Regulate tumor necrosis factor ligand superfamily member 15. Medical search. Frequent questions

The exogenous pathway mediated by death receptors and death ligands is a very important pathway for cell apoptosis. (bvsalud.org)
Objective To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. (bmj.com)
This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, [6] although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein). (wikidoc.org)
NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. (spandidos-publications.com)
Small‑molecule γ‑secretase inhibitors (AL101, MRK‑560, nirogacestat and others) and antibody‑based biologics targeting Notch ligands or receptors [ABT‑165, AMG 119, rovalpituzumab tesirine (Rova‑T) and others] have been developed as investigational drugs. (spandidos-publications.com)

This protein has been shown to stimulate the proliferation of T cells, trigger apoptosis of various tumor cells and play a role in vascular normalisation processes. (wikipedia.org)
This protein is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes. (wikipedia.org)
NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting caspase 8. (wikipedia.org)
Many members of the TNF superfamily regulate apoptosis and/or immune cell functions, such as T cell co-stimulation, natural killer cell activation, and B cell homeostasis. (rndsystems.com)
Background: Apoptosis regulates normal development, homeostasis, immune tolerance and response to environmental stress by eliminating unwanted or diseased cells, and plays a key role in non-specific immunity of invertebrates. (bvsalud.org)
The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. (cancerindex.org)
Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (biomedcentral.com)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
to the resistance to cytotoxic therapies indicating that IAPs are important therapeutic targets for cancer treatment [16 17 Among the IAP family members cIAP1 and cIAP2 inhibit apoptosis by suppressing the apoptotic signaling pathway rather than by directly inhibiting caspase activity [18]. (healthweeks.com)

Conclusion: Our study suggests that the RANKL/RANK pathway contributes to the development and maintenance of the immunosuppressive tumor microenvironment and denosumab may be a promising adjuvant therapy targeting TAMs in cancer of apocrine origin. (iiarjournals.org)
Of these, tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) create an immunosuppressive microenvironment through various pathways. (iiarjournals.org)
For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)
Accordingly, investigating the characteristics of cancer-related factors is important to determine the immunological background of the tumor microenvironment in each type of skin cancer. (iiarjournals.org)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)

Homeostatic osteoclastogenesis is effectively induced by RANKL (Receptor activator of nuclear factor kappa-B ligand). (frontiersin.org)
TNF and RANKL are members of the TNF superfamily. (frontiersin.org)
Osteoclast differentiation is induced by the master osteoclastogenic factor, RANKL, which acts in concert with M-CSF and ITAM-mediated co-stimulatory signaling. (frontiersin.org)
As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). (iiarjournals.org)
Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
Bone homeostasis is maintained by the interplay between the receptor activator of nuclear factor kappa-B (RANK), its soluble activation ligand (RANKL), and OPG. (biomedcentral.com)

The Periodic Table of Cytokine and Chemokine Families poster includes members of the tumor necrosis factor (TNF) superfamily, and cytokines belonging to the different families of interleukins, interferons, and chemokines. (rndsystems.com)
Ligands for the class I cytokine receptor family include short-chain and long-chain helical cytokines. (rndsystems.com)
The short-chain helical cytokine family includes members of the common gamma-chain and common beta-chain families of cytokines. (rndsystems.com)
The four short-chain helix bundle cytokines that signal through class III receptor tyrosine kinases include M-CSF, SCF, Flt-3 Ligand, and IL-34, and are shown in columns four and five of the poster. (rndsystems.com)
Ligands for the class II cytokine receptor family includes the IL-10 family cytokines, along with the type I, type II, and type III interferons, which are shown in columns three, four, and nine of the poster. (rndsystems.com)
Members of the IL-10 family cytokines have structural similarities and signal through heterodimeric receptor complexes with common subunits. (rndsystems.com)
These cytokines belong to the cysteine-knot superfamily and bind to members of the IL-17 receptor family. (rndsystems.com)
Cytokines in the TNF superfamily bind to oligomeric, type I or type II transmembrane proteins that have multiple extracellular cysteine-rich domains. (rndsystems.com)
OBJECTIVE- Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. (diabetesjournals.org)
Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)
The same basic principle has been applied successfully to other types of fusion partners, including cytokines, growth factors and enzymes. (coek.info)
Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)

It is closely associated with B cell-activating factor of the TNF family (BAFF) receptor, transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) [ 14 ]. (biomedcentral.com)

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. (wikipedia.org)
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. (wikipedia.org)
This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). (wikipedia.org)
This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. (wikipedia.org)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
We further demonstrated that in vitro administration of pro-inflammatory lipopolysaccharide (LPS) significantly upregulated expression levels of CCL2 and CXCL1 as well as phosphorylation (activation) of the stress-associated transcription factor nuclear factor-kappa B (NF-κB) and the mitogen-activated protein kinases (MAPKs) c-jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 in cultured astrocytes prepared from cerebral cortices of neonatal rats. (researchsquare.com)
The protein encoded by this gene is a member of the TNF-receptor superfamily. (cancerindex.org)
The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. (cancerindex.org)
B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
[5] TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). (wikidoc.org)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
The N-terminal baculovirus IAP repeat (BIR) domains of IAP family members have been demonstrated to bind to Smac/DIABLO (second mitochondrion-derived activator of caspase) protein which induces rapid proteasomal degradation of cIAPs [27 28 In addition cIAP1/2 also contain an ubiquitin-associated (UBA) domain that binds to polyubiquitin chains [29] and a less well characterized caspase-recruitment domain (CARD) which was found to be an intrinsic inhibitory domain. (healthweeks.com)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
More recent data show that OPG is also produced in breast tumor cells, and that it can promote tumor growth and metastasis [ 5 , 6 ]. (biomedcentral.com)

Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)

Following tissue damage, RNase T2 is secreted and participates in resistance against RNA viruses or functions as an alarm signaling molecule to regulate the host immune response and contributes to tissue remodeling and repair ( 12 , 13 ). (frontiersin.org)
It has been reported that CD70, a B cell costimulatory molecule encoded by the gene TNFSF7 (tumor necrosis factor ligand superfamily member 7), is overexpressed in CD4 + T cells from patients with SLE due to the demethylation of its promoter. (biomedcentral.com)
CD70, a B cell costimulatory molecule encoded by the TNFSF7 (tumor necrosis factor ligand superfamily member 7) gene [ 21 ], is typically expressed by activated CD4 + T and CD8 + T cells and early B cell progenitors. (biomedcentral.com)

BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikidoc.org)

Moreover HAX1 regulates the non-canonical Nuclear Factor-κB (NF-κB) signaling pathway by modulating the stability of NF-κB-Inducing Kinase (NIK) which is one of the substrates of cIAPs. (healthweeks.com)
We are beginning to understand the power of co-inhibitors in the context of lymphocyte homeostasis and the pathogenesis of leukemia, which involves several newly described co-inhibitory pathways, including the programmed death-1 (PD-1) and PD-1 ligand (PD-L1) pathway. (biomedcentral.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)

OBJECTIVE- We identified lipocalin 2 ( Lcn2 ) as a gene induced by dexamethasone and tumor necrosis factor-α in cultured adipocytes. (diabetesjournals.org)

Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity. (stanford.edu)

Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)
The PD-1 gene is a CD28 family member that is a member of the immunoglobulin gene superfamily. (biomedcentral.com)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)

Faculty av K Aripaka · 2019 · Citerat av 8 - TRAF6 positively regulated mRNA expression of b-Catenin and subsequent activation of Wnt target genes in prostate cancer cells in vitro. (web.app)
In the cerebellar cortex, tenascin-C mRNA in Golgi epithelial cells was down-regulated 3 days after the lesion and returned to control values 80 days after the lesion. (researchgate.net)

Members of the IL-1 R family contain extracellular Ig-like domains and mediate signaling through an intracellular Toll/IL-1 R (TIR) domain. (rndsystems.com)

Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. (mdpi.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)

Chemokines such as chemokine C-C motif ligand 2 (CCL2) and chemokine C-X-C motif ligand 1 (CXCL1) are critical signaling factors regulating post-TBI neuroinflammation. (researchsquare.com)
Immunohistochemical staining of MMP1 and MMP25 as well as chemokine (C-C motif) ligand (CCL) 5 in the lesional skin from five patients with PCAC showed a substantial number of MMP1-bearing cells and MMP25-bearing cells, as well as CCL5-producing cells, that were distributed in the lesional skin. (iiarjournals.org)
Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)

These genome wide transcriptional responses are very tightly regulated and complex. (biomedcentral.com)

The interaction of PRRSV with the immune system is believed to be of critical importance for defining immunological and clinical outcomes of the infection and, along with other factors, is associated with an inefficient development of the adaptive immunity. (biomedcentral.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. (cancer-genetics.org)

A potential disadvantage of BCMA is that soluble BCMA can be released or shed from tumors into the the surrounding tissues and into the circulation. (biomedcentral.com)

BACKGROUND: Fas ligand (FasL) is expressed by activated T cells and induces death in target cells upon binding to Fas. (bvsalud.org)
BCMA, a member of the tumor necrosis factor (TNF) superfamily, is exclusively expressed in a subpopulation of B cells, normal plasma cells, and malignant plasma cells. (biomedcentral.com)
Remarkably, Clec4a4+ eosinophils were instructed by the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that imprints many gut immune cells. (stanford.edu)
Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)
In this study, we compared the expression level of MBD4 in CD4 + T cells between SLE patients and healthy subjects and investigated whether MBD4 was involved in regulating CD70 expression and methylation status. (biomedcentral.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
On the other hand, phagosomes are formed when the pathogen is engulfed by macrophages and fuse with lysosomes to release enzymes and toxic substances, resulting in killing or having cytotoxic effects on bacteria and tumor cells. (frontiersin.org)
CD137 signaling plays a significant role in multiple cells and regulates the activity of many immune cells. (biocare.net)
The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity. (diabetesjournals.org)
Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
A membrane-bound tumor necrosis family member that is expressed on activated antigen-presenting cells such as B-LYMPHOCYTES and MACROPHAGES. (bvsalud.org)

The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)

Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)
In comparing the factors that contribute to the buildup of excess calories in obesity, an imbalance of energy homeostasis can be considered as the basis. (wjgnet.com)
Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)

Additionally, they can regulate cell type-specific responses and can play a significant role in regulating the pathogenesis of certain diseases, including chronic inflammation, cancer, and autoimmune diseases. (rndsystems.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)

In ex vivo experiments the effects of proNGF differ from those of mNGF, suggesting that the balance of p75NTR and TrkA expression represents a critical factor in regulating mNGF/proNGF functions, determining which intracellular pathways and biological activities are triggered. (bmj.com)

Two main advantages of BCMA as an antigen for CAR-T therapy are the potential reduction of on-target/off-tumor toxicity and the lack of antigen-dependent reduction in CAR-T cell expansion [ 16 ]. (biomedcentral.com)

TNF (Tumor necrosis factor) is a pleiotropic cytokine that plays an important role in immunity and inflammatory bone destruction. (frontiersin.org)

All RNase T2 family members exhibit a conserved α/β core structure. (frontiersin.org)
In human, RNase T2 is the only identified member of the RNase T2 family ( 4 ). (frontiersin.org)
On the far left-hand side of the poster, members of the IL-1 family are shown. (rndsystems.com)
All IL-1 family members share a conserved beta-trefoil structure and bind to members of the IL-1 receptor (IL-1 R) family. (rndsystems.com)
Members of the common beta-chain family signal through heterodimeric receptor complexes that contain the common beta-chain subunit, while members of the common gamma-chain family signal through heterodimeric or heterotrimeric receptor complexes that contain the common gamma-chain subunit. (rndsystems.com)
The causative agent is an enveloped, single-stranded 15-kb positive-sense RNA virus belonging to the Arteriviridae family in the order Nidovirales [ 3 ] known as PRRS virus (PRRSV). (biomedcentral.com)
Death ligands are mainly members of the tumour necrosis factor (TNF) family, of which FasL is an important member. (bvsalud.org)
Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)

These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)

Growing evidence has implicated epigenetic factors in the pathogenesis of SLE. (biomedcentral.com)

The intracellular distribution pattern suggests that RNase T2 may be involved in degrading exogenous or endogenous RNAs in lysosome and regulating mitochondrial RNA metabolism ( 6 - 8 ). (frontiersin.org)

CD137 (4-1BB), or tumor necrosis factor receptor superfamily member 9 (TNFRSF9), is a promising target for enhancing antitumor immune responses without the autoimmune side effects associated with immunotherapy approaches (1). (biocare.net)
Anti-CD137 or anti-CD137L (the ligand of CD137) targeted immunotherapy has been extensively studied, seeking to enhance anticancer immune responses (2). (biocare.net)

Moving to the right, the next eight families shown in the poster belong to the four-helix bundle cytokine superfamily. (rndsystems.com)

A number of studies have suggested that MGMT deficiency is closely related to the sensitivity of brain tumors to alkylating agents ( 4 - 6 ). (aacrjournals.org)

Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)

1.02E-02), and regulation of TNF superfamily member 15 and miR181. (biomedcentral.com)

Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. (cancer-genetics.org)

And then we have what's called the VEGF, which is the vascular endothelial growth factor, which is responsible for formation of blood vessels, and then bFGF. (chiroeco.com)

they account for 30% of adult primary brain tumors. (aacrjournals.org)

Anatomy4

Organisms1

Diseases1

Chemicals and Drugs24

Phenomena and Processes7

Information Science3

Receptors7

Apoptosis9

Microenvironment8

RANKL6

Cytokines12

Cyclophilin ligand interactor1

Protein13

Growth and metastasis2

Promote tumor growth1

Molecule3

BAFF1

Pathway3

Adipocytes1

Intestinal mucosa1

Gene3

MRNA2

Extracellular1

Antibody3

Motif3

Transcriptional1

Clinical3

Soluble1

Cells18

Oncogenic1

Homeostasis3

Inflammation2

Functions1

BCMA1

Immunity1

Family8

Mechanisms1

Pathogenesis1

Metabolism1

Immunotherapy2

Belong1

Sensitivity1

Insulin Resistance1

Regulation1

Role1

Vascular1

Adult1