IntakePathwaysDietaryMTORFastingLifespan extensionMechanismsProteinsDietsLongevityMimeticsInterventionsDietObesityNutrientCalorie restrictionRestrictiveHumansBehaviorsAgingMetabolicSignalingEffectsInflammatoryApproachesResistanceGlucoseResearchersExerciseEnergyPhysical activitySirt1EmotionalLevelsResponseResearchAlcohol
Intake14
- Increased caloric intake and obesity related comorbidities, in turn, can also work through these pathways to induce translation and cause disease, indicating the role of protein synthesis in health and disease is of great importance. (escholarship.org)
- Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. (bournemouth.ac.uk)
- This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
- In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
- Another method of the invention comprises reducing the caloric intake or the glucose intake by the subject and administering to the subject a chemotherapy agent. (justia.com)
- Her research focuses on appetite and food-intake regulation in response to lifestyle interventions such as dietary restriction and exercise. (utah.edu)
- Specifically we evaluate the effect of increased dietary protein intake and caloric restricted diets on gene expression in skeletal muscle, particularly focusing on biosynthesis, degradation and the expression of genes in the ubiquitin-proteosome (UPP) and mTOR signaling pathways, including MuRF-1, MAFbx/atrogin-1, mTORC1, and S6K1. (biomedcentral.com)
- 30% of total energy) diet with reduced caloric intake and participate in increased physical activity to create a negative energy balance. (biomedcentral.com)
- Effects of Acute Exercise on Appetite Regulation and Energy Intake in Men and Women. (utah.edu)
- The breakthrough came when scientists discovered that the benefits of dietary restriction may be coming not from the restriction of calories, but from the restriction of protein intake. (nutritionfacts.org)
- If we look at "the first comprehensive comparative meta-analysis of [dietary restriction],…the proportion of protein intake was more important for life extension via [dietary restriction] than the degree of caloric restriction. (nutritionfacts.org)
- However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. (bvsalud.org)
- Нервова анорексія Anorexia nervosa is characterized by a relentless pursuit of thinness, a morbid fear of obesity, a distorted body image, and restriction of intake relative to requirements, leading to a significantly. (msdmanuals.com)
- Ipecac induces vomiting reducing the total food available for digestion and decreasing total caloric intake. (msdmanuals.com)
Pathways8
- Caloric Restriction (CR) takes advantage of these metabolic pathways, retarding the aging process by slowing down the metabolic rate. (escholarship.org)
- Studies also show that Sirt1 regulates apoptosis through other pathways, such as the anti-inflammatory pathway of NF-κB acetylation and the regulation of AMPK in autophagy ( 6 , 7 ). (frontiersin.org)
- These pathways include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, and DNA repair. (eurospe.org)
- Finally, it will describe the impact of different dietary restrictions in modulating the genetic pathways that regulate metabolism and aging. (iospress.com)
- Caloric restriction is one of the most efficient ways to promote weight loss and is known to activate protective metabolic pathways. (biomedcentral.com)
- That's good news, because "[p]rotein restriction is much less difficult to maintain than dietary restriction, and may be more powerful than dietary restriction," because it suppresses both TOR and IGF-1-the two pathways thought responsible for the "drastic longevity and health benefits" of caloric restriction. (nutritionfacts.org)
- Blackwell and his team analyzed the levels of proteins and actions of genetic pathways during periods of caloric restriction. (innovitaresearch.com)
- the underlying mechanism was found to be that caloric restriction is regulated by a series of interconnected nutrient-sensing pathways all leading to epigenetic confluence on genes known as the FOXO transcription genetic complex leading to the upregulation of factors that lead to improved healthspan and longevity. (physicianwrites.com)
Dietary8
- The effects of 40% daily dietary restriction (DR) and intermittent feeding (EOD) on the age-related changes in the endocrine regulation of autophagic proteolysis were studied by monitoring the rate of valine release from isolated rat liver cells. (unipi.it)
- Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. (springer.com)
- and (v) the impact of protein feeding in combination with dietary restriction will be discussed as a potential intervention to maintain SkM mass while increasing longevity and enabling healthy aging. (bournemouth.ac.uk)
- Non-Exercise Activity during Dietary Restriction or Aerobic Exercise Interventions in Individuals with Overweight or Obesity. (utah.edu)
- The lifespan extension associated with dietary restriction may be due less to a reduction in calories, and more to a reduction in animal protein (particularly the amino acid leucine, which may accelerate aging via the enzyme TOR). (nutritionfacts.org)
- Modulating immune activity is an important aspect of dietary restriction," said senior author on the paper Keith Blackwell , professor of genetics in the Blavatnik Institute at Harvard Medical School and associate director of research and senior investigator at Joslin. (innovitaresearch.com)
- Regulation of life span by increasing the accessibility of dietary nutrients. (antiwaft.com)
- [ 4 , 5 ] Caloric restriction (CR), without malnutrition, is a well-known dietary intervention that consistently extends life span when initiated in both young and old animals. (medscape.com)
MTOR2
- The slides from my presentation, entitled " mTOR and caloric restriction: the ultimate weight loss/fitness gain protocol " can be sent on request . (anhinternational.org)
- Maintenance of fat free mass is dependent upon nutrient stimulation of protein synthesis via the mTOR complex, although during caloric restriction a decrease (atrophy) in skeletal muscle may be driven by a homeostatic shift favouring protein catabolism. (biomedcentral.com)
Fasting2
- Fasting vs. Keto: The Science of Caloric restriction. (physicianwrites.com)
- Caloric restriction and intermittent fasting have been shown to be tratamiento coadyuvante novel and beneficial strategies in neurodegenerative diseases, through immune, metabolic, and physiological mechanisms. (bvsalud.org)
Lifespan extension1
- But in a new study, published in Cell Metabolism , Harvard Medical School researchers at Joslin Diabetes Center have uncovered a new mechanism of lifespan extension that links caloric restriction with immune-system regulation. (innovitaresearch.com)
Mechanisms2
- Autophagy is a process that sequesters and degrades altered organelles and macromolecular cytoplasmic constituents for cellular restructuring and repair, and as a source of nutrients for metabolic use in early starvation it may be involved in anti-aging mechanisms of caloric restriction. (unipi.it)
- Currently, she is investigating how type of exercise (e.g. aerobic vs resistance) influences hormonal and behavior indices of appetite regulation, and mechanisms underlying response variation in body mass regulation with exercise. (utah.edu)
Proteins1
- In general, lower leucine levels are only reached by restriction of animal proteins. (nutritionfacts.org)
Diets2
- Caloric Restriction and Restrictive Diets: Interventions that Target the Biology of Aging," as the latest special issue of The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences is titled, contains a collection of articles with new research on a proven method for increasing longevity in many organisms -- including the results of the first-ever clinical trial of caloric restriction (CR) in humans. (sciencedaily.com)
- You may have even turned to extreme and unhealthy eating behaviors, such as bulimia, fad diets, diet pills or engaged in dangerous caloric restrictive eating, in an effort to try and lose the excess weight. (morethanfat.com)
Longevity2
- New research has been published on a proven method for increasing longevity in many organisms -- including the results of the first-ever clinical trial of caloric restriction (CR) in humans. (sciencedaily.com)
- And it is important for longevity regulation and, in this context, increasing lifespan. (innovitaresearch.com)
Mimetics2
- Overall, the work reported in this dissertation demonstrates how global proteome dynamics require NO for proper regulation, CR mimetics influence the proteome in similar mode, aerobic exercise has very different effects and CR effects on proteome fluxes are activated within a narrow and discrete time period. (escholarship.org)
- In terms of mitochondria biogenesis, these include caloric restriction, certain nutrient restrictions or shortages, caloric restriction mimetics, and exercise. (totalhealthmagazine.com)
Interventions2
- CR, as well as other lifespan extending interventions such as rapamycin treatment and inhibition of insulin growth factors, are subject to translational regulation. (escholarship.org)
- Many restrictive food-related policy-level interventions to address the obesity epidemic have been proposed but have yet to be adopted broadly, including taxes on low-nutrient foods and beverages, advertising restrictions, and restrictions on fast-food outlets. (cdc.gov)
Diet3
- Emerging evidence suggests a high ratio of protein to carbohydrate in a low-fat, caloric restricted (CR) diet may mitigate FFM reductions during weight loss through increasing muscle protein synthesis and/or reducing protein catabolism, thereby improving net muscle protein balance[ 6 ]. (biomedcentral.com)
- Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, reduced the extent of changes occurring during the first year of life in these genomic regions. (aging-us.com)
- glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
Obesity2
Nutrient2
- Scientists have only recently appreciated the role of the nutrient sensing-AAR pathway in immune regulation and metabolic signaling. (scienceblog.com)
- Hence one of the most critical factors that directly interact with the DNA genes to maintain optimal health is nutrient sensing and regulation. (physicianwrites.com)
Calorie restriction1
- Indeed, drunkorexia refers to indulging in a purposeful calorie restriction pattern on days when drinking alcohol is planned. (biomedcentral.com)
Restrictive1
- One of the restrictive nutritional approaches, caloric restriction (CR) achieves stunning results in extending health span and life span via coordinated changes in multiple biological functions from the molecular, cellular, to the whole-body levels. (encyclopedia.pub)
Humans3
- Remarkably, caloric restriction has been shown to be effective in delaying aging in multiple species and the results in humans look equally promising," Anderson said. (sciencedaily.com)
- Caloric restriction (CR) has been shown to extend lifespan and prevent cellular senescence in various species ranging from yeast to humans. (molcells.org)
- The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in humans are controversial. (medscape.com)
Behaviors4
- The following study investigates the different associations between two emotion regulation strategies (i.e. emotional suppression and cognitive reappraisal) and drunkorexia behaviors in a sample of Lebanese adults, exploring the possible indirect effects of positive and negative alcohol-related metacognitions. (biomedcentral.com)
- The positive metacognitive beliefs about cognitive self-regulation significantly mediated the association between cognitive reappraisal and drunkorexia behaviors. (biomedcentral.com)
- however, it displays specific prominent features with an ultimate association between binge drinking behaviors and caloric restriction [ 3 ]. (biomedcentral.com)
- Access, salience, and impulsive drinking behaviors are addressed with regulations including alcohol outlet density limits, constraints on retail displays of alcoholic beverages, and restrictions on drink "specials. (cdc.gov)
Aging2
- microRNAs-mediated regulation of insulin signaling in white adipose tissue during aging: Role of caloric restriction. (clinbioinfosspa.es)
- This regulation is sive loss of neurons and white matter that believed to positively impact these diseases can lead to brain atrophy and different by promoting normal aging and delaying types of disability. (bvsalud.org)
Metabolic1
- These include activating metabolic sensors such as AMP kinase/ AMPK (adenosine monophosphate kinase) and the protein known as SIRT1 (sirtuin 1, i.e., silent mating type information regulation 2 homolog 1). (totalhealthmagazine.com)
Signaling1
- EETs upregulate HO-1-adiponectin-AKT signaling and play essential roles in the regulation of adipocyte differentiation, indicating the existence of a crosstalk between HO-1 and EETs. (nymc.edu)
Effects2
- Although the beneficial effects of caloric restriction on lifespan and health have been clearly demonstrated, it is difficult to implement such restrictions in our lives. (nutritionfacts.org)
- In fact, just reducing protein, "without any changes in calorie level, have been shown to have similar effects as caloric restriction. (nutritionfacts.org)
Inflammatory2
- There is also evidence that it extends lifespan and delays age-related inflammatory diseases in animal studies on caloric restriction. (scienceblog.com)
- Caloric restriction is known to improve inflammatory and autoimmune diseases. (bvsalud.org)
Approaches1
- This study is an exciting example of how solving the molecular mechanism of traditional herbal medicine can lead both to new insights into physiological regulation and to novel approaches to the treatment of disease," said Tracy Keller, an instructor in Whitman's lab and the first author on the paper. (scienceblog.com)
Resistance1
- Caloric restriction disrupts the microbiota and colonization resistance. (antiwaft.com)
Researchers3
- The researchers think that HF treatment mimics cellular proline deprivation, which activates the AAR response and subsequently impacts immune regulation. (scienceblog.com)
- Even researchers who study caloric restriction rarely practise it. (nutritionfacts.org)
- That's why researchers were so excited about rapamycin, a drug that inhibits TOR, thinking it could be caloric restriction in a pill. (nutritionfacts.org)
Exercise2
- That's what caloric restriction is all about, and for it to be truly effective, it can't be considered without giving at least equal priority to your exercise regimen. (anhinternational.org)
- Dr. Halliday is also examining how sex as a biological variable, may influence the appetitive responses to energy deficits elicited through both increased exercise energy expenditure and caloric restriction. (utah.edu)
Energy1
- For instance, low energy levels (caloric restriction) and increased reactive oxygen species/free radicals can promote the activity of special cellular control points. (totalhealthmagazine.com)
Physical activity1
- I hope it helps to provide not only some guidance, but also some good reasons why it's so important to incorporate caloric restriction and increased physical activity into your daily life. (anhinternational.org)
Sirt11
- In summary, these results confirmed that Sirt1 is a potent protective factor for neurons subjected to oxidative stress, and the protective effect of Sirt1 is attributed to its regulation of PGC-1α. (frontiersin.org)
Emotional1
- This study demonstrated that emotional and metacognitive processes are associated with drunkorexia, addressing as well the mediating effect between deficient emotional regulation and risky behavioral patterns. (biomedcentral.com)
Levels1
- In the study, Blackwell and his team found that caloric restriction reduces levels of innate immunity by decreasing the activity of a regulatory protein called p38, triggering a chain reaction effect ending in a reduced immune response. (innovitaresearch.com)
Response1
- This self-imposed caloric restriction then leads to the lowering of the innate immune response. (innovitaresearch.com)
Research1
- La estancia postdoctoral que disfruté en el Dementia Research Laboratory (King's College, Londres), me permitió, además de desarrollar mi habilidades técnicas e intelectuales, el ponerme en contacto y comenzar colaboraciones de investigación, que se mantiene a dia de hoy. (unav.edu)
Alcohol1
- In contrast, many regulations that do not assume people make rational choices have been successfully applied to control alcohol, a substance -- like food -- of which immoderate consumption leads to serious health problems. (cdc.gov)