Regulates gene factor. Medical search. Frequent questions

However, a strong association between DNA methylation and age-dependent gene expression was found for various transcription factors (i.e. (ugent.be)
However, GRF and GIF transcription factors in ginseng have not been reported. (biomedcentral.com)
In recent years, studies have shown that GRF transcription factors play essential roles in plant growth development and defence responses to biological and abiotic stresses. (biomedcentral.com)
Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
Nuclear receptors are transcription factors that regulate gene expression through the ligand-controlled recruitment of the different group of protein referred to as coregulators. (biodiversityhotspot.org)
The broadest definition is that a coregulator is a protein that participates in a complex that is recruited to the genome by DNA-binding transcription factors, and through this recruitment, the complex regulates (up or down) the rate of transcription of one or more genes. (biodiversityhotspot.org)
Furthermore the transcription factors themselves may be tethered to other transcription factors instead of straight destined to DNA themselves. (biodiversityhotspot.org)
MADS-domain proteins are important transcription factors involved in several biological processes of plants. (isaaa.org)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
Transcription factors are divided into two groups. (intechopen.com)
The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation. (rochester.edu)
For the study, the researchers looked at how STRs interact with proteins called transcription factors. (stanford.edu)
Transcription factors attach to noncoding DNA, regulating the expression of protein-coding genes. (stanford.edu)
Researchers have spent a lot of time characterizing these transcription factors and figuring out which sequences - called motifs - they like to bind to the most," Fordyce said. (stanford.edu)
But current models don't adequately explain where and when transcription factors bind to noncoding DNA to regulate gene expression. (stanford.edu)
Other times, transcription factors bind to stretches of DNA that aren't motifs. (stanford.edu)
To solve the puzzle of why transcription factors go to some places in the genome and not to others, we needed to look beyond the highly preferred motifs," Fordyce said. (stanford.edu)
To better understand the role of short tandem repeats in gene expression, the researchers stripped the mechanisms down to their basics: transcription factors and naked DNA. (stanford.edu)
The experiments compared how tightly transcription factors attached to thousands of DNA sequences - those with a preferred motif, those without one, and those surrounded by random sequences or by a wide variety of STRs. (stanford.edu)
To discover how the DNA and transcription factors interacted, Horton made hundreds of mutated transcription factors. (stanford.edu)
The researchers concluded that the transcription factors directly interact with the repetitive genetic code, attaching to it and the motif with the DNA binding domain. (stanford.edu)
Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)

Nevertheless, NDRG1 sequencing assay disclosed no mutations in the gene. (scirp.org)
Analysis of GFM1 gene mutations in a family with combined oxidative phosphorylation deficiency 1]. (nih.gov)
Laron syndrome is caused by mutations in the GHR gene. (medlineplus.gov)
Mutations in the GHR gene impair the receptor's ability to bind to growth hormone or to trigger signaling within cells. (medlineplus.gov)
Researchers are working to determine how mutations in the GHR gene may protect people with Laron syndrome from developing cancer and type 2 diabetes. (medlineplus.gov)
[ 1 ] As of a 2001 review by Richards et al, 14 point mutations, 9 deletions, 2 nucleotide splice mutations, and 3 insertions of the KIT gene were believed to be mutations causing piebaldism. (medscape.com)
[ 8 ] Piebaldism results from mutations of the KIT proto-oncogene, which encodes the cell surface receptor transmembrane tyrosine kinase for an embryonic growth factor, steel factor. (medscape.com)
[ 9 ] Several pathologic mutations of the KIT gene now have been identified in different patients with piebaldism. (medscape.com)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
At least 200 mutations in the SOD1 gene have been found to cause amyotrophic lateral sclerosis (ALS), a condition characterized by progressive muscle weakness, a loss of muscle mass, and an inability to control movement. (medlineplus.gov)
About half of all Americans with ALS caused by SOD1 gene mutations have a particular mutation that replaces the amino acid alanine with the amino acid valine at position 5 in the enzyme, written as Ala5Val or A5V. (medlineplus.gov)
It is unclear why these cells are particularly sensitive to SOD1 gene mutations. (medlineplus.gov)
People with rare mutations of genes in the leptin-signaling pathway (e.g., complete deficiencies of leptin or its receptor) have a very high likelihood of developing obesity. (cdc.gov)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
Mutations of the KIT proto-oncogene produce variations in phenotype in relation to the site of the KIT gene mutation. (medscape.com)
In an analysis of 26 unrelated patients with piebaldismlike hypopigmentation (ie, 17 typical patients, 5 patients with atypical clinical features or family histories, and 4 patients with other disorders that involve white spotting), novel pathologic mutations or deletions of the KIT gene were observed in 10 (59%) of the typical patients and in 2 (40%) of the atypical patients. (medscape.com)
Overall, pathologic KIT gene mutations were identified in 21 (75%) of 28 unrelated patients with typical piebaldism. (medscape.com)

Incomplete dosage compensation, independent of DNA methylation, was found to be largely responsible for sexually dimorphic gene expression, with dosage compensation increasing throughout life. (ugent.be)
In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)

Notably, a nucleus-resident actin (R62D NLS ) also regulates SRF's transcriptional activity. (jneurosci.org)
PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. (wikipedia.org)
Both jejunal and colonic SMC expressed genes into multiple transcriptional variants, of which most appeared to be specific to SMC [6]. (informationalwebs.com)
SMC express the 1C subunit of L-type Ca2+ channels (CACNA1C) [13], and a recent study showed that myotonic dystrophy protein kinase (DMPK) regulates transcriptional expression and alternative splicing of the 1S subunit of L-type Ca2+ channels (CACNA1S) in skeletal muscle [14]. (informationalwebs.com)
However, it is still unknown whether a transcriptional factor is involved in driving the muscle-specific expression of DMPK or whether DMPK regulates the excitation-contraction coupling. (informationalwebs.com)
Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)
In other animals, heat shock response is a transcriptional response driven by the heat shock transcription factor 1 ( HSF1 ) and thermal stress can trigger HSP70 expression to protect the organism via HSF1 . (biomedcentral.com)
Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)
For old rats, a muted transcriptional profile (13 and 2 differentially expressed genes at 6 and 120 h, respectively) coincided with deficiencies in demethylation, muscle remodeling, and torque recovery. (cdc.gov)

Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
20 differentially expressed genes at each time point) and was accompanied by robust DNA demethylation, tissue remodeling, and isometric torque recovery. (cdc.gov)

GRFs are a large gene family with highly conserved proteins. (biomedcentral.com)
92623-83-1 supplier Computational analysis of genome-wide CArG boxes (CArGome) in mice and humans has identified many SRF-dependent genes that encode for cytoskeletal/contractile or adhesion proteins suggesting that SRF is an ancient master regulator of the actin cytoskeleton [2]. (informationalwebs.com)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
For decades, scientists have known that, despite its name, "junk DNA" in fact plays a critical role: While the coding genes provide blueprints for building proteins, which direct most of the body's functions, some of the noncoding sections of the genome, including regions previously dismissed as "junk," seem to turn up or down the expression of those genes. (stanford.edu)
But it's been unclear how certain noncoding regions influence gene-expression levels - that is, the number of times a gene is copied into RNA and used to make proteins. (stanford.edu)
Sigma factors are a class of proteins constituting essential dissociable subunits that confer sequence-specific DNA binding properties to RNA polymerase (RNAP). (hindawi.com)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)

In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
In addition to regulation of cytoplasmic cytoskeletal dynamics, a little appreciated property of actin signaling is modulation of gene expression so far only reported for non-neuronal cells. (jneurosci.org)
factor that drives smooth muscle cell (SMC)-specific gene expression and is necessary for contractile and cytoskeletal functions. (informationalwebs.com)

N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
MicroRNAs are a kind of small noncoding RNAs, which are involved in the posttranscriptional regulation of gene expression by binding the translation section and lead to either mRNA degradation or translational inhibition and have been found to regulate crucial biological processes, including proliferation, differentiation, and apoptosis [ 10 - 12 ]. (hindawi.com)
Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)
Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)

Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)

However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
One pathway results from the direct effect of increased [Ca 2+ ] i , which activates calcineurin, and in turn, it upregulates insulin gene transcription via NFAT. (diabetesjournals.org)
The second pathway also involves glucose metabolism but appears to be driven by glucose-derived factors that target insulin gene transcription independently of [Ca 2+ ] i . (diabetesjournals.org)
An amygdalo-parabrachial pathway regulates pain perception and chronic pain. (iasp-pain.org)
We show that this pathway regulates the activity of pain-related neurons in PB, and that, in chronic pain, this inhibitory pathway is suppressed, and that this suppression is causally related to pain perception. (iasp-pain.org)

Currently there is intense interest to define the mechanism of action of glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including insulin gene transcription. (diabetesjournals.org)
In this study, GLP-1 (100 nmol/l), in the presence of glucose (11 mmol/l), induced a ∼71-fold increase in insulin gene promoter activity in INS-1 pancreatic β-cells, an effect that was an order of magnitude larger than with either stimulant alone. (diabetesjournals.org)
These data suggest that the synergistic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via PKA- and calcineurin-dependent pathways in pancreatic β-cells. (diabetesjournals.org)
The rate of insulin gene transcription in pancreatic β-cells is regulated by a complex integration of signals derived from nutrients, hormones, and neurotransmitters ( 1 - 5 ). (diabetesjournals.org)
We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
NFAT binds to three distinct NFAT elements within the rat I insulin promoter and activates insulin gene transcription. (diabetesjournals.org)
Two signaling pathways arising from glucose metabolism converge to activate NFAT-mediated insulin gene transcription. (diabetesjournals.org)
It also increases insulin production by enhancing glucose-induced insulin gene expression. (diabetesjournals.org)
This signaling also leads to the production, primarily by liver cells, of another important growth-promoting hormone called insulin-like growth factor I (IGF-I). (medlineplus.gov)
Resistance to the effects of insulin is a major risk factor for type 2 diabetes. (medlineplus.gov)
Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. (uc.edu)

Pancreatic pericytes directly support β-cells through mostly unidentified secreted factors. (nature.com)

R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). (jneurosci.org)

Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
Nevertheless, recruitment to nuclear receptors and additional sequence-specific transcription elements implies that coregulator activity can be directed to particular genomic loci resulting in particular adjustments in gene rules. (biodiversityhotspot.org)
Glucose and GLP-1 also synergistically activated NFAT (nuclear factor of activated T-cells)-mediated transcription from a minimal promoter construct containing tandem NFAT consensus sequences. (diabetesjournals.org)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance. (medlineplus.gov)
Nuclear Egr-1 protein as well as its binding to the responsive element E1 (-196 to -174) of the apoA-1 gene promoter were markedly decreased in the ZD cells. (usda.gov)
Age-dependent stress response DNA demethylation and gene upregulation accompany nuclear and skeletal muscle remodeling following acute resistance-type exercise in rats. (cdc.gov)

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. (bvsalud.org)

In a piece of work carried out by the Carbohydrate Metabolism Research Team of the Institute of Agrobiotechnology, the discovery has been made of the way in which the glgS gene (now renamed as the "surface composition regulator", scoR) acts in bacteria and how the mechanisms involved in bacterial infection can be altered by manipulating this gene, which indirectly affects glycogen production. (europa.eu)
Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)

will attempt to draw out some of the general concepts that have surfaced concerning the system of actions of coregulator complexes i.e. the way they are recruited to particular genomic loci, what enzymatic actions they consist of, the way the complexes are geared to chromatin, how coregulator complexes are constructed, and exactly how coregulators themselves could be regulated finally. (biodiversityhotspot.org)
We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. (uc.edu)

In studies during the early 1990's, Gregg Semenza identified, and then in 1995 purified and cloned, a transcription factor that regulates these oxygen-dependent responses. (nobelprize.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
They partially and/or temporarily replace the vegetative sigma factor and are thus crucial for many stress responses [ 2 ]. (hindawi.com)
Whether these age-specific responses occur early in training and constitute primary factors in adaptation/maladaptation was not addressed. (cdc.gov)

Based on the available public RNA-Seq data, the expression patterns of PgGRF and PgGIF genes were analysed from 14 different tissues. (biomedcentral.com)
GRF genes are usually expressed at higher levels in young tissues but at lower levels in mature tissues [ 6 ]. (biomedcentral.com)
pqbp1 and wbp11 genes are similarly expressed in mesoderm and neural tissues during Xenopus development. (xenbase.org)
Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)

Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder. (nih.gov)

However, it 92623-83-1 supplier remains unclear how SRF regulates physiological contractile function of SMC in the GI tract. (informationalwebs.com)
These alternative sigma factors are further classified by the physiological processes that they control, for example, stress response and flagella biosynthesis [ 3 , 4 ]. (hindawi.com)

This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. (springer.com)
Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. (xenbase.org)
Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. (lu.se)

SRF controls gene transcription of various actin isoforms (e.g. (jneurosci.org)
We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)

The WRC domain can be combined with the cis-acting regions of downstream genes to regulate their expression. (biomedcentral.com)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

Plasma and tissue samples were collected and levels of Vdr, Shp, Cyp7a1, Cyp24a1, and rodent fibroblast growth factor (Fgf) 15 expression, as well as levels of cholesterol, were measured. (nih.gov)

Risk factors for obesity range from individual factors, such as behavior and genetics, to environmental and societal factors, such as food environment, education and skills, and food promotion and marketing. (cdc.gov)

We've known for a while that short tandem repeats, or STRs, aren't junk because their presence or absence correlates with changes in gene expression," Fordyce said. (stanford.edu)

However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)

it was induced by GA3 (gibberellin) [ 3 ] and played an essential role in regulating stem elongation. (biomedcentral.com)
This gene encodes one of the mitochondrial translation elongation factors. (nih.gov)
First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)

A protein factor known to induce gene expression was also decreased in the zinc-deficient cells. (usda.gov)

Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). (springer.com)

This gene provides instructions for making a protein called the growth hormone receptor . (medlineplus.gov)
Most piebald patients have the above-described mutation of the KIT gene encoding a tyrosine kinase receptor involved in pigment cell development. (medscape.com)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
Inadequate efficacy similarly halted the development of agents impinging on the activity of the activin receptor-like kinase (ALK)1, a member of the transforming growth factor-β superfamily. (lu.se)

BRC1 encodes a transcription factor that can inhibit branching. (europa.eu)
The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)

In the present study, we identify a mechanism in which the tumor‐suppressor gene, cylindromatosis (CYLD), confers protection from hepatocellular injury and fibrosis. (uni-regensburg.de)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)

Serum response factor (SRF) transcriptionally regulates expression of contractile genes in smooth muscle cells (SMC). (informationalwebs.com)
SRF transcriptionally activates the expression of SMC-specific genes by binding to CArG [CC (A/T)6 GG] boxes in promoters and introns of most SMC-restricted genes [1]. (informationalwebs.com)

and a second, previously identified and constitutively expressed and non-oxygen-regulated protein known as ARNT. (nobelprize.org)

However, for most of the 20th century, it was not clear how adaptations to oxygen flux were regulated at the fundamental level of gene expression. (nobelprize.org)
A study led by researchers at Stanford Medicine have unraveled some of the mystery of how non-coding DNA changes the level of gene expression. (stanford.edu)

T. Okuda and H. Kondoh, "Identification of New Genes ndr2 and ndr3 Which Are Related to Ndr1/RTP/Drg1 but Show Distinct Tissue Specificity and Response to Nmyc," Biochemical and Biophysical Research Communications, Vol. 266, No. 1, 1999, pp. 208-215. (scirp.org)
This demonstrates that age-related constitutive elevations in stress response gene expression was accompanied by diminished SSC-induced responsiveness in epigenomic regulation and tissue remodeling. (cdc.gov)

Notably, HSP genes, which function as molecular chaperones, play an important role in heat shock response. (biomedcentral.com)

Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)

A recent prospective cohort study with 8828 female (Nurses' Health Study) and 5218 male (Health Professionals Follow-up Study) participants showed the importance of genetic and environmental factors in obesity. (cdc.gov)
How people respond to these obesity-favorable environments may be related to psychological, social, and economic factors (to name a few) as well as genetic variations. (cdc.gov)
Identifying additional genetic, metabolic, behavioral, and environmental factors that make people susceptible to obesity and better clarifying the differences that affect the success of obesity treatment, could lead to newer precision approaches to obesity prevention and treatment. (cdc.gov)

We identified 150 genes responsive to heat shock including seven HSP genes, six of which belonging to the group of 17 HSP genes enriched in response to heat shock, according to weighted gene co-expression network analysis (WGCNA). (biomedcentral.com)

Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)

A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)

To reveal the effects of IL-10 on involution, expression profiles of apoptosis-related genes were examined in mice transgenic for IL-10 as well as in IL-10(-/-) mice. (ewha.ac.kr)

Most PgGRF and PgGIF gene promoters contain some hormone- and stress- related cis-regulatory elements. (biomedcentral.com)

The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)

New revelations about how such changes increase and decrease gene expression may provide insight into these and other disorders. (stanford.edu)
With additional insight into genes regulating body weight, more targeted treatments may be on the horizon. (cdc.gov)

Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. (nih.gov)
Past studies have shown that growth-regulating factors ( GRFs ) and GRF -interacting factors ( GIFs ) are involved in regulating plant growth and development, responding to environmental stress, and responding to the induction of exogenous hormones. (biomedcentral.com)
The results of this study may be helpful for further study of the function of PgGRF and PgGIF genes and lay a foundation for further study of their role in the growth and development of Panax ginseng . (biomedcentral.com)
These results reveal that SlMBP11 plays a role in regulating plant architecture and reproductive development in tomato plants. (isaaa.org)
The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling. (xenbase.org)
Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)
The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
A complex network of interacting genes regulates embryonic melanocyte development. (medscape.com)
Scientists have also identified several genes that play a role in regulating brain chemicals and may contribute to ADHD development. (medlineplus.gov)

These findings suggest an important role for GTF2IRD1 in regulating the level and topology of rod and cone gene expression, and in maintaining normal retinal function. (wustl.edu)
The results expand on information that explains the role of zinc in regulating cell function. (usda.gov)
Computational analysis unveiled a hitherto unknown role for ACVRL1 in relation to genes modulating the functionality of the immune cell compartment. (lu.se)
But research suggests that several factors probably play a role. (medlineplus.gov)

Changes in hepatic Cyp7a1 messenger RNA (mRNA) correlated with those of Cyp24a1 (a Vdr target gene) and inversely with Shp mRNA, but not ileal Fgf15 mRNA. (nih.gov)
In addition, the TNFSF11 was confirmed to be the target gene of miR-217. (hindawi.com)
At the molecular level, knockdown of PQBP1 in Xenopus animal cap explants inhibits target gene induction by FGF but not by BMP, Nodal or Wnt ligands, and knockdown of either PQBP1 or WBP11 in embryos inhibits expression of fgf4 and FGF4 -responsive cdx4 genes. (xenbase.org)

Here we report the importance of general transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) in maintaining M cone cell identity and function as well as rod function. (wustl.edu)

In the absence of CYLD, gene transcription of HGF in hepatic stellate cells was repressed through binding of histone deacetylase 7 (HDAC7) to the promoter of HGF. (uni-regensburg.de)

In an apparent paradox, although GTF2IRD1 is widely expressed in multiple cell types across the retina, knock-out of GTF2IRD1 alters the retinal expression of only a limited number of annotated genes. (wustl.edu)
SDF, stromal cell-derived factors. (cdc.gov)
A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
Loss of the ECM during the islet isolation process is considered to be a significant factor in the poor engraftment rate of transplanted β-cells, thus limiting cell replacement therapy to diabetes 6 . (nature.com)
May regulate other genes in the cell. (lu.se)

Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)

Within the RNAP holoenzyme, sigma factors provide promoter recognition specificity to the polymerase and contribute to DNA strand separation, then they dissociate from RNAP core enzyme and transcription initiation follows [ 1 ]. (hindawi.com)

Considering the lack of reagents for ALK1 detection that has hampered the field to date, our work provides the opportunity to validate the 8-gene signature and CLEC14A as biomarkers for ALK1 activity. (lu.se)

It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES. (bvsalud.org)

It is also possible to analyze the underlying factors that contribute to behavior in C. elegans , because it has a relatively simple and well-defined nervous system. (elifesciences.org)

Anatomy3

Organisms1

Diseases1

Chemicals and Drugs18

Phenomena and Processes5

Humanities1

Information Science4

Geographicals1

Transcription factors22

Mutations18

Sexually dimorphic gene expression2

Transcriptional9

Differentially expressed genes2

Proteins7

Secretion1

Cytoskeletal3

Differentiation9

Proliferation1

Pathway5

Insulin11

Pancreatic1

Phenotypes1

Nuclear7

Cardiac1

Metabolism3

Chromatin3

Responses4

Tissues4

Neurodevelopmental1

Physiological2

Mechanisms3

Isoforms2

Downstream2

Fibroblast1

Genetics1

Changes in gene expression1

Microbiome1

Elongation3

Induce1

Interaction1

Receptor4

Encodes2

Tumor‐su2

Transcriptionally2

Previously identified1

Level of gene expression2

Tissue2

Notably1

Inflammatory gene expression2

Genetic3

WGCNA1

Neurons1

Ontology1

Mice1

Promoters1

Inhibition1

Insight2

Development11

Role4

Target gene3

Function1

Histone1

Cell6

Cellular1

Initiation1

Biomarkers1

Consists1

Behavior1