• The remaining genes provide instructions for making molecules called transfer RNA (tRNA) and ribosomal RNA (rRNA), which are chemical cousins of DNA. (medlineplus.gov)
  • Phylogenetic affiliations of mesopelagic acantharia and acantharian-like environmental 18S rRNA genes off the southern California coast. (mbl.edu)
  • To address this research gap, we assessed the effects of carbendazim on the survival, pollen consumption, and sequenced 16 S rRNA gene to determine the bacterial composition in the midgut and hindgut. (bvsalud.org)
  • He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
  • The isolated nucleoid contains 80% DNA, 10% protein, and 10% RNA by weight. (wikipedia.org)
  • We recently discovered a new type of stress-responsive, protein-directed human RNA switch that regulates expression of vascular endothelial growth factor-A in human monocytic cells (Ray, PS, et al. (rochester.edu)
  • Intriguingly, some of these RNA switches involve the interplay between microRNA and RNA-binding protein (Jafarifar, F, et al. (rochester.edu)
  • All 13 protein-coding genes use ATN or TTG as start codon, and end with TAA/G or incomplete stop codons (single T-). Twenty-one transfer RNA genes have the typical clover-leaf structures, while the dihydrouridine (DHU) arm of trnS1 is missing. (researchsquare.com)
  • To address this question, we have studied how the tumor suppressor protein p53 regulates the DNA damage responses of ESCs. (nih.gov)
  • These types of RNA help assemble protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)
  • Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)
  • PTEN also dephosphorylates Src homology 2-containing protein (Shc) directly, and inhibits the activation of Shc/Raf/ERK1/2 (extracellular signal-regulated kinase) signaling cascade. (biomedcentral.com)
  • Long non-coding RNAs (lncRNAs) are a class of noncoding RNA over 200 nucleotides without protein coding capacity. (amegroups.org)
  • Then, we identified hub genes via protein-protein interaction analysis and constructed a core ceRNA sub-network. (bvsalud.org)
  • Recently, the RNA polymerase (PB2) protein has also been recognized as a critical factor in host range restriction, while the nonstructural (NS1) protein affects the initial host immune responses. (cdc.gov)
  • One of the microRNA strands of the duplex is loaded onto the RNA-induced silencing complex (RISC) where it is then able to either cleave RNA targets or repress protein translation dependent upon its complementarity to the target mRNA. (biomedcentral.com)
  • Instead, the nucleoid forms by condensation and functional arrangement with the help of chromosomal architectural proteins and RNA molecules as well as DNA supercoiling. (wikipedia.org)
  • Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. (rochester.edu)
  • A high-mannose oligosaccharide precursor is synthesized and transferred to proteins in the endoplasmic reticulum and then processed in the Golgi apparatus ( 4 ). (frontiersin.org)
  • There were 3954 correlations and a total of 15 correlations for differentially expressed proteins (DEPs) and differentially expressed genes (DEGs) from proteomics and transcriptomics. (hindawi.com)
  • The mitochondrial genes associated with cytochrome c oxidase deficiency provide instructions for making proteins that are part of a large enzyme group (complex) called cytochrome c oxidase (also known as complex IV). (medlineplus.gov)
  • Tensin is a gene family with four members (tensin1, tensin2, tensin3, and cten), and their encoding proteins are localized to the cytoplasmic side of focal adhesions. (rupress.org)
  • The mitogenome is 18,680 bp in length, and includes the 37 typical mitochondrial genes and a large control region (length: 1,997 bp). (researchsquare.com)
  • Mutations in at least three mitochondrial genes can cause cytochrome c oxidase deficiency, which is a condition that can affect several parts of the body, including the muscles used for movement (skeletal muscles), the heart, the brain, or the liver. (medlineplus.gov)
  • Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs. (utah.edu)
  • Meanwhile, synonymous mutations decreasing codon optimality slowed down translation, and were enriched in tumor suppressor genes. (biomedcentral.com)
  • Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants. (frontiersin.org)
  • Jasmonate acid (JA) is a vital endogenous hormone that regulates taxol biosynthesis and other biological processes, especially (a)biotic stress tolerance in various plants ( Roberts, 2001 ). (frontiersin.org)
  • CircRNAs often act as competing endogenous RNA (ceRNA) to regulate gene expression by acting as miRNA sponges. (bvsalud.org)
  • While the observation that NHR-67 forms punctae associated with transcriptional repressors in non-invasive cells is intriguing, the work does not yet established a clear link between the formation and dissolution of NHR-67 condensates with the activation of downstream genes that NHR-67 is actively repressing. (elifesciences.org)
  • They have the capacity to control the expression of many downstream genes which can affect several cell regulatory pathways, such as cell growth, differentiation, mobility and apoptosis. (biomedcentral.com)
  • The activity of the enzyme is regulated positively and negatively by several allosteric effectors, such as leucine, ADP, and GTP. (diabetesjournals.org)
  • Epigenetics refers to heritable changes in gene expression without changing the nucleotide sequence of the gene, including DNA methylation, histone modifications, and RNA modifications. (beds.ac.uk)
  • DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
  • With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (beds.ac.uk)
  • MicroRNAs are a group of small noncoding functional RNAs that are approximately 22 nucleotides in length [ 1 ]. (biomedcentral.com)
  • Transferred mitochondria accumulate reactive oxygen species, promoting proliferation. (utah.edu)
  • Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
  • My research interest centers around understanding gene expression regulation in both stem cells and cancer cells. (nih.gov)
  • The detection of RNA modifications is fundamental to the study of m7G modifications in the regulation of gene expression. (beds.ac.uk)
  • Transcriptomics focuses on gene transcription and regulation of transcription in cells [ 25 , 26 ]. (hindawi.com)
  • Furthermore, candidate genes at these intervals harboring major and stable QTLs were predicted, and they were associated with plant development and water transportation in most cases. (chinaagrisci.com)
  • Another challenge to using transgenic plant technology in citrus is the long juvenile phase of immature tissues that ranges from 5 to 20 years, which greatly delays analysis of the effects of candidate genes. (springer.com)
  • The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
  • MicroRNAs are small noncoding RNAs that function to control gene expression. (biomedcentral.com)
  • Our team has found that CBFB and its binding partner RUNX1 have a tumor-suppressive function in some subtypes of breast tumors by regulating the translation of hundreds of mRNAs (Malik et al. (nih.gov)
  • Systems for regulating biological responses with small molecules have broad utility. (nature.com)
  • Molecular formula of common RNA modifications. (beds.ac.uk)
  • With all six genotypes of citrus tested including Eureka lemon, a cultivar difficult to be transformed, our results demonstrate that the kn1 gene may provide an effective molecular tool to enhance genetic transformation efficiencies of various citrus varieties. (springer.com)
  • During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)
  • And in addition, they form a variety of regulatory networks to regulate diverse pathophysiological processes in vivo ( 6 ). (amegroups.org)
  • Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation. (medlineplus.gov)
  • Our research has shown that p53 plays an essential role in regulating ESC differentiation after DNA damage by down-regulating the transcription of many ES cell critical genes (Li et al. (nih.gov)
  • These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. (biomedcentral.com)
  • The current effort focuses on cellular processes regulated by CBFB and RUNX1, which encode two subunits of a transcriptional complex. (nih.gov)
  • 3. Principal Investigator, Systematic characterization and analysis of tissue/cell-specific lincRNAs in elegans (系统性鉴定和分析线虫组织/细胞特异(基 (sustech.edu.cn)
  • High transformation efficiency of citrus is of great importance for large scale characterization of gene functions and also cultivar development via transgenic and genome editing technologies. (springer.com)
  • We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. (rochester.edu)
  • By comparing the gene expression profiles of somatic cells, intermediate-phase cells, and iPSCs, we found that carnitine palmitoyltransferase (Cpt)1b, a rate-limiting enzyme in fatty acid oxidation, was significantly upregulated in the early stage of the reprogramming process. (biomedcentral.com)
  • START, steroidogenic acute regulatory-related lipid transfer. (rupress.org)
  • Plant biologists subsequently discovered that many phytohormones regulate signaling through CID mechanisms. (nature.com)
  • In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
  • Glycans are one of the four fundamental macromolecular components of all cells and are highly regulated in immune cells, including macrophages. (frontiersin.org)
  • The maize homeobox gene knotted1 ( kn1 ) encodes an AP2/ERF transcription factor (Hake et al. (springer.com)
  • Single-cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing. (utah.edu)
  • CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. (thermofisher.com)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • but how these cell states are regulated in the context of development is not well understood. (elifesciences.org)
  • 2. Principal Investigator, Dlx3b-4b and Gata3 regulate otic hair cell development in zebrafish (Dlx3b-4b和Gata3是斑马鱼内耳毛细胞发育的主要调节因子), a (sustech.edu.cn)
  • T-DNA flanking sequence analysis of the transgenic line JL42 showed that the cry1C gene was inserted into the intergenic region of chromosome 11, indicating that its insertion may not interfere with the genes near insertion site. (chinaagrisci.com)
  • Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)
  • The gram-negative bacterium Escherichia coli is a model system for nucleoid research into how chromosomal DNA becomes the nucleoid, the factors involved therein, what is known about its structure, and how some of the DNA structural aspects influence gene expression. (wikipedia.org)
  • Starting with the Escherichia coli lac operon in the 1970s, many synthetic ligand-regulated circuits have been built by rewiring natural systems for new functions 1 . (nature.com)
  • Additionally, TcERF15, which played the positive role to regulate tasy gene, was up-regulated by TcMYC2a. (frontiersin.org)
  • Circular RNAs (circRNAs) are reported to play important role in the physiology and pathology of IS. (bvsalud.org)
  • TcMYC2a overexpression also led to significantly increased expression of TASY , tat , dbtnbt, t13h , and t5h genes. (frontiersin.org)
  • Methods: CircRNAs, miRNAs and mRNAs expression profiles were downloaded from the Gene Expression Omnibus (GEO) datasets. (bvsalud.org)
  • In this study, a synthetic cry1C gene encoding Bacillus thuringiensis (Bt) δ-endotoxin, which is toxic to lepidopteran pest, was transformed into a japonica rice variety (Jigeng 88) in Northeast China by Agrobacterium -mediated transformation. (chinaagrisci.com)
  • In addition, important genes related to osmoregulation, such as ion transport and carbonic anhydrase, were also detected in the correlation analysis for same trend DEPs_DEGs. (hindawi.com)
  • Using PCR/single-strand conformation polymorphism analysis of the gene encoding GDH in 12 Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI), we found a mutation (Y266C) in one PHHI patient. (diabetesjournals.org)
  • In this study, an up-regulated polyamine oxidase gene GmPAO1 was obtained by transcriptome sequencing analysis and screening at soybean seedling stages. (techscience.com)
  • Mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. (medlineplus.gov)
  • EVs transfer their cargo to recipient cells, thereby altering the biological function of the recipient cells. (researchsquare.com)
  • Circular dichroism study of nine species of transfer ribonucleic acid. (colorado.edu)
  • The main tool used in transcriptomics is total RNA sequencing, which is a powerful tool for analyzing gene expression changes in response to various environmental stresses [ 27 ]. (hindawi.com)