Regulate metabolic improves cardiovascular cardiovascular physiological phenomena. Medical search. Frequent questions

There are several mechanisms of TEI that have shown to affect germline reprogramming, such as transgenerational increases in susceptibility to diseases, mutations, and stress inheritance. (wikipedia.org)
Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. (frontiersin.org)
We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. (frontiersin.org)
The abnormal morphology and dysfunction of mitochondria have been proven as the principal mechanisms in the pathogenesis of cardiovascular diseases, such as heart failure, myocardial infarction, atherosclerosis, and hypertension ( 4 - 6 ). (frontiersin.org)
So mitochondria-targeted therapy is suggested to be a potential treatment strategy for cardiovascular diseases. (frontiersin.org)
However, clinical trials of these agents for cardiovascular diseases were hardly approved to carry out, even less to evaluate their clinical effectiveness and safety. (frontiersin.org)
Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
Many remain small to adulthood and are at an increased risk for developing metabolic diseases such as obesity and type 2 diabetes. (bcm.edu)
Next, data from animal and human studies on the involvement of the RAGE pathway in obesity, diabetes, and cardiovascular diseases are summarized. (bvsalud.org)
Animal cell technology is an area of rapid expansion and one that produces a wide range of high-value products, including vaccines, recombinant proteins, drugs for cardiovascular, respiratory and immune diseases, and monoclonal antibodies. (imperial.ac.uk)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
Additionally, cortisol helps regulate blood sugar levels and modulates immune responses to protect the body against infections and diseases. (stressrelatedweightgain.com)
Excess belly fat is not only aesthetically undesirable but also poses significant health risks such as an increased likelihood of developing cardiovascular diseases and insulin resistance. (stressrelatedweightgain.com)
Excess body fat not only impacts physical appearance but also increases the risk of various chronic diseases, including cardiovascular disease, type 2 diabetes, and certain types of cancer. (well-choices.com)
Prolonged stress can increase the risk of cardiovascular diseases like heart disease and stroke. (fitelo.co)
This review describes, analyzes and compares the effects of different types of diets in reducing the onset of typical Western countries non-communicable diseases (NCDs) (cardiovascular diseases, tumors, chronic respiratory diseases, diabetes, etc.), thus increasing the average lifespan. (iospress.com)
Cardiovascular diseases (CVDs) account for most NCDs deaths (17.7 million people annually), followed by cancers (8.8 million), respiratory diseases (3.9 million) and diabetes (1.6 million) [ 1 ]. (iospress.com)
Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). (biomedcentral.com)
Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)
scholarship on "Effects of snoring and obstructive sleep apneas on attention and supervision and on the cardiovascular system" delivered by the Consortium for the management of the clinic for nervous and mental diseases, University of Bologna. (unibo.it)
Pathogenetic mechanisms and medical behaviours which can improve health in patients with dementia, Parkinson disease and motoneuron diseases" scientific coordinator: C. Caltagirone. (unibo.it)
The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. (oatext.com)
Since this discovery, these vesicles have been identified as playing a role in a huge range of physiological and pathological functions in the human body, including ageing, cancer, infectious diseases and obesity 2 . (lemalab.co)
In an article published last year, scientists from the Institute of Metabolic and Cardiovascular Diseases in France 6 reviewed research on the influence of exercise on lipolysis. (lemalab.co)
Disturbance of circadian rhythms underlies various metabolic diseases. (researchgate.net)

The process of burning body fat is a complex metabolic phenomenon that involves various physiological and biochemical mechanisms. (well-choices.com)
AT1 and AT2 are involved in various physiological changes such as an increase in BP, volume overload, and facilitation of aldosterone release. (hindawi.com)
Besides generating vision, light modulates various physiological functions, including mood. (researchgate.net)

The IS regulates critical cell functions including molecular-regulated cellular metabolite fluxes, protein and energetic metabolism, cell proliferation and apoptosis with consequent regulation of cell life including endothelial homeostasis and blood coagulation. (biomedcentral.com)
Now, Guo and García have revealed that a protein called SIR-2.1, which regulates metabolism in worms, also helps to protect the animals from the effects of aging. (elifesciences.org)
Cortisol performs various essential functions in the body, including regulating metabolism, blood sugar levels, and immune responses. (stressrelatedweightgain.com)
One of its primary roles is to regulate metabolism by promoting the breakdown of stored glycogen into glucose, which can be used as a source of energy. (stressrelatedweightgain.com)
Finally, it will describe the impact of different dietary restrictions in modulating the genetic pathways that regulate metabolism and aging. (iospress.com)
Muscles are an integral part of whole-body metabolism 3 , and there is growing evidence that they act as an endocrine organ 4 -that is, they release hormones directly into the circulatory system to regulate distant target organs as part of our body's messenger system. (lemalab.co)
Other researchers have reported that fat metabolism is increased when exercising the day after a workout, compared to exercising after a rest day, even when exactly the same activity is performed. (lemalab.co)
In a similar manner, exercising in the fasted state-or after a high-protein breakfast 8 -has been shown to increase whole-body fat metabolism 9 . (lemalab.co)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
The intense bursts of exercise in HIIT elevate the heart rate and stimulate the metabolism, leading to an increased calorie burn both during and after the workout. (litesport.com)

The stress-induced cortisol release can disrupt the body's metabolic processes and promote fat storage in the abdominal area. (stressrelatedweightgain.com)
This can lower the body's metabolic rate and reduce overall calorie burn, making it more challenging to maintain or lose weight. (stressrelatedweightgain.com)
The body's core temperature is tightly regulated in the "thermoneutral zone" between 36.5°C and 37.5°C, outside of which thermoregulatory responses are usually activated. (medscape.com)
In this article, we talk about how our bodies handle thermoregulation (the body's ability to self-regulate temperature), heat acclimation (the body's ability to adjust to the effects of heat over time), and the tools you can use to prepare for future hot-weather runs and races. (irunfar.com)
Chronic stressors may not be as intense as acute stressors such as natural disaster or a major accident, but persist over longer periods of time, tend to have a more negative effect on health because they are sustained and thus require the body's physiological response to occur daily. (wikipedia.org)
2013). The disruption of the body's internal clock, known as the circadian rhythm, due to sleep deprivation can negatively impact metabolic processes, hormone regulation, and immune function (Taheri et al. (cheapessay.us)
Sleep deprivation activates the body's stress response, leading to increased levels of stress hormones such as cortisol (Meerlo et al. (cheapessay.us)
High concentrations, which are a sign of overshoot of the body's compensatory reaction, are harmful to the cardiovascular system. (wikilectures.eu)

Therefore, inhibiting the production and accumulation of AGEs, as well as interfering with the metabolic pathways they activate, may be a promising therapeutic strategy for restoring normal adipose tissue function and, thus, combating obesity-related comorbidities. (bvsalud.org)
Glycolysis is a central pathway for glucose catabolism because it connects glucose with other metabolic pathways. (stemcelldaily.com)
It is essential for generating energy from glucose and providing intermediates for other metabolic pathways. (stemcelldaily.com)
Genetic, environmental, behavioral and dietary factors influence the pathways that regulate aging and life expectancy, thus rendering longevity a very complex phenomenon. (iospress.com)
GSE-related anti-cancer activity mostly relies on the induced increase in reactive oxygen species, followed by the orchestrated down- and up-regulation of several key-molecular pathways, including MAPK kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases. (oatext.com)
While these vesicles were once thought to just remove waste from our cells, it was recently discovered that they actually contain a 'cargo' of genetic material that is capable of regulating the cellular pathways of target cells 1 . (lemalab.co)
This happen due to to the oxidation of the food and of the NADH and FADH2, produced in different metabolic pathways, such as glycolysis, β‐oxidation, and the same Krebs cycle. (psychosocialsomatic.com)
The oxidation of amino acid residues, the subsequent formation of protein aggregates by cross‐linking and the production of protein fragments may result in the loss of activity and inactivation of enzymes and metabolic pathways, finally ending up with cell death. (psychosocialsomatic.com)

This suggests that certain metabolic processes and the production of reactive oxygen species, are increased in the knockout worms, which speeds up the aging process. (elifesciences.org)
Models of animal cell culture systems have a wide range of potential applications, such as analysis and prediction of experimental results, optimisation of culture conditions for prolonged viability, and perhaps most importantly, the investigation of fundamental metabolic processes and their subsequent elucidation. (imperial.ac.uk)
This means we are an animal that maintains a relatively constant body temperature (homeotherm) and we do so by primarily producing our own heat via metabolic processes (endotherm). (irunfar.com)
Several intricate mechanisms and processes contribute to this metabolic phenomenon. (well-choices.com)
To understand the role of the transcription factor Nrf2 in regulating the processes of antioxidant defense, it must also know the role of many of the endogenous antioxidants that occur because of its activation. (psychosocialsomatic.com)

Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. (hindawi.com)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
Cortisol serves several important functions in the body, helping to maintain homeostasis and ensure optimal physiological functioning. (stressrelatedweightgain.com)
The mechanisms whereby forces regulate leaflet homeostasis are incompletely understood. (stanford.edu)

Despite recent progress in our understanding of the physiological mechanisms regulating body weight and energy expenditure, obesity remains a major worldwide health crisis with an array of vascular, metabolic, and psychosocial consequences [ 1 , 2 ]. (hindawi.com)
In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
A reduced expression of mTOR may reflect an increased risk of vascular thrombosis. (biomedcentral.com)
Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
Vasomotor vascular tone is affected by several mechanisms: nerve and humoral factors, blood gas composition, local metabolic regulation, endothelial function, and vascular media smooth muscle. (wikilectures.eu)
The mechanism that regulates vascular resistance in one region may be completely ineffective in another region. (wikilectures.eu)
Humoral factors that regulate vascular tone include renin-angiotensin-aldosterone system (RAAS), ADH , bradykinin , histamine , serotonin , thyroxine , natriuretic peptides and many others. (wikilectures.eu)
Some factors such as histamine, serotonin, thyroxine probably affect vascular resistance only in pathological conditions and do not apply in physiological conditions. (wikilectures.eu)
It also increases vascular permeability. (wikilectures.eu)

Body weight is tightly regulated by complex homeostatic mechanisms. (hindawi.com)
The goal of this project is to identify the mechanisms that regulate the diminished growth and altered metabolic responses to nutrition in premature and low birth weight infants and to develop new nutritional strategies to optimize their growth and development. (bcm.edu)
We will determine whether being born prematurely blunts the anabolic response to feeding and identify mechanisms by which amino acids, particularly leucine, regulate lean growth. (bcm.edu)
Thus, understanding the mechanisms by which gluconeogenesis is regulated is paramount to effectively treating type 2 diabetes. (bcm.edu)
Together, these projects will advance our understanding of how the liver regulates glucose production using neural, hormonal, and intracellular mechanisms, and increase the overall body of knowledge. (bcm.edu)
Epigenetic mechanisms regulate cell-type specific gene expression, are established during development, and persist for life. (bcm.edu)
CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). (endocrine-abstracts.org)
The mechanisms behind this phenomenon are complex and not yet fully understood. (stressrelatedweightgain.com)

As little as 10 grams/day of non-alkalized dark chocolate (75% or higher cocoa content) improves endothelial function and flow-mediated dilation, both of which help to decrease blood pressure. (healthyfellow.com)

Postprandial plasma glucose and triglyceride concentrations are predictive of relative cardiovascular disease (CVD) risk, and the pathogenesis of both insulin resistance and atherosclerosis has been attributed to acute states of hyperglycemia and hypertriglyceridemia. (encyclopedia.pub)
Indeed, IS is a very complex phenomenon which is influenced not only by the cellular metabolic status but also interacts with circulating molecules such as hormones (including insulin), nutrients and inflammatory molecules. (biomedcentral.com)
In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1). (biomedcentral.com)
With this experiment, he had shown, in 1930, that insulin increases the permeability of the cell membrane. (iptq.com)
The flavanols present in this cocoa powder have demonstrated the capacity to enhance insulin sensitivity, regulate blood sugar levels, and mitigate the oxidative stress associated with diabetes. (skyswancocoa.com)
Insulin resistance is considered a component of the metabolic syndrome . (wikipedia.org)
Insulin resistance can be improved or reversed with lifestyle approaches, such as exercise and dietary changes. (wikipedia.org)
[1] Various genetic factors can increase risk, such as a family history of diabetes, and there are some specific medical conditions associated with insulin resistance, such as polycystic ovary syndrome . (wikipedia.org)
Foods that have independently been linked to insulin resistance include those high in sugar with high glycemic indices , low in omega-3 and fiber, and which are hyperpalatable which increases risk of overeating. (wikipedia.org)
[3] It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and reduced insulin resistance. (wikipedia.org)
Sedentary lifestyle increases the likelihood of development of insulin resistance. (wikipedia.org)
A mismatch between the circadian rhythm and the meals schedule, such as in circadian rhythm disorders , may increase insulin resistance. (wikipedia.org)
Being exposed to light during sleep has been shown to cause insulin resistance and increase heart rate. (wikipedia.org)
Cortisol counteracts insulin and can lead to increased hepatic gluconeogenesis , reduced peripheral utilization of glucose, and increased insulin resistance. (wikipedia.org)

It also plays a role in regulating blood glucose levels and responding to hormonal signals. (stemcelldaily.com)
Hormonal regulation plays a pivotal role in initiating and regulating lipolysis. (well-choices.com)
The achievement, at a global level, of a "healthy aging phenotype" defined as "the condition of being alive, while having highly preserved functioning metabolic, hormonal and neuroendocrine control systems at the organ, tissue and molecular levels" [ 10 ], is the most ambitious objective that modern science should achieve. (iospress.com)

Epidemiological studies suggest that chronically-high consumption of milk and milk products is associated with a reduced risk of type 2 diabetes, metabolic syndrome, and CVD. (encyclopedia.pub)
Objective Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. (researchgate.net)

Chronic sleep deprivation has been linked to a range of medical conditions, including cardiovascular disease, obesity, and diabetes (Cappuccio et al. (cheapessay.us)

The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. (frontiersin.org)
In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)
We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
can act as donors or recipients during mitochondrial transfer under physiological conditions ( 8 - 12 ). (frontiersin.org)
Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)

However, as a compensatory response to reduce altered catabolism/ROS production, anabolic enzymes expression levels are also increased, resulting in higher gluconeogenesis and lipid synthesis. (elifesciences.org)

and a second, previously identified and constitutively expressed and non-oxygen-regulated protein known as ARNT. (nobelprize.org)

The hypothalamus controls thermoregulation via increased heat conservation (peripheral vasoconstriction and behavior responses) and heat production (shivering and increasing levels of thyroxine and epinephrine). (medscape.com)
When humans are under chronic stress, permanent changes in their physiological, emotional, and behavioral responses may occur. (wikipedia.org)
Notably, the innate and adaptive immune responses under physiological conditions are typically regulated with high sensitivity to avoid the exacerbation of inflammation, but any dysregulation can probably be associated with CVDs. (biomedcentral.com)
Therefore, immune cells are typically expected to play a vital role in regulating the immune system responses in the heart. (biomedcentral.com)
In studies during the early 1990's, Gregg Semenza identified, and then in 1995 purified and cloned, a transcription factor that regulates these oxygen-dependent responses. (nobelprize.org)
it also allowed the development of complex physiological responses. (nobelprize.org)

Major impairment of IS was confirmed by reduced upstream and downstream mTOR molecules which regulate fundamental cells metabolic functions. (biomedcentral.com)
Sleep is a fundamental physiological process that plays a vital role in maintaining optimal health and functioning. (cheapessay.us)
[2] Overconsumption of fat- and sugar-rich meals and beverages have been proposed as a fundamental factor behind the metabolic syndrome epidemic. (wikipedia.org)
However, for most of the 20th century, it was not clear how adaptations to oxygen flux were regulated at the fundamental level of gene expression. (nobelprize.org)

Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar levels. (wjgnet.com)

For example, histone H3K4 trimethylation (H34me3) and a network of lipid metabolic genes interact to increase the transcription response to TEI obesogenic effects. (wikipedia.org)
A subset of highly regulated genes was validated using quantitative PCR. (stanford.edu)
Here, we assessed the combined effect of diet composition and feeding time on (1) body composition, (2) energy balance, and (3) circadian expression of hepatic clock and metabolic genes. (researchgate.net)

Since diabetes is associated with cardiovascular and kidney complications, we investigated the influence of SBE on blood glucose, blood pressure and renal function in some experimental animal paradigms. (endocrine-abstracts.org)

Glycolysis is an important metabolic pathway that generates energy in various cells of the blood vessel wall. (wjgnet.com)
Glycolysis is an ancient metabolic pathway that evolved long ago and is found in almost all living organisms. (stemcelldaily.com)

Traditionally, fasting plasma glucose and triglyceride concentrations have been used as clinical determinants of CVD (cardiovascular disease). (encyclopedia.pub)
By incorporating this cocoa powder into their diets, individuals can potentially exert a positive influence on their glucose management and overall metabolic health. (skyswancocoa.com)

To explore the correlation structure of individual components of the Metabolic Syndrome and identify combinations of correlated variables we used principal component analysis (PCA) in a multiethnic group of women with a history of GDM (pGDM) (185 European, 103 South Asian, 80 African Caribbean), recruited at 20.0 (18.2 22.1) months (geometric mean (95% CI)) after pregnancy and 482 control women of similar ethnicities. (endocrine-abstracts.org)
Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. (biomedcentral.com)

This narrative review summarizes data on the involvement of the RAGE pathway in adipose tissue dysfunction in obesity and the development of its metabolic complications. (bvsalud.org)
PGRN also acts as a protective factor in hyperhomocysteinemia, probably by down-regulating the wingless-related integration site Wnt/β-catenin signaling pathway. (biomedcentral.com)

It results in an increased vulnerability to stressors for decreased physiological reserves. (mdpi.com)
It is often referred to as the "stress hormone" because its levels increase in response to physical or psychological stressors. (stressrelatedweightgain.com)
Reactive cortisol levels are increases in cortisol in response to stressors. (wikipedia.org)
2014). Sleep deprivation disrupts the brain's ability to regulate emotions effectively, resulting in heightened emotional reactivity and decreased resilience to stressors (Yoo et al. (cheapessay.us)

Most of the metabolic energy of neurons is expended on maintaining ion gradients across the cell membrane. (benbest.com)
Voltage-gated ion channels and ion-exchangers in the cell membrane also regulate ion concentrations. (benbest.com)

Some of these effects include impaired cognitive function, suppressed immune system, increased blood pressure, decreased bone density, and an increased risk of weight gain and abdominal fat storage. (stressrelatedweightgain.com)
2008). Elevated cortisol levels can have detrimental effects on various bodily systems, including immune function and cardiovascular health. (cheapessay.us)
A previous blueberry trial bolsters this finding and goes on to document immune enhancing activity as well - an increase in natural kill cells. (healthyfellow.com)

With energy balance, the secretory and metabolic activity of adipose tissue determines the normal function of many organs, including the endocrine glands. (bvsalud.org)
These phenomena contribute to the development of obesity-related complications, which also affect the major tropic axes regulating the endocrine glands. (bvsalud.org)
However, there is increasing evidence that weight reduction is an effective treatment for obesity-related adipose tissue dysfunction, thereby restoring endocrine function. (bvsalud.org)
This narrative review presents the impact of adipose tissue on endocrine gland activity both in the physiological state and in obesity-related dysfunction. (bvsalud.org)
It secretes a number of hormones which regulate the working of other endocrine glands. (vedantu.com)

This high level of effort triggers physiological adaptations and leads to the many benefits associated with HIIT. (litesport.com)

These unfavorable phenomena can be partially restored by hormone replacement therapy, suggesting a significant role for estrogen in the regulation of adipocytes' function. (bvsalud.org)
High cortisol levels can influence appetite regulation , leading to an increased desire for calorie-dense foods, especially those high in sugar and unhealthy fats. (stressrelatedweightgain.com)

Many studies have further demonstrated that SARS-CoV-2 (COVID-19) has dramatically increased the risks of CVDs due to inflammation, so PGRN has drawn much more attention among scholars. (biomedcentral.com)

Menopause-related decline in estrogen levels is accompanied by a change in adipose tissue distribution from a gynoid to an android and an increased prevalence of obesity in women. (bvsalud.org)
Next, their role in regulating adipogenesis and adipose tissue activity in health and the course of obesity is described. (bvsalud.org)

The decline could be due to physiological alterations toward a non-optimal state, which leads to the failure of proper behavioral execution. (elifesciences.org)

Overweight or obese individuals (body mass index 25-30) have an increased risk of developing diabetes, coronary heart disease, and hypertension [ 2 , 3 ]. (hindawi.com)
In pediatric congenital heart disease (CHD) patients, manipulation of resident progenitor cells may provide important new approaches to improving outcomes. (stanford.edu)
2010. Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease. (cdc.gov)
CONCLUSIONS: The prevalence of reported diabetes among adults with TB disease has increased. (cdc.gov)

The correlation between cocoa consumption and cardiovascular health is a topic that has garnered significant scientific interest. (skyswancocoa.com)
Consequently, the reports of toxicologic and pharmacologic effects of crude extracts or synthetic derivatives of cannabis published before 1968 lack precision and uniformity and preclude any quantitative correlation between physiological effects and chemical composition. (unodc.org)

We will determine the role of the enterokine, FGF19, in the anabolic response to enteral feeding in the preterm and whether augmentation of its secretion will enhance growth and metabolic function. (bcm.edu)
Nitric oxide plays a pivotal role in dilating blood vessels, thus promoting improved blood circulation and reducing hypertension. (skyswancocoa.com)

However, very little data are available on IS of circulating cells of MetS patients although clinical data show that inhibited mTOR, with specific inhibitors such as Serolimus or Everolimus after kidney transplantation, significantly increase the presence of de novo thrombotic micro-angiopathy with artery lesion characterized by intimal cell proliferation, necrosis and narrowed lumen. (biomedcentral.com)

The SAM and HPA axes are regulated by several brain regions, including the limbic system , prefrontal cortex , amygdala , hypothalamus , and stria terminalis . (wikipedia.org)

ADH levels decrease in septic shock, while they increase in hypovolemia, congestive heart failure and liver cirrhosis . (wikilectures.eu)

During stressful times, the body releases the hormone cortisol, which can increase appetite and lead to overeating, especially foods high in fat, sugar, or calories. (fitelo.co)

It is present centrally in the brain with about 90% being expressed in astroglial cells and in some neurons present in regions of the brain controlling cardiovascular and other metabolic functions [ 18 , 19 ]. (hindawi.com)

It produces neurohormones which regulate the synthesis and secretion of pituitary hormones. (vedantu.com)

The second major physiological stress-response center, the HPA axis, regulates the release of cortisol , which influences many bodily functions such as metabolic, psychological and immunological functions . (wikipedia.org)
About 8 ounces a day of red beetroot juice increases bodily production of nitric oxide, a substance which enhances blood flow, exercise capacity and lowers blood pressure. (healthyfellow.com)

Thermoregulation and metabolic heat exchange in humans. (irunfar.com)

The presence of polyphenols in alkalized cocoa powder brings forth a cascade of cognitive benefits that extend to improved blood flow to the brain and enhanced brain function. (skyswancocoa.com)

Hypovolaemia leads to increased production of renin in the kidney, which converts angiotensinogen to angiotensin I. Angiotensin I is converted to active angiotensin II by angiotensin converting enzyme (ACE) in the endothelium, especially in the pulmonary circulation. (wikilectures.eu)
Its concentration increases with the release of renin. (wikilectures.eu)

however, a progressive increase of sick people, elderly people in particular, which are affected by multiple chronic conditions [ 8 ], will render this approach less and less sustainable. (iospress.com)

Stress is either physiological , biological or psychological , is an organism's response to a stressor such as an environmental condition. (wikipedia.org)
A hormetic response to a stress not only maintains a functional internal environment but also improves it. (anti-agingfirewalls.com)

Furthermore, the precise pathophysiological characteristics underlying the association of different cardiovascular risk factors in MetS remain elusive [ 5 ]. (biomedcentral.com)
As a bonus, other cardiovascular risk factors such as cholesterol and triglycerides also improved. (healthyfellow.com)
Using higher doses or using it long-term can increase the risk of serious side effects including cancer. (medlineplus.gov)

By incorporating this cocoa powder into one's diet, individuals may experience a gradual reduction in blood pressure, contributing to overall cardiovascular health. (skyswancocoa.com)
Skyswan Alkalized Cocoa Powder manufacturer acknowledges the importance of offering a product that encapsulates these heart-protective properties, paving the way for consumers to safeguard their cardiovascular well-being. (skyswancocoa.com)

The human body carefully regulates cortisol levels, which can vary throughout the day in a pattern known as the circadian rhythm. (stressrelatedweightgain.com)

Sleep deprivation is a common phenomenon in modern society that affects a large proportion of individuals across various age groups. (cheapessay.us)

In this article, we will summarise our current understanding of the physiological interactions between the gut and brain, termed the "gut-brain axis," focussing particularly on the interactions of gut hormones with the CNS and vagus nerve [ 6 ]. (hindawi.com)

In times of high metabolic demand and adequate availability of oxygen, elevated calcium in mitochondria can increase ATP production by stimulation of three enzymes in the Krebs citric acid cycle: pyruvate dehydrogenase, alpha-ketoglutarate and isocitrate dehydrogenase. (benbest.com)

They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
The decline in functional capacity is a heterogeneous phenomenon in the elderly. (mdpi.com)
In this study, we show that the mating circuits' functional durability depends on the metabolic regulator SIR-2.1, a NAD + -dependent histone deacetylase. (elifesciences.org)

Therefore, it is urgent to uncover the molecular mechanism(s) underlying the physiological changes, so that certain actions could prevent or postpone the non-optimal modifications that occur during aging. (elifesciences.org)

Taking 30-500 mg of DHEA by mouth daily seems to improve symptoms of depression. (medlineplus.gov)

Diseases1

Phenomena and Processes29

Diseases25

Various physiological3

Metabolism10

Body's8

Pathways8

Processes5

Homeostasis4

Vascular10

Mechanisms8

Endothelial function1

Insulin14

Hormonal3

Type 2 diabet2

Including cardiovascular disease1

Mitochondrial5

Gluconeogenesis1

Protein1

Responses6

Fundamental4

Diabetes mellitus1

Genes3

Blood glucose1

Glycolysis2

Glucose2

Syndrome2

Pathway2

Stressors4

Cell membrane2

Immune3

Endocrine5

Adaptations1

Regulation2

CVDs1

Adipose2

Behavioral1

Disease4

Correlation2

Role2

Clinical1

Axes1

Liver1

Hormone1

Neurons1

Secretion1

Bodily2

Thermoregulation1

Polyphenols1

Renin2

Chronic1

Stress2

Risk3

Cocoa2

Cortisol levels1

Common phenomenon1

Hormones1

Availability of oxygen1

Functional3

Mechanism1

Symptoms of Depression1