Regulation transcription gene rearrangement. Medical search. Frequent questions

Specifically, this protein helps control the transcription of certain genes important in the maturation (differentiation) of white blood cells beyond the promyelocyte stage. (medlineplus.gov)
These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
The FLI protein controls the growth and development of some cell types by regulating the transcription of certain genes. (medlineplus.gov)
Instead of finding a single clear cause, their results showed large epigenetic disturbances - changes that don't occur in the DNA sequence itself, but are responsible for enhancing or reducing the activity of certain genes. (embl.org)

A rearrangement of genetic material (translocation) between chromosomes 15 and 17, written as t(15;17), fuses part of the PML gene with part of the RARA gene. (medlineplus.gov)
A rearrangement (translocation) of genetic material between chromosomes 22 and 11, written as t(11;22), fuses part of the EWSR1 gene with part of the FLI1 gene, creating the EWSR1/FLI1 fusion gene. (medlineplus.gov)
The genes involved in the translocation were determined in one case (Meyer et al. (atlasgeneticsoncology.org)
This translocation seems to create nonfunctional fusion genes. (atlasgeneticsoncology.org)
This translocation involves the immunoglobulin heavy-chain gene on chromosome 14 and the BCL1 locus on chromosome 11. (medscape.com)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)

Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
As the proteins catalyze all the biochemical reactions in our body, the implication is that the genes ultimately control and determine all the characteristics of the organism. (i-sis.org.uk)
Epigenetic regulation refers to the multiple chemical modifications of DNA or DNA-associated proteins that alter chromatin structure and DNA accessibility in a heritable manner, without changing DNA sequence. (frontiersin.org)
Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
which is the first step in the production of proteins from genes. (medlineplus.gov)
The fusion proteins produced from the less common gene translocations have the same function as the EWS/FLI protein. (medlineplus.gov)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
These epigenetic changes can affect the activity of proteins called transcription factors and DNA sequences called enhancers, known as the gene regulatory network. (embl.org)
These are sequences of DNA that don't carry instructions for making proteins, but are responsible for other functions such as gene regulation. (embl.org)
The expression of the PCWDE-encoding genes has been so far primarily investigated on the level of transcriptional regulation by regulatory proteins, especially the transactivator Xyr1 and the repressor Cre1. (tuwien.at)
Otherwise, the impact of chromatin remodeling, i.e. the dynamic modification of chromatin architecture to allow the regulatory proteins access to genomic DNA, on gene expression in T. reesei has received hardly any attention so far. (tuwien.at)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
List of genes also include 84 hypothetical proteins. (cdc.gov)

We have previously shown that disruption of the human CREB binding protein ( CREBBP or CBP ) gene, either by these gross chromosomal rearrangements or by point mutations, leads to RTS. (bmj.com)
We find that chromosomal rearrangements and related recombination defects are major but not sole causes of hybrid infertility. (elifesciences.org)
Mosaic) aneuploidies and chromosomal rearrangements are a frequent cause of idiopathic MCA/MR. Starting in 1959 with the identification of trisomy-21 as the genetic basis of Down syndrome [ 10 ], microscopic observation of metaphase chromosomes has for several decades been the method of choice for detecting chromosome abnormalities in MCA/MR patients. (biomedcentral.com)

Genes, Chromosomes and Cancer. (lu.se)

Genomic cis regulatory elements support the gene transcriptional landscape which fine tune spatiotemporal gene expression via interaction with different transcription factors and co modulators during development. (fortuneonline.org)
Such candidate based analysis of features within cis regulatory element on a gene can help elucidate intricate genomic architecture, gene regulation and its impact on complex disorders. (fortuneonline.org)
My lab studies how the genomic sequences that control gene expression function and evolve. (berkeley.edu)
For each of the approximately 40 transcription factors critical in shaping anterior-posterior and dorsal-ventral patterns, our goals are to: 1) measure the factor s in vitro affinity to each of its potential target sequences, 2) identify the genomic regions bound by each factor in living embryos, 3) determine the expression pattern of the factor and its targets in three-dimensions at cellular resolution. (berkeley.edu)
Interestingly, most of their encoding genes reside in hypermethylated genomic regions: thus, their tumor suppressor function is normally disallowed in these tumors. (oncotarget.com)
Genetic analyses have provided a wealth of information on the genectic constitution of STT, and clearly nonrandom patterns of genetic changes, ranging from point mutations and gene fusions to massive genomic imbalalnces, have been identified in each histological entity studied in sufficient detail. (lu.se)

Genome-wide studies in Saccharomyces cerevisiae , for example, have revealed that promoters of most actively transcribed genes are depleted of nucleosomes and that histone density is inversely proportional to the transcription rate within coding regions, suggesting that nucleosomes are dynamically disassembled and reassembled at each passage of the polymerase ( 16 ). (asm.org)
Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones. (nih.gov)
in one study, 31 genes in breast CAFs, which were identified using Affymetrix Human Genome U133 Plus 2.0 and an empirical Bayesian model, were different from those in NFs ( 11 ). (spandidos-publications.com)
Here we use a well-known human tumor suppressor gene, Breast Cancer Type 1 ( BRCA1 ) and UCSC human genome browser database to report the in-silico putative cis regulatory enhancer element and its features. (fortuneonline.org)
The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. (ki.se)
We are a hybrid computational and experimental lab who couple genome-scale computational and experimental analysis of gene regulation in Drosophila melanogaster and Saccharomyces cerevisiae with extensive analysis of comparative sequence data and experimental analysis of species closely related to these model systems. (berkeley.edu)
We focus on short evolutionary timescales where it is possible to couple specific changes in genome sequences with alterations in gene regulation and expression. (berkeley.edu)
The detailed experimental data we are generating for D. melanogaster , and the genome sequences of 12 Drosophila species are a tremendous resource for studying the evolution of gene regulation. (berkeley.edu)
Two of the subunits, Rpb1 and Rbp2, are more commonly known as A and B. In the human genome they are encoded by the genes POLR2A and POLR2B respectively [ RNA Polymerase Genes in the Human Genome ]. (blogspot.com)
RefSeq annotates one representative transcript (NM included in AceView variant.a), but Homo sapiens cDNA sequences in GenBank, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 11 spliced variants. (blogspot.com)
We studied chromosome structure in complete genome sequences from 167 Bordetella species isolates, as well as 469 B. pertussis isolates, to gain a generalized understanding of rearrangement patterns among these related pathogens. (cdc.gov)

This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)
Based on all these data, we propose that miR-29a-3p, miR-34b-3p, miR-181c-5p and miR-517a-3p are disallowed tumor suppressor genes in neuroblastoma and suggest them as new therapeutic targets in neuroblastoma. (oncotarget.com)

The most common mutation that causes Ewing sarcoma involves two genes, the EWSR1 gene on chromosome 22 and the FLI1 gene on chromosome 11 . (medlineplus.gov)

Chromosome aberrations can affect one or more genes in a complex manner, such as by changing the regulation of gene expression, by disrupting exons, and by creating fusion genes. (biomedcentral.com)

In addition, the density and positioning of nucleosomes have also been linked to transcriptional regulation. (asm.org)
Gene ontology analysis supports the hypothesis that pair-bond formation involves transcriptional regulation, and changes in neuronal structure. (cdc.gov)

Chromatin also regulates Pol I transcription, although its mechanistic details are less understood. (asm.org)
The EWS protein, produced from the EWSR1 gene, also regulates transcription. (medlineplus.gov)
Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). (proteopedia.org)
The interplay between these two transcription factors mainly regulates the expression of PCWDEs. (tuwien.at)

Genes and genomes are stable, and except for rare, random mutations, are passed on unchanged to the next generation. (i-sis.org.uk)
Genes and genomes cannot be changed directly in response to the environment. (i-sis.org.uk)
In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)
We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and are using these data to characterize how the individual building blocks of regulatory sequences (transcription factor binding sites) and higher order structures (e.g. developmental enhancers) evolve. (berkeley.edu)
These data were further used to predict all possible rearrangements between IS element copies present in Bordetella genomes, revealing that only a subset is observed among circulating strains. (cdc.gov)

However, the actual chromatin structure and transcription pattern of individual V segments on the two alleles has not yet been identified. (estme.org)
Although it is clear that switching among BESs does not involve DNA rearrangements and that regulation is probably epigenetic, it remains unknown why BESs are transcribed by Pol I and what roles are played by chromatin structure and histone modifications. (asm.org)
The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)

Whooping cough (pertussis), primarily caused by Bordetella pertussis, has resurged in the United States, and circulating strains exhibit considerable chromosome structural fluidity in the form of rearrangement and deletion. (cdc.gov)
Over time, OspC genes were transferred between strains through recombinations involving the whole or parts of the gene and one or both flanks. (cdc.gov)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Studies of genes transcribed by RNA polymerase II (Pol II) have shown that open and closed chromatin structures are dynamically regulated through multiple mechanisms, including histone modifications, histone variant incorporation, and DNA methylation (reviewed in reference 17 ). (asm.org)
To date, most of our understanding of epigenetic regulation and its participation in leukemogenesis is based on the enzymatic activities and protein-protein interactions of histone and DNA modifiers. (frontiersin.org)
GH17J043079 showed histone activity in human embryonic stem cells, cancerous cells, housed transcription factors specific to liver cells and was enriched with Alu elements, indicative of ability for potential gene rearrangements. (fortuneonline.org)
Change in gene expression associated with pancreatic cancer could be attributed to the variation in histone posttranslational modifications leading to subsequent remodeling of the chromatin template during transcription. (nebraska.edu)
Our study explores the possibility that regulation of histone methylation by hPaf1 can contribute towards alteration in gene expression by nucleosomal rearrangement. (nebraska.edu)

Scholars@Duke publication: Regulation of T cell receptor-alpha gene recombination by transcription. (duke.edu)
Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. (duke.edu)
Transcription increases the recombination of J(alpha) segments located within several kilobases of a promoter and prevents the activation of downstream promoters through transcriptional interference. (duke.edu)
Intragenic recombination among ospC genes is known, but the extent to which recombination extended beyond the ospC locus itself is undefined. (cdc.gov)

Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. (cancerindex.org)
Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. (atlasgeneticsoncology.org)

The PML-RARα protein functions differently than the protein products of the normal PML and RARA genes. (medlineplus.gov)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
The protein produced from the EWSR1/FLI1 fusion gene, called EWS/FLI, has functions of the protein products of both genes. (medlineplus.gov)
He is firmly convinced that most human genes express a number of different protein products that are produced as the result of alternatively spliced mRNA precursors. (blogspot.com)

The transcription factor RBPJ forms a coactivator complex in the presence of a Notch signal, whereas it represses Notch target genes in the absence of a Notch stimulus. (uni-ulm.de)
In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. (uni-ulm.de)

These findings highlight a new level of Shikimic acid (Shikimate) immune system regulation that optimizes gene diversity. (estme.org)
We are driven by a desire to understand the molecular basis of organismal diversity, and the belief that many differences in physiology, morphology and behavior arise from changes in gene regulation. (berkeley.edu)
To take advantage of sequence diversity outside of the genus Drosophila, we are sequencing developmentally important loci from several non-Drosophilid fly families to provide insights into the underlying principles of gene regulation. (berkeley.edu)
240 copies of IS481, IS elements appear less numerous in other species and yield less chromosome structural diversity through rearrangement. (cdc.gov)

A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
By showing that epigenetic changes may prime endothelial cells to differentiate into smooth muscle cells, which would then obstruct arteries, it also raises the question of what exactly triggers this huge rearrangement. (embl.org)

The enhancer interacts with NBR1, NBR2, TMEM106A and RPL27 and VAT1 gene promoters. (fortuneonline.org)
Unlike the amount of methylation of their encoding gene promoters, all these miRNAs were significantly overexpressed following treatment with 5'-AZA. (oncotarget.com)

Furthermore, cytoskeletal elements such as for example MAPs and Tau will also be regarded as controlled by ERK for cytoskeleton rearrangements influencing mobile morphology [16]. (ampkpathway.com)

The transcriptionally regulated genes have different roles under stress response. (intechopen.com)

This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)

and (iv) genes harboring germline non-silent variants presumed to confer a risk of sporadic ALL. (haematologica.org)
Acquired characters are not inherited, as germline genes are not influenced by the environment. (i-sis.org.uk)

However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than the karyotype structure. (cancerindex.org)
We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)

Our results demonstrate two key functions for transcription in Tcra locus regulation. (duke.edu)

Analyses of the entire CBP gene by the protein truncation test showed 4/37 truncating mutations. (bmj.com)

Additionally, we identified genes that were differentially expressed across species after mating in each of our regions of interest. (cdc.gov)

A diagram showing the major cancer genes for some cancers. (cancerquest.org)
The larger the gene name, the more frequently that gene is defective in that cancer type. (cancerquest.org)
These genes have been found to be either malfunctioning or non-functioning in many different kinds of cancer. (cancerquest.org)
ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
Specific intervention by gene therapy is a possible alternative and complementary strategy for the treatment of breast cancer. (hum-molgen.org)

1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
Acquisitions of OspC genes that are novel for the region confer to recipients unique identities to host immune systems and, presumably, selective advantage when immunity to existing types is widespread among hosts. (cdc.gov)

CAFs are different from NFs, and their unique phenotypes and functions are partly determined by differences in gene expression. (spandidos-publications.com)
We examined gene expression in the amygdala, hypothalamus, and combined ventral pallidum/nucleus accumbens in virgins and at three time points after mating to understand species differences in gene expression at baseline, in response to mating, and during bond formation. (cdc.gov)

ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)α phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction. (sigmaaldrich.com)
My colleague is very knowledgeable about the genes for the major subunits of eukaryotic RNA polymerase since it was his lab that cloned the first one. (blogspot.com)

These results are consistent with another study concerning the gene expression profiling of breast CAFs, which were detected using a complementary DNA microarray ( 15 ). (spandidos-publications.com)
Here, we employed single-cell gene expression profiling to describe the dynamic transition between cell proliferative states in three different cell lines using a panel consisting of 93 marker genes. (frontiersin.org)

Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication (PubMed:18033802). (proteopedia.org)
Two articles describe tools for the detection of large-scale structural rearrangements in individual chromosomes. (hum-molgen.org)
Therefore, aside from its structural part in the forming of caveolae, small is known regarding any part of caveolin-2, in the regulation of cell mitogenesis specifically. (ampkpathway.com)
All organisms-bacteria, archaea, and eukaryotes-have a transcription initiation factor that contains a structural module that binds within the RNA polymerase (RNAP) active-center cleft and interacts with template-strand single-stranded DNA (ssDNA) in the immediate vicinity of the RNAP active center. (osti.gov)
This transcription initiation-factor structural module preorganizes template-strand ssDNA to engage the RNAP active center, thereby facilitating binding of initiating nucleotides and enabling transcription initiation from initiating mononucleotides. (osti.gov)
However, this transcription initiation-factor structural module occupies the path of nascent RNA and thus presumably must be displaced before or during initial transcription. (osti.gov)
The chromosome of B. pertussis has previously been shown to exhibit considerable structural rearrangement, but insufficient data have prevented comparable investigation in related species. (cdc.gov)

HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)
This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)

The mutation that causes acute promyelocytic leukemia involves two genes, the PML gene on chromosome 15 and the RARA gene on chromosome 17 . (medlineplus.gov)

Rearrangement of immune receptor loci in B and T lymphocytes takes place in an ordered developmental manner using transcription factors and regulatory elements to open up and turn on the rearrangement process at each individual cluster during its specific stage of differentiation1,2,3,4,5. (estme.org)
Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)

It makes no sense that conserved genes would be producing alternative protein variants that are species specific. (blogspot.com)
I asked him if he had ever looked at his favorite genes to see if the predicted variants make any sense. (blogspot.com)
I suggested that he look at the predicted alternative splice variants of the two human genes and let me know if he is still convinced that these variants make biological sense. (blogspot.com)
Before following this link to the POLR1A variants, let's note that on the annotated Entrez Gene website there are no alternative splice variants listed. (blogspot.com)
Alternative mRNA variants and regulation: The gene contains 29 different introns (28 gt-ag, 1 gc-ag). (blogspot.com)
Transcription produces 13 different mRNAs, 11 alternatively spliced variants and 2 unspliced forms. (blogspot.com)

Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
Numerous transcription factors, including Elk-1, Egr-1, and c-Jun, are modulated by ERK in the nucleus for regulation of gene transcription [8C11, 14, 15]. (ampkpathway.com)

Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)

They underlie genetic disease in roughly 15% of patients with multiple congenital abnormalities and/or mental retardation (MCA/MR). In genetic diagnostics, the pathogenicity of chromosomal aberrations in these patients is typically assessed based on criteria such as phenotypic similarity to other patients with the same or overlapping aberration, absence in healthy individuals, de novo occurrence, and protein coding gene content. (biomedcentral.com)
Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
To test the hypothesis that neural gene expression differences underlie differential capacities to bond, we performed RNA-sequencing on tissue from three brain regions important for bonding and other social behaviors across bond-forming prairie voles and non-bonding meadow voles. (cdc.gov)

Translocations involving the RARA gene and other genes have been identified in a few cases of acute promyelocytic leukemia. (medlineplus.gov)
Translocations that fuse the EWSR1 gene with other genes that are related to the FLI1 gene can also cause these types of tumors, although these alternative translocations are relatively uncommon. (medlineplus.gov)

Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
We are particularly interested in understanding how selection to maintain transcription factor binding sites affects the evolution of target sequences, and how the extensive plasticity seen in the organization of developmental enhancers is related to their function. (berkeley.edu)

Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)
Genes mainly involved in coding adhesion molecules and growth factors have also been found to be upregulated in other types of CAFs, including colon ( 12 ) and pancreatic ( 13 ). (spandidos-publications.com)
Cooperative activity of GR with other transcription factors and a plethora of coregulators contribute to the tissue- and context-specific response toward the endogenous and pharmacological glucocorticoids (GCs). (uni-ulm.de)
RESULTS: We first identified species and brain region as the factors most strongly associated with gene expression in our samples. (cdc.gov)

The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)

We are particularly interested in regulatory sequences that have undergone extensive rearrangements in their binding site repertoires without altering their function. (berkeley.edu)
Although extensive rearrangements are observed among Drosophla regulatory sequences, there must be limits to this plasticity. (berkeley.edu)

This high concentration of AChR in the synapse is achieved through clustering of AChR, up-regulation of the AChR gene transcription in the post-synaptic nuclei, and down-regulation of the AChR gene in the non-synaptic nuclei. (wikipedia.org)
Majority of the affected genes identified in the study cohort are involved in synaptic formation, transcription and its regulation, ubiquitination and chromatin remodeling. (biomedcentral.com)
Next, we found gene categories related to cell structure, translation, and metabolism that differed in expression across species in virgins, as well as categories associated with cell structure, synaptic and neuroendocrine signaling, and transcription and translation that varied among the focal regions in our study. (cdc.gov)
These include genes involved in regulating transcription, neuron structure, and synaptic plasticity. (cdc.gov)

These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)

Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. (nebraska.edu)

The present review summarizes the recent achievements in understanding the gene profiles of CAFs and pays special attention to their possible epigenetic alterations. (spandidos-publications.com)
Genetic alterations include genetic mutation, gene copy number variation (CNV), loss of heterozygosity (LOH), allelic imbalance (AI) and microsatellite instability (MSI). (spandidos-publications.com)

Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)

Therefore, while it appears that rearrangement occurs less frequently in other species than in B. pertussis, these clinically relevant respiratory pathogens likely experience similar mutation of gene order. (cdc.gov)

These regulatory elements are poorly conserved, highly heterogenous with limited understanding of their role in gene expression. (fortuneonline.org)
My lab is applying the high-resolution fluorescent imaging methods developed for D. melanogaster to systematically analyze gene expression, and dissect regulatory networks, in other Drosophila species and in several inbred lines of D. melanogaster . (berkeley.edu)
To understand the role of these changes in the disease, the Zaugg group developed a computational tool to reconstruct an enhancer-based gene regulatory network in a specific cell type, which they applied to their data. (embl.org)
In addition to the insights gained into this specific disease, the study also describes a computational tool to generate gene regulatory networks. (embl.org)

The EWSR1/FLI1 fusion gene occurs in approximately 85 percent of Ewing sarcomas. (medlineplus.gov)

To identify the most predictive genes we used a variable selection strategy. (frontiersin.org)
Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)

Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)

tures and gene expression patterns. (lu.se)

In contrast, genes transcribed by Pol II are organized in a more compact, regularly spaced, nucleosomal structure. (asm.org)

Originally, it was thought that at the time of rearrangement the two alleles in each cell are equal substrates for activation, with the choice being made in a stochastic manner10,11. (estme.org)
Through the use of pre-B-cell clones, it was then demonstrated that it is this same allele that undergoes the first rearrangement in each cell12. (estme.org)
e) Summary of active alleles across 5 different pre-B cell clones and pools of bone-marrow-derived pre-B cells as determined by H3ac enrichment, ncRNA transcription and lack of H3K27me3 enrichment. (estme.org)
The genes that have been identified to date have been categorized into two broad categories, depending on their normal functions in the cell. (cancerquest.org)
This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation (By similarity). (proteopedia.org)
Fusion with the host cell is most likely mediated by both E1 and E2, through conformational rearrangements of the heterodimer required for fusion rather than a classical class II fusion mechanism (PubMed:16533059, PubMed:29505618, PubMed:24698129). (proteopedia.org)
Induction from the caveolin-2 gene was up-regulated in response to insulin as well as the endogenous caveolin-2 improved the G1 to S stage changeover of cell routine whereas caveolin-1 inhibits when cells were expressed with recombinant caveolin-1. (ampkpathway.com)
It shows that there is much more information to be found in the chromatin states of a cell, rather than only looking at gene expression levels," says Judith. (embl.org)
role in cell cycle regulation. (atlasgeneticsoncology.org)
Here, we used quantitative real-time PCR, profiling the expression of 93 genes in single-cells from three different cell lines. (frontiersin.org)
We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
By applying the random forests algorithm, a supervised machine learning approach, we show how a multi-gene signature that classifies individual cells into their correct cell cycle phase and cell size can be generated. (frontiersin.org)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

Anatomy9

Diseases8

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes45

Information Science3

Certain genes4

Translocation6

Proteins14

Chromosomal rearrangements3

Chromosomes and Cancer1

Genomic6

Genome13

Tumor suppr2

Chromosome 111

Changing the regulation1

Transcriptional regulation2

Regulates4

Genomes5

Chromatin structure3

Strains3

Histone5

Recombination4

Partner genes2

Protein products5

Target genes2

Diversity4

Epigenetic changes2

Promoters2

Cytoskeleton1

Transcriptionally1

Differentiation3

Germline2

KMT2A2

Locus1

Truncating mutations1

Differentially1

Cancer5

Confer2

Differences in gene expression2

Eukaryotic2

Expression Profiling2

Structural7

Encodes3

Mutation that causes1

Loci2

Variants6

Numerous3

Targets1

Underlie3

Translocations2

Developmental2

Factors4

Oncogenes4

Sequences2

Synaptic4

MRNA1

Oncogenic2

Alterations2

Roles1

Pathogens1

Regulatory4

Fusion gene1

Predictive4

Intracellular1

Patterns1

Contrast1

Cell15