• Thus, inhibitor-1 serves as a critical junction between kinase- and phosphatase-signaling pathways, linking PP-1 to not only PKA and calcineurin but also Cdk5. (elsevierpure.com)
  • We discovered that our RET + cell lines had differential regulation of the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B (AKT) pathways. (nih.gov)
  • Cancer cells survive by co-opting intracellular growth pathways regulated through kinase signaling. (escholarship.org)
  • Many kinases in these pathways are validated drug targets and kinase inhibitors are first-line treatment for several advanced cancers. (escholarship.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • c-Src tyrosine kinase plays an important role in signal transduction pathways, where its activity is regulated by phosphorylation of the two tyrosine residues. (intechopen.com)
  • The pathways involved in cellular differentiation or transformation are Smad, Rho proteins, and PI3-kinase. (molvis.org)
  • Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. (abmole.com)
  • Since inhibitors of protein synthesis are known to activate cellular signal transduction pathways, our findings demonstrate new mechanisms for the regulation of HSV-1 IE gene expression which may be important during latency and reactivation. (microbiologyresearch.org)
  • Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia. (ox.ac.uk)
  • Our findings identify key roles for transcriptional mechanisms and protein kinase signaling pathways for IL-8 induction and provide insights into the mechanisms regulating lung inflammatory responses to organic dust exposure. (cdc.gov)
  • Cyclin-dependent kinase inhibitor proteins use ATP as a phosphate contributor to phosphorylate serine and threonine residues. (wikipedia.org)
  • In the cyclin-dependent kinase (CDK) family or CDK, Cyclin, and CKIs, serine/threonine kinases play an integral role in regulating the eukaryotic cell cycle. (wikipedia.org)
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
  • Cdk5 is named after its structural similarity to members of the serine/threonine cyclin-dependent kinase family. (frontiersin.org)
  • Gene ontology (GO) analysis suggested platelet-derived growth factor A (PDGFA) and proto-oncogene, Serine/Threonine kinase Raf-1 (RAF1) as new CRC candidate markers in CTCs and TDEs. (researchsquare.com)
  • Background Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine proteins kinase, may play functions in lots of biological procedures. (techblessing.com)
  • Background Glycogen synthase kinase 3 (GSK3) encodes a multifunctional serine/threonine proteins kinase, which is usually ubiquitously indicated in organisms which range from yeasts to mammals [1-3]. (techblessing.com)
  • A subset of these compounds potently, and sometimes selectively, inhibit the mammalian target of rapamycin (mTOR), a Ser/Thr kinase in the PI3K family, placing mTOR in kinase space at the intersection of PI3Ks and PTKs. (escholarship.org)
  • This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
  • BACKGROUND: Inhibitors of the phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathway are currently in clinical trials. (ox.ac.uk)
  • A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein which inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as tumor suppressors. (wikipedia.org)
  • The mTOR inhibitor PP242, which inhibits formation of eIF4F (a complicated of eIF4E/G/A)14,15, represses a subset of the Hipp-sensitive mRNAs (Prolonged Data Shape 4f and g). (ampkpathway.com)
  • Ser-9 in GSK3) catalyzed by either MAPKAP kinase-1/or p70S6K [11,12], whereas proteins kinase C phosphorylates and partly inhibits GSK3, however, not GSK3 [13]. (techblessing.com)
  • Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
  • Basal levels of phospho-Ser 6 inhibitor-1, as detected by a phosphorylation state-specific antibody against the site, existed in specific regions of the brain and varied with age. (elsevierpure.com)
  • Inhibition of Cdk5 by olomoucine enhanced phosphorylation of kinesin, suggesting that the effect was mediated by negative regulation of other kinases. (frontiersin.org)
  • Phosphorylation at CDK1, CDK4, and CDK9 sites on, respectively, protein phosphatase 1alpha, retinoblastoma protein, and RNA polymerase II is inhibited in neuroblastoma SH-SY5Y cells exposed to meriolins. (rcsb.org)
  • These data indicate that the effects of GM-CSF are not mediated by protein kinase C and that a phosphorylation event down-modulates the neutrophil response to GM-CSF. (ashpublications.org)
  • By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)
  • 1 nM IC 50 ) to inhibition of two cell cycle-regulating proteins, polo-like kinase 1 and Aurora kinase A. Finally, we show that two of these cell lines, CUTO32 and CUTO42, successfully establish xenografted tumors in nude mice. (nih.gov)
  • SIGNIFICANCE STATEMENT: We have derived and characterized three novel rearranged during transfection (RET) fusion non-small cell lung cancer cell lines and demonstrated that they have differential responses to RET inhibition as well as regulation of downstream signaling, an area that has previously been limited by a lack of diverse cell line modes with endogenous RET fusions. (nih.gov)
  • Notably, inhibition of the CaMKK (calmodulin-dependent protein kinase kinase) had little affect on GLUT translocation, whereas the inhibition or knockdown of AMPK (compound C, siRNA) activity prevented GLUT3 translocation to the cell surface after glutamate excitation. (jneurosci.org)
  • Next, we studied the effect of IL-11 on IL-3-dependent colony formation and its inhibition by these protein kinase inhibitors. (nii.ac.jp)
  • Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation : The isoform that may mediate G1/S inhibition. (researchmap.jp)
  • Protein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells. (researchmap.jp)
  • Vertex described its progress on inhibition of Flt-3, AstraZeneca presented on mTor inhibitors and Boehringer Ingelheim discussed its programme on Plk1 inhibitors. (soci.org)
  • Expression from the HSV-1 IE promoters that control synthesis of ICP0 and ICP27 was, unexpectedly, stimulated by inhibition of protein synthesis. (microbiologyresearch.org)
  • Expression from the human cytomegalovirus major IE promoter, when cloned into the genome of HSV-1 mutants, was also increased by inhibition of protein synthesis. (microbiologyresearch.org)
  • Establishment of a rat cell line inducible for the expression of human cytomegalovirus immediate early gene products by protein synthesis inhibition. (microbiologyresearch.org)
  • Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
  • Phosphatidylinositol 3-kinase-independent signal transduction pathway for PDGF-induced chemotaxis. (researchmap.jp)
  • It suggests that internalization of the receptor-ligand complex is not a rate-limiting step in signal transduction, and that regulation of the rate of internalization may be an important level of control of the activity of GM-CSF. (ashpublications.org)
  • IGF2 , or insulin-like growth factor 2, is a paternally expressed protein-coding gene. (medscape.com)
  • CDKN1C , or cyclin-dependent kinase inhibitor 1C, is a gene that encodes a protein implicated in cell cycle regulation. (medscape.com)
  • KCNQ1OT1 , or potassium voltage-gated channel subfamily Q member 1 opposite transcript 1 is the antisense transcript of the protein-coding gene KCNQ1 . (medscape.com)
  • What does this gene/protein do? (cancerindex.org)
  • Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 finger. (researchmap.jp)
  • Protein tyrosines and protein kinase C are required for gene expression of monocyte chemoattractant protein-1 in human monocytes. (researchmap.jp)
  • c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)
  • or the transmembrane protein gene cassettes of some pathogenic bacteria ( Santoyo and Romero, 2005 ), gene conversion can also generate sequence diversity. (elifesciences.org)
  • We have analysed the effect of cycloheximide on IE gene expression with HSV-1 mutants deficient in the production of functional levels of the three major transactivators, the virion protein (VP16) and two IE proteins (ICP0 and ICP4). (microbiologyresearch.org)
  • Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis. (microbiologyresearch.org)
  • Effect of protein synthesis inhibitors on growth factor activation of c- fos , c- myc , and actin gene transcription. (microbiologyresearch.org)
  • The CDKN1B gene provides instructions for making a protein called p27. (medlineplus.gov)
  • Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. (medlineplus.gov)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)
  • Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
  • For example, they use small molecule protein degraders to destroy cancer-causing proteins. (fredhutch.org)
  • Several organizations have recognized small-molecule GSK3 inhibitors [17,18]. (techblessing.com)
  • UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
  • Agrin, a protein extracted from the electric organ of Torpedo californica, induces the formation of specializations on cultured chick myotubes that resemble the postsynaptic apparatus at the neuromuscular junction. (rupress.org)
  • T315 Induces Down-Regulation of Protein Kinase W (Akt) and Phosphorylated Akt in AML Cell Lines T315 has been reported as an ILK inhibitor [2]. (exposed-skin-care.net)
  • The design of dual PI3K/PTK inhibitors is chemically challenging because PI3Ks and PTKs are members of significantly divergent kinase families. (escholarship.org)
  • Purpose: To determine the maximum tolerated dose (MTD), safety, pharmacokinetics, pharmacodynamics, and preliminary evidence of antitumor activity of the PI3K/mTOR inhibitor PF-04691502, administered orally once daily. (researchgate.net)
  • These alterations in tumor hypoxia should be considered in the design of clinical trials using PI3K/mTOR inhibitors, particularly in conjunction with radiotherapy. (ox.ac.uk)
  • Tyrosine kinase inhibitors (TKIs) against the human epidermal growth factor receptor (EGFR) are now standard treatment in the clinic for patients with advanced EGFR mutant non-small-cell lung cancer (NSCLC). (researchgate.net)
  • Two kinase families, phosphoinositide-3-kinases (PI3Ks) and protein tyrosine kinases (PTKs), are activated by mutations and amplifications in a disproportionate number of human cancers. (escholarship.org)
  • Additionally, PPPm-1 could effectively activate the Wnt/ß-catenin signaling pathway, promote the expressions of Wnt/1, ß-catenin, CyclinD1, and TCF-4 mRNA and protein, and inhibit GSK-3ß mRNA and protein expression to improve the learning and memory abilities of offspring mice. (bvsalud.org)
  • Rocaglamide A (RocA) typifies a course of proteins synthesis inhibitors that selectively wipe out aneuploid tumor cells and repress translation of particular mRNAs1-4. (ampkpathway.com)
  • Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. (microbiologyresearch.org)
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
  • Protein tyrosine kinase inhibitors inhibit both proliferation and chemotaxis of vascular smooth muscle cells. (researchmap.jp)
  • Tyrosine kinase ingibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells. (researchmap.jp)
  • However, Nabet admits that one major limitation to this approach is that it "leverages already available molecules [or chemical tools] that bind or inhibit a protein. (fredhutch.org)
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
  • If cell mutations surpass the cell cycle checkpoints during cell cycle regulation, it can result in various types of cancer. (wikipedia.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • First-generation EGFR TKIs, binding competitively and reversibly to the ATP-binding site of the EGFR tyrosine kinase domain, have resulted in a significant improvement in outcome for NSCLC patients with activating EGFR mutations (L858R and Del19). (researchgate.net)
  • In this review, we summarize the available post-progression therapies including third-generation EGFR inhibitors and combination treatment strategies for treating patients with NSCLC harboring EGFR mutations and address the known mechanisms of resistance. (researchgate.net)
  • Some mutations impair the protein's ability to interact with regulatory proteins, while others lead to the production of an unstable version of p27 that is quickly broken down. (medlineplus.gov)
  • The active cyclin/CDK complex then phosphorylates proteins, activates them, and sends the cell into the next phase of the cell cycle. (wikipedia.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The testis and epididymis were rapidly collected, and the sperm quality, testicular histology, Sertoli cell numbers, tight junction (TJ) ultrastructure, and blood-testis barrier-associated protein expression and localization were assessed. (bvsalud.org)
  • Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)
  • Webb, J. H., Villoutreix, B. O., Dahlbäck, B. and Blom A. M. (2001) Localization of a hydrophobic binding site for protein S on the b-chain of C4BP. (lu.se)
  • In this publication, the authors took a medicinal chemistry approach to identify an inhibitor for cyclin-dependent kinase 11 (CDK11), an understudied protein with important roles in cell cycle regulation, neuronal function and cell death. (fredhutch.org)
  • Rearranged during transfection ( RET ) rearrangements occur in 1% to 2% of lung adenocarcinomas as well as other malignancies and are now established targets for tyrosine kinase inhibitors. (nih.gov)
  • These data offer important insight into regulation of response to RET tyrosine kinase inhibitors and other potential therapeutic targets. (nih.gov)
  • Protein Kinases Promising Targets for Anticancer Drug Researc. (intechopen.com)
  • Protein kinases represent promising anticancer drug targets. (rcsb.org)
  • Consequently, the regulation/ misregulation of kinases has linked them to a number of diseases and they provide a wealth of opportunity as targets for drug discovery. (soci.org)
  • There was no switch in protein reflection of extracellular signalCregulated kinase 1 and 2 (ERK1/2) Doramapimod Doramapimod and phosphorylated ERK1/2 after Testosterone levels315 treatment. (exposed-skin-care.net)
  • Unexpectedly, this specificity problem led to the development of clinically useful, multi-targeted kinase inhibitors. (escholarship.org)
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors. (rndsystems.com)
  • A selectivity study done on 32 kinases showed that, compared with variolin B, meriolins display enhanced specificity toward CDKs, with marked potency on CDK2 and CDK9. (rcsb.org)
  • A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM. (bvsalud.org)
  • Homologues of GSK3 isoforms from varieties as faraway from one another as flies, zebrafishes and human beings screen over 90% series similarity inside the kinase domain name [7,8]. (techblessing.com)
  • The protein-protein interaction (PPI) of differentially expressed genes was drawn by the STRING website, and the results were imported into Cytoscape for visualization. (hindawi.com)
  • Cyclin-dependent kinase inhibitor proteins work by inactivating the CDKs by degradation. (wikipedia.org)
  • Further research has demonstrates that Cdks, cyclins and CKIs play essential roles in processes such as transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions and spermatogenesis. (wikipedia.org)
  • Identification of a novel inhibitor of mitogen-activated protein kinase kinase. (rndsystems.com)
  • Increase in IL-8 promoter activity was due to enhanced binding of activator protein 1 and NF-?B. IL-8 induction was associated with protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) activation and inhibited by PKC and MAPK inhibitors. (cdc.gov)
  • Role in cancer: Cyclin-dependent kinase inhibitors (CKIs) mutants are frequent in human cancers. (wikipedia.org)
  • Testosterone levels315, an integrin-linked kinase (ILK) inhibitor, provides been proven to suppress the growth of breasts cancers, abdomen chronic and tumor lymphocytic leukemia cells. (exposed-skin-care.net)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • CKIs are vital proteins within the control system that point out whether the process of DNA synthesis, mitosis, and cytokines control one another. (wikipedia.org)
  • GSK3β and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Aβ plaque formation, tau hyperphosphorylation and neurodegeneration. (frontiersin.org)
  • So far, both kinases have mostly been examined in isolation, leading to a schism of the research field into defenders of the GSK3β-versus the Cdk5 hypotheses of AD. (frontiersin.org)
  • Therefore activities of the other kinases Erk, CK1 and GSK3β were tested after oloumucine treatment. (frontiersin.org)
  • These included a talk on GSK3 inhibitors for Alzheimer's disease and JNK inhibitors for type II diabetes. (soci.org)
  • GSK3 and GSK3 are extremely homologous of their kinase domains [6]. (techblessing.com)
  • Nevertheless, these inhibitors aren't just inhibiting GSK3, but will also be influencing CDK kinase (2 and 5) and several other kinases. (techblessing.com)
  • Furthermore, there is apparently only an individual amino acidity difference (Glu196 in GSK3, Asp133 in GSK3), rendering it difficult to recognize an inhibitor that may be selective against GSK3 or CXCR7 GSK3 [19]. (techblessing.com)
  • Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells. (researchmap.jp)
  • Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)
  • Inhibitor-1, the first identified endogenous inhibitor of protein phosphatase 1 (PP-1), was previously reported to be a substrate for cyclin-dependent kinase 5 (Cdk5) at Ser 67 . (elsevierpure.com)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • We have examined the effects of the isoquinolinesulfonamide protein kinase inhibitors H7 and H8 on these functions of GM-CSF using whole blood assays. (ashpublications.org)
  • The first three proposals, on protein-based diagnosis, diagnostic materials and assays for less reactogenic vaccines, have been approved for one year. (who.int)
  • Dephosphorylation of inhibitor-1 at Thr 35 is equivalent to inactivation of the protein, as inhibitor-1 only serves as an inhibitor of PP-1 when phosphorylated by cAMP-dependent kinase (PKA) at Thr 35 . (elsevierpure.com)
  • Body 2 Testosterone levels315 induce dephosphorylation of proteins kinase T (Akt) without transformation of integrin-linked kinase (ILK) in AML cell lines. (exposed-skin-care.net)
  • RNA-binding proteins (RBPs) play key roles in RNA metabolism and post-transcriptional regulation. (buyresearchchemicalss.net)
  • In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. (uml.edu)
  • Cell cycle progression is stopped by Cyclin-dependent kinase inhibitor protein at the G1 phase. (wikipedia.org)
  • Cyclin-dependent kinase inhibitor proteins are essential in the regulation of the cell cycle. (wikipedia.org)
  • These cyclin-dependent kinase inhibitor protein emerges only in their specific cell cycle phase. (wikipedia.org)
  • The discovery of Cyclin-dependent kinase inhibitor proteins in 1990 opened the door in how we think about cell cycle control. (wikipedia.org)
  • We confirmed each of our cell lines expresses the RET fusion protein and assessed their sensitivity to RET inhibitors. (nih.gov)
  • Our RET+ cell lines effectively recapitulate the interpatient heterogeneity observed in response to RET inhibitors and reveal opportunities for alternative or combination therapies. (nih.gov)
  • In summary, our data suggest that the activation of AMPK and its regulation of cell surface GLUT3 expression is critical in mediating neuronal tolerance to excitotoxicity. (jneurosci.org)
  • The heterologous regulation of the α2C-adrenergic receptor (α2C-AR) was investigated in the HepG2 cell line. (aspetjournals.org)
  • Involved in regulation of mitotic cell cycle. (nih.gov)
  • Autocrine FGF-2 is responsible for the cell density-dependent susceptibility to apoptosis of HUVEC : a role of a calpain inhibitor-sensitive mechanism. (researchmap.jp)
  • Bidirectional regulation of smooth muscle cell proliferation by IFN gamma. (researchmap.jp)
  • Furthermore, WZ increased the number of Sertoli cells, restored the ultrastructure of the Sertoli cell TJ, and upregulated the expression of TJ-associated proteins (zonula occludens-1 and Claudin11), ectoplasm specialized-associated proteins (N-Cadherin, E-Cadherin and ß-Catenin), and gap junction-associated protein (connexin 43), but did not affect the expression of Occludin and cytoskeletal protein (Vimentin). (bvsalud.org)
  • ST caused G0/G1 cell cycle arrest which was accompanied by a decrease in CDK4 and cyclin D1, and an increase in p21/Cip1and p27/Kip1 protein levels. (biomedcentral.com)
  • Recombinant Human PDGF-AA Protein (HEK293) is a potent mitogen for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. (abmole.com)
  • We evaluated the influence of T315 on the manifestation of pThr173-ILK and total ILK, as well as proteins regulating cell proliferation and survival in AML cells (Physique 2). (exposed-skin-care.net)
  • Raf-1 kinase inhibitor protein: structure, r"le, regulation of cell signaling, and critical task in apoptosis. (upb.ro)
  • For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
  • studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • Similarly, depletion in the STRIPAK component STRIP1 affects activation of GCKIII kinases and cell cycle disruption through elevated expression of cyclin dependent kinase inhibitors p21 and p27, enhanced levels of which lead to a protective effect from therapeutic treatments and increased proliferation. (lu.se)
  • Both of these altered proteins lead to the eventual ability of cancer cell recurrence. (lu.se)
  • The tumour microenvironment (TME) contains several other cell types apart from cancer cells which play a role not only in the regulation of the environment but in response to treatments. (lu.se)
  • The determination of the actual cis - and trans -acting elements involved will be the object of future investigation, but the present study provides evidence for transcriptional regulation of human α2C-AR by cAMP. (aspetjournals.org)
  • Thus locating all RNA-binding proteins (RBPs) in a genome and determining protein-RNA complex structures are key steps for understanding the mechanism of post-transcriptional regulation and for mapping the network of protein-RNA interactions. (buyresearchchemicalss.net)
  • Transcriptional mechanisms and protein kinase signaling mediate organic dust induction of IL-8 expression in lung epithelial and THP-1 cells. (cdc.gov)
  • Recombinant Human VEGF165 Protein (HEK293, C-His) is a powerful growth and angiogenic cytokine, it promotes the proliferation and survival of endothelial cells, promotes angiogenesis and vascular permeability. (abmole.com)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • c-Src tyrosine kinase consists of the N-terminal unique region, the Src homology 3 (SH3), SH2, linker, kinase domain, and the regulatory C-terminal tail. (intechopen.com)
  • Blom A. M. , Kask L. and B. Dahlbäck (2001) Structural requirements for the complement regulatory activities of C4b-binding protein. (lu.se)
  • To do this, he wondered if he could "hijack the cell's garbage disposal machinery" to trick cancer cells into degrading the oncogenic proteins that made them cancer cells to begin with, Dr. Nabet explains. (fredhutch.org)
  • Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. (lu.se)
  • We demonstrated that the RET inhibitor BLU-667 was effective at inhibiting tumor growth in CUTO42 tumors but had a much less profound effect in CUTO32 tumors, consistent with our in vitro experiments. (nih.gov)
  • The coproheme decarboxylase, chdC, of Listeria monocytogenes , is shown from both views, with both the substrate and inhibitor prodigiosin that was identified on the screen. (mdpi.com)
  • Agrin-induced receptor aggregation also was inhibited by phorbol 12-myristate 13-acetate, an activator of protein kinase C, and by inhibitors of energy metabolism. (rupress.org)
  • Enzyme-linked immunosorbent assay and real-time polymerase chain reaction revealed that the expressions of P19 and P21 mRNA and protein were inhibited in offspring mice administered low- and high-dose PPPm-1. (bvsalud.org)
  • and negative regulation of meiotic nuclear division. (nih.gov)
  • Also, the INK4 proteins help stop the G1-CDK activity when they encounter anti-proliferative signals within the environment. (wikipedia.org)
  • These agents were developed by exploiting structural similarities in kinase active sites. (escholarship.org)
  • Blom A. M. , Mörgelin M., Öyen M., Jarvet J. and Fries E. (1999) Structural characterization of inter-a-inhibitor - evidence for an extended shape. (lu.se)
  • First, effects of calphostin C, a specific inhibitor for protein Kinase C(PKC), and genistein and herbimycin A, specific tyrosine kinase (TK) inhibitors on colony formation of 5-FU resistant, dormant, primitive hematopoietic progenitors supported by IL-6 which receptor has the same signal transducer gp 130 of IL-11 receptor and 12-o-tetradecanoyl phorbol-13-acetate(TPA). (nii.ac.jp)
  • Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester. (rupress.org)
  • The typical inactivation mechanism of the CDK/ Cyclin complex is based on binding a CDK inhibitor to the CDK cyclin complex and a partial conformational rotation of the CDK. (wikipedia.org)
  • Recombinant Human IL-11 Protein (HEK293) is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. (abmole.com)