HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. (wikipedia.org)
Antibody3
The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. (wikipedia.org)
A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
OBJECTIVES: We sought to determine vaccine antibody titres and the prevalence of hepatitis B surface antigen (HBsAg) in both HIV-positive and HIV-negative infants born to HIV-positive mothers in Botswana. (bvsalud.org)
Hepatitis2
Some diseases found associated with A1 actually link to the extended A1-B8 haplotype, viral induced hepatitis and accelerated progression of HIV are examples. (wikipedia.org)
We determined hepatitis B virus (HBV) genotypes by amplifying 415 base-pairs of the surface region. (bvsalud.org)
Infectious diseases1
Within the early studies, A1 was found associate with or protected against some infectious diseases. (wikipedia.org)
Responses1
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Infection2
While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype. (wikipedia.org)
A1 with B8 showed an increase risk of measles infection, however, the significance was not consistent. (wikipedia.org)
Immune3
A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. (wikipedia.org)
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
Molecular docking, molecular dynamic simulation, and immune simulation were performed to ensure the binding between HLA and TLR4. (springeropen.com)
Group2
For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
Group A has 15 serotypes, group B has 8 serotypes, group C has 19 serotypes, and group D has 1 serotype. (medscape.com)
Study2
A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
People2
With rubella, A1-B8 was more frequently found in people infected as a result of maternal transference. (wikipedia.org)
Cryptococcal meningitis affects millions of people worldwide and is especially prevalent in regions with a high burden of HIV/AIDS. (bvsalud.org)
Positivity2
A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. (wikipedia.org)
hence, a normal HBV serology profile is characterized by HBV surface antigen (HBsAg) and anti-HBc positivity. (bvsalud.org)
Peptide1
High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). (nih.gov)
Allele2
For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis. (nih.gov)
Viral1
Some diseases found associated with A1 actually link to the extended A1-B8 haplotype, viral induced hepatitis and accelerated progression of HIV are examples. (wikipedia.org)
Genes2
A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
Antigens encoded by the genes in the group II took part in the rejection of transplanted tumors and other tissues. (slideshare.net)
Chain1
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. (nih.gov)
Risk4
In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
As DRw3 was characterized, autoimmune risk drifted toward the class II region. (wikipedia.org)
A1 with B8 showed an increase risk of measles infection, however, the significance was not consistent. (wikipedia.org)
Most of the disease risk conferred by A*01:01 are represented by either A1 serotype risks, or A1-B8 serotype risk (In Europe A1-B8 is almost always composed of A*01:01 and B*08:01). (wikipedia.org)
Association6
Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
While type 1 diabetes shows an extended association on the HLA A1-B8-DR3-DQ2 haplotype, the association appears not to extend beyond the HLA-B locus. (wikipedia.org)
Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
An association between A1 and cold sores was also described. (wikipedia.org)
The A1-B8-DR3-DQ2 haplotype has a known association with Enteropathy-associated T-cell lymphoma, approximately 70% of patients are homozygotes for DQ2 with at least one copy of DR3-DQ2. (wikipedia.org)
Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1. (nih.gov)