• LTBI
  • The new regimen is recommended as an equal alternative to the 9-month INH regimen for otherwise healthy patients aged ≥12 years who have LTBI and factors that are predictive of TB developing (e.g., recent exposure to contagious TB). (cdc.gov)
  • Recommendations against the use of INH-RPT (without a reference to quality of evidence) were made for patient categories in which 1) previous experience with treatment of TB or LTBI with any regimen has revealed an increased risk for adverse effects, drug interactions, or low efficacy or 2) studies have not provided adequate evidence of safety or efficacy. (cdc.gov)
  • Any ART regimen can be used when isoniazid alone is used for LTBI treatment (AII) . (nih.gov)
  • hepatitis
  • In September 2000, a man in New York died of hepatitis after 5 weeks of RIF-PZA, and in December, a woman in Georgia was admitted to a hospital because of hepatitis after 7 weeks of this regimen. (cdc.gov)
  • Isoniazid has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.3% in people 21 to 35 years old and over 2% in those over age 50. (wikipedia.org)
  • Infection
  • It found a 12-week two-drug regimen is as effective as the traditional nine-month single-drug approach to treating latent infection, which is not contagious but without treatment can progress to active disease. (presstelegram.com)
  • Vitamin B6 is used to prevent isoniazid-induced B6 deficiency and neuropathy in people with a risk factor, such as pregnancy, lactation, HIV infection, alcoholism, diabetes, kidney failure, or malnutrition. (wikipedia.org)
  • resistant
  • She chose this regimen because of suspected exposure to drug-resistant TB and concern about liver injury from INH. (cdc.gov)
  • clinical trials
  • The three clinical trials of the INH-RPT regimen were limited by open-label (i.e., unblinded) design, and one was limited by small numbers of participants ( 3 ). (cdc.gov)
  • months
  • However, self-supervised daily INH regimens have completion rates of 60% or less in typical settings, attributable largely to the duration of ≥6 months. (cdc.gov)
  • the preferred regimen for children aged 2 to 11 years remains daily isoniazid for 9 months. (nih.gov)
  • When it happens, isoniazid-induced liver toxicity has been shown to occur in 50% of patients within the first 2 months of therapy. (wikipedia.org)
  • Liver toxicity occurs in up to 5% of patients and follows a pattern similar to isoniazid, usually arising in the first 1 to 3 months of therapy, but can occur even after more than 6 months of therapy. (wikipedia.org)
  • Daily
  • With DOT, patients on the above regimens can be switched to 2- to 3-times per week dosing after an initial 2 weeks of daily dosing. (medscape.com)
  • patients
  • The new regimen also can be considered for other categories of patients when it offers practical advantages. (cdc.gov)
  • Regimens of INH monotherapy have been shown to prevent TB in diverse categories of patients, and use of these regimens has been extended based on expert opinion ( 2 ). (cdc.gov)
  • A special regimen exists for patients with TB who are actively seizing or who have overdosed on antimycobacterial medication. (medscape.com)
  • In these patients, overdose with isoniazid should be suspected. (medscape.com)
  • Recent advances in medical technology, such as bone marrow and hematopoietic stem cell transplantation and the use of intensive chemotherapeutic regimens, have added substantially to the number of patients who are able to survive neoplastic disorders but do so with seriously impaired host defense mechanisms that compromise their ability to resist or contain infections. (nih.gov)
  • drug
  • In the United States, treatment of MDR-TB should be individualized based on drug susceptibility test (DST) results (in cases where DST results for the child are not available, then DST results for the source case should be used to guide initial choice of regimen) (AII) . (nih.gov)
  • Drug regimens are similarly abbreviated in a standardised manner. (wikipedia.org)
  • liver
  • Researchers were also reassured to see the 12-dose regimen was well tolerated - even by jail inmates who have a higher rate of substance abuse, which can harm the liver. (presstelegram.com)
  • We were worried that this regimen might lead to more liver damage, because it is once a week at a higher dose," said Shah. (presstelegram.com)
  • Isoniazid is thought to induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form. (wikipedia.org)
  • given
  • Most regimens have an initial high-intensity phase, followed by a continuation phase (also called a consolidation phase or eradication phase): the high-intensity phase is given first, then the continuation phase, the two phases divided by a slash. (wikipedia.org)
  • Lower
  • The other evidence was of lower quality (i.e., indirect or generalized from treatment trials and observational studies of other regimens). (cdc.gov)