• The group of common γ-chain receptor cytokines encompassing interleukin (IL)-2, IL-4, IL-9, IL-15, and IL-21 has been studied intensively over the recent years. (frontiersin.org)
  • In conjunction with other β common chain cytokines GM-CSF and IL-5, IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor. (wikipedia.org)
  • The signal transmission is ensured by high affinity between cell surface interleukin-3 receptor and IL-3. (wikipedia.org)
  • IL-3/Receptor complex induces JAK2/STAT5 cell signalization pathway. (wikipedia.org)
  • Western immunoblotting was used to analyze the effect of EGCG on the interleukin-1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF-6) proteins in IL-1β-stimulated chondrocytes. (biomedcentral.com)
  • Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. (tamu.edu)
  • [ 3 ] If you knock out that receptor, they get spontaneous enterocolitis. (medscape.com)
  • The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)
  • Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. (wikipedia.org)
  • The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. (wikipedia.org)
  • Inflammatory factors, including IL‑1β and transforming growth factor (TGF)‑β/1, α‑smooth muscle actin (SMA) and protein levels of nucleotide‑binding oligomerization domain, leucine rich repeat containing family, pyrin domain containing 3 (NLRP3), caspase‑1 and pro‑IL‑1β were measured. (spandidos-publications.com)
  • This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress. (allenpress.com)
  • Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
  • In this study, we found that NS1 protein inhibits IRF-3-dependent gene transcription in constitutively active IRF-3 overexpressing cells, demonstrating that NS1 directly targets IRF-3. (microbiologyresearch.org)
  • Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. (microbiologyresearch.org)
  • Guselkumab is a human monoclonal antibody that targets the protein interleukin (IL)-23, which has been shown to play a key role in the development of immune-mediated inflammatory diseases. (prnewswire.co.uk)
  • Guselkumab is a human monoclonal antibody with a novel mechanism of action that targets the protein interleukin (IL)-23 and is in Phase 3 development as a subcutaneously administered therapy for the treatment of moderate to severe plaque psoriasis. (prnewswire.co.uk)
  • The protein signal transducer and activator of transcription 3 (STAT3) plays the leading role - its activation by another protein called interleukin 6 (IL6) has been a focus for cancer researchers in connection with tumour progression for some time now. (technologynetworks.com)
  • Galectin-3 is a member of a carbohydrate-binding protein family involved in cell activation and inflammation. (lu.se)
  • It has also been reported that triiodothyronine (T3) alleviates oxidative stress, inflammation and apoptosis caused by hepatic ischemia-reperfusion injury, and its mechanism of action is associated with negative regulation of the NLRP3 signaling pathway ( 10 ). (spandidos-publications.com)
  • 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
  • IL-3 is mainly produced by activated T cells with the goal of initiating proliferation of various other immune cell types. (wikipedia.org)
  • In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines, e.g. (wikipedia.org)
  • IL-3 is a T cell-derived, pluripotent and hematopoietic factor required for survival and proliferation of hematopoietic progenitor cells. (wikipedia.org)
  • Here, in the presence of KL+FL+megakaryocyte growth and development factor (MGDF), which recruits virtually all Lin(-)Sca-1(+)kit(+) bone marrow cells into proliferation and promotes their self-renewal under serum-free conditions, IL-3 and IL-11 revealed an indistinguishable ability to further enhance proliferation. (lu.se)
  • Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. (peprotech.com)
  • Interleukin-3, which promotes the proliferation of both pluripotent stem cells and unipotent progenitor cells. (wikilectures.eu)
  • The regulation of haematopoiesis is dependent on glycoprotein growth factors which drive the proliferation and differentiation of progenitor cells. (sysmex.es)
  • Interleukin 3 was originally discovered in mice and later isolated from humans. (wikipedia.org)
  • Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. (wikipedia.org)
  • Interleukin-17A stimulates the release of degradation enzymes from the matrix metalloproteinases family, which cause cartilage destruction. (archivesofrheumatology.org)
  • IL-3 receptors can be found on a variety of cell types including many immature myelomonocytic cells in the hemopoietic system such as hemopoietic progenitor cells, as well as certain myeloid progenitors, basophils, and eosinophils. (wikipedia.org)
  • abstract = "Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. (wustl.edu)
  • ABSTRACT Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon--ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. (who.int)
  • Hill T, Krougly O, Nikoopour E, Bellemore S, Lee-Chan E, Fouser LA, Hill DJ and Singh B. The involvement of Interleukin-22 in the expression of Pancreatic Beta cell Regenerating REG genes. (bepress.com)
  • The expression and activity of mRNA for several MMPs (2, 3, 9, and 10) was assessed. (allenpress.com)
  • 3 Because this bone cell culture model demonstrates a capacity to respond to mechanical changes, we hypothesize that this model may also show differences in expression of metalloproteinases in response to cyclic mechanical stretch that can be used to model changes at the bone-implant interface. (allenpress.com)
  • Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene expression. (biomedcentral.com)
  • In disorders such as leukemia, increased expression of antiapoptotic proteins, such as Bcl-2, is required for disease maintenance ( 3 ), confers drug resistance ( 4 ), and is associated with poor clinical outcome ( 5 ). (aacrjournals.org)
  • changes in expression of the immunomodulating cytokines interleukin (IL)-1 beta, IL-6, and IL-8. (nih.gov)
  • We then reduced the levels of galectin-3 expression using siRNA or pharmacologically targeting galectin-3 activity using bis-(3-deoxy-3-(3-fluorophenyl-1H-1,2,3-triazol-1-yl)-β-D-galactopyranosyl)-sulfane. (lu.se)
  • The cytokine was originally discovered via the observation that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3). (wikipedia.org)
  • IL-5, IL-3, and GM-CSF are hematopoietic cytokines that are key mediators of the allergic inflammatory response. (tamu.edu)
  • IL-3 β induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells. (irvinesci.com)
  • Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
  • We confirmed these findings using primary microglial cells obtained from wild-type and galectin-3 null mutant mice. (lu.se)
  • Finally, we performed injections of α-synuclein in the olfactory bulb of wild type mice and observed that some of the α-synuclein was taken up by activated microglia that were immunopositive for galectin-3. (lu.se)
  • C57BL/6 wild-type (WT), SRA KO, and IL-10 KO mice were intranasally challenged daily for 8 days with HDE and subsequently rested for 3 days with/without recombinant IL-10 (rIL-10) treatment. (cdc.gov)
  • Lung lymphocyte aggregates and neutrophils were elevated in in vivo HDE-treated SRA and IL-10 KO mice after a 3-d recovery, and treatment during recovery with rIL-10 abrogated these responses. (cdc.gov)
  • IL-3 is capable of stimulating differentiation of immature myelomonocytic cells causing changes to the macrophage and granulocyte populations. (wikipedia.org)
  • IL-3 is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. (wikipedia.org)
  • However, only IL-3 treatment in bone marrow failure disorders such as myelodysplastic syndrome (MDS) and aplastic anemia (AA) was disappointing. (wikipedia.org)
  • Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. (peprotech.com)
  • Although it has been shown that low-power laser illumination may stimulate bone healing ( 1 - 3 ), endothelial regeneration ( 4 ), smooth muscle relaxation ( 5 ) and reduce restenosis rate after coronary angioplasty procedures ( 6 - 9 ), little is still known about cellular mechanisms underlying these effects. (iiarjournals.org)
  • We traditionally recognize vitamin D as the key vitamin for regulation of bone metabolism and homeostasis, but I want you to think out of the box here. (medscape.com)
  • However, mutations in genes involved in cytokines synthesis like interleukin 10 (IL-10) appear to be strong predictors of cervical cancer risk (Zidi et al. (researchsquare.com)
  • The transcription factor interferon regulatory factor (IRF)-3 is essential for viral-induced IFN-β synthesis. (microbiologyresearch.org)
  • Our data also demonstrate that NS1 associates with IRF-3 and its transcriptional coactivator CBP, leading to disrupted association of IRF-3 to CBP and subsequent reduced binding of IRF-3 to the IFN-β promoter without blocking viral-induced IRF-3 phosphorylation, nuclear translocation and dimerization, thereby identifying a novel molecular mechanism by which RSV inhibits IFN-β synthesis. (microbiologyresearch.org)
  • Although the pathogenesis of BD is still not clear, numerous studies have suggested that environmental factors, infection triggers, abnormal autoimmune regulation and genetic susceptibility are closely associated with BD [ 3 ]. (oncotarget.com)
  • Although these diseases are idiopathic, recent investigations support the role of eosinophils, T helper 2 (Th2) cytokines (interleukin [IL]-3, IL-4, IL-5, and IL-13), and eotaxin as the critical factors in the pathogenesis of eosinophilic gastroenteritis. (medscape.com)
  • In one study, immunohistochemistry detected IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5 in the granule matrix of eosinophils, the release of which is thought to be involved in the perpetuation of intestinal eosinophil infiltration and inflammation. (medscape.com)
  • Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase. (uchicago.edu)
  • Post-chemotherapy, IL-3 application reduces chemotherapy delays and promotes regeneration of granulocytes and platelets. (wikipedia.org)
  • IL-3 is also involved in the reconstruction of platelets via the development of megakaryocytes. (wikipedia.org)
  • Nuclear factor kappa B (NF- κ B) is the most important downstream pathway component that regulates the activity of cytokines, including interleukin (IL)-1 β , IL-6, and tumor necrosis factor (TNF)- α , in airway pathology [ 10 , 11 ]. (hindawi.com)
  • In striking contrast, the ex vivo expansion of murine HSC in fetal calf serum-containing medium resulted in extensive loss of reconstituting activity, an effect further facilitated by the presence of IL-3. (lu.se)
  • This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation. (archivesofrheumatology.org)
  • part integrals 'm the Signal resonance and water of Transcription 3( STAT3) Pathway: behavior of Constitutive and Interleukin independent need by Iron Depletion. (ogtechnology.com)
  • In the course of the study, the researchers also found that activation of STAT3 in the prostate leads to increased levels of cell components (LKB1/pAMPK) that are responsible for the regulation of glucose metabolism and are linked to type 2 diabetes mellitus. (technologynetworks.com)
  • Frontiers in Cell and Developmental Biology , 3 (JAN), Article 85. (wustl.edu)
  • In the early 1960s Ginsberg and Sachs discovered that IL-3 is a potent mast cell growth factor produced from activated T cells. (wikipedia.org)
  • In contrast, numerous studies have implicated a unique and potent negative regulatory role of IL-3, suggesting perhaps distinct regulation of HSC fate by different cytokines. (lu.se)
  • IL-17 family molecules hold a crucial role in immune regulation and inflammation. (betalifesci.com)
  • Because interleukin (IL)-10 production can limit excessive inflammation, it was hypothesized here that HDE-induced IL-10 would require CD204 to effect inflammatory responses. (cdc.gov)
  • IL-3 is produced as a monomer by activated T cells, monocytes/macrophages and stroma cells. (wikipedia.org)
  • HL-60 cells incubated with various amounts (1, 3, 5, 7.5, and 10 micro l/mL) of the extracts for 1-3 days showed dose-dependent, time-dependent growth suppression and decrease in cell viability. (nih.gov)
  • Using a complex mouse model, the research team under Lukas Kenner (MedUni Vienna Department of Pathology, Department of Laboratory Animal Pathology at Vetmeduni Vienna) examined prostate cancer cells and identified the key factors in the regulation of tumour cell growth and the way they interact with each other. (technologynetworks.com)
  • Growth factors include for example erythropoietin (EPO), thrombopoietin (TPO), interleukins (e.g. (sysmex.es)
  • its role is correlated with activation of the nucleotide-binding oligomerization domain, leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome ( 5 ). (spandidos-publications.com)
  • Our results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading. (allenpress.com)
  • Over the past several years, a number of studies have been conducted which point to the role of interleukin-17A (IL-17A) in the development of chronic arthritis. (archivesofrheumatology.org)
  • Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding. (microbiologyresearch.org)
  • The inflammasome is a large multiprotein complex which plays a key role in innate immunity by participating in the production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. (invivogen.com)
  • Conclusions: We show that α-synuclein aggregates induce microglial activation and demonstrate for the first time that galectin-3 plays a significant role in microglia activation induced by α-synuclein. (lu.se)
  • Surprisingly, and similar to IL-11, IL-3 supported KL+FL+MGDF-induced expansion of multilineage, long-term reconstituting activity in primary and secondary recipients. (lu.se)
  • Hypercholesterolaemia is frequently sayed on the same day for the determination associated with enhanced lipid peroxida- of glutathione peroxidase activity and lipid tion [3]. (who.int)
  • Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. (wikipedia.org)
  • The IL-17 family encompasses an array of members, including IL-17B, IL-17C, IL-17D, and IL-17F, which possess significant roles in immune regulation and inflammatory responses. (betalifesci.com)
  • Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. (hindawi.com)
  • Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. (rochester.edu)
  • This treatment induced a significant increase in the levels of proinflammatory mediators including the inducible Nitric Oxide Synthase (iNOS), interleukin 1 Beta (IL-1β) and Interleukin-12 (IL-12). (lu.se)
  • These bacteria liberate intercellular mediators, humoral antibodies and effector molecules for periapical tissues 3 . (bvsalud.org)
  • They are also able to secrete additional mediators, which are not performed by their granules such as interleukins (IL) 5 . (bvsalud.org)
  • These results suggest that genetic down-regulation or pharmacological inhibition of galectin-3 might constitute a novel therapeutic target in PD and other synucleinopathies. (lu.se)
  • IL-3 β also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases. (irvinesci.com)
  • The increased levels of the inflammatory cytokines interleukin (IL)-1 β and IL-6 indicated a chronic inflammatory state in the COPD rats. (hindawi.com)
  • However, IL-3 has also been shown to be produced in IgG+ B cells and may be involved in earlier antibody isotype switching. (wikipedia.org)
  • IL-3 also induces various effector functions in both immature and mature cells that more precisely modulate the body's defense against microbial pathogens. (wikipedia.org)
  • IL-3 is produced by T cells only after stimulation with antigens or other specific impulses. (wikipedia.org)
  • Scientists have known for years that cytokines are necessary for the production and regulation of blood cells. (cancernetwork.com)
  • Here, we show that Mcl-1 down-regulation by the cyclin-dependent kinase (CDK) inhibitor roscovitine or Mcl-1-shRNA dramatically increases ABT-737 lethality in human leukemia cells. (aacrjournals.org)
  • DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
  • It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
  • Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
  • Interleukin-1beta (IL-1β) is the principal cytokine linked to cartilage degradation in osteoarthritis (OA). (biomedcentral.com)
  • Thus, IL-1β can shift the balance between the biosynthesis and the degradation of extracellular matrix components (via production of matrix metalloproteinases (MMPs), and disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs], in the cartilage and transform chondrocytes to display the catabolic phenotype seen in OA [ 3 ]. (biomedcentral.com)
  • IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). (wikipedia.org)
  • Crystals of uric acid and calcium pyrophosphatedihydrate , the aetiological agents of gout and pseudogout respectively, were the first crystals shown to engage the NLRP3 inflammasome [3] . (invivogen.com)
  • Organic dust-induced lung injury and repair: bi-directional regulation by TNFa and IL-10. (cdc.gov)
  • Collectively, these findings suggest down-regulation of Mcl-1 by either CDK inhibitors or genetic approaches dramatically potentiate ABT-737 lethality through cooperative interactions at two distinct levels: unleashing of Bak from both Bcl-xL and Mcl-1 and simultaneous induction of Bak activation and Bax translocation. (aacrjournals.org)
  • The CD4+ T-lymphocyte is the primary target for HIV infection because of the affinity of the virus for the CD4 surface marker (3). (cdc.gov)
  • Sequence and functional characterization of feline interleukin 2. (uchicago.edu)
  • The major function of IL-3 cytokine is to regulate the concentrations of various blood-cell types. (wikipedia.org)
  • IL-3 signaling is able to give rise to widest array of cell linages which is why it has been independently named "multi-CSF" in some older literature. (wikipedia.org)
  • However, it was observed that IL-3 is present in the myelomonocytic leukaemia cell line WEHI-3B. (wikipedia.org)
  • Furthermore, high-resolution cell division tracking demonstrated that all HSC underwent a minimum of 5 cell divisions, suggesting that long-term repopulating HSC are not compromised by IL-3 stimulation after multiple cell divisions. (lu.se)