• gene
  • His single-cell imaging experiments decoded the intracellular calcium signaling requirements for gene transcriptional activation and cell motility in lymphocytes. (uci.edu)
  • Transcriptome analysis of BCR-engaged B cells from Bach2 −/− mice revealed reduced expression of the antiapoptotic gene Bcl2l1 encoding Bcl-x L and elevated expression of cyclin-dependent kinase inhibitor (CKI) family genes, including Cdkn1a , Cdkn2a , and Cdkn2b . (jimmunol.org)
  • The aim of this study is to determine the distribution of gene encoding cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a T-cell negative regulator, in T2DM patients and health subjects. (medsci.org)
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • This results in fusion gene products, which can have bad consequences for cells. (wikipedia.org)
  • Mutations in the Btk gene are responsible for X-linked agammaglobulinemia, a disease characterized by the lack of mature B-cells. (wikipedia.org)
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • genes
  • BTB and CNC homology 2 (Bach2) is a transcriptional repressor that is required for the formation of the germinal center (GC) and reactions, including class switch recombination and somatic hypermutation of Ig genes in B cells, within the GC. (jimmunol.org)
  • This study had systematically identified the global genes and pathways by RNA sequencing in chicken lymphocytes after REV infection. (frontiersin.org)
  • The clone of eosinophils bear a mutation in any one of several genes that code for proteins that regulate cell growth. (wikipedia.org)
  • MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
  • calcium
  • Calcium is a vital second messenger in lymphocytes. (uci.edu)
  • We characterized the biophysical and molecular properties of five channel types in T lymphocytes: a voltage-gated K+ channel (Kv1.3), a calcium-activated K+ channel (KCa3.1), a swelling-activated Cl- channel (now identified as Swell1), a nonselective cation channel-kinase (TRPM7), and a store-operated Ca2+ channel (Orai1 activated by STIM1 in the endoplasmic reticulum). (uci.edu)
  • The intermediate conductance calcium-activated potassium channel KCa3.1 contributes to a variety of cell activation processes in pathologies such as inflammation, carcinogenesis, and vascular remodeling. (pubmedcentralcanada.ca)
  • 2001 ) showed that, at the same doses at which it suppresses T-cell proliferation, Glu hinders the sustained calcium response that follows the stimulation of the cell and is absolutely necessary for activation and cell cycle progression. (aspetjournals.org)
  • The fact that Glu affects the sustained phase of intracellular Ca 2+ levels and thus calcium-dependent processes, such as activation and proliferation, points to cellular components that take part in the mediation and regulation of this phase. (aspetjournals.org)
  • They were first discovered in 1958 by Gardos who saw that Calcium levels inside of a cell could affect the permeability of potassium through that cell membrane. (wikipedia.org)
  • Inside of the cell, the main portion to note is the calcium bowl. (wikipedia.org)
  • In any muscle cell, increased intracellular calcium causes contraction. (wikipedia.org)
  • In smooth muscle cells the elevated levels of intracellular calcium cause the opening of BK channels which in turn allow potassium ions to flow out of the cell. (wikipedia.org)
  • All human T cells express roughly 300 Kv1.3 channels per cell along with 10-20 calcium-activated KCa3.1 channels. (wikipedia.org)
  • migration
  • To establish causality, we show that knockdown of Gstm1 by small interfering RNA results in increased proliferation of VSMCs in a dose-dependent manner, as well as in increased reactive oxygen species levels and VSMC migration. (ahajournals.org)
  • physiology
  • 3 To whom correspondence should be addressed: Dept. of Physiology and Cell Biology, University of Nevada School of Medicine, 1664 N Virginia St., MS0575, Reno NV 89557. (pubmedcentralcanada.ca)
  • miR-650 has been found to be important in chronic lymphocytic leukaemia (CLL) and in normal B-lymphocyte physiology. (wikipedia.org)
  • Expression
  • Pharmacological stimulation of KCa3.1 unexpectedly suppressed proliferation by abolishing the expression and activity of KCa3.1 and PDGF β-receptors and inhibiting the rise in [Ca 2+ ] i . (pubmedcentralcanada.ca)
  • Reconstitution of Bcl-x L expression partially rescued the proliferation defect of Bach2 −/− B cells. (jimmunol.org)
  • However, its expression has traditionally been thought to be limited to cell types in the brain and eye ( 11 ), with co-expression of both ABCG1 and ABCG4 in neurons and astrocytes ( 12 ). (pubmedcentralcanada.ca)
  • Compared to the LN-non-B-cell/BAFF expression group, proteinuria (g/24 hour), blood urea nitrogen, serum creatinine levels, LN renal activity, and chronicity indices, were all significantly greater in the LN-B-cell/BAFF expression groups. (hindawi.com)
  • The expression of BAFF was strongly associated with the quantity of B-cell infiltrate in the interstitium. (hindawi.com)
  • As BAFF expression was strongly associated with B-cell infiltration, we hypothesize that altered B-cell differentiation and tolerance induced by excess BAFF may be central to the pathogenesis of LN. (hindawi.com)
  • van Parijs L, Refaell Y, Abbas AK, and Baltimore D (1999) Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes. (wikipedia.org)
  • down-regulate the expression of proinflammatory proteins. (wikipedia.org)
  • Upon activation, naive and central memory T cells increase expression of the KCa3.1 channel to approximately 500 channels per cell, while effector-memory T cells increase expression of the Kv1.3 channel. (wikipedia.org)
  • Among human B cells, naive and early memory B cells express small numbers of Kv1.3 and KCa3.1 channels when they are quiescent, and augment KCa3.1 expression after activation. (wikipedia.org)
  • stimulation
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • intracellular
  • Platelet-derived growth factor-BB (PDGF)-induced proliferation of human coronary artery VSMCs was attenuated by lowering intracellular Ca 2+ concentration ([Ca 2+ ] i ) and was enhanced by elevating [Ca 2+ ] i . (pubmedcentralcanada.ca)
  • Intracellular second messengers such as cGMP and cAMP undergo rapid changes in concentration in a response to a wide variety of cell specific stimuli. (wikipedia.org)
  • high doses
  • They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. (wikipedia.org)
  • vivo
  • van Parijs L, Perez VL, Biuckians A, Maki RG, London CA, and Abbas AK (1997) Role of interleukin 12 and costimulators in T cell anergy in vivo. (wikipedia.org)
  • In vivo, Kv1.3 blockers paralyze effector-memory T cells at the sites of inflammation and prevent their reactivation in inflamed tissues. (wikipedia.org)
  • immune response
  • To activate an immune response an T-lymphocyte has to come into contact with an macrophage. (wikipedia.org)
  • Consequently, it should be possible to selectively suppress effector-memory T cells with a Kv1.3-specific blocker and thereby ameliorate many autoimmune diseases without compromising the protective immune response. (wikipedia.org)
  • proteins
  • Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. (genecards.org)
  • In addition, it influences the proliferation capacity in B-cells through the targeting of proteins CDK1, ING4 and EBF3 (early B-cell factor 3). (wikipedia.org)
  • The studies were performed by Menkin and Beeson in 1943-1948 on the fever-producing properties of proteins released from rabbit peritoneal exudate cells. (wikipedia.org)
  • receptors
  • Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. (wikipedia.org)
  • stem
  • IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant. (wikipedia.org)
  • This finding has sparked further exploration surrounding these channels and researchers have found that IK channels regulate the cell cycle in cancer cells, B and T lymphocytes, and stem cells. (wikipedia.org)
  • Malignant transformation of these stem or precursor cells results in the development of various hematological malignancies. (wikipedia.org)
  • Stem cells are taken from an affected child's blood or bone marrow. (wikipedia.org)
  • Similarly, in bone transplant, stem cells are able to find their way back through tracking mechanisms. (wikipedia.org)
  • extracellular
  • RANKL's extracellular domains are similar to other TNF family members in regards to the structural homology and are able to cleave from the cell surface. (wikipedia.org)
  • inflammation
  • Intrarenal inflammation is a common feature in LN. However, little is known about the role of B cells as part of the infiltrating cell population. (hindawi.com)