP receptor protein (CRP) indirectly increases ltxA expression but the intermediary regulator is unknown. (usda.gov)

Anatomy14

Organisms10

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes87

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Regulation20

Effector6

Signaling pathway6

Genome9

Strains3

Metabolism1

Biofilm5

Collection of bacterial1

Upstream9

Encodes6

Infections7

Kinases2

Putative1

Homology4

Signal Transduction2

Regulates4

Pathogens2

Pathogen5

Interaction4

Accessory gene regulator1

Bacteria9

Antimicrobial1

Uptake7

Promoters5

Plasmid3

Escherichia1

Immune8

Response regulator1

Kinase6

Bind6

Resistance8

Regulatory proteins1

Pathogenesis-related1

Subcellular localization2

Coli4

Mediate1

Biofilms2

Target genes3

Sequences1

Mechanisms1

Genomes2

Sepsis5

Factor12

Encode2

MEFs1

Viral1

Repressor1

Deletion2

Enzyme3

Binds3

Operon2

Enzymes2

Immunity3

Clusters1

Ribosome2

Biosynthesis1

Elucidate1

Mutations6

Species2

Recognize1

Pilus1

Highly conserved2

Staphylococcus1

Activator2

Strain1

Motifs1

Receptor1