Regulate neural neural crest. Medical search. Frequent questions

As a result, the PAX3 protein cannot control the activity of other genes and cannot regulate the differentiation of neural crest cells. (medlineplus.gov)
Our group uses developmental genetic approaches in the mouse to identify genes, gene interactions, and signaling pathways that impact the development of neural crest progenitors as they undergo migration and differentiation within these organ systems. (vumc.org)
Current efforts in the lab are aimed at using these tools and gene expression analyses in inbred strains of mice to better understand the processes that regulate normal neural crest cell differentiation as well as the mechanisms that cause gastrointestinal dysmotility. (vumc.org)
Sox10-positive neural crest cells in the sacral region of the embryo also populate the lower urinary tract but until recently very little has been known about the timing, migration routes, signaling pathways, or genes that regulate differentiation of progenitors in this organ system. (vumc.org)
As a means to identify the signaling pathways that regulate the migration and differentiation of sacral neural crest into the bladder we are capturing these progenitors by flow sorting and generating transcriptional profiles via RNASeq. (vumc.org)
In vitro pharmacological studies using explants of pelvic ganglia are being used to study specific effects of sacral neural crest signaling pathways on migration and differentiation. (vumc.org)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
In this thesis, I dissect the roles of the de novo DNA methyltransferases (DNMTs) 3A and 3B in neural crest specification, migration and differentiation. (caltech.edu)
Thus, DNMT3B regulates the duration of neural crest production by the neural tube and the timing of their differentiation. (caltech.edu)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
In zebrafish, Blimp1 promotes differentiation from the embryonic sluggish muscle tissue lineage (9) and specifies neural crest and sensory neuron progenitors (10). (immune-source.com)
We investigated the role of Col2a1a in neural crest migration and differentiation during early zebrafish eye development. (mdpi.com)
MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
This commentary discusses the findings from Wagh and colleagues published in this issue of Stem Cell Research and Therapy demonstrating a critical role for miR-363 in post-transcriptional regulation of CM differentiation via the hand and neural crest derivative expressed HAND1 transcription factor [ 1 ]. (biomedcentral.com)
Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. (rndsystems.com)
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis. (rndsystems.com)
We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells in an undifferentiated state. (lu.se)

Ocular Origami: Bryan and colleagues discover that in the developing zebrafish eye, cell and tissue movements in the optic cup are dependent on the extracellular matrix protein nidogen provided by surrounding neural crest cells. (biologists.com)

In neural crest mutants, these cells traveled farther, faster, and were found in a wider area than cells in control embryos. (biologists.com)
Here we show that zebrafish embryos with mutations in the colourless gene have severe defects in most crest-derived cell types, including pigment cells, neurons and specific glia. (bath.ac.uk)
We then discuss recent studies on the role of neural crest and placodes-and their developmental association-in the head of lamprey embryos, and how comparisons with jawed vertebrates can provide insights into the causes and consequences of this event in early vertebrate evolution. (frontiersin.org)
C ) Histogram representing the percentage of embryos lacking fluorescent neural crest cell in the migration pathway. (elifesciences.org)
D ) Photographs of representative embryos with or without fluorescent migrating neural crest cells. (elifesciences.org)
Each injection was compared to RFP injected in control embryos in which RFP positive cranial neural crest cells have successfully migrated into the branchial and hyoid arches (0% inhibition). (elifesciences.org)
My results in avian embryos suggest that de novo DNA methylation, exerted by both DNMT3A and DNMT3B, plays a dual role in neural crest development, with each individual paralogue apparently functioning during a distinct temporal window. (caltech.edu)
Characterization of Pax3 and Sox10 transgenic Xenopus laevis embryos as tools to study neural crest development. (ucl.ac.uk)

Here we describe a completely novel role for natriuretic peptide signaling in the control of neural crest (NC) and cranial placode (CP) progenitors formation. (gene-tools.com)
However, it is essential that neural crest and placodes associate together throughout embryonic development to coordinate the emergence of several features in the head, including almost all of the cranial peripheral sensory nervous system and organs of special sense. (frontiersin.org)
B-C ) Cranial neural crest explants on fibronectin. (elifesciences.org)
The red arrows indicate the tip of the cranial neural crest segments. (elifesciences.org)
Modulation of β-catenin levels regulates cranial neural crest patterning and dispersal into first pharyngeal arch. (ncbs.res.in)

The lab works on neural crest, mostly in Xenopus but also in zebrafish. (biologists.com)

In this preprint, Bryan and colleagues take advantage of advances in microscopy and live imaging technology to examine in detail the role of the POM neural crest cells in regulating tissue movements during optic cup morphogenesis. (biologists.com)
Blocking the function of nidogen perturbed lens morphogenesis, and the general overexpression of nidogen partially rescued eye defects in neural crest mutants. (biologists.com)
What do the authors speculate is the role, if any, of the mesoderm-derived mesenchyme cells of the POM in regulating optic cup morphogenesis? (biologists.com)
Required for neural tube morphogenesis and neural crest cell migration. (thermofisher.com)

For this, they employ the vast transgenic toolkit available to zebrafish researchers by crossing two fish lines: one in which GFP labels all cell membranes, and the other in which RFP labels only neural crest membranes. (biologists.com)
Thus, the cls mutant phenotype reveals a segregation of ectomesenchymal and non-ectomesenchymal fates during zebrafish neural crest development. (bath.ac.uk)
Kelsh, RN & Eisen, JS 2000, ' The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives ', Development , vol. 127, no. 3, pp. 515-525. (bath.ac.uk)
Pitpnc1a Regulates Zebrafish Sleep and Wake Behavior through Modulation of Insulin-like Growth Factor Signaling. (ucl.ac.uk)

In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)
Neuroblastoma tumors are derived from the sympathetic nervous system and exhibit neural crest features. (lu.se)
In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)
ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. (lu.se)
Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma. (lu.se)

Sox10 is a transcription factor that is expressed in neural crest stem cells when they first form atop the neural tube in the developing embryo and is maintained as these progenitors migrate out to form elements of the peripheral nervous system. (vumc.org)
First, I show that DNMT3A limits the spatial boundary between neural crest versus neural tube progenitors within the neuroepithelium. (caltech.edu)

prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. (ucdenver.edu)
Our studies with these tools indicate that Sox10 not only affects the initial migration of neural crest stem cells but also impacts the balance of enteric neurons and glia that are present later in the postnatal intestine. (vumc.org)
Neural crest cells are the primary innovation that led to evolution of the vertebrates, and transcription factors of the SoxE family (Sox8, Sox9 and Sox10) are among the central players regulating the development of these cells. (nih.gov)

In this review, we briefly summarize the developmental mechanisms and genetics of neural crest and placodes in both jawed and jawless vertebrates. (frontiersin.org)
pink) populations in vertebrates, with some neural crest and placode derivatives listed on either side. (frontiersin.org)
The forkhead box D3 ( FOXD3 ) gene encodes a forkhead transcription factor that plays an important role in neural crest specification in vertebrates and therefore may be involved in human eye disease. (molvis.org)
In all vertebrates examined to date, one or more SoxE proteins are required for the formation of neural crest cells, the maintenance of their multipotency, and their survival. (nih.gov)
Elucidating the mechanisms that control SoxE function is essential to understand the evolutionary origin of the vertebrates, as well as a host of SoxE-linked syndromes and diseases, and may prove crucial for developing stem cell based therapies that target SoxE-regulated cell types. (nih.gov)

In recent years, growing evidence supports an important role for epigenetic regulation as a new mechanism for controlling aspects of neural crest development. (caltech.edu)
The lab started out by working on induction and specification of the neural crest, but in the last few years the majority of the lab has worked on different aspects of neural crest migration. (biologists.com)

Here, we review the evolution of the developmental association of neural crest and placodes from the perspective of the jawless (cyclostome or "agnathan") vertebrate lineage. (frontiersin.org)
Smed-ETS-1 regulates cathepsin+ cell function and epidermal lineage landscape via basement membrane remodeling. (ncbs.res.in)

The proteins produced from the genes Noggin and Chordin inhibit these BMPs, and subsequently allow neural commitment genes, like SOX, to be expressed. (wikipedia.org)
The final adhesion of the converging neural folds is due to several different types of intercellular binding proteins. (wikipedia.org)
Later, SoxE proteins drive the formation of multiple neural crest derivatives including chondrocytes, melanocytes, and cells of the peripheral nervous system, particularly Schwann cells/peripheral glia. (nih.gov)
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
p53 binds to and regulates mRNA and proteins are significantly elevated after BLIMP1 depletion favorably, which is normally accompanied with the induction of p53 focus on genes. (immune-source.com)
Neurofibromin, the protein product of the NF1 gene, functions at least in part as a GTPase activating protein that regulates Ras proteins by stimulating their intrinsic GTPase activity. (iu.edu)

When the peaks of the folds (known as the neural crest regions) touch, they merge and involute, creating the neural tube beneath the newly formed epidermal layer. (wikipedia.org)
2017. Cytoplasmic poly (A) binding protein (PABPC2) critically regulates epidermal maintenance and turnover in planarian Schmidtea mediterranea. . (ncbs.res.in)

Neural crest forms four major categories of derivatives: pigment cells, peripheral neurons, peripheral glia, and ectomesenchymal cells. (bath.ac.uk)

The results suggest that de novo DNA methylation is a critical epigenetic mark used for cell fate restriction of progenitor cells during neural crest cell fate specification. (caltech.edu)

ndst1 overexpression expanded the neural crest (NC) region, whereas translational inhibition reduced not only the trigeminal region, but also the adjacent NC region, especially the anterior part. (bvsalud.org)

Among the components of this signaling pathway, we show that natriuretic peptide receptor 3 (Npr3) plays a pivotal role by differentially regulating two developmental programs through its dual function as clearance and signaling receptor. (gene-tools.com)
To better understand how developmental alterations of neural crest lead to lower urinary tract dysfunction. (vumc.org)
Given their multiple diverse roles in the development of the neural crest, it is important to understand how the activity of SoxE factors is controlled such that they direct the correct developmental outcome. (nih.gov)

Results from 4-dimensional time lapse imaging in these double-labeled fish show the gradual migration of neural crest cells around and in close contact with the developing optic cup until they surround the RPE. (biologists.com)

Literature review part: The enteric nervous system (ENS) often called "the second brain" is considered its own autonomic division that can independently regulate gut function. (helsinki.fi)
The ENS is derived from enteric neural crest-derived cells (ENCCs), which colonize the gut during development. (helsinki.fi)

Simultaneously, SC precursors (SCP) derive from the neural crest cells and migrate from the neural tube around embryonic day E10.5 to contact axons and differentiate into immature SC (iSC) around E15/E16 ( Woodhoo and Sommer, 2008 ). (elifesciences.org)
In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)

miR-149 is a type of miRNA, which can regulate the biological functions of tumors by targeting multiple genes, such as TGF- β 2, GIT1, and HDAC4 [ 7 - 9 ]. (hindawi.com)
Mutations in NF1 cause the common genetic disorder neurofibromatosis type 1 (NF1) which is associated with a predisposition to neural crest derived tumors and juvenile myelomonocytic leukemia (JMML). (iu.edu)

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. (thermofisher.com)

These genes encode transcription factors, which alter the genomic expression of these cells, furthering them along the path of neural cell commitment. (wikipedia.org)
Outcomes p53 Regulates BLIMP1 Transcription Positively. (immune-source.com)
The recent publication by Wagh and colleagues sought to identify the novel miRNAs regulating cardiac-specific transcription factors that determine left versus right ventricular determination [ 1 ]. (biomedcentral.com)

Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells. (lu.se)
Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres. (lu.se)

Noggin and Chordin have other roles in the neurulation process, including stimulating the neural crest cells to emigrate from the newly formed neural tube. (wikipedia.org)
Second, I find that DNMT3B restricts the temporal window during which the neural crest cells emigrate from the dorsal neural tube. (caltech.edu)

miRNAs play an important role in regulating gene expression by binding with 3 - UTR of the target gene. (hindawi.com)
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)

The neurons and glia that make up the peripheral ganglia in these organs derive from neural crest stem cells during fetal development. (vumc.org)

The neural fold is a structure that arises during neurulation in the embryonic development of both birds and mammals among other organisms. (wikipedia.org)
During embryonic development, the PAX3 gene is active in cells called neural crest cells. (medlineplus.gov)
The neural crest is a group of migratory, multipotent stem cells that play a crucial role in many aspects of embryonic development. (caltech.edu)

Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. (rndsystems.com)
In vitro maintenance of multipotent neural crest stem cells as crestospheres. (lu.se)

Why some neural tube cells undergo a change from neural to neural crest cell fate is unknown as is the timing of both onset and cessation of their emigration from the neural tube. (caltech.edu)
Thus, DNMT3A functions as a molecular switch, repressing neural to favor neural crest cell fate. (caltech.edu)

Most contemporary researchers in the fields of neural crest and placode "evo-devo" have directed their efforts and expertise toward the study of either neural crest or placodes in isolation, the inevitable result of specialization that characterizes modern scientific research. (frontiersin.org)
We describe shared and derived patterns of neural crest and placode development in these animals and compare them to well-studied examples from traditional jawed vertebrate model systems. (frontiersin.org)

My main finding was that, at least in the neural crest, cells that undergo contact inhibition do not express different cadherins. (biologists.com)

The migratory neural crest cell population makes a significant contribution to the anterior segment structures of the eye. (molvis.org)

Likewise, it is this diminished affinity between cells expressing different types of cadherin that allows the neural tube precursor cells to separate from the ectoderm, forming the neural tube on the interior of the embryo and the true epidermis on the exterior. (wikipedia.org)
[ 1 ] Mongolian spot results from entrapment of melanocytes in the dermis during their migration from the neural crest into the epidermis. (medscape.com)

Morphogen distribution is generally regulated by binding to an extracellular matrix component, heparan sulfate (HS) proteoglycan. (bvsalud.org)

As the basement membrane of the RPE was disorganized in neural crest mutants, it was plausible that some component of the ECM was missing in the absence of neural crest cells. (biologists.com)
In situ hybridization data revealed that nidogen, an ECM crosslinking protein known to regulate basement membrane assembly, was expressed in neural crest cells surrounding the RPE and lost in neural crest mutants. (biologists.com)
The authors conclude that nidogen produced by the neural crest cells is required for the proper formation of the basement membrane of the RPE. (biologists.com)

Our team is also focused on defining the cell types ("lineages") that come from neural crest in the bladder wall and urethra. (vumc.org)

Understanding the mechanisms that regulate activation / inactivation of the GTPases is of obvious biological significance and is a subject of intense investigation. (cytoskeleton.com)

Taken together, our results indicate for the first time that ESRRa is essential for cartilage development by regulating sox9 expression during vertebrate development. (nature.com)
Neural crest and placodes are key innovations of the vertebrate clade. (frontiersin.org)
This uniquely vertebrate cell population forms within the dorsal neural tube but then emigrates out and migrates long distances to different regions of the body. (caltech.edu)

In humans, the neural folds are responsible for the formation of the anterior end of the neural tube. (wikipedia.org)
The folds give rise to neural crest cells, as well as bringing about the formation of the neural tube. (wikipedia.org)
The thumbnail below shows this process, as well as the subsequent formation of the neural crest cells and the neural tube, which arise from the joining of the neural folds. (wikipedia.org)
Thus, when the neural tube precursor cells begin expressing N-cadherin in the place of E-cadherin, this causes the neural tube to form and separate from the ectoderm and settle inside the embryo. (wikipedia.org)
As the neural folds continue to extend, dorsolateral hinge points form, allowing the folds to curve into a tube-like structure. (wikipedia.org)
Knockdown of DNMT3B causes an excess of neural crest emigration, by extending the time that the neural tube is competent to generate emigrating neural crest cells. (caltech.edu)

In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)

Cadherins and their CAM receptor molecules, for example, are present in two types in the neural precursor tissue: E-cadherin keeps the cells of the neural plate and surrounding ectoderm adhered to each other, while N-cadherin does the same for the cells of the neural fold. (wikipedia.org)
A lack of specialization of neural crest cells leads to the impaired growth of craniofacial bones, nerve tissue, and muscles seen in craniofacial-deafness-hand syndrome. (medlineplus.gov)
Neural tissue is derived from three precursor regions: neural plate, neural crest, and preplacodal ectoderm. (bvsalud.org)

In order to allow for the growth of precursor neural tissues, as opposed to precursor bone or cartilage tissues, BMP expression is decreased in the neural plate, specifically along the medial line, where the neural groove will soon form. (wikipedia.org)

Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. (nature.com)
Furthermore, several reviews claim that Blimp1 might regulate varied cellular processes including cell survival or growth. (immune-source.com)
Furthermore, several reports claim that Blimp1 might regulate different cellular procedures including cell development or success. (immune-source.com)

DNMT3A promotes neural crest specification by directly mediating repression of neural genes, like Sox2 and Sox3. (caltech.edu)

Its knockdown causes ectopic Sox2 and Sox3 expression at the expense of neural crest territory. (caltech.edu)

p53 regulates the manifestation of downstream focus on genes, which serve as mediators of p53 features (17C19). (immune-source.com)

How do neural crest cells control cell migration? (biologists.com)

We are pursuing strategies to derive a comprehensive map of all the lower urinary tract cell types that derive from neural crest in normal development and in mouse models of Spina bifida. (vumc.org)

Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth. (gene-tools.com)
In the neural crest it mediates collective behaviour (in combination with other processes). (biologists.com)

We propose that Npr3 acts as a clearance receptor to regulate local concentrations of natriuretic peptides for optimal cGMP production through Npr1 activation, and as a signaling receptor to control cAMP levels through inhibition of adenylyl cyclase. (gene-tools.com)
This process of BMP inhibition allows for the anchoring of the medial hinge point cells, providing the neural folds with the foundation necessary for folding and closure to occur. (wikipedia.org)
In 2008 Roberto's lab published a paper about contact inhibition of locomotion, showing that this process is required for neural crest directionality, and hinting at the molecular mechanism behind it. (biologists.com)

In the embryo, the formation of the neural folds originates from the area where the neural plate and the surrounding ectoderm converge. (wikipedia.org)

These observations suggest that colourless has a key role in development of non-ectomesenchymal neural crest fates, but not in development of ectomesenchymal fates. (bath.ac.uk)
The Sonic hedgehog gene also plays a role in attenuating BMP expression, forming the medial hinge point while inhibiting the formation of the dorsolateral hinge points, and in ensuring the proper closure of the neural folds. (wikipedia.org)

Importantly, we identify putative ESRRa binding elements in upstream regions of sox9 to which ESRRa can directly bind, indicating that Esrra may directly regulate sox9 expression. (nature.com)

Anatomy57

Organisms17

Diseases10

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes23

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Differentiation17

Surrounding neural crest1

Embryos8

Cranial5

Xenopus1

Morphogenesis4

Zebrafish4

Neuroblastoma5

Progenitors2

Sox103

Vertebrates5

Aspects of neural crest2

Lineage2

Proteins6

Epidermal2

Derivatives1

Progenitor cells1

Overexpression1

Developmental3

Migration of neural1

Enteric2

Migrate2

Tumors2

Ectodermal1

Transcription3

Trunk2

Emigrate2

Gene expression2

Fetal development1

Embryonic development3

Stem2

Fate2

Placode2

Undergo1

Migratory1

Epidermis2

Extracellular1

Basement membrane3

Lineages1

Biological1

Vertebrate3

Tube6

Populations1

Tissue3

Precursor1

Cellular3

Specification1

Ectopic1

Downstream1

Cell migration1

Derive1

Processes2

Inhibition3

Embryo1

Role2

SOX91