Regulate gene expression gene expression. Medical search. Frequent questions

Here, we analyze the expression signature associated with all 687 RNA-binding proteins (RBPs) and identify 39 that significantly correlate with cell cycle mRNAs. (iric.ca)
Skeletal muscles were analyzed for expression of ER genes and proteins and antioxidant genes. (gsu.edu)
GRFs are a large gene family with highly conserved proteins. (biomedcentral.com)
A collaboration between researchers in the Department of Biomedical Engineering and the College of Medicine at Texas A&M University identifies the crucial role of minerals in regulating gene expression, thus controlling the number of proteins that a cell should make, thereby encouraging tissue regeneration and redefining cellular identity. (sciencedaily.com)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
2001). Polycomb group (PcG) proteins and trithorax groups (TrxG) proteins act as key regulators of gene expression through histone lysine methylation. (wikipedia.org)
PcG proteins repress target genes via Histone 3 lysine 27 trimethylation (H3K27me3), whereas TrxG proteins activate gene expression via histone 3 lysine 4 trimethylation (H3K4me3) (Kleinmanns et al. (wikipedia.org)
2014). Long non-coding RNA can associate with DNA in tandem with proteins to alter the rate of gene expression. (wikipedia.org)
Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. (en-journal.org)
How BES1/BZR1 and their interacting proteins function to regulate the large number of genes are not completely understood. (duke.edu)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

Incomplete dosage compensation, independent of DNA methylation, was found to be largely responsible for sexually dimorphic gene expression, with dosage compensation increasing throughout life. (ugent.be)
In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)

Intravenous infusion of albumin into normal rats also decreased transcriptional activity of the albumin gene by 50-60%, and this decrease correlated with changes in serum colloid osmotic pressure after albumin infusion. (jci.org)
Evolutionarily ancient myeloid antigen-presenting cells appear to have evolved a transcriptional sensitivity to socioenvironmental conditions that may allow them to shift basal gene expression profiles to counter the changing microbial threats associated with hostile vs. affine social conditions. (nih.gov)
Translational gene-reporter fusion experiments revealed that Esr41 regulates ler expression at a post-transcriptional level, and pch transcription, probably via an unknown target of Esr41. (nih.gov)
Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. (iric.ca)
The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)
The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. (nottingham.ac.uk)
These findings provide new insights into the role of nCaRE sequences in the transcriptional regulation of mammalian genes. (cnr.it)
2013). To direct transcriptional silencing, a non-coding RNA will associate with a polycomb group protein which to tether it to a specific gene for silencing (Kleinmanns et al. (wikipedia.org)
Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)
Primer extension and transcriptional fusions showed that its expression was induced in the presence of PQ. (uandes.cl)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)

To clarify the biological rationale for social regulation of gene expression, this study sought to identify the specific immune cell types that are transcriptionally sensitive to subjective social isolation (loneliness). (nih.gov)
Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
in this way, vesicle-free miRNA may regulate cell-to-cell communication including the regulation of gene expression and cellular signaling. (frontiersin.org)
This statement suggests that protein X plays a role in the regulation of gene expression by selectively activating the transcription of certain genes. (microbiologynote.com)
This selective activation of transcription allows for precise control and regulation of gene expression patterns in response to specific cellular signals or environmental cues. (microbiologynote.com)
Our results thus reveal a major mechanism by which histone modifications dictate hormonal regulation of gene expression. (duke.edu)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Principles for regulation of gene expression through intercellular signalling. (lu.se)

Using reference distributions for the expression of each human gene in each major leukocyte subtype, we mapped the cellular origin of transcripts found to be differentially expressed in the circulating immune cells from chronically lonely individuals. (nih.gov)
We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
In addition, more than half of BR-regulated genes are differentially affected in sdg8 mutant. (duke.edu)
Six CYP genes (CYP4F3, CYP1A1, CYP27A1, CYP1B1, CYP2B6, and CYP51) were found to be differentially expressed between benzene -exposed patients and controls. (cdc.gov)

New research data from scientists at USC San Diego suggests that the human exosome maintains progenitor cell function, functioning as a surveillance system in cells to regulate the normal turnover of RNAs as well as to destroy RNAs with errors in them. (scitechdaily.com)
In short," said George L. Sen, PhD, assistant professor of medicine and cellular and molecular medicine, "the exosome functions as a surveillance system in cells to regulate the normal turnover of RNAs as well as to destroy RNAs with errors in them. (scitechdaily.com)
MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression inside the cell. (frontiersin.org)

Their synergistic study hoped to decipher how cooperation between the de novo DNA methyltransferase DNMT3A and Ten-eleven translocation methylcytosine dioxygenase TET1 regulates DNA methylation at regulatory regions such as promoters, CpG islands (CGIs), and large under-methylated regions known as canyons/valleys . (epigenie.com)
While the authors highlight how synergism between DNMT3A1 and TET1 helps to regulate both the epigenome and gene expression, they also note that their findings emphasize how the interplay between DNA methylation and histone modifications regulates gene expression, rather than one epigenetic mechanism predominating. (epigenie.com)
DNA methylation regulates transcripti. (ugent.be)
Only a small fraction of the massive differential expression in the developing zebra finch telencephalon could be explained by differential CpG and CpH DNA methylation. (ugent.be)
However, a strong association between DNA methylation and age-dependent gene expression was found for various transcription factors (i.e. (ugent.be)

it was induced by GA3 (gibberellin) [ 3 ] and played an essential role in regulating stem elongation. (biomedcentral.com)
BES1 interacts with SDG8, directly or indirectly through IWS1, a transcription elongation factor involved in BR-regulated gene expression. (duke.edu)

However, other viral genes are expressed during latency and this is correlated with activatory epigenetic modifications at latent gene promoters. (cam.ac.uk)
Here, we show that in the absence of LUNA, the expression of multiple latency-associated transcripts is reduced during latent infection, which is correlated with a lack of activatory marks at their promoters. (cam.ac.uk)
Interestingly, we also show that LUNA interacts with the hematopoietic transcription factor GATA-2, which has previously been shown to bind to a number of latency-associated gene promoters, and that this interaction is dependent on the deSUMOylase domain of LUNA. (cam.ac.uk)
Finally, we show that the deSUMOylase activity of LUNA is required for the establishment and/or maintenance of an open chromatin configuration around latency-associated gene promoters. (cam.ac.uk)
Most PgGRF and PgGIF gene promoters contain some hormone- and stress- related cis-regulatory elements. (biomedcentral.com)
Another, poorly characterized function is its ability to bind to negative calcium responsive elements (nCaRE) of some gene promoters. (cnr.it)
We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)

Upon receiving differentiation inducing signals, the progenitor cells lose expression of certain subunits of the exosome which leads to higher levels of GRHL3 protein. (scitechdaily.com)
Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
These nanoparticles are known specifically as nanosilicates, and with them, the team is able to determine the role of minerals in regulating gene expression profiles to direct stem cell differentiation. (sciencedaily.com)
Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)
Also, under/over-expression studies of the master regulator Oct4 have revealed that some self-renewal/pluripotency as well as differentiation genes are expressed in a biphasic manner with respect to the concentration of Oct4. (lu.se)
The model also predicts that reprogramming the network from a differentiated state, in particular the endoderm state, into a stem cell state, is best achieved by over-expressing Nanog, rather than by suppression of differentiation genes such as Gata-6. (lu.se)
TFs being expressed and the downstream differentiation target been established as candidates to regulate both pluripotency and genes being shut off [11]. (lu.se)

The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. (nottingham.ac.uk)
In the absence of CYLD, gene transcription of HGF in hepatic stellate cells was repressed through binding of histone deacetylase 7 (HDAC7) to the promoter of HGF. (uni-regensburg.de)
In WT cells, CYLD removed HDAC7 from the HGF promoter and induced HGF expression. (uni-regensburg.de)
EMSA and dual-luciferase reporter assays further confirmed that STM3 could directly bind the promoter region to activate FUL1 expression. (nature.com)
We demonstrate that APE1 is part of a multiprotein complex including hOGG1, Ku70, and RNA Pol II, which is recruited on SIRT1 promoter to regulate SIRT1 gene functions during early response to oxidative stress. (cnr.it)
The SoxS site is in the forward orientation and its location suggests that the ompW gene has a class I SoxS-dependent promoter. (uandes.cl)
Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
Jakobsson expression under a human GFAP (hGFAP) promoter. (lu.se)
2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)

Notably, CPEB3 partially modulated differential gene splicing enhanced in the modulation of neural development, neuron cycle, neurotrophin, synapse, and specific development pathway, implying an alternative splicing regulatory mechanism associated with neurogenesis. (aging-us.com)
Together, our results provide new insights into the potential role of miR-1908-5p in the pathogenesis of BD and also propose a hypothesis that neuronal synapses could be a key converging pathway of some BD-associated protein-coding genes and miRNAs. (en-journal.org)
It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)

Sen said the findings could have particular relevance if future research determines that mutations in exosome genes are linked to skin disorders or other diseases. (scitechdaily.com)
Once mutations in exosome complex genes are identified in either skin diseases or other diseases like pontocerebellar hypoplasia, it may be possible to design drugs targeting these defects. (scitechdaily.com)
X-linked intellectual disability, Siderius type is caused by mutations in the PHF8 gene. (medlineplus.gov)
Most PHF8 gene mutations lead to an abnormally short protein that gets transported out of the cell's nucleus. (medlineplus.gov)
[ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
SCID results from mutations in any of more than 15 known genes. (medscape.com)

In the mammalian brain, alternative pre-mRNA splicing is a fundamental mechanism that modifies neuronal function dynamically where secretion of different splice variants regulates neurogenesis, development, pathfinding, maintenance, migration, and synaptogenesis. (aging-us.com)

Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)
Combining interdisciplinary techniques and biomedical engineering and genomics methods, the lead authors of this study, doctoral students Anna Brokesh and Lauren Cross, identify and characterize significant genes that are turned "on" and activated by different signaling pathways due to treatment with minerals. (sciencedaily.com)

The hepatic fatty acid composition was analyzed using gas chromatography mass (GC-MS). The relative expression of lipids metabolism genes was analyzed using reverse transcriptase-polymerase chain reaction (RT-PCR). (biomedcentral.com)
60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
It also plays a role in gene expression regulation and RNA metabolism. (cnr.it)
1] The increased oxidative stress associated with all of these factors has been shown to reduce hepatic expression of the gene encoding hepcidin, a regulator of iron absorption and metabolism, thus increasing iron absorption and iron overload. (medscape.com)

The expression patterns of drought regulated genes were monitored during plant ontogeny, mapped and the location of these genes was incorporated into a comprehensive barley SNP linkage map. (biomedcentral.com)
Based on the available public RNA-Seq data, the expression patterns of PgGRF and PgGIF genes were analysed from 14 different tissues. (biomedcentral.com)

Although several minerals have been shown to regulate gene expression and cellular activity, very little work has focused on understanding underlying molecular mechanisms. (sciencedaily.com)
In addition, mutual antagonism between two of these and other master regulators have been shown to regulate lineage determination. (lu.se)

We find that NF45 and NF90 play essential roles in mitosis, and transcriptome analysis reveals that they are necessary for the expression of a subset of mitotic mRNAs. (iric.ca)
Levels of cel5D mRNAs in the mutant were 16 fold lower than that of the wild-type strain suggesting that GlyR2 acts as an activator of cel5D expression. (nottingham.ac.uk)
Moreover, expression of the siRNA-attenuated NDP-MSH mediated induction of the mRNAs encoding Il-6, Cox2/Ptgs2, and Pck-1 expression. (edu.au)
Therefore, Dicer-independent tRF-3s, generated upon tRNA overexpression, repress genes post-transcriptionally through an Argonaute-GW182 containing RISC via sequence matches with target mRNAs. (bvsalud.org)
miRNA binding downregulates the expression of target mRNAs either by decreasing their stability or by inhibiting translation. (en-journal.org)

Silencing of Chl1 gene expression has been previously reported to reduce insulin secretion. (lu.se)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)

Epigenetic modifications regulate gene expression. (wikipedia.org)

While, gene-regulating lipogenesis (ADIPOQ) was expressed simi-larly in fat and liver tissues, but increased its expression in muscle of fast and intermediate growing lambs. (preprints.org)
JWFT could mitigate the obesity-induced hepatic steatosis by regulating hepatic lipogenesis and lipolysis. (biomedcentral.com)

Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. (en-journal.org)
These loci include several protein-coding genes (e.g. (en-journal.org)

The molecular basis for this proposed regulation has now been investigated by adding oncotically active macromolecules to the circulation of normal or genetically albumin-deficient Nagase analbuminemic rats (NAR) and analyzing the hepatic expression of genes, including albumin after 24 h. (jci.org)

RNA polymerase II mainly transcribes microRNA genes as primary miRNA transcripts (pri-miRNAs) that contain 5′cap and 3′poly(A) tails ( 28 ). (frontiersin.org)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)

Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. (elifesciences.org)
Yet the molecular basis of the differential regulation of latent and lytic gene expression by epigenetics is unclear. (cam.ac.uk)
In addition, gene set enrichment analysis (GSEA) was performed to identify possible molecular signatures that associate with Chl1 expression silencing. (lu.se)
Regeneration is mediated by the molecular processes that regulate gene expression to control tissue renewal, restoration and growth. (sciencedaily.com)
Gene technology: basic and applied molecular genetic methods. (lu.se)

The findings provide new insights into the role and importance of exosomes and their targeted gene transcripts, and may help point the way to new drugs or therapies for not just skin diseases, but other disorders in which stem and progenitor cell populations are affected. (scitechdaily.com)
289 transcripts altered in expression following APC loss in human cells were linked to APC-associated genomic regions. (duke.edu)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)

Our results indicate that canonical WNT signaling can collaborate with or antagonize the AP-1 transcription factor to fine-tune the expression of shared target genes in the colorectal epithelium. (duke.edu)
p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

To look for functional nCaRE sequences within the human genome, we performed bioinformatic analyses and identified 57 genes potentially regulated by APE1. (cnr.it)
Moreover, bioinformatic analyses of human brain expression profiles revealed that the expression levels of miR-1908-5p and its synaptic target genes show an inverse-correlation in many brain regions. (en-journal.org)

We show that endogenous 18 nucleotide tRFs derived from the 3' ends of tRNAs (tRF-3) post-transcriptionally repress genes in HEK293T cells in culture . (bvsalud.org)

A novel feedback regulatory mechanism operating on transcription of the albumin gene is described in the rat. (jci.org)
We report here that a small regulatory RNA (sRNA), Esr41, mediates LEE repression and flagellar gene activation. (nih.gov)
While a few important genes for tomato inflorescence-branching development have been identified, the regulatory mechanism underlying inflorescence branching is still unclear. (nature.com)
A series of regulatory genes that have received much attention makes major contributions to inflorescence architecture in tomato by changing the inflorescence-branching pattern. (nature.com)
Is the Subject Area "Gene regulatory networks" applicable to this article? (plos.org)
PAI-1 gene expression has been observed in various cell types, and many regulatory factors have been identified to play a role in PAI-1 gene transcription. (tmu.edu.tw)
A model based which contains the Oct4/Sox2/Nanog core as well its interaction upon regulatory mechanisms inferred from ChIP-on-chip and with a few other key genes. (lu.se)

When LEE expression is activated, flagellar gene expression is down-regulated because bacterial flagella induce the immune responses of host cells at the infection stage. (nih.gov)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)

RNA-seq demonstrates that endogenous target genes are specifically decreased upon tRF-3 induction. (bvsalud.org)
Using toxin-induced lesions we investigated to what extent transgene expression could be regulated in accordance with the activation of the endogenous GFAP gene. (lu.se)
The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)
An aspect of gene delivery to the brain that is currently being regulate the endogenous GFAP expression in a lesioned brain. (lu.se)

Prospective association analysis based on core drought-regulated genes may simplify the process of identifying favourable alleles, and help to understand the genetic basis of the response to terminal drought. (biomedcentral.com)
We report haplotyping data for 17 starch biosynthesis/degradation genes demonstrating the broad diversity among H. spontaneum accessions and H. vulgare landraces but rather limited genetic variance in the current elite breeding germplasm by fixing certain haplotypes. (biomedcentral.com)
Biochemical and genetic evidence from our laboratory indicates that OmpW is involved in efflux of and resistance towards paraquat (PQ), and its expression has been shown to be activated in response to oxidative stress. (uandes.cl)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)
Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
9] Reduction of hepatic UROD activity to approximately 25% of normal, most often reflecting effects of multiple genetic and/or exogenous inhibitory factors, is required for clinical disease expression. (medscape.com)
Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis. (cdc.gov)

Differential expression and 5' end mapping of actin genes in Dictyostelium. (wikidata.org)
Differential expression of cytochrome P450 genes associated with benzene -induced hematotoxicity. (cdc.gov)
To identify CYP genes whose expression is aberrant in benzene poisoning, a cDNA microarray containing 32 CYP genes was used to detect differential expression of CYPs in patients with hematopoietic dysfunction of benzene exposure. (cdc.gov)

Scholars@Duke publication: Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. (duke.edu)
Here we report that histone lysine methyltransferase SDG8, implicated in histone 3 lysine 36 di- and trimethylation (H3K36me2 and me3), is involved in BR-regulated gene expression. (duke.edu)

The WRC domain can be combined with the cis-acting regions of downstream genes to regulate their expression. (biomedcentral.com)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

Excitingly, the talented team now report that teamwork between DNMT3A and TET1 makes the stem cell dream work by regulating poised bivalent gene expression in mouse embryonic stem cells ( mESCs )! (epigenie.com)
Background: Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. (lu.se)

Microarray analysis reveals that inhibition of Notch signalling causes downregulation of stem cell-associated genes in parallel with decreased proliferation and increased numbers of ciliated cells and that organoids also respond to oestradiol and progesterone treatment in a physiological manner. (nature.com)

Feedback regulation of albumin gene expression by serum colloids may serve as a specific homeostatic mechanism to maintain the steady-state level of total protein in the circulation. (jci.org)
Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. (nottingham.ac.uk)
In the present study, we identify a mechanism in which the tumor‐suppressor gene, cylindromatosis (CYLD), confers protection from hepatocellular injury and fibrosis. (uni-regensburg.de)
While the exact disease mechanism is unknown, it is likely that a lack of PHF8 protein in the nucleus of brain cells before birth prevents chromatin remodeling, altering the normal expression of genes involved in intellectual function and formation of structures along the midline of the skull. (medlineplus.gov)

CPEB3 overexpression had insignificant effects on gene expression in HT22 cells. (aging-us.com)

NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. (iric.ca)
In situ hybridization experiments have shown that the down-regulation of calcitonin gene-related peptide-like immunoreactivity is strictly related to a reduction in CGRP mRNA levels in the spinal motor neurons. (uninsubria.it)
Similar experiments demonstrated that the mRNA expression profile induced by cAMP and NDP-MSH treatment displayed unique but also overlapping properties and suggested that melanocortin-mediated induction of gene expression involves cAMP-dependent and -independent signaling. (edu.au)
In vivo, ip administration of NDP-MSH to C57 BL/6J (male) mice significantly induced the expression of the mRNA encoding Nur77 and increased IL-6, Cox2, Pck1, and Pdk4 mRNA expression in (inguinal) adipose tissue. (edu.au)
CBS mRNA and protein expression were increased in hypoxic cells. (elsevierpure.com)
Transcription is the process by which the information encoded in a gene is transcribed into messenger RNA (mRNA) molecules. (microbiologynote.com)

Furthermore, Notch is responsible for the regulation of known stem cell factor genes. (nature.com)
In this study, they analyzed whole transcriptomic sequencing (RNA-seq) data to evaluate the effect of nanosilicates and ionic dissolution products on the gene expression profiles of stem cells. (sciencedaily.com)

will attempt to draw out some of the general concepts that have surfaced concerning the system of actions of coregulator complexes i.e. the way they are recruited to particular genomic loci, what enzymatic actions they consist of, the way the complexes are geared to chromatin, how coregulator complexes are constructed, and exactly how coregulators themselves could be regulated finally. (biodiversityhotspot.org)
Nevertheless, recruitment to nuclear receptors and additional sequence-specific transcription elements implies that coregulator activity can be directed to particular genomic loci resulting in particular adjustments in gene rules. (biodiversityhotspot.org)
Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. (wustl.edu)

RNA sequencing data revealed a high expression of CHL1 in pancreatic islets and adipose tissues compared to liver and muscles tissues. (lu.se)
Genes involved in protein biosynthesis (RPL7), fatty acid oxidation (CPT1) and lipolysis (FABP4) were up regulated in fast and intermediate growing lambs in all studied tissues. (preprints.org)
In conclusion, the current study providing an evidence for the im-portance of co-expression of these genes in main body tissues linked with growth performance of Barki lambs. (preprints.org)
GRF genes are usually expressed at higher levels in young tissues but at lower levels in mature tissues [ 6 ]. (biomedcentral.com)

Materials and methods approach to regulate transgenic expression. (lu.se)

Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)

RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)

JWFT normalized hepatic fatty acid composition of hyperlipidemia rats by up-regulating hepatic acetyl-CoA carboxylase ( ACC ), stearoyl-CoA desaturase 1 ( SCD1 ) and fatty acid synthase ( FAS ) gene expression, and down-regulating carnitine palmitoyl transferase-1 ( CPT1 ). (biomedcentral.com)

We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

In addition, Esr41 activated the expression of flagellar Class 3 genes by indirectly inducing the transcription of fliA, which encodes the sigma factor for flagellar synthesis. (nih.gov)

However, little information has been gathered to date regarding the genomic location of drought-regulated genes, either expressed throughout plant development or at late reproductive stages influencing seed yield and quality. (biomedcentral.com)

Estrogen Regulates Estrogen Receptors and Antioxidant Gene Expression " by Kristen A. Baltgalvis, Sarah M. Greising et al. (gsu.edu)
Aging is also associated with an increase in antioxidant stress, and estrogens can improve antioxidant status via their interaction with estrogen receptors (ER) to regulate antioxidant gene expression. (gsu.edu)
Nuclear receptors are transcription factors that regulate gene expression through the ligand-controlled recruitment of the different group of protein referred to as coregulators. (biodiversityhotspot.org)
BRs signal through receptors localized to the plasma membrane and other signaling components to regulate the BES1/BZR1 family of transcription factors, which modulates the expression of thousands of genes. (duke.edu)

Those dynamics reflected per-cell changes in the expression of inducible genes and related more strongly to the subjective experience of loneliness than to objective social network size. (nih.gov)

Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)
The use of viral vectors to deliver foreign genes to the brain is highly logical states in the human brain (Eng et al. (lu.se)

The expression of the PgGRF gene was significantly upregulated under GA3 induction and three weeks of heat treatment. (biomedcentral.com)

A Chromatin Immunoprecipitation (ChIP) experiment showed that H3K36me3 is reduced in BR-regulated genes in the sdg8 mutant. (duke.edu)

The purpose of this study was to determine if ER and antioxidant gene expression in skeletal muscle are responsive to changes in circulating estradiol, and if ERs regulate antioxidant gene expression in this tissue. (gsu.edu)
Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase. (wikidata.org)
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. (wikidata.org)

Conversely, ectopic HB9 expression causes an expansion of ventral motoneuron projections and repression of Even-skipped. (jneurosci.org)

Multiple copies of esr41 abolished LEE expression by down-regulating the expression of ler and pch, which encode positive regulators of LEE. (nih.gov)

Nanosilicates dissociate into individual minerals inside the cells and turn "on" a set of key genes that result in information flow throughout the cells, known as signaling pathways. (sciencedaily.com)
RNA-seq, a transcriptome-wide high throughput sequencing assay, provides an unbiased and holistic overview of the gene expression profiles to identify pathways that are perturbed by specific treatments. (sciencedaily.com)

We used RNA-seq to analyze CPEB3-regulated alternative splicing on control and CPEB3-overexpressing cells. (aging-us.com)

Mutation of FUL1 could partially restore inflorescence-branching phenotypes caused by high STM3 expression in ST024. (nature.com)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)

The high level of haplotype variation among starch biosynthesis/degradation genes in the progenitors of cultivated barley shows that domestication and breeding have greatly eroded their allelic diversity in current elite cultivars. (biomedcentral.com)

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Information Science8

Health Care3

Proteins12

Sexually dimorphic gene expression2

Transcriptional11

Regulation of gene ex8

Differentially4

RNAs3

Methylation5

Elongation2

Promoters7

Differentiation7

Promoter10

Pathway3

Mutations6

Mammalian1

Identify and characterize2

Metabolism4

Patterns2

Shown to regulate2

MRNAs5

Secretion2

Epigenetic1

Lipogenesis2

Protein-codin2

Hepatic expression1

MiRNA2

Molecular5

Transcripts3

Transcription factor2

Analyses2

Repress1

Regulatory7

Induce2

Endogenous4

Genetic8

Differential expression3

Histone lysine2

Downstream2

Embryonic2

Proliferation1

Mechanism4

Overexpression1

MRNA6

Stem2

Loci3

Tissues4

Transgenic1

H3K4me31

Tumor‐su1

CPT11

Cytokine2

Inducing the transcription1

Genomic1

Receptors4

Dynamics1

Viral vectors2

Significantly1

Chromatin immunoprecipitation1

Tissue3

Repression1

Encode1

Pathways2

Analyze1

Phenotypes2

Progenitors1