Regulation drug resistance multiple. Medical search. Frequent questions

His Excellency the Governor General in Council, on the recommendation of the Minister of Health, pursuant to subsection 30(1) (see footnote a) of the Food and Drugs Act (see footnote b) , makes the annexed Regulations Amending the Food and Drug Regulations (Veterinary Drugs - Antimicrobial Resistance) . (gc.ca)
Antimicrobial resistance (AMR) remains an alarming public health threat worldwide. (who.int)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Antimicrobial resistance, or AMR, occurs when pathogenic microbes evolve to evade drugs meant to kill them, a process that can be hastened by overuse of the drugs. (vin.com)
Antimicrobial resistance was prevalent among Gram-negative isolates, with 86.9% resistant to third- or fourth-generation cephalosporins, 63.1% to aminoglycosides, 61.9% to fluoroquinolones, and 42.0% to carbapenems. (cdc.gov)
Reemergence may occur because of the development of antimicrobial resistance in existing infections (e.g., gonorrhea, malaria, pneumococcal disease) or breakdowns in public health measures for previously controlled infections (e.g., cholera, tuberculosis [TB], pertussis). (cdc.gov)

Her current research analyzes multiple antibiotic resistance plasmids in different clinical isolates of Salmonella and their role in the pathogenesis of the bacteria. (marian.edu)
Antibiotic resistance can be selected for by metals through the process known as co-selection. (rutgers.edu)
Together, this work describes the abundance and inventory of antibiotic resistance genes and mechanisms in the mummichog gut microbiome and establishes the fish gut as a reservoir of such genes. (rutgers.edu)
Other top priorities for FDA involve tobacco regulation, combating antibiotic resistance, reducing high-risk drug compounding, and developing medical countermeasures to Ebola and Zika. (appliedclinicaltrialsonline.com)
Resistance to linezolid, a last-resort antibiotic in human medicine, was found in half of the raw samples. (vin.com)
ABSTRACT We investigated the antibiotic resistance of various strains of Salmonella isolated from dif- ferent sources in Oman, namely sewage water, chicken and food handlers. (who.int)

Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. (techscience.com)
MicroRNAs (miRNAs), short non-coding RNA molecules that play a key role in post-transcriptional gene regulation, have been found to be associated with different hallmarks of MM. Previous studies have indicated that abnormally functioning miRNA-mediated gene regulation followed by oncogene activation and tumor suppressor gene silencing results in drastic alterations in cell proliferation, apoptosis, growth, and metabolism. (helsinki.fi)
Studies employing Bax and/or Bak knockout mouse embryonic fibroblasts (MEFs) confirm that Bax is required for ABT-737 ± roscovitine lethality, whereas Bak is primarily involved in potentiation of ABT-737-induced apoptosis by Mcl-1 down-regulation. (aacrjournals.org)
c-IAP2 (inhibitor of apoptosis protein-2) belongs to IAPs family and besides exerting antiapoptotic effects through its interaction with multiple cytokines, it participates in inflammation, immunity and mitogenic kinase signal transduction, cell proliferation, invasion and metastasis also. (novusbio.com)
These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli. (nih.gov)
Resistant sublines exhibited a marked decrease in sensitivity to gefitinib and resistance to apoptosis. (univr.it)

The insulin resistance syndrome was first described in 1988 and contributes to both conditions and indeed is generally accepted to represent a pathophysiological link between the two. (pharmiweb.com)
Considerable attention has been paid to the development of molecules able to reduce insulin resistance. (pharmiweb.com)
Here we highlight a second strategy for reducing insulin resistance, the inhibition of 11beta-hydroxysteroid dehydrogenases (11beta-HSD)1, an enzyme which activates glucocorticoid. (pharmiweb.com)
Biomarkers of all three AD diagnostic criteria (amyloid/tau/neurodegeneration) were improved, as well as markers of inflammation, insulin resistance and dysfunctional lipid metabolism - results that demonstrate "peripheral targeted engagement," Didsbury said. (medscape.com)
Diabetes mellitus involves absence of insulin secretion (type 1) or peripheral insulin resistance (type 2), causing hyperglycemia. (msdmanuals.com)
Diabetes Mellitus (DM) Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)
Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal adipose tissue), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (msdmanuals.com)

Enterococci found in all 14 of the raw-frozen samples were resistant to three or more different families of antimicrobial drugs - in other words, they were multidrug resistant. (vin.com)
Among the main mechanisms of this multidrug resistance is the overexpression of ATP-binding cassette (ABC) transporters that mediate drug efflux, and, specifically, ABCB1, ABCG2 and ABCC1 are known to cause cancer chemoresistance. (nature.com)
Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches. (nature.com)

Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
Among ligand-gated channel genes, the genes encoding gamma-aminobutyric acid (GABA) receptors are considered a hotspot for susceptibility of IGE because of the extensive distribution of GABA receptors in the central nervous system (CNS), their potential for postsynaptic inhibition, and regulation by therapeutically important antiepileptic drugs [ 10 ]. (hindawi.com)
Following her doctoral research, Dr. Akbar studied regulation of virulence genes in the Gram-Negative pathogen Salmonella Typhimurium, virulence gene expression in Chlamydia Trachomatis, and multiple drug resistance in Salmonella Enterica species. (marian.edu)
Therefore, the identification of mechanisms underlying the regulation of the malignant behavior of MM and key genes in disease progression has the greatest significance for the establishment of novel therapeutic strategies and improvement of the prognosis in patients. (spandidos-publications.com)
Co-selection occurs through two primary mechanisms: i) co-resistance, when genes encoding both are located together in the genome and ii), cross-resistance, when the same mechanism provides resistance to both (e.g. efflux pump proteins). (rutgers.edu)
Genome analyses revealed few instance of co-resistance, and instead, presented various chromosomally-encoded resistance genes, including some of public health concern, (i.e. a blaOXA carbapenemase), and contributions from cross-resistance. (rutgers.edu)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability. (nature.com)
tritici ( Pgt ) races over the past two decades 1 , 2 has motivated global efforts to identify effective stem rust (Sr) resistance genes. (nature.com)
Consequently, there is an ongoing need to expand resistance resources and to enhance gene stewardship through co-deployment of multiple resitance (R) genes, rather than single genes, to increase resistance durability. (nature.com)
Since genetic dissection of genes within alien segments in wheat was not possible due to lack of recombination, the question arose as to whether the apparent durability of such resistances might be due to multiple genes rather than a single gene. (nature.com)
However, as there is no current Pgt race known to be virulent to either resistance gene, it was not possible to unambiguously determine whether the recombinant introgression carried a single or both genes. (nature.com)

Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
We have generated paclitaxel resistant ovarian cell lines from their corresponding native cell lines to determine driver mechanisms of drug resistance using gene expression arrays. (biomedcentral.com)
These pre-clinical models were used to observe cytotoxicity, cell cycle modulation and changes in gene expression to examine the mechanisms driving drug resistance. (biomedcentral.com)
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression. (broadinstitute.org)
Background Regulation of gene expression is obligatorily dependent on the structure of chromatin that is dynamically re modeled via posttranslational modifications of its histone and non histone constituents. (ampk-signal.com)
Loss of ybeY function, which results in a marked resistance to HU, had global affects on sRNA-mediated gene expression. (biomedcentral.com)

The aim of the present study was to assess the effects of sprouty homolog 2 (SPRY2) gene regulation by miR-21 on the occurrence, development and tumor metastasis in multiple myeloma (MM). The miR‑21 expression lentiviral vector (LV)‑anti‑miR‑21 and a liposome transfection method were used to screen MM cell lines with stable silent SPRY2. (spandidos-publications.com)
According to the study's lead author, Jin Q. Cheng, Ph.D., M.D., senior member of the Molecular Oncology Department and Molecular Oncology and Drug Discovery Program at Moffitt, certain miRNAs can cause therapeutic resistance and cancer metastasis by regulating multiple gene targets. (sciencedaily.com)
In cancers, tumor cell-derived exosomal circRNAs can act on target cells or organs through the transport of exosomes, and then participate in the regulation of tumor development and metastasis. (ijbs.com)
Therefore, chemotherapy-induced EMT in tumor cells has been linked to chemotherapeutic resistance and metastasis. (biomedcentral.com)
Next we explored the roles of miR-27a and its target Raf Kinase Inhibitory Protein (RKIP) in regulating cisplatin resistance and metastasis in lung adenocarcinoma. (biomedcentral.com)
Our results show that miR-27a has the potential as key regulatory factors for the chemotherapy resistance and metastasis of lung adenocarcinoma. (biomedcentral.com)

This chapter summarizes the main molecular mechanisms to C. albicans antifungal drug resistance, besides offering an overview of new antifungal agents and new antifungal targets to combat fungal infections. (intechopen.com)
In addition, the specific gene targets of miRNAs involved in the regulation of drug responses and MM progression were predicted by identifying statistically significant, negatively correlated interactions between the miRNA and RNA sequencing data of 45 MM patients in pairwise comparative correlation analysis. (helsinki.fi)
This edition of 'Emerging Drug Discovery Targets' features a potent histone deacetylase inhibitor from Norvartis for the treatment of cancer, two new approaches to metabolic disorders and VEGFR-1 as a target for rheumatoid arthritis. (pharmiweb.com)
Emerging Drug Discovery Targets " provides a twice monthly summary of some of the most exciting breaking information recently featured by the pharmaceutical analysts, LeadDiscovery . (pharmiweb.com)
Please feel free to pass this mail onto colleagues that may benefit from registration to Emerging Drug Discovery Targets . (pharmiweb.com)
The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL but not Mcl-1, which may confer resistance to this novel agent. (aacrjournals.org)
Based on the relevant research on the existing drug resistance mechanism, the current treatment plan for reversing the resistance of breast cancer to neoadjuvant chemotherapy is explored, and the potential drug targets are analyzed, aiming to provide a new idea and strategy to reverse the resistance of neoadjuvant chemotherapy drugs in breast cancer. (encyclopedia.pub)
Disruption of MtrAB by tunable CRISPR interference confirms that the signaling system regulates multiple peptidoglycan hydrolases, among other targets, that are important for cell division. (providence.org)
Actuate's lead drug, elraglusib (a novel GSK-3 inhibitor), targets multiple molecular pathways in cancer that are involved in promoting tumor growth and resistance to conventional cancer drugs such as chemotherapy. (actuatetherapeutics.com)
11 Chemoresistance, either acquired or intrinsic, is associated with a complicated and multifactorial process, including decreases of intracellular drugs, changes of drug targets, aberrant regulation of cell survival or death, and crosstalks between tumor microenvironment and cancer cells. (dovepress.com)
The involvement of miRNAs in drug resistance is just beginning to emerge, and more studies are needed to identify other miRNAs, their molecular targets and the processes they affect. (biomedcentral.com)

This study was designed to understand the mechanism of tissue invasion and drug resistance in AML, including the possible role of Epithelial-to-Mesenchymal (EMT) in AML progression. (assignology.com)
Although the findings of this study are pivotal to understanding the mechanism of drug resistance, the focus has only been on tissue invasion. (assignology.com)
METHODS: Using the commercial anti-angiogenic drug bevacizumab as a positive control, the mechanism and developability of mVEGF165b were evaluated and explored. (bvsalud.org)
High-resolution structures, biophysical and in silico studies have led to tremendous progress in understanding the mechanism of drug transport by these ABC transporters, and several promising therapies, including irradiation-based immune and thermal therapies, and nanomedicine have been used to overcome ABC transporter-mediated cancer chemoresistance. (nature.com)
We suggest that current information regarding the structure, mechanism and regulation of ABC transporters should be used in clinical trials to improve the efficiency of chemotherapeutics for patients with cancer. (nature.com)
9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)

MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance. (providence.org)
Further, MtrA decreases the effectiveness of antibiotics by mechanisms of both intrinsic resistance and drug tolerance. (providence.org)

Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)
This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)
miR-27a regulates epithelial-mesenchymal transition (EMT) and cisplatin resistance in vitro and modulates response of lung adenocarcinoma cells to cisplatin in vivo . (biomedcentral.com)

However, there is some incidence for antifungal resistance among some Candida strains, limiting treatment options. (intechopen.com)
Furthermore, gene overexpression is also frequently associated to antifungal resistance as well as an increase in the activity of proteins that reduce oxidative damage. (intechopen.com)

Multiple potential mechanisms of drug resistance could be active in patients with FLT3-ITD AML including mutations in the FLT3 kinase, exogenous signaling from the bone marrow microenvironment, and altered epigenetic regulation. (ashpublications.org)
www.thesgc.org) that included 38 probes that target a spectrum of proteins involved in epigenetic regulation. (ashpublications.org)

The following chemotherapeutic drugs: paclitaxel, docetaxel, doxorubicin, epirubicin and carboplatin were purchased from Sigma Aldrich (St. Louis, MO), dissolved in dimethyl sulfoxide (DMSO) from Sigma Aldrich (St. Louis, MO) and supplemented in complete media at increasing concentrations. (biomedcentral.com)
The SEs consist of critical epigenetic regulatory elements, which modulate the biological characteristics of digestive system tumors including tumor cell identity and differentiation, tumorigenesis, environmental response, immune response, and chemotherapeutic resistance. (ijbs.com)

Despite recent advances in research and novel therapeutics, MM remains incurable, mainly due to the mechanisms underlying disease progression and drug resistance. (helsinki.fi)
Topline results provide "clinical evidence of a modification of multiple AD pathologies associated with amyloid plaque burden," said John Didsbury, PhD, chief executive officer of T3D Therapeutics, Inc, the company developing the drug. (medscape.com)
Letter: On drugs and therapeutics 44(1121):1-4. (cdc.gov)

Thioredoxin (Trx) overexpression is known to be a cause of chemotherapy resistance in various tumor entities. (uni-koeln.de)

Data are emerging to support the role of both miRNAs and transcription factor p53 in cancer stem cell regulation. (sciencedaily.com)
These changes in cellular functions have been indicated to be associated with the pathogenesis, progression, and formation of drug resistance in MM. Therefore, the role and potential of miRNAs to act as biomarkers to predict MM progression and drug sensitivity should be further investigated to ultimately improve the survival rates of patients. (helsinki.fi)
In addition, the RT-qPCR validation demonstrated that the disease progression and drug sensitivity associated mir-92b, mir-363 and mir-221, would potentially regulate the expression of FGF2, MFF, and TMEM248, respectively, providing novel insights into the functional roles of miRNAs in MM pathways. (helsinki.fi)
Accumulating evidence has demonstrated that miRNAs have a key role in drug resistance and EMT. (biomedcentral.com)

The purpose of this case-control research is to determine if GABRG2 polymorphisms contribute to IGE susceptibility and antiepileptic drug resistance in Pakistani population. (hindawi.com)
Moreover, we validated the pair-risk model as a potential tool for studying the tumor microenvironment of colon cancer and drug susceptibility. (biomedcentral.com)

However, cancer treatment by drugs is seriously limited by P-glycoprotein (P-gp) associated multi-drug resistance (MDR) in various tumor cells. (nih.gov)

Elraglusib is also emerging as a mediator of anti-tumor immunity through the inhibition of multiple immune checkpoints and the regulation of immune cell function. (actuatetherapeutics.com)

In the use of chemotherapy drugs, anthracyclines, such as doxorubicin and epirubicin, are generally used in combination with drugs such as cyclophosphamide, epirubicin, and fluorouracil. (encyclopedia.pub)
This paper presents an overview of the investigations on the feasibility and application of flavonoids as P-gp modulators for improved efficacy of anti-cancer drugs like taxanes, anthracyclines, epipodophyllotoxins, camptothecins and vinca alkaloids. (nih.gov)

Biedler, J. L. & Riehm, H. Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies. (nature.com)
Here as a complement to genetic profiling, we used unbiased, combinatorial in vitro drug screening to identify pathways that drive AML and to develop personalized combinatorial treatments. (lu.se)

Multiple myeloma (MM) is a type of malignant plasma cell and has a high incidence in malignant tumors of the blood system, accounting for ~2% of the total mortality of cancer ( 1 ). (spandidos-publications.com)
Multiple myeloma (MM) is a heterogeneous plasma cell cancer that results from the excessive proliferation of mutated B cells in the bone marrow and the accumulation of ineffective antibodies, monoclonal proteins, in the blood. (helsinki.fi)

Increasing evidence suggests that several sirtuins play a critical role in multiple aspects of cancer drug resistance. (tmu.edu.tw)

Recently, multiple mutations in gamma 2 subunit of GABA receptors are discovered in two families which furnished the genetic evidence for possible role of GABA receptor system in epileptogenesis. (hindawi.com)
Multiple studies conducted around the globe have reported mutations in both the exonic and intronic regions of GABRG2 to be associated with different epilepsy phenotypes. (hindawi.com)
FLT3-ITD mutations are seen in 20-30% of adult and 15% of pediatric acute myeloid leukemia (AML) patients and are associated with poor prognosis with higher rates of relapse and therapy resistance. (ashpublications.org)
First, we screened 513 natural compounds on primary AML cells and identified a novel diterpene (H4) that preferentially induced differentiation of FLT3 wild-type AMLs, while FLT3-ITD/mutations conferred resistance. (lu.se)

Ovarian cancer is frequently sensitive to chemotherapy at diagnosis but rapid development of drug resistance leads to disease progression and ultimately death in the majority of patients. (biomedcentral.com)
We have generated model systems to explore drug resistance in ovarian cancer, which have revealed a key pathway related to the spindle assembly checkpoint underlying paclitaxel resistance in ovarian cell lines. (biomedcentral.com)
Paclitaxel is a frontline therapy used to treat advanced ovarian cancer, and in many instances, paclitaxel is combined with platinum based therapeutic drugs, such as carboplatin to improve overall survival [ 4 , 7 ]. (biomedcentral.com)
Thus, in the present study, we investigated cell response to the epidermal growth factor receptor (EGFR) inhibitor gefitinib of ovarian carcinoma cell lines, including cells selected for resistance to cisplatin (IGROV-1/Pt1) and oxaliplatin (IGROV-1/OHP). (univr.it)

All three organisms contained a large number of efflux pump proteins, including multiple RND efflux pump operons. (rutgers.edu)
Testing of the strains shows that RND efflux pumps may be involved in resistance to several classes of drugs. (rutgers.edu)
A transcriptomic study is in progress to understand the regulation of arsenate resistance and the potential involvement of RND efflux pumps under metal stress. (rutgers.edu)
This work further adds to the understanding of the role of RND efflux pumps in resistance to antibiotics, which is critical in understanding multi-drug resistance in Gram negative bacteria. (rutgers.edu)
Clinical significance of above mentioned carrier is appreciated from the fact that more than fifty percent of existing anti-cancer drugs undergo inhibitable and saturable P-gp mediated efflux. (nih.gov)

We will, therefore, discuss the effect of ERK1/2 MAPK feedback regulation on cancer treatment and how it contributes to reduced clinical efficacy of therapeutic agents and the development of drug resistance. (aston.ac.uk)

Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. (techscience.com)
The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. (techscience.com)
This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. (techscience.com)

Identification of effective P-gp modulator among herbal compounds have an added advantage of being safe, thereby making them ideal candidates for bioavailability enhancement, tissue-penetration (e.g. blood brain barrier (BBB)), decreasing biliary excretion and multi-drug resistance modulating agents. (nih.gov)

Resistance of GBM cell lines and primary cells to drugs and signaling inhibitors was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. (uni-koeln.de)
Collectively, these findings suggest down-regulation of Mcl-1 by either CDK inhibitors or genetic approaches dramatically potentiate ABT-737 lethality through cooperative interactions at two distinct levels: unleashing of Bak from both Bcl-xL and Mcl-1 and simultaneous induction of Bak activation and Bax translocation. (aacrjournals.org)

The review also focuses on flavonoid-drug interactions as well as the reversal activity of flavonoids useful against MDR. (nih.gov)

One prominent transporter, breast cancer resistance protein (BCRP), participates in the placental transfer of drugs and chemicals. (rutgers.edu)
With its E3 ubiquitin-protein ligase activity via interaction with several proteins such as RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, BCL10 etc., c-IAP2 can regulate NFkB signaling - positive regulation of canonical and negative regulation of non-canonical pathway. (novusbio.com)

Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. (broadinstitute.org)

In addition to classical gene regulatory networks noted above, we have recently identified a central role for additional biologic mechanisms, namely gene regulation by chromatin regulators and by noncoding RNAs. (stanford.edu)
To combat drug resistance, regulators worldwide have been for years discouraging doctors from overprescribing antibiotics and other antimicrobial medications. (vin.com)

Juliano, R. L. & Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. (nature.com)

For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. (techscience.com)

Description Microbial resistance to antibiotics is one of the most pressing health care concerns we are currently facing. (rutgers.edu)

Among the multiple items on the "to-do" list of new FDA Commissioner Robert Califf is to make clinical research more efficient and reliable to accelerate the development of safe and effective treatments for patients. (appliedclinicaltrialsonline.com)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
In disorders such as leukemia, increased expression of antiapoptotic proteins, such as Bcl-2, is required for disease maintenance ( 3 ), confers drug resistance ( 4 ), and is associated with poor clinical outcome ( 5 ). (aacrjournals.org)
In clinical use, no matter single drug or combination drugs, taxane drugs all show good anti-tumor activity. (encyclopedia.pub)
Although the efficacy of neoadjuvant chemotherapy has been confirmed, clinical trial data show that the effects of neoadjuvant chemotherapy for different breast cancer patients are very different, and it is easy to develop drug resistance, which is not conducive to subsequent treatment [ 6 ] . (encyclopedia.pub)
Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)

The aim of this master's thesis was to investigate the relationships between drug sensitivity, disease progression and miRNA regulation in MM patients. (helsinki.fi)
Here, we provide an overview of the regulation of cellular metabolic processes and epigenetic modifications of innate immune memory in monocytes/macrophages as well as the potential endogenous and exogenous stimulations involved in the progression of atherosclerosis that have been reported recently. (biomed.news)

Mitochondria engage in multiple cellular and extracellular signaling pathways ranging from metabolic control, antiviral and antibacterial host defense to the modulation of inflammatory responses following cellular damage and stress. (biomed.news)
We focused on nAChR pathways activated by nicotine and its downstream signaling involved in regulating apoptotic factors of mitochondria and drug resistance in lung cancer. (tmu.edu.tw)

Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. (wikipedia.org)

Even when there is a broad range of antifungals drugs for Candida infections, azoles, polyenes, and echinocandins are considered among the most effective treatment. (intechopen.com)

Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)

In the present study, we analyzed the impact of the Trx system on intrinsic chemoresistance of human glioblastoma multiforme (GBM) cells to cytostatic drugs. (uni-koeln.de)
In past research, miR-214 has also been associated with resistance to the chemotherapy drug cisplatin, but the role played by miR-214 in cancer stem cells had not been determined. (sciencedaily.com)
The results indicate that therapeutic drugs induce a migratory EMT phenotype that may facilitate the interaction of AML cells with microglial cells. (assignology.com)
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse anticancer drugs, limiting therapeutic success. (nature.com)
Here, we show that Mcl-1 down-regulation by the cyclin-dependent kinase (CDK) inhibitor roscovitine or Mcl-1-shRNA dramatically increases ABT-737 lethality in human leukemia cells. (aacrjournals.org)
Cells were exposed to an incremental dose escalation of paclitaxel (2 nM) for approximately 2 passages, up to a final concentration of 25 nM, once paclitaxel resistance was achieved. (biomedcentral.com)
Our results suggest that up-regulation of miR-27a could suppress RKIP expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin. (biomedcentral.com)

A limited study had indicated that in Sinorhizobium meliloti the YbeY ortholog regulates the accumulation of sRNAs as well as the target mRNAs, raising the possibility that YbeY may play a previously unrecognized role in bacterial sRNA regulation. (biomedcentral.com)

4 As the primary type of lung cancer, non-small cell lung cancer (NSCLC) exhibits multiple histological types, such as bronchoalveolar carcinoma, large cell carcinoma, squamous cell carcinoma, and adenocarcinoma. (dovepress.com)

Uniquely, this drug also activates PPAR gamma, which may provide potential additive or synergistic effects in regulating dysfunctional brain glucose energy and lipid metabolism in AD. (medscape.com)
The treatment focuses on improving regulation of glucose and lipid metabolism in the brain. (medscape.com)
Treatment depends on type but includes drugs that reduce blood glucose levels, diet, and exercise. (msdmanuals.com)
Prediabetes is impaired glucose regulation resulting in intermediate glucose levels that are too high to be normal but do not meet criteria for diabetes. (msdmanuals.com)

Previous evidence points to numerous components of the spindle assembly checkpoint and mitotic regulation playing a major role in several cancers [ 11 , 12 ]. (biomedcentral.com)
The role of RICTOR amplification in targeted therapy and drug resistance. (nih.gov)
Multiple mechanisms have evolved to perform this role. (aston.ac.uk)

In a March appearance before a Senate Appropriations subcommittee to discuss FDA's requested budget for fiscal year 2017, Califf noted the agency's success in approving more innovative drugs for market, many facilitated by expedited review programs and patient engagement in product development. (appliedclinicaltrialsonline.com)
Califf promised to soon issue guidances and regulations to further biosimilar development and to better manage FDA's IT infrastructure. (appliedclinicaltrialsonline.com)
He recently opened a meeting of FDA's Science Board that was called to advise the agency on the development and regulation of medical treatments for pain, where new product research is important for lowering opioid abuse. (appliedclinicaltrialsonline.com)
Our target audience includes business development personnel, senior management and researchers within the drug development sector as well as bioscience investors and analysts. (pharmiweb.com)
It has been widely established that cancer is associated with epigenetic modification, which is reversible and becomes an attractive target for drug development. (frontiersin.org)

Activation of nicotine/nAChR signaling is associated with lung cancer risk and drug resistance. (tmu.edu.tw)

The drug-resistant pathogens can sicken victims immediately or establish themselves more subtly in the digestive tracts of pets and their owners. (vin.com)

Anatomy8

Organisms22

Diseases14

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes76

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science5

Health Care6

Geographicals4

Antimicrobial Resistance6

Antibiotic6

APOPTOSIS7

Insulin resistance7

Multidrug3

Genes12

Gene expression6

Metastasis6

Targets11

Mechanism6

Intrinsic Resistance2

Cisplatin resistance3

Antifungal resistance2

Epigenetic Regulation2

Chemotherapeutic2

Therapeutics3

Overexpression1

MiRNAs4

Susceptibility2

Various tumor1

Inhibition1

Anthracyclines2

Vitro2

Myeloma2

Cancer drug resistance1

Mutations4

Ovarian4

Efflux5

MAPK1

Gastric cancer3

Multi-drug resis1

Inhibitors2

Interactions1

Protein2

Therapeutically1

Regulators2

Glycoprotein1

Antitumor1

Microbial1

Clinical6

Progression2

Mitochondria2

Immune1

Candida1

Sensitivity1

CELLS7

Regulates1

NSCLC1

Glucose4

Role3

Development5

Lung1

Pathogens1