• Using a kinase inhibitor, we demonstrate that the enzymatic activity of MINK1 is involved in PRICKLE1-LL5β complex assembly and localization, as well as in cell migration. (hal.science)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • Rather, a mixture or inhibitor cocktail of several different inhibitor compounds are used to ensure that protein extracts do not degrade before analysis for targets of interest. (thermofisher.com)
  • Research experiments may necessitate the use of single inhibitors or customized mixtures, but most protein work is best served by using a suitable protease inhibitor cocktail . (thermofisher.com)
  • Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. (endocrine-abstracts.org)
  • NEMO/IKK -gamma is the regulatory subunit of the inhibitor kappa kinase (IKK) complex and is required for the activation of the transcription factor NF-kappaB (NF-kB). (medscape.com)
  • NF-kB activity is normally regulated via the inhibitor kB protein. (medscape.com)
  • Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency. (harvard.edu)
  • Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
  • Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
  • In whole cells, protease and phosphatase activities are tightly regulated by compartmentalization or inhibitors to prevent indiscriminate damage to cellular proteins and to maintain proper function of signaling pathways. (thermofisher.com)
  • Gene ontology annotation revealed a number of critical signalling pathways that were differentially expressed in cells treated with LA, including biological processes involved in establishment of cell polarity, molecular functions that regulate junctional structures, and cellular components associated with epithelial repair (cell leading edge, ruffle and apical junctional complex). (ecco-ibd.eu)
  • Mechanistically, ALK directly interacts with epidermal growth factor receptor (EGFR) to trigger serine-threonine protein kinase AKT phosphorylation and activate interferon regulatory factor 3 (IRF3) and nuclear factor κB (NF-κB) signaling pathways, enabling STING-dependent rigorous inflammatory responses. (medicalxpress.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Myogenic transcription is tightly regulated by various intracellular signaling pathways, which include members of the protein kinase D (PKD) family. (bvsalud.org)
  • In this study, we show that porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 1alpha (nsp1alpha) escapes innate immunity and also promotes virus proliferation by modulating nuclear to cytoplasmic translocation and distribution ratio of tumor necrosis factor (TNF) receptor associated factors (TRAF) interacting protein (TRAIP). (usda.gov)
  • Pim kinases play a major role in cell cycle regulation , anti-apoptotic activity and the homing and migration of receptor tyrosine kinases mediated via the JAK/STAT pathway . (axonmedchem.com)
  • Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
  • We have elucidated the molecular mechanisms involved in the increase in IL-6 expression caused by CXCL1 incubation in SFs, which was regulated by its receptor CXCR2, c-Raf and MAPK signaling components, and activator protein-1 (AP-1) transcriptional activation. (researchsquare.com)
  • Sorafenib (Sor) can block receptor tyrosine kinases, which are involved in the development of new blood vessels, as well as cell proliferation as a result [ 22 ]. (biomedcentral.com)
  • The growth/survival signal is initially carried by these receptor ligands - proteins such as epidermal growth factor (EGF), fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) - which bind cell-surface receptor tyrosine kinases (RTKs). (tocris.com)
  • Additionally, transforming growth factor β signals through receptor serine/threonine kinases (RSTKs) and activates downstream SMAD proteins to regulate the expression of specific genes. (tocris.com)
  • Deregulation of growth factor receptor activity is found in nearly all epithelial tumors, and the expression of mutant forms of growth factor proteins may also lead to cancer . (tocris.com)
  • We provide evidence to support a role for anaplastic lymphoma kinase (ALK), a tumor-associated receptor tyrosine kinase, in the regulation of innate immunity during lethal sepsis. (medicalxpress.com)
  • Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)
  • Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) pipeline Target constitutes close to 7 molecules. (researchandmarkets.com)
  • The latest report SerineThreonine Protein Kinase A Raf - Pipeline Review, H1 2020, outlays comprehensive information on the Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (researchandmarkets.com)
  • Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) - Serine/threonine-protein kinase A-Raf is an enzyme that in humans is encoded by the ARAF gene. (researchandmarkets.com)
  • Furthermore, this report also reviews key players involved in Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics development with respective active and dormant or discontinued projects. (researchandmarkets.com)
  • Tumor Progression Locus-2 (Tpl2) is a proto-oncogene, first cloned in 1993 (PNAS, 1993, 90:2251) that codes for a serine/threonine protein kinase. (tuftsmedicalcenter.org)
  • RIPK1 also directly regulates caspase-8-mediated apoptosis or, if caspase-8 activity is blocked, RIPK3-MLKL-dependent necroptosis. (nih.gov)
  • Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors. (cam.ac.uk)
  • RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
  • To date, it is well known that lncRNAs participate in chromatin modifications and transcriptional and translational regulation of protein-encoding genes or regulate protein function and activity through specific binding [ 3 - 5 ]. (jcancer.org)
  • However, many Notch-regulated genes identified in genome-wide studies are involved in fundamental aspects of cell behaviour, suggesting a more direct influence on cellular properties. (cam.ac.uk)
  • Thus, besides its well-known roles in regulating the expression of cell-fate-determining transcription factors, Notch signalling also has the potential to directly affect cell morphology and behaviour by modulating expression of genes such as Reck, rhea/talin and trio. (cam.ac.uk)
  • Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
  • Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. (wikipedia.org)
  • A group of enzymes that are dependent on cyclic GMP and catalyzes the phosphorylation of serine or threonine residues of proteins. (harvard.edu)
  • Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)
  • In addition to autoinhibition, CR3 is also inhibited when the protein is not post-translationally phosphorylated at certain serine and tyrosine residues in the CR2 hinge region. (news-medical.net)
  • Phosphorylation is the most common post-translational modification on proteins, with approximately 80% occurring on serine, 20% on threonine, and 0.1 to 1% on tyrosine residues. (thermofisher.com)
  • Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer, and a way to overcome resistance to cancer immunotherapy. (wikipedia.org)
  • PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. (harvard.edu)
  • Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylation and oxidative stress may cause an accumulation of unfolded proteins in the endoplasmic reticulum (ER), leading to the unfolded protein response (UPR) and autophagy. (spandidos-publications.com)
  • In this report, we show that class I histone deacetylase (HDAC) inhibition, and in particular HDAC8 inhibition, attenuated PKD phosphorylation in skeletal C2C12 myoblasts in response to phorbol ester, angiotensin II and dexamethasone signaling independent of changes in total PKD protein expression. (bvsalud.org)
  • Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • This gene, therefore, may regulate cell proliferation. (thermofisher.com)
  • Growth factors initiate numerous different signaling cascades in order to regulate cell differentiation and proliferation. (tocris.com)
  • A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
  • Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
  • Protein kinase C (PKC) is a key enzyme which regulates proliferation, apoptosis and differentiation, representing a pharmacological target for tumor therapy. (endocrine-abstracts.org)
  • Protein kinase C (PKC) is a family of serine-threonine kinases that regulate many cellular processes including proliferation and survival. (endocrine-abstracts.org)
  • PKD is a family of serine-threonine kinases that regulate gene expression, protein secretion, cell proliferation, differentiation and inflammation. (bvsalud.org)
  • Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation. (medlineplus.gov)
  • Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. (uchicago.edu)
  • Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation. (harvard.edu)
  • cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. (harvard.edu)
  • Enrichment of nsp1alpha-induced cytoplasmic TRAIP in turn leads to excessive K48 ubiquitination and degradation of serine/threonine-protein kinase (TBK1), thereby antagonizing TBK1-IRF3-IFN signaling. (usda.gov)
  • These proteins are considered to be constitutively active and, therefore, regulated by expression and proteosomal degradation. (axonmedchem.com)
  • Protein degradation during cell lysis. (thermofisher.com)
  • Disruption of cellular and tissue architecture during protein extraction distorts the in vivo state by making all proteins potentially accessible for degradation or modification by endogenous proteases and phosphatases. (thermofisher.com)
  • Protease and phosphatase inhibitors can be added to the lysis reagents in order to prevent degradation of extracted proteins, and to obtain the best possible protein yield and activity following cell lysis. (thermofisher.com)
  • The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)
  • These mutations change single protein building blocks (amino acids) in the BRAF protein. (medlineplus.gov)
  • The BRAF gene mutations change single amino acids in the BRAF protein: One mutation replaces the amino acid threonine with the amino acid proline at position 241 (written as Thr241Pro or T241P) and the other mutation replaces the amino acid leucine with the amino acid phenylalanine at position 245 (written as Leu245Phe or L245F). (medlineplus.gov)
  • In a previous report, we identified the role of glycogen synthase kinase-3β (GSK-3β) in NF-κB activation by regulating IKKγ/NEMO. (mdpi.com)
  • Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). (cellsignal.com)
  • TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. (wikipedia.org)
  • In addition, although protective functions are well documented for AMP-activated protein kinase (AMPK), paradoxically, disease-promoting effects have also been demonstrated for this enzyme. (mdpi.com)
  • inositol-requiring enzyme 1 (IRE1α), PRKR-like ER kinase (PERK) and activating transcription factor-6 (ATF-6). (spandidos-publications.com)
  • We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
  • These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
  • Some pharmaceutical companies are developing inhibitors of B-Raf protein as anticancer therapies. (news-medical.net)
  • The two antibodies function as a capture-target-detection sandwich (#46835 and #79774, respectively) to detect endogenous protein expression in positive and negative controls (with or without phosphatase inhibitors). (cellsignal.com)
  • 2] Pim kinase inhibitors: a survey of the patent literature. (axonmedchem.com)
  • Protease and phosphatase inhibitors are essential components of most cell lysis and protein extraction procedures. (thermofisher.com)
  • These inhibitors block or inactivate endogenous proteolytic and phospholytic enzymes that are released from subcellular compartments during cell lysis and would otherwise degrade proteins of interest and their activation states. (thermofisher.com)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • The ribosomal protein S6 kinase 1 (S6K1) is one of two mammalian p70-RSK proteins, acting as a downstream mediator of mammalian target of rapamycin (mTOR) in the phosphoinositide 3-kinase (PI3K) pathway and/or the Ras-MAPK pathway . (axonmedchem.com)
  • B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
  • This protein is part of a signaling pathway known as the RAS/MAPK pathway, which controls several important cell functions. (medlineplus.gov)
  • Almost all of these genetic changes abnormally activate the protein, which disrupts the tightly regulated RAS/MAPK signaling pathway in cells throughout the body. (medlineplus.gov)
  • Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (thermofisher.com)
  • A member of the family of PI3Ks/mTOR is a physiologically stable serine/threonine protein kinase [ 11 ]. (biomedcentral.com)
  • Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
  • They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits. (uchicago.edu)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • This kinase is mainly known for its role in innate immunity antiviral response. (wikipedia.org)
  • This study proposes a novel mechanism by which PRRSV utilizes host proteins to regulate innate immunity. (usda.gov)
  • They transduces anabolic signals that indicate nutritional status to regulate cell size and growth and metabolism through various mechanisms. (axonmedchem.com)
  • This specific family member regulates cell motility and morphology. (antikoerper-online.de)
  • The RSK family of kinases: emerging roles in cellular signaling. (axonmedchem.com)
  • HGF forms a family with HGF-like protein (HLP), a unique protein with a domain structure similar to that of HGF ( 12 ). (spandidos-publications.com)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • Pim-1, 2 and 3 (EC 2.7.11.1) make up a distinct and highly homologous family of serine/threonine kinases belonging to the Ca2+/ calmodulin -dependent protein kinase-related (CAMK) family. (axonmedchem.com)
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
  • serine/threonine protein kinase family. (ece-inhibitor.com)
  • PKD is a unique PKC family member that shares distant sequence homology to calcium-regulated kinases and plays an important role in muscle physiology. (bvsalud.org)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • This is provided by adaptor proteins that interact with the dimerization domain of TBK1 to determine its location and access to substrates. (wikipedia.org)
  • Another adaptor protein that determines the location of TBK1 is TAPE. (wikipedia.org)
  • TANK-binding kinase 1 has been shown to interact with: NCK1, TANK, TRAF2 and TBKBP1 aka SINTBAD Transcription factors activated upon TBK1 activation include IRF3, IRF7 and ZEB1. (wikipedia.org)
  • Deregulation of TBK1 activity and mutations in this protein are associated with many diseases. (wikipedia.org)
  • Phosphatases play a key role in regulating signal transduction events in eukaryotic cells. (thermofisher.com)
  • Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)
  • A diverse range of physiological stimuli induce Akt kinase activity, including many trophic factors which promote survival, at least in part, through Akt activation via the phosphatidylinositide 3-OH kinase 123653-11-2 manufacture (PI3K) signaling cascade. (bioinf.org)
  • Emk is a serine/threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics. (jcvi.org)
  • 1] Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span. (axonmedchem.com)
  • Elevated CO(2) levels caused a rapid activation of AMP-activated protein kinase (AMPK) in AECs, a key regulator of metabolic homeostasis. (ilh-giessen.de)
  • Activation of AMPK was mediated by a CO(2)-triggered increase in intracellular Ca(2+) concentration and Ca(2+)/calmodulin-dependent kinase kinase-beta (CaMKK-beta). (ilh-giessen.de)
  • The autophosphorylation of serine 172, which requires homodimerization and ubiquitinylation of lysines 30 and 401, is necessary for kinase activity. (wikipedia.org)
  • Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)
  • CR1 inhibits the activity of CR3, the kinase domain, regulating the overall signaling activity of the molecule. (news-medical.net)
  • This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
  • We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation and cooperate with E(Spl) activity in a dose-dependent manner. (biologists.com)
  • and protein kinase activity. (nih.gov)
  • The resulting unregulated proteolytic activity can reduce protein yield and function. (thermofisher.com)
  • The p70 ribosomal S6 kinases (S6K) and p90 ribosomal S6 kinases (RSK) are distinct families of Ser/Thr kinases (EC 2.7.11.1) that regulate diverse cellular processes by phosphorylation of ribosomal protein S6 (Rps6). (axonmedchem.com)
  • In conclusion, this study successfully screened candidate circRNAs involved in the regulation of porcine myogenesis and demonstrated that circIGF1R promotes myoblast differentiation via miR-16, which lays a theoretical foundation for understanding the role and mechanism of circRNAs in regulating porcine myoblast differentiation. (bvsalud.org)
  • They regulate all cellular processes by transducing inter- and intracellular signals via the phosphorylation of specific protein substrates. (dissertation.com)
  • The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)
  • Endoplasmic reticulum (ER) is an essential organelle responsible for protein synthesis, folding, post-translational modification of proteins and protein trafficking in eukaryotes ( 8 ). (spandidos-publications.com)
  • These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. (antikoerper-online.de)
  • This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
  • Many of the cellular proteins are kept separate from proteolytic enzymes. (thermofisher.com)
  • The eukaryotic protein kinases (ePKs) constitute one of the largest families of enzymes encoded by eukaryotic genomes. (dissertation.com)
  • p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. (axonmedchem.com)
  • Cyclic GMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Cyclic GMP-Dependent Protein Kinases" by people in Harvard Catalyst Profiles by year, and whether "Cyclic GMP-Dependent Protein Kinases" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Cyclic GMP-Dependent Protein Kinases" by people in Profiles. (harvard.edu)
  • A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. (uchicago.edu)
  • In eukaryotes, DNA is organized together with histones and non-histone proteins into a highly complex nucleoprotein structure called chromatin, with the nucleosome as its monomeric subunit. (ece-inhibitor.com)
  • H19 gene is reactivated and up-regulated during tissue regeneration or tumorigenesis [ 11 , 12 ]. (jcancer.org)
  • GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5). (cellsignal.com)
  • The protein encoded by this gene is similar to IKB kinases and can mediate NFkB activation in response to certain growth factors. (wikipedia.org)
  • One is in the activation segment of the kinase domain. (news-medical.net)
  • In order to become active, the CR3 kinase domain must be converted to its active form by phosphorylation of the activation loop. (news-medical.net)
  • Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
  • Secondly, I studied the functional roles of two extremely conserved phosphosites that exist ubiquitously in the activation T-loops of most protein-serine/threonine kinases. (dissertation.com)
  • I also examined the substrate specificities of more than 200 human protein kinases with peptide microarrays populated with semi-optimal substrate sequences. (dissertation.com)
  • Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Nuclear protein-1 (NUPR1) is a regulator of glioma progression. (techscience.com)