• Intercellular signaling through the CLV3 pathway restricts stem cell accumulation by limiting the expression of the WOX family transcription factor gene WUSCHEL (WUS), which in turn promotes stem cell fate and directly activates CLV3 transcription. (berkeley.edu)
  • Our present goals are to further characterize the biochemical properties and downstream targets of ULT1 and the related ULT2 protein, and to identify additional components of the pathway. (berkeley.edu)
  • Strikingly, each signal and signaling pathway can generate a wide range of cell types and organizations in diverse contexts 3 . (biorxiv.org)
  • Transforming Growth Factor-beta ( TGF-beta , TGF-β) this is a superfamily signaling pathway with many different roles during development. (edu.au)
  • Prenatal nicotine exposure increases osteoarthritis susceptibility in male elderly offspring rats via low-function programming of the TGFβ signaling pathway [3] "Epidemiological investigations indicate that effects related to prenatal adverse environments on the organs of the offspring could continue to adulthood. (edu.au)
  • Immunohistochemistry results showed decreased expression of transforming growth factor beta (TGFβ) signaling pathway. (edu.au)
  • And, the expression of the TGFβ signaling pathway was inhibited. (edu.au)
  • Although all Ca2+ mobilizing agonists in pancreatic acinar cells utilize the phosphoinositide-signaling (PI) pathway, stimulation by individual agents results in markedly different temporal and spatial patterns of Ca2+ signaling. (rochester.edu)
  • Given that tremendous molecular diversity is expressed at all levels of this signaling pathway, our working hypothesis is that individual agonists do not couple to the signaling machinery in an identical fashion. (rochester.edu)
  • This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. (rochester.edu)
  • We are utilizing fluorescence imaging techniques including high-speed confocal microscopy to monitor [Ca2+]i while manipulating the signaling pathway with neutralizing antibodies and antisense technology. (rochester.edu)
  • Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
  • The SD protein endocytosis and recycling pathway was found to contain clathrin , dynamin , AP-2 complex, like-AP180 (Lap) , auxilin and Hsc70-4 (the endocytosis part) followed by Rab11 and the exocyst complex (the recycling part). (sdbonline.org)
  • Disrupting any component in this pathway led to disrupted SD on the cell surface and intracellular accumulation of mislocalized SD proteins. (sdbonline.org)
  • This study provides the first in vivo evidence of trapped SD proteins in clathrin-coated pits at the plasma membrane when this pathway is disrupted. (sdbonline.org)
  • All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
  • Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
  • Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. (uc.edu)
  • Additionally, immunoblot assay was performed to investigate the effects of OD on the nuclear factor-κb (NF-κB) pathway and 5' adenosine monophosphate-activated protein kinase (AMPK) pathway. (qascf.com)
  • High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)
  • The ensemble of the data highlights sp2-IGLs as a promising new class of molecules against inflammation by interfering in Toll-like receptor intracellular signaling. (cnrs.fr)
  • All teneurins, especially in mouse, are type II transmembrane proteins that are composed of a large extracellular C terminal domain of ~2400 amino acid residues, a single transmembrane helical domain of ~30 hydrophobic residues and an intracellular N terminal domain of ~300-375 residues. (wikipedia.org)
  • Pathologic features of AD are characterized by persistent deposition of the intercellular amyloid β-peptide (Aβ) plaques and intracellular tau protein and impairment of the neuron-to-neuron synaptic communication and nutrient transportation inside neuron 3 . (nature.com)
  • The activity of these regulators depends on their phosphorylation status, which is controlled by the activity of specific kinases that can sense a wide array of environmental and intracellular signals, and phosphorylate their corresponding response regulators accordingly. (nature.com)
  • In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. (rochester.edu)
  • Amy Medlock Associate Professor Biochemistry & Molecular Biology Understanding intracellular and intercellular heme transport. (uga.edu)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • Intercellular signaling pathways convey cell fate information, regulate cell division and differentiation processes, and propagate and amplify specific signaling states. (berkeley.edu)
  • We have determined that most Arabidopsis tissues express multiple CLE genes in highly specific patterns, indicating that CLE-mediated signaling pathways are likely to play roles in many biological processes. (berkeley.edu)
  • Piguel NH, Yoon S, Gao R, Horan KE, Garza JC, Petryshen TL, Smith KR, Penzes P . Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3β and cyclic AMP signaling pathways. (neurotree.org)
  • These conserved families of secreted morphogens/signals, such as Fibroblast Growth Factor (FGF), Hedgehog (Hh), Wingless (Wg)/Wnt, Epidermal Growth Factor (EGF), and Decapentaplegic (Dpp - a BMP homolog), act away from their sources and, upon binding to receptors, activate gene regulatory pathways to induce functions in recipient cells 1 , 2 . (biorxiv.org)
  • Essential roles of cytonemes or cytoneme-like filopodia have been discovered in many vertebrate and invertebrate systems and are implicated in most signaling pathways, including Hh, Dpp, FGF, EGF, Ephrin, and Wnt under various contexts 4 - 18 . (biorxiv.org)
  • The Miller laboratory is interested in the mechanisms by which viral pathogens manipulate host cell signal transduction pathways. (uc.edu)
  • We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
  • Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)
  • Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
  • This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. (rochester.edu)
  • In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied. (rochester.edu)
  • neuropeptide Y and also human being neuropeptide Y, insulin-like peptides, along with human insulin shots) in comparison to humans. (prmtsignal.com)
  • The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
  • 60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
  • Our findings included a significant class of proteoglycans not previously associated with lymphomas as well as significant modulation of genes that code for extracellular matrix-associated proteins. (fortunepublish.com)
  • With 35,000 genes and hundreds of thousands of protein states to identify, correlate, and understand, it no longer suffices to rely on studies of one gene, gene product, or process at a time. (genomicglossaries.com)
  • Nucleic acid sequences involved in regulating the expression of genes. (lookformedical.com)
  • The cytoplasmic Rap proteins exert their regulatory function by inhibiting the activity of their target regulator (Spo0F, DegU, or ComA) via dephosphorylation, or by directly blocking DNA binding. (nature.com)
  • ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
  • Loss of Pcs impairs Rab11 localization on the trans-side of Golgi units and induces the cytoplasmic accumulation of post-Golgi vesicles bearing rhabdomere proteins, as observed in Rab11-deficiency. (sdbonline.org)
  • Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
  • These vesicles are carriers of active or non-autonomous function biomolecules, such as proteins, lipids, DNA, mRNA and non-coding regulatory RNA. (spandidos-publications.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • His laboratory having moved to the École normale supérieure, he then became interested in the molecular signals responsible for certain neuronal morphogenesis processes and, in 1991, highlighted in particular the role of homeoboxes of certain transcription factors (but also of different extracellular matrix proteins such as tenascin, glycoaminoglycans. (wikipedia.org)
  • The first key publication supporting this theory was in 1998 with the in vitro demonstration that a large proportion of the nuclear transcription factor Engrailed is effectively secreted in the extracellular medium by Cos cells and recaptured by cocultured neurons acting as a potential intercellular peptide messenger. (wikipedia.org)
  • The Rap proteins are, in turn, inhibited by their cognate Phr peptides, which are produced as pre-Phr proteins that are exported to the extracellular milieu and cleaved to produce mature five to six amino acid Phr peptides. (nature.com)
  • More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
  • In contrast, traditional models predict that the signal presentation from the source via free secretion and extracellular diffusion is a non-selective process. (biorxiv.org)
  • The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. (cancerindex.org)
  • It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
  • Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
  • Histological and histochemical analysis to detect glycosylated protein identified a severe loss in attractin-deficient mice of extracellular proteoglycan between kidney tubules in addition to a loss of glycosylated material within the intratubular brush border. (biomedcentral.com)
  • Moreover, PVRL4 triggers a form of signaling between the cells called integrin β4 signaling that allows them to survive without being anchored to the extracellular matrix. (elifesciences.org)
  • A direct regulation of apelin expression by insulin is observed in both human and mouse adipocytes and clearly associated with the stimulation of phosphatidylinositol 3-kinase, protein kinase C, and MAPK. (nih.gov)
  • protein kinase signaling in plants, pathogens and microbes. (uga.edu)
  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
  • An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling. (uc.edu)
  • To address this and to also study the oncogenic potential of unregulated function of dominant regulators of epithelial homeostasis noted above, we developed Multi-Functional Human Tissue Genetics noted above which, when combined with skin tissue regeneration on immune deficient mice, has permitted the molecular reconstruction of events sufficient to trigger human cancer. (stanford.edu)
  • aux depletion leads to excessive ISC proliferation and midgut homeostasis disruption, which is unlikely caused by defective Notch signaling. (sdbonline.org)
  • Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
  • Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)
  • The GTPase Rab11 regulates endosomal protein trafficking and previous work has shown that loss of Rab11 caused intestinal inflammation and hyperplasia in mice and flies. (sdbonline.org)
  • Neuroscience Role of glycosylation in regulating Notch signaling, assisting protein folding, and development. (uga.edu)
  • Here we have synthesized and investigated new variants of sp2-IGLs for their ability to suppress the activation of human monocyte-derived dendritic cells (DCs) by lipopolysaccharide (LPS) signaling through Toll-like receptor 4. (cnrs.fr)
  • Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons. (rochester.edu)
  • Mutations that alter the ability of Escherichia coli cyclic AMP receptor protein to activate transcription. (microbiologyresearch.org)
  • Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
  • Previous mutational scanning studies have suggested that some substitutions corresponding to single nucleotide variants (SNVs) in human ACE2 affect the binding affinity to the receptor binding domain (RBD) of the SARS-CoV-2 S protein. (bvsalud.org)
  • However, hormone receptor negative (triple negative) tumors overwhelmingly overexpress p53 protein in tumor cells. (cancerindex.org)
  • Mutations at the Atrn locus in the mouse result in the mahogany phenotype where, despite normal levels of the agouti protein that acts as an antagonist of α-melanocyte stimulating hormone (α-MSH), the agouti protein does not appear to be appropriately presented to the Melanocortin-1 receptor (Mc1R) and black/brown eumelanin synthesis persists rather than that of the lighter yellowish phaeomelanin [ 2 ]. (biomedcentral.com)
  • They found that the gene that codes for a protein called poliovirus receptor-like 4 (PVRL4) allows attachment-free cell growth and also makes cells cluster together once detached from the matrix. (elifesciences.org)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon pathfinding and synaptic organisation in the motor and visual system. (wikipedia.org)
  • Aβ-mediated oxidative stress results in mitochondrial dysfunction, impairment of glucose metabolism, loss of proteostasis and synaptic plasticity, altered signal transduction, neuroinflammation, and progressive loss of neurons 9 . (nature.com)
  • Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). (bvsalud.org)
  • This study found that auxilin (Aux) restricts intestinal stem cell (ISC) proliferation mainly through EGFR signaling. (sdbonline.org)
  • Review - TGF-β Family Signaling in Early Vertebrate Development [2] "TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate embryonic body plan. (edu.au)
  • Nodal signaling is essential for the specification of mesendodermal tissues and the concurrent cellular movements of gastrulation. (edu.au)
  • Bone morphogenetic protein ( BMP ) signaling patterns tissues along the dorsal-ventral axis and simultaneously directs the cell movements of convergence and extension. (edu.au)
  • To test the idea that loss of Rab11 may promote cancer progression, archival human patient tissues were analyzed and 51 out of 70 colon cancer tissues had lower Rab11 protein staining. (sdbonline.org)
  • We have demonstrated that ULT1 acts as a trithorax Group (trxG) factor that regulates the chromatin conformation of large numbers of target gene loci. (berkeley.edu)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
  • MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression inside the cell. (frontiersin.org)
  • in this way, vesicle-free miRNA may regulate cell-to-cell communication including the regulation of gene expression and cellular signaling. (frontiersin.org)
  • Tim Bolger Associate Professor, Department of Biochemistry and Molecular Biology Post-transcriptional regulation of gene expression and control of mRNA-protein dynamics by RNA helicases in normal conditions and cell stress. (uga.edu)
  • A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)
  • What does this gene/protein do? (cancerindex.org)
  • Inherited risk for stroke is likely multigenic, although specific single-gene disorders with stroke as a component of the phenotype demonstrate the potency of genetics in determining stroke risk. (medscape.com)
  • Contact-mediated FGF-FGFR binding induces bidirectional signaling, which, in turn, promotes ASP and source cells to polarize cytonemes toward each other and reinforce signaling contacts. (biorxiv.org)
  • Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. (uc.edu)
  • Each time an amino acid is added to a growing polypeptide during protein synthesis, a tRNA anticodon pairs with its complementary codon on the mRNA molecule, ensuring that the appropriate amino acid is inserted into the polypeptide. (genome.gov)
  • In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. (genome.gov)
  • For example, exosomes and nanovesicles secreted by living cells serve as intercellular couriers of mRNA, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteins and have thus garnered considerable interest [ 3 ]. (jcancer.org)
  • The S protein of these CoVs binds to the ACE2 molecule on the plasma membrane and mediates virus entry into cells. (bvsalud.org)
  • Burgdorf JS, Yoon S, Dos Santos M , Lammert CR, Moskal JR, Penzes P . An IGFBP2-derived peptide promotes neuroplasticity and rescues deficits in a mouse model of Phelan-McDermid syndrome. (neurotree.org)
  • Notch3 signalling promotes tumour growth in colorectal cancer. (ox.ac.uk)
  • This review focuses on the mechanisms by which vesicle-free miRNAs are secreted from neuroendocrine cells and will discuss potential functions of vesicle-free miRNAs and how vesicle-free miRNAs regulate cell-to-cell communication. (frontiersin.org)
  • Drosha, RNase III, and DGCR8, the RNA-binding protein, further process pri-miRNAs into stem-loop structured precursor miRNAs (pre-miRNAs) of ~70 nt ( 29 ). (frontiersin.org)
  • After pre-miRNAs are transported to the cytoplasm, RNase III Dicer and TRBP (transactivation-response RNA-binding protein) cleave them into double-stranded miRNA duplexes of ~22 nt ( 30 , 31 ). (frontiersin.org)
  • There were 11 different miRNAs in exosomes of MHFMD and ESHFMD compared to healthy children, of which 4 were up-regulated and 7 were down-regulated. (biomedcentral.com)
  • Exosome contain proteins, miRNAs, and mRNAs, and the exosomal lipid bilayer protects this genetic information from degradation. (biomedcentral.com)
  • These models are being used to systematically elucidate proteins required for cutaneous carcinogenesis and to test their potential role as therapeutic targets. (stanford.edu)
  • An amino acid is the fundamental molecule that serves as the building block for proteins. (genome.gov)
  • Dendrite pruning requires the developmentally regulated degradation of the cell adhesion molecule Neuroglian , and loss of Rab11 causes defects in the developmental degradation of Neuroglian and another target, the ion channel Ppk26 . (sdbonline.org)
  • Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
  • The TCAP is the resulting peptide from cleaving a putative furin cleavage site found immediately on the N-terminal of TCAP. (wikipedia.org)
  • Rapid and comprehensive analysis of putative proteinous allergens ( allergenome ) by applying such a proteomic strategy … With allergenomics, we can not only detect and assign the putative allergens (proteins specifically interacting with IgE antibodies in a patient's blood) in a short time, but also analyze the quantitative and qualitative change of the antigens, depending on the surroundings and environmental conditions of an allergenic causative. (genomicglossaries.com)
  • In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
  • A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. (ibecbarcelona.eu)
  • The gut needs to produce a strong protective immune response to resist the invasion of pathogenic antigens, while similar reactions to harmless antigens such as dietary proteins or symbiotic microorganisms, may lead to chronic inflammatory diseases. (frontiersin.org)
  • Teneurin protein was first identified and characterised in Drosophila by Baumgartner and Chiquet-Ehrismann in early 1990s. (wikipedia.org)
  • The embryonic Drosophila cDNA library was screened using polymerase chain reaction (PCR) and a primer derived from the EGF-like repeats region of chicken tenascin-C protein. (wikipedia.org)
  • Since discovery of teneurins in Drosophila, many other laboratories have independently described the Ten-a and Ten-m/Odz homolog proteins in different vertebrates. (wikipedia.org)
  • The primary structure, or amino acid sequence identity, of the proteins between paralogs is ~60% identical and between orthologs is ~90%, whilst between vertebrates and Drosophila or C. elegans is only 33-41% identical. (wikipedia.org)
  • In Drosophila , FGF produced in wing-disc cells regulates the development of the disc-associated air-sac-primordium (ASP). (biorxiv.org)
  • The present study unravels a new molecular system for vesicle-based axonal transport of proteins in male and female flies (Drosophila melanogaster). (sdbonline.org)
  • Interestingly, aux depletion causes a dramatic increase in EGFR signaling, with a strong accumulation of EGFR at the plasma membrane and an increased expression of EGFR ligands in response to tissue stress. (sdbonline.org)
  • Finally, blocking EGFR signaling completely suppresses the defects caused by aux depletion. (sdbonline.org)
  • However, going against a certain number of knowledge, or even dogmas in the field of molecular biology, he reports that domains of transcription factors, or even whole proteins such as Hox5, can be internalized in a cell and therefore suggests the possible secretion of a given transcription factor by a nerve cell A that can be internalized by a neighbouring cell B and have a biological effect on it. (wikipedia.org)
  • Our approach involves a combination of genetics, molecular biology, cell biology and biochemistry. (berkeley.edu)
  • Adam W. Barb Associate Professor Biochemistry & Molecular Biology Our goal is to define the impact of protein post-translational modifications on structure and function in the immune system. (uga.edu)
  • Natalie Krahn Assistant Professor, Biochemistry & Molecular Biology Department Engineering tRNA technology to build novel proteins with selenocysteine. (uga.edu)
  • Martín-de-Saavedra MD, Santos MD, Penzes P . Intercellular signaling by ectodomain shedding at the synapse. (neurotree.org)
  • One possibility is that the membrane-anchored ectodomain may help present agouti protein by binding the positive N-terminal leaving the C-terminal free to interact with the Mc1R [ 5 ]. (biomedcentral.com)
  • These results suggested that PNE enhanced the susceptibility of OA in male elderly offspring rats by down-regulating TGFβ signaling, which increased articular cartilage local inflammation, matrix degradation, and cell apoptosis. (edu.au)
  • In this study, we developed reverse genetics systems, including minigenomes and recombinant viruses, that will facilitate the study of these pathogens. (cdc.gov)
  • Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)
  • His team then demonstrated the involvement of Engrailed-1/2 proteins in the development and survival of dopaminergic neurons by using heterozygous mouse models (En1+/-) for them and by proposing a mechanism of action on the transcriptional activation of the Ndufs1 and Ndufs3 subunits of complex I of the mitochondrial respiratory chain. (wikipedia.org)
  • In this review, we summarize the current knowledge of the function and regulation of TGF-β family signaling in these processes. (edu.au)
  • Due to large complexness associated with obesity, it is sometimes complicated to discover a great product for the studies that is suited to hereditary along with bodily evaluation such as specs of various compounds' (bodily hormones, neuropeptides) functions, and for signaling walkways evaluation. (prmtsignal.com)
  • Alain Prochiantz continues his work in evolutionary developmental genetics and directs his research towards the physiological aspects of his fundamental molecular discoveries, particularly for the understanding of neuronal plasticity and axonal guidance processes. (wikipedia.org)
  • The Phr peptides are imported back into the cell upon reaching threshold concentrations at high cell density and bind to their cognate Rap phosphatase, inducing conformational changes that inhibit its activity 10 , 11 . (nature.com)
  • Here, we show that FGF is Glycosylphosphatidylinositol-anchored to the producing cell surface and that this modification both inhibits free FGF secretion and activates target-specific bidirectional FGF-FGFR signaling through cytonemes. (biorxiv.org)
  • However, recent advances in microscopy revealed that both signal-producing and receiving cells could extend signaling filopodia named cytonemes and selectively deliver or receive signals through cytoneme-cell contact sites 4 - 9 . (biorxiv.org)
  • We asked: (1) How do cytonemes recognize a specific target cell and form signaling contacts? (biorxiv.org)
  • Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 have a single envelope glycoprotein (S protein) that binds to human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane. (bvsalud.org)
  • also showed that interactions between the PVRL4 in one cell and a related protein called PVRL1 in a neighboring cell were responsible for holding the cells together in clusters. (elifesciences.org)
  • Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
  • How signaling proteins generate a multitude of information to organize tissue patterns is critical to understanding morphogenesis. (biorxiv.org)
  • Understanding how signals might inform cells of their positional identity, directionality, and interactions and organize these functions in diverse tissue-specific patterns is critical to understanding morphogenesis. (biorxiv.org)
  • These findings bring along a paradox - not only do signals instruct cells and organize discrete cellular patterns, but cells also control the patterns of signal presentation and reception by organizing the distribution of cytonemes and cytoneme contacts 6 , 9 . (biorxiv.org)
  • Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells. (rochester.edu)
  • We started the current investigation with the premise that a better understanding of the processes that produce cytoneme contacts and control contact-driven signal release is essential to understanding morphogenesis. (biorxiv.org)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • Specifically, we link increases in cellular apoptosis and TGF-BR2 signalling to MC breakdown in opossums. (edu.au)
  • We analyzed the impact of the ACE2 SNVs on the cellular entry of SARS CoVs using pseudotyped VSIVs having the S protein on the viral surface. (bvsalud.org)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • We also use functional genomics to characterize members a plant-specific family of CLV3-related signaling molecules called CLE proteins and determine their roles in plant development. (berkeley.edu)
  • Instead, no regular assembly is obtained from solutions with high peptide concentrations, as their dynamics is dominated by strong repulsive peptide-peptide electrostatic interactions, and from solutions at pH 10, in which the total peptide charge is zero. (ibecbarcelona.eu)
  • Furthermore, loss of Rab11 can act synergistically with the oncoprotein Ras(V12) to regulate these cancer related phenotypes. (sdbonline.org)
  • Netrin1 elevated the neuronal difference fee associated with BMSCs and NSCs and also upregulated the actual appearance in the neuronal marker pens, microtubule-associated health proteins (Map2), neurofilament, along with β3-tubulin. (pgdsreceptor.com)
  • To discover in the event that nephrolithiasis-associated atherosclerosis provides pediatric beginnings and contemplate possible connection among renal stones as well as atherosclerosis-related protein. (kinasepathway.com)
  • Piguel NH, Sanders SS, De Simone FI, Martin-de-Saavedra MD, McCoig E, Dionisio LE, Smith KR, Thomas GM , Penzes P . Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium. (neurotree.org)
  • Aggregates with poorly defined morphology are obtained from solutions with low and moderate CREKA concentrations at pH 4, whereas well-defined dendritic microstructures with fractal geometry are obtained from CRENKA solutions with similar peptide concentrations at pH 4 and 7. (ibecbarcelona.eu)
  • During development, intercellular communication of morphogens is critical for embryonic cells to determine their positional identity, directionality, and interactions in an organized pattern to sculpt tissue. (biorxiv.org)