Regulation heterodimer alpha receptors interleukin 4 type i. Medical search. Frequent questions

Some cytokines (that are highly inducible, secreted proteins mediating intercellular communication within the nervous and immune technique), which includes interleukin 1 (IL-1), interleukin 6 (IL-6) plus the tumor necrosis factor alpha (TNF), act as endogenous pyrogens.202 The role of intrinsic disorder in cytokine function was currently discussed.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptJ Proteome Res. (estrogen-receptor.com)
Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)
Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
This stimulates the expression of transfer factors that allows for the expression of humoral immunity or T helper 2 (Th2) cytokines, such as interleukin (IL) IL-4, IL-5, IL-10, IL-13, TGF-β (Elenkov et al. (nature-nurture.org)
Th1 cytokines for cellular immunity are proinflammatory cytokines, e.g. interleukin (IL) IL-2, IL-12, IFN-γ, TNF-αβ (Elenkov et al. (nature-nurture.org)
The NLRP3 inflammasome is a multiprotein complex that activates cysteine protease caspase-1, which leads to the maturation and secretion of pro-inflammatory cytokines, such as interleukin-1β (IL)-1β and IL-18 ( 7 ). (spandidos-publications.com)
Endothelial and epithelial cells, and resident macrophages are potent producers of inflammatory cytokines, interleukins, IL-1, IL-6, and TNF-α, which are distinguished from another set that is treated in this study. (pharmaceuticalintelligence.com)

The signaling of IL-13 begins through a shared multi-subunit receptor with IL-4. (wikipedia.org)
Interleukin-13 and its associated receptors with α subunit of the IL-4 receptor (IL-4Rα) allows for the downstream activation of STAT6. (wikipedia.org)
The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)
The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
These calpains work as a heterodimer, comprising a big (80 kDa) and a little (28 kDa) subunit (1,4,5). (exposed-skin-care.net)

The JAK Janus kinase proteins on the cytoplasmic end of the receptors allows for the phosphorylation of STAT6, which then forms an activated homodimer and are transported to the nucleus. (wikipedia.org)
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)
This family of proteins comprises two subfamilies that share a DNA-binding and dimerization domain called the Rel homology domain (RHD) [ 4 ] and form homo- or hetero- dimers. (oncotarget.com)
p100 and p105 can however undergo limited proteolysis to generate p52 and p50, respectively, which can form heterodimers with Rel proteins to form transcriptional activators [ 5 ]. (oncotarget.com)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
From that we are to coupled sites and inactivated receptors, docking both interactions as viable including climates and used sine download proteins. (evakoch.com)
P2Y12 receptor (P2YR) is a G-coupled7-membrane-spanning proteins. (researchsquare.com)
Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. (lookformedical.com)
Epinephrine and norepinephrine through alpha -adrenoreceptors (α1ARs and α2ARs) and beta -adrenoreceptors (β1ARs, β2ARs, β3ARs) bind to proteins in the peripheral nervous system. (nature-nurture.org)
2001). The most prominent, NF-κB, is a heterodimer that consists of two proteins, p65 (also called RelA) and p50. (nature-nurture.org)
In its quiescent state NF-κB is found in the cytoplasm bound to two proteins, IκBα and IκBβ (Inhibitor kappa B alpha and beta) that prevent it from translocating to the cell's nucleus for gene expression (Barnes & Karin, 1997). (nature-nurture.org)
Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)

Peroxisome proliferator-activated receptor-γ(PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors [ 10 ]. (biomedcentral.com)

They represent the first line of defense against pathogens in the lower airspace and recognize microbial ligands via pattern recognition receptors ( 4 , 5 ). (frontiersin.org)
Toll-like receptors (TLRs) are the major pattern recognition receptors of the innate immune system that sense a wide range of "danger" signals or pathogen-associated molecular patterns (PAMPs) ( 6 - 8 ). (frontiersin.org)
Identification of pathogen-associated molecules, such as dsRNA and lipopolysaccharide (LPS), by host pattern recognition receptors (PRRs) is a critical step in innate immune response (IIR). (biomedcentral.com)
Lipopeptides act as immunomodulators by interacting with pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), expressed on antigen-presenting cells (macrophages and dendritic cells) to activate immune functions [ 14 ]. (biomedcentral.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and IL-17F activates many signaling pathways. (hindawi.com)
Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
AMPK pathways are energy regulation pathways. (springer.com)
Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
These findings agree with recent experimental data reporting crosstalk between pathways activated by RIG-I and TLR3 receptors in response to pathogens. (biomedcentral.com)
Maintaining bile acid (BA) homeostasis is important and regulated by BA activated receptors and signaling pathways. (aspetjournals.org)
The importance of immunity can't be understated, it involves a large portion of immune system and primitive Toll-like receptors (TLRs) that trigger signaling pathways. (pharmaceuticalintelligence.com)

Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, thereby promoting inflammation. (frontiersin.org)
Treatment of human alveolar macrophages (AMs) with the synthetic GC dexamethasone (Dex) did not alter the expression of TLRs −1, −4, and −6. (frontiersin.org)

The apparently anomalous binding data were clarified by the fact that washed platelets (1) contained mineralocorticoid receptor and that (2) it was associated with GR. Taken together, our data suggest that platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands. (ashpublications.org)

2000). PPARs form heterodimers with the Retinoid-X Receptors (RXRs). (bodybuilding.com)

They are encoded by separate but linked genes termed regulation of complement activation (RCA) genes, located on the q32 region of chromosome 1. (medscape.com)

Activation of P2Y12 receptor first phosphorylates BAD through the PI3K Akt pathway, and the liquid acidified BAD binds to 14-3-3 protein to separate BAD from BAD Bcl-XL complex, thus releasing free Bcl-XL. (researchsquare.com)
9 ] who proposed that the activation of NF-κB by TRIF-dependent pathway is a result of a secondary response to TNFα, which is induced by IRF3 (this latter activated by the TLR4/TRIF-mediated pathway in the first response to LPS) and signals through the TNFα receptor (TNFR)/RIP1 pathway to activate NF-κB. (biomedcentral.com)
In the results of microarray using back skin obtained from animals, we found that S. lappa 's properties are closely associated with cytokine-cytokine receptor interaction and the JAK-STAT signaling pathway. (molcells.org)
Activation of the classical NF-κB pathway in macrophages and type II pneumocytes was indicated by enhanced immunostaining of phospho-IκBα in these specific lung cell types. (biomedcentral.com)

Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
It is presently unknown whether peroxisome proliferator-activated receptor (PPAR) β/δ activation prevents inflammation in adipocytes. (diabetesjournals.org)

IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. (wikipedia.org)
IL-13 has effects on immune cells that are similar to those of the closely related cytokine IL-4. (wikipedia.org)
IL-13Rα2 (which is labelled as a decoy receptor) is derived from Th2 cells and is a pleotropic immune regulatory cytokine. (wikipedia.org)
It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. (lookformedical.com)
Similarly, the IL-17 receptor family (IL-17RA-RE) is not related to any of the other known cytokine receptors [ 2 ]. (hindawi.com)
Thus, the IL-17 cytokine family appears to represent a distinct ligand-receptor signaling system. (hindawi.com)
Our results suggest that the NLRP3/ASC/caspase-1 axis participates in the regulation of pro-imflammatory cytokine secretion in RAW264.7 cells, particularly the generation of IL-1β and IL-18. (spandidos-publications.com)

IL-13 also binds to another receptor known as IL-13Rα2. (wikipedia.org)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
The PPAR/RXR dimer then binds to a peroxisome proliferators-response element (Staels and Fruchart 2005), a DNA-specific sequence of which many types exist. (bodybuilding.com)
CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)

Peroxisome Profilerator-Activated Receptors (PPARs) are nuclear hormone receptors that belong to the steroid/ thyroid /retinoid superfamily of receptors (Keller et al. (bodybuilding.com)
The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that encompasses, among others, estrogen receptor and peroxisome proliferators-activated receptor. (ashpublications.org)

The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
This interaction can be responsible for the regulation of cellular events ranging from glucose and lipid homeostasis to cell differentiation and apoptosis [ 12 ]. (biomedcentral.com)
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. (edu.au)
8, 9 Therefore, tight regulation of cellular responses to the microenvironment is needed. (bmj.com)

PPAR-alpha activation increases the expression of lipoprotein lipase and apolipoprotein A-V (apoA-V) while simultaneously decreasing expression of apoC-III in the liver, which decreases VLDL particles and lowering plasma triglycerides in chylomicrons (Staels and Fruchart 2005). (bodybuilding.com)
This suggests that use of a PPAR-alpha agonist may be beneficial in aiding fat loss . (bodybuilding.com)
In addition to the change in plasma fatty acid levels, hepatic apoA-I andapoA-II are increased by PPAR-alpha activation, which improves cholesterol levels by increasing HDL levels (Chinetti et al. (bodybuilding.com)

The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. (edu.au)
Here, we report for the first time that human platelets contain the glucocorticoid receptor (GR) as identified by a combination of biochemical and functional techniques. (ashpublications.org)

RU486), suggesting the functional importance of the ligand-receptor complex. (ashpublications.org)

however it only has 25% sequence identity to IL-4 and is capable of IL-4 independent signaling. (wikipedia.org)
protruding of the MRN leukemia to DNA DSBs is ATM-dependent DNA government mimicking type, by signaling KAT5( Tip60) found 5-pyrophosphate of side and interleukin-12 exchanger phosphorylation. (erik-mill.de)
The impact of exposures on bile acid (BA) signaling and Farnesoid X receptor-mediated gut-liver crosstalk is emerging. (aspetjournals.org)
Roles of NF-κB signaling in the regulation of miRNAs impacting on inflammation in cancer. (ac.ir)

Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium. (wikipedia.org)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)

This study aimed to evaluate the role of miR-146a-5p in the pathogenesis of diabetic retinopathy and its interaction with oxidative stress and inflammation in the ocular tissue of rats with type 2 diabetes mellitus (T2DM). (ac.ir)

tightly you dissipate your download, contribute the nursing of it, and bind in with your triphosphatase endocytosis promoter and bilayer pore( the activation Early occurs to the endocytic 4 products of your source phosphorylation). (evakoch.com)

The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)

Several clinical trials using inhibitors of NF-κB activation have been performed, and have shown variable results in a few types of cancers [ 17 - 21 ]. (oncotarget.com)
The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
transiting of such constituent c receptor type VIa regions in kinase during activation. (evakoch.com)
download history Thanks and genes Activation include the acid of and precursor between targets with exciting regulated students and SRC-phosphorylated types. (erik-mill.de)
Research on NF-κB-deficient cells has shown that the initial kinetics of the type I interferon (IFN) response depends on concurrent NF-κB activation [ 12 ]. (biomedcentral.com)
During completed HPA expression, simultaneous activation and release of norepinephrine by locus coeruleus and brainstem alpha and beta adrenergic receptors and epinephrine in the adrenal medulla stimulate peripheral sympathetic nervous system neurons (SNS) (Elenkov et al. (nature-nurture.org)
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. (edu.au)
Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. (hindawi.com)

Once, in the nucleus, STAT6 heterodimer molecule regulates gene expression of cell types critical to the balance between host immune defense and allergic inflammatory responses such as the development of Th2. (wikipedia.org)

This entry represents a subtype of the immunoglobulin domain, and is found in a diverse range of protein families that includes glycoproteins, fibroblast growth factor receptors, vascular endothelial growth factor receptors, interleukin-6 receptor, and neural cell adhesion molecules. (embl.de)

The high affinity of IL-13 to the IL-13R1 leads to their bond formation which further increase the probability of a heterodimer formation to IL-4R1 and the production of the type 2 IL-4 receptor. (wikipedia.org)
Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)

It is a single-chain membrane glycoprotein of approximately 200 kd that has 4 allotypic forms on myeloid cells (eg, erythrocytes, granulocytes, monocytes), lymphoid cells (mostly B cells), follicular dendritic cells, and glomerular podocytes. (medscape.com)
CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha (9). (rndsystems.com)

Orally Administered Exosomes Suppress Mouse Delayed-Type Hypersensitivity by Delivering miRNA-150 to Antigen-Primed Macrophage APC Targeted by Exosome-Surface Anti-Peptide Antibody Light Chains. (krakow.pl)
The so called B-cells have receptors that recognize foreign antigen, but the T-cells have similar receptors and are tied to both the innate and the adaptive immune response. (pharmaceuticalintelligence.com)

In the initiation and progression of pulmonary inflammation, macrophages have classically been considered as a crucial cell type. (biomedcentral.com)

prolonged activity oxidation highly with CREBP1 and EP300 induces blood of GZMB( granzyme B), which is continual for the C-terminal member of CD8+ types( Maekawa et al. (evakoch.com)

Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases, and endogenous GCs play a key role in immune regulation. (frontiersin.org)
In addition, the presence of EVs reduced inflammatory responses in Pam 3 CSK 4 -treated endothelial cells and HEK Dual reporter cells, demonstrating that TLR2-EVs can act as decoy receptors. (frontiersin.org)
Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) have recently been identified as innate immune receptors that play a pivotal role in initiating the inflammatory response ( 4 ). (spandidos-publications.com)

Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. (cancer-genetics.org)
If severe, biologic therapy is used to treat patients with severe Crohn's disease that does not respond to any other types of medication, such as a TNF (tumor necrosis factor) inhibitor which can have secondary effects, and they are not universally effective. (pharmaceuticalintelligence.com)

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane. (lookformedical.com)

Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
The role of hypoxia-inducible factors-1 and -2 in the regulation of CXCL12 expression was examined using over-expression and short hairpin RNA knockdown constructs, electrophoretic mobility shift assays and chromatin immunoprecipitation. (haematologica.org)
13. Nasiri K, Akbari A, Nimrouzi M, Ruyvaran M, Mohamadian A. Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis, inflammation and oxidative stress. (ac.ir)

We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1. (biomedcentral.com)

Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. (springer.com)

Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)

However, while prednisolone (1-10 μM) reduced adenosine diphosphate (ADP, 4 μM) and thromboxane A 2 receptor agonist U46619 induced platelet aggregation (up to 75%), dexamethasone had no effect. (ashpublications.org)

Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. (wikipedia.org)
Interleukin-13 has a critical role in goblet cell metaplasia. (wikipedia.org)
Vitamin D receptors are expressed on the principal cell populations involved in the innate and adaptive immune responses. (springer.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Prostaglandins are hormone-like compounds produced in body tissue that help control blood pressure, smooth muscle activity, inflammation, glandular secretion, calcium movement, hormone regulation, and cell growth control. (bodybuilding.com)
[ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)
The hypoxic regulation of CXCL12 was examined in multiple myeloma plasma cell lines using polymerase chain reaction and western blotting. (haematologica.org)
Most IRF family members are expressed only in specialized cell types, but IRF-3 is widely expressed [ 10 ], stimulating synthesis of IFNβ in infected cells. (biomedcentral.com)
In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. (jci.org)
A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (edu.au)
Cell surface receptors that are specific for INTERLEUKIN-1. (edu.au)
Phenotypic and functional alterations in lupus T cells including expansion of the Th17 population, perturbations of the physiology of T-cell receptors (TCRs) and postreceptor downstream signalling, oxidative stress, and epigenetic changes result in exaggeration of TCR response to stimuli and the propensity of lupus T cells to get activated [ 6 ]. (hindawi.com)

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. (wikipedia.org)
Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)

In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)

Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)

The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome plays pivotal roles in inflammation and autoimmunity. (spandidos-publications.com)
However, evidence for the role of epithelial type II cells in pulmonary inflammation has been accumulating. (biomedcentral.com)

Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. (jci.org)
Hyperinsulinism decreases: the number of insuin receptors, insulin-like factor receptors, insulin-like growth factor binding globulin-1 and sex hormone binding globulin. (gremjournal.com)

The functional status and medical fragility of the patient - Studies have shown that hospitalized patients, those with poor functional status or comorbid conditions, and older adults are more likely to develop immune complications when treated with glucocorticoids, and this is likely to be the case for other immunosuppressant drugs [ 4 ]. (medilib.ir)

Genes that are upregulated by GC treatment, such as dual-specificity phosphatase 1 (DUSP1), GC-induced leucine zipper (GILZ), and interleukin (IL)-10, are highly immunosuppressive and contribute to the overall effect of GC treatment ( 1 - 3 ). (frontiersin.org)

Interleukin-17 is predominantly expressed by a specific subset of human T-helper cells-Th17 cells. (biomedcentral.com)

It is evidenced in conditions presenting site-specific symptoms of rheumatoid arthritis, multiple sclerosis, auto-immune thyroid disease, and type 1 diabetes mellitus along with a proinflammatory shift to IL-12, TNF-α, IFN-γ and a deficit in IL-10 secretion (Elenkov et al. (nature-nurture.org)

Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation. (nih.gov)

There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). (embl.de)
Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)

Anatomy27

Organisms12

Diseases4

Chemicals and Drugs141

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Cytokines7

Subunit8

Proteins15

Member of the nuclear receptor superfamily1

Pattern recogniti4

Pathways8

TLRs2

Ligands1

Form heterodimers1

Chromosome1

Pathway4

Peroxisome prolifer2

Cytokine7

Binds4

Superfamily2

Cellular4

PPAR3

Glucocorticoid receptor2

Ligand-receptor1

Signaling4

Differentiation2

Interaction1

Phosphorylation1

Nuclear1

Activation8

Regulates1

Molecules1

High affinity2

Monocytes2

ANTIGEN2

Macrophages1

Induces1

Inflammatory3

Tumor2

Membrane2

Expression3

Transcription factors1

Immunity1

Role in immune1

Agonist1

Cell15

Protein2

Proliferation1

Dendritic cells1

Inflammation2

Insulin2

Glucocorticoids1

Immunosuppressive1

Th171

Secretion1

Gene2

Gamma2