• protein
  • KCa3.1 blockade or knockdown inhibited proliferation by suppressing the rise in [Ca 2+ ] i and attenuating the expression of phosphorylated cAMP-response element-binding protein (CREB), c-Fos, and neuron-derived orphan receptor-1 (NOR-1). (pubmedcentralcanada.ca)
  • The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is being studied in several tissues where cells respond to conditions of low pH including bone and inflamed tissues. (wikipedia.org)
  • Using liquid chromatography mass spectrometry, we identified two HECT domain E3 ligases associated with ABCG1, named HUWE1 (HECT, UBA, and WWE domain containing 1, E3 ubiquitin protein ligase) and NEDD4-1 (Neural precursor cell-expressed developmentally down regulated gene 4), of which the latter is the founding member of the NEDD4 family of ubiquitin ligases. (pubmedcentralcanada.ca)
  • Silencing both HUWE1 and NEDD4-1 in cells overexpressing human ABCG1 significantly increased levels of the ABCG1 monomeric and dimeric protein forms, however ABCA1 protein expression was unaffected. (pubmedcentralcanada.ca)
  • Like ABCG1, ABCG4 protein levels and cholesterol export activity were significantly increased after silencing both HUWE1 and NEDD4-1 in cells overexpressing this closely related ABC half-transporter. (pubmedcentralcanada.ca)
  • Grap2 cyclin D interacting protein (GCIP), Id like HLH protein, was down-regulated in the rheumatoid synovial cells. (springer.com)
  • Treibel F, Hacene K, Pichon MF: A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors. (springer.com)
  • Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). (abcam.com)
  • Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions. (nih.gov)
  • SAP97 plays a conserved role in regulating 5-HT2AR endocytosis and ERK1/2 signaling, but plays a novel role in regulating 5-HT2AR G protein coupling. (nih.gov)
  • In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases (MMP), causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1. (biomedsearch.com)
  • HTLV-I+ T-cells differed significantly from other T-lymphocyte-derived cells in also having a higher proportion of PDE4 activities, which apparently were not related to selective induction of any one PDE4 mRNA (judged by reverse transcription-polymerase chain reaction) or expression of the HTLV-I regulatory protein Tax. (lu.se)
  • Growth of MJ cells was inhibited by herbimycin A and a protein kinase C (PKC) inhibitor, and was arrested in G1 by rolipram, a specific PDE4 inhibitor. (lu.se)
  • The disease is due to conversion of the tightly regulated tyrosine kinase of ABL1 protein to being unregulated and continuously active in the BCR-ABL1 fusion protein. (wikipedia.org)
  • This nuclear localization is regulated by the protein kinases AKT and p38. (wikipedia.org)
  • In human mast cells (MCs), ALDOA has been observed to undergo post-translational regulation by protein tyrosine nitration, which may alter its relative affinity for FBP and/or IP3. (wikipedia.org)
  • RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. (wikipedia.org)
  • RANKL may also bind to osteoprotegerin, a protein secreted mainly by cells of the osteoblast lineage which is a potent inhibitor of osteoclast formation by preventing binding of RANKL to RANK. (wikipedia.org)
  • This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), which indicated this protein may have a role in the regulation of cell apoptosis. (wikipedia.org)
  • This means that when the ERG gene was not actively transcribed and the ERG protein produced, a mouse's hematopoietic cells were unable to function properly. (wikipedia.org)
  • This means that the protein transcribes for with the gene could be produced in excess or under- produced resulting in unnatural activity in cells. (wikipedia.org)
  • Atacicept is a recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease. (wikipedia.org)
  • Atacicept blocks activation of B cells by the tumor necrosis factor receptor superfamily member 13B (more commonly known as TACI), a transmembrane receptor protein found predominantly on the surface of B cells. (wikipedia.org)
  • The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. (wikipedia.org)
  • The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. (wikipedia.org)
  • It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. (wikipedia.org)
  • AK2 protein allows hematopoietic stem cells to differentiate and proliferate. (wikipedia.org)
  • The energy metabolism of mitochondria is regulated by the AK2 protein. (wikipedia.org)
  • If there is a mutation in the protein, that means that the mitochondria metabolism most likely will be altered and will not be able to provide enough energy to the hematopoietic stem cells. (wikipedia.org)
  • receptor
  • Similarly, REV infection would destroy the immune defense of lymphocytes through MAPK-AP1 via Toll-like receptor-, NOD-like receptor-, and salmonella infection pathways to reduce the secretion of IL8 and IL18. (frontiersin.org)
  • Moreover, the immune response for REV in lymphocytes would activate by up-regulating the expression of NOD1, MYD88 , and AP1 through Toll-like receptor-/NOD-like receptor/salmonella-MAPK-AP1 pathways. (frontiersin.org)
  • In this study, we demonstrate novel dose-related effects of the endogenous ligand glutamate and its metabotropic and non- N -methyl- d -aspartic acid receptor agonists on the electrophysiological properties of native K v 1.3 channels of human T lymphocytes. (aspetjournals.org)
  • DPP4_HUMAN ] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. (proteopedia.org)
  • Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. (proteopedia.org)
  • Ikushima H, Munakata Y, Ishii T, Iwata S, Terashima M, Tanaka H, Schlossman SF, Morimoto C. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation. (proteopedia.org)
  • We reveal a local intestinal intraepithelial lymphocyte (IEL)-GLP-1 receptor (GLP-1R) signaling network that controls mucosal immune responses. (diabetesjournals.org)
  • This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. (wikipedia.org)
  • Knockout mice which genetically lack IL-7 receptor exhibit thymic atrophy, arrest of T-cell development at the double positive stage, and severe lymphopenia. (wikipedia.org)
  • Thirty-two non-receptor tyrosine kinases have been identified in human cells (EC 2.7.10.2). (wikipedia.org)
  • When antigen binds to T-cell receptor, Lck becomes autophosphorylated and phosphorylates the zeta chain of the T-cell receptor, subsequently another nRTK, Zap70, binds to this T-cell receptor and then participates in downstream signaling events that mediate transcriptional activation of cytokine genes. (wikipedia.org)
  • Another Src family member Lyn is involved in signaling mediated by B-cell receptor. (wikipedia.org)
  • Lyn is activated by stimulation of B-cell receptor, which leads to the recruitment and phosphorylation of Zap70-related nRTK, Syk. (wikipedia.org)
  • Another nRTK, Btk, is also involved in signaling mediated by the B-cell receptor. (wikipedia.org)
  • Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor (GR), that is present in almost every vertebrate animal cell. (wikipedia.org)
  • GCs affect cells by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression). (wikipedia.org)
  • As discussed in more detail below, glucocorticoids function through interaction with the glucocorticoid receptor: up-regulate the expression of anti-inflammatory proteins. (wikipedia.org)
  • IL-1Ra regulates IL-1α and IL-1β proinflammatory activity by competing with them for binding sites of the receptor. (wikipedia.org)
  • Kv1.3 is physically coupled through a series of adaptor proteins to the T-cell receptor signaling complex and it traffics to the immunological synapse during antigen presentation. (wikipedia.org)
  • apoptosis
  • Since 1996, he is the head of the research team "Indolent B-cell proliferation" currently affiliated with the Laboratoire de Biologie Moléculaire de la Cellule (UMR5239 : ENS-Lyon, CNRS, Université Claude Bernard, Hospices Civils de Lyon), that examines several aspects of lymphoma biology (senescence and apoptosis in lymphocytes, biology of splenic marginal zone, prognostic factors in lymphoma). (wikipedia.org)
  • inflammation
  • KCa3.1 is highly expressed in a variety of nonexcitable and proliferating cells ( 2 ), and an increase in KCa3.1 expression has been associated with cancer development, immune disorders, and vascular inflammation. (pubmedcentralcanada.ca)
  • Intrarenal inflammation is a common feature in LN. However, little is known about the role of B cells as part of the infiltrating cell population. (hindawi.com)
  • RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
  • In vivo, Kv1.3 blockers paralyze effector-memory T cells at the sites of inflammation and prevent their reactivation in inflamed tissues. (wikipedia.org)
  • gene
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • This results in fusion gene products, which can have bad consequences for cells. (wikipedia.org)
  • Mutations in the Btk gene are responsible for X-linked agammaglobulinemia, a disease characterized by the lack of mature B-cells. (wikipedia.org)
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • peripheral blood
  • These results indicate that REV could affect lymphocytes from peripheral blood by inhibit the cell proliferation and the immune system. (frontiersin.org)
  • Total PDE, PDE3, and PDE4 activities were measured in phytohemagglutinin (PHA)-activated peripheral blood mononuclear cells (PBMC-PHA), normal natural killer (NK) cells, Jurkat and Kit225-K6 leukemic T-cells, T-cell lines transformed with human T-lymphotropic virus (HTLV)-I (a retrovirus that causes adult T-cell leukemia/lymphoma) and HTLV-II (a nonpathogenic retrovirus), normal B-cells, and B-cells transformed with Epstein-Barr virus (EBV). (lu.se)
  • Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. (wikipedia.org)
  • expression
  • Pharmacological stimulation of KCa3.1 unexpectedly suppressed proliferation by abolishing the expression and activity of KCa3.1 and PDGF β-receptors and inhibiting the rise in [Ca 2+ ] i . (pubmedcentralcanada.ca)
  • However, its expression has traditionally been thought to be limited to cell types in the brain and eye ( 11 ), with co-expression of both ABCG1 and ABCG4 in neurons and astrocytes ( 12 ). (pubmedcentralcanada.ca)
  • Compared to the LN-non-B-cell/BAFF expression group, proteinuria (g/24 hour), blood urea nitrogen, serum creatinine levels, LN renal activity, and chronicity indices, were all significantly greater in the LN-B-cell/BAFF expression groups. (hindawi.com)
  • The expression of BAFF was strongly associated with the quantity of B-cell infiltrate in the interstitium. (hindawi.com)
  • Huang, Zhao, Ran, Wang: Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4⁺CD25⁺Foxp3⁺ regulatory T cells. (antibodies-online.com)
  • Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. (abcam.com)
  • van Parijs L, Refaell Y, Abbas AK, and Baltimore D (1999) Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes. (wikipedia.org)
  • down-regulate the expression of proinflammatory proteins. (wikipedia.org)
  • Upon activation, naive and central memory T cells increase expression of the KCa3.1 channel to approximately 500 channels per cell, while effector-memory T cells increase expression of the Kv1.3 channel. (wikipedia.org)
  • Among human B cells, naive and early memory B cells express small numbers of Kv1.3 and KCa3.1 channels when they are quiescent, and augment KCa3.1 expression after activation. (wikipedia.org)
  • migration
  • To establish causality, we show that knockdown of Gstm1 by small interfering RNA results in increased proliferation of VSMCs in a dose-dependent manner, as well as in increased reactive oxygen species levels and VSMC migration. (ahajournals.org)
  • thymus
  • This antibody gave a positive signal in Mouse Thymus Tissue Lysate, as well as NIH3T3 and MEF1 whole cell lysates. (abcam.com)
  • Physiology
  • 3 To whom correspondence should be addressed: Dept. of Physiology and Cell Biology, University of Nevada School of Medicine, 1664 N Virginia St., MS0575, Reno NV 89557. (pubmedcentralcanada.ca)
  • miR-650 has been found to be important in chronic lymphocytic leukaemia (CLL) and in normal B-lymphocyte physiology. (wikipedia.org)
  • intracellular
  • Platelet-derived growth factor-BB (PDGF)-induced proliferation of human coronary artery VSMCs was attenuated by lowering intracellular Ca 2+ concentration ([Ca 2+ ] i ) and was enhanced by elevating [Ca 2+ ] i . (pubmedcentralcanada.ca)
  • Intracellular second messengers such as cGMP and cAMP undergo rapid changes in concentration in a response to a wide variety of cell specific stimuli. (wikipedia.org)
  • pathways
  • MTT, Q-PCR, and FCM indicated that REV reduced the number of lymphocytes by inhibiting the transition of S/G1 phase through FOXO and p53 pathways. (frontiersin.org)
  • In addition, the reduction of lymphocytes also might be responsible for the lower levels of IL8 and IL18, and the rescue of lymphocytes would been activated still through FOXO and p53 pathways. (frontiersin.org)
  • high doses
  • They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. (wikipedia.org)
  • vivo
  • van Parijs L, Perez VL, Biuckians A, Maki RG, London CA, and Abbas AK (1997) Role of interleukin 12 and costimulators in T cell anergy in vivo. (wikipedia.org)
  • immune response
  • To activate an immune response an T-lymphocyte has to come into contact with an macrophage. (wikipedia.org)
  • Consequently, it should be possible to selectively suppress effector-memory T cells with a Kv1.3-specific blocker and thereby ameliorate many autoimmune diseases without compromising the protective immune response. (wikipedia.org)
  • tyrosine
  • In MJ cells (an HTLV-I+ T-cell line), Jurkat cells, and PBMC-PHA cells, the tyrosine kinase inhibitor herbimycin A strongly inhibited PDE activity. (lu.se)
  • receptors
  • Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. (abcam.com)
  • Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin (EpoR) and prolactin receptors. (wikipedia.org)
  • CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck. (wikipedia.org)
  • Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. (wikipedia.org)
  • stimulation
  • The ED 50 as determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells was found to be less than 2.0ng/ml, corresponding to a specific activity of 5.0×10 5 IU/mg. (prospecbio.com)
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • proteins
  • In addition, it influences the proliferation capacity in B-cells through the targeting of proteins CDK1, ING4 and EBF3 (early B-cell factor 3). (wikipedia.org)
  • The studies were performed by Menkin and Beeson in 1943-1948 on the fever-producing properties of proteins released from rabbit peritoneal exudate cells. (wikipedia.org)
  • Signaling
  • These discoveries were noted by Science magazine as "Cell Signaling Breakthroughs of the Year" in 2005 and 2006. (uci.edu)
  • It is well established by now that neurotransmitters and neuropeptides, apart from their signaling role in the CNS, can also directly influence T lymphocyte functions ( Levite, 2000 ). (aspetjournals.org)
  • activate
  • Glutamate, at concentrations within normal plasma levels, positively modulates K v 1.3 channel gating, causing currents to activate faster and at significantly more hyperpolarized potentials, hence rendering the T lymphocyte readily responsive to immune stimuli. (aspetjournals.org)
  • role
  • To determine the role of Gstm1 in vascular smooth muscle cells (VSMCs), we isolated VSMCs from mouse aortas. (ahajournals.org)
  • Local B-cell infiltrates could play a role in tissue injury such as tissue fibrosis, neolymphangiogenesis, and ectopic lymphomagenesis [ 7 ]. (hindawi.com)
  • Intrarenal B cells may be part of a local system that plays a pivotal role in the pathogenesis of LN. (hindawi.com)
  • Nevertheless, the low levels of circulating active GLP-1 together with the distal location of L cells have led some to question whether the major role of GLP-1 is to function as a circulating incretin hormone ( 7 ). (diabetesjournals.org)
  • malignant
  • Clonal hypereosinophilia, also termed Primary hypereosinophelia or clonal eosinophilia, is a grouping of hematological disorder characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell, in the bone marrow, blood, and/or other tissues. (wikipedia.org)
  • Malignant transformation of these stem or precursor cells results in the development of various hematological malignancies. (wikipedia.org)