Regenerative medicine cell membrane potentials. Medical search. Frequent questions

In this context, several parameters need to be addressed towards the development of advanced regenerative therapies employing myogenic cells. (mdpi.com)
The success of this work represents a new approach in how new human tissue or organ can be regenerated and human disease can be treated, and may have a broad impact on regenerative therapies by harnessing the regenerative power of our own body," said Zhang, who also has an appointment at Veterans Affairs San Diego Healthcare System. (sciencedaily.com)
However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. (lww.com)
By banking all four, cord blood, cord tissue, amniotic membrane and chorionic villi (placental cells), Cells4Life believes parents gain the potential to access the widest range of treatments possible, as various regenerative therapies begin to transition from clinical trials to the clinic. (parentsguidecordblood.org)
The emerging consensus amongst scientists is that MSCs from different sources are likely to vary in the types of therapies for which they are best suited: "MSC origins may have significant impact on the therapeutic potentials of such cells and should be taken into consideration in clinical applications" 1 . (parentsguidecordblood.org)
Another consideration when banking stem cells is to have more options for accessing new therapies. (parentsguidecordblood.org)
Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)
Regenerative therapies, including stem cell therapies hold great promise for all of us and while some are FDA approved, others are not. (dallasvitality360.com)
Joanne Kurtzberg, MD , Director of the Marcus Center for Cellular Cures at Duke University, is our Key Note speaker and will present her groundbreaking work in a lecture titled "Extending Cord Blood to Regenerative Therapies for the Brain. (parentsguidecordblood.org)
This new combination of regenerative cell therapies will open a new age of medicine, forever changing how it is practiced. (forbes.com)
Regenerative medicine is not only driven by new evidence indicating these therapies are capable of curing diseases, but also by the fact that the world's population is aging. (forbes.com)
The biggest concern with stem cell therapies, and the reason why the FDA halted human trials, is that undifferentiated, or pluripotent, stem cells can be influenced to differentiate by a number of factors (including growth factors, growth matrices or media, and physical forces). (asu.edu)
Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
In Papers I and Paper III of my thesis, we examined stem cell-derived therapies' potential on two most common conditions of xerostomia, which are acute irradiated and chronic immune dysregulation-caused salivary gland hypofunction. (lu.se)
Due to the complexity and multiorgan involvement typically associated with ARDS, animal models remain the most commonly used research tool for investigating potential new therapies. (lu.se)

Salivary exosomes are extracellular vesicles of 30-150 nm in diameter that exist in saliva and play an important role in substance exchange and signal transduction between cells, delivering the lipids, proteins and nucleic acids they carry to the recipient cells and regulating the physiological and pathological processes of the recipient cells. (bvsalud.org)
miRNA, as an important "cargo" in exosomes, is transported to the recipient cells and regulates the signaling pathways of the recipient cells, thus playing a regulatory role in disease progression. (bvsalud.org)
Exosomes, small extracellular vesicles derived from cells, are known to carry important bioactive molecules such as proteins, nucleic acids, and lipids. (bvsalud.org)
These bioactive components play crucial roles in cell signaling, immune response, and tumor metastasis, making exosomes potential diagnostic biomarkers for various diseases. (bvsalud.org)
Mesenchymal stem cell-derived exosomes have emerged as a promising cell-free therapy for tissue engineering. (bvsalud.org)
Compared to intact stem cells, exosomes have advantages like low immunogenicity and ability to carry regenerative cargo. (bvsalud.org)
This review examined the potential of exosomes to treat defects in skin, bone and cartilage. (bvsalud.org)
Exosomes represent a promising cell-free therapy for tissue engineering. (bvsalud.org)
Understanding these challenges will enable the successful clinical translation of exosomes for regenerative medicine applications. (bvsalud.org)
Since 2022, we have principally employed a business-to-business model in which we produce and commercialize a new generation of topical skincare products that contain our proprietary stem cell-derived Elevai Exosomes TM designed to enhance the appearance of skin. (iposcoop.com)
Specifically, as referenced herein "exosomes" are small membrane-bound vesicles that are released by cells that are involved in intercellular communication. (iposcoop.com)
Exosomes are small membrane-bound vesicles secreted into the body's cellular environment. (mayoclinic.org)
Exosomes are messenger particles that release naturally from a cell. (enhancetexas.com)
Exosomes carry genetic information and proteins to cells throughout your body, creating paths for communication between cells. (enhancetexas.com)
Exosomes are released naturally from cells upon the fusion of a discontinuous closed membrane system, also known as the intermediate endocytic compartment. (enhancetexas.com)
Exosomes are tiny, single-membrane organelles of ∼30 to ∼200 nm diameter, released in high quantities from rapidly growing cells, including stem cells and t and B cells. (enhancetexas.com)
Exosomes contain an array of membrane-associated proteins, lipids, nucleic acids, and glycoconjugates and are believed to facilitate intercellular communication through the paracrine effect. (enhancetexas.com)
Exosomes may also be used by stem cells to detect their environment and repair damaged tissue. (enhancetexas.com)
Exosomes are derived from cells in the body. (enhancetexas.com)
Exosomes are formed within cells through exocytosis, during which the cell's endosomes (small, membrane-bound compartments within the cell) fuse with the cell membrane and release their contents into the extracellular space. (enhancetexas.com)
Once they are released into the extracellular space, exosomes can be taken up by other recipient cells and affect their functions. (enhancetexas.com)
Cell derived exosomes have been found to contain various types of molecules, such as proteins, lipids, and genetic material, that are specific to the cells that produced them. (enhancetexas.com)
These exosomes can be taken up by other cells, even if they are far away from where the exosomes were released. (enhancetexas.com)
When this happens, the molecules within the exosomes can alter the function of the recipient cells. (enhancetexas.com)
For example, exosomes have been shown to contain a variety of immune-related molecules, such as cytokines and antigens, and to be involved in the immune system's response to infection by influencing a recipient cell. (enhancetexas.com)
In addition, exosomes are involved in the communication between neurons and other cells in the nervous system. (enhancetexas.com)
Research states that Exosomes are primarily messenger molecular mechanisms According to a 2019 study published in the Cell and Bioscience Journal, Exosomes are nano-sized vesicles released into surrounding body fluids upon the fusion of multivesicular bodies and the plasma membrane. (enhancetexas.com)
Exosome therapy involves using exosomes, small vesicles that are naturally produced by stem cells, to deliver therapeutic molecules to specific cells in the body. (enhancetexas.com)
Among these, exosomes are small (30-100 nm) vesicles derived from the endosomal pathway while microvesicles are of various sizes and generated by budding of the plasma membrane (50-1000 nm) [ 3 , 5 ]. (biomedcentral.com)
In the field of Regenerative Medicine, Exosomes are receiving a lot of attention. (thrivewellcenter.com)
To understand exosomes and the valuable role they play in the body, we must first understand the basic unit of life: The Cell. (thrivewellcenter.com)
In 2007, a Swedish researcher showed that cells used exosomes to transfer genetic material between cells. (thrivewellcenter.com)
Exosomes are a subtype of extracellular vesicles (EV) that, once released into the extracellular space, can be picked up by adjacent cells. (thrivewellcenter.com)
In this way, exosomes are used to facilitate cell-to-cell communication or cell signaling. (thrivewellcenter.com)

The presence of embryonic and foetal cells from all germ layers in the amniotic fluid was gradually determined since the 1980s. (wikipedia.org)
In addition, evidence indicated that embryonic stem cells are part of the fluid, although in very small quantities. (wikipedia.org)
This characteristic differentiates them from embryonic stem cells but indicates similarities with adult stem cells. (wikipedia.org)
As opposed to mesenchymal stem cells, embryonic-like stem cells are not abundant in the amniotic fluid, making up less than 1% of amniocentesis samples. (wikipedia.org)
Embryonic-like stem cells were originally identified using markers common to embryonic stem cells such as nuclear Oct4, CD34, vimentin, alkaline phosphatase, stem cell factor and c-Kit. (wikipedia.org)
The pluripotency of these embryonic-like stem cells remains to be fully established. (wikipedia.org)
Understanding how embryonic cells biomolecularly restrict their early developmental potential and promote specific cell commitment helps to provide key insights on cancer plasticity and could improve fertilization protocols. (zeiss.com)
Researchers at the University of Southern California (USC) Roski Eye Institute at Keck Medicine, and Regenerative Patch Technologies, used embryonic stem cells that had been turned into retinal pigment epithelium (RPE) cells - the kind of cell destroyed by AMD. (ca.gov)
Due to their capacity to differentiate in all embryonic germ layers, amnioticﬂuid stem cells (AFCs), represent a highly promising cell type for tissue regeneration, which however is still poorly studied and in turn underutilized. (123dok.org)
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
When James Thomson of the University of Wisconsin announced in 1998 that he had derived and cultured human embryonic stem cells (hESCs), Americans widely believed-and accepted-that stem cells would one day be the basis of a multitude of regenerative medical techniques. (asu.edu)
For advanced disease treatment, the CSCC offers treatments that use umbilical cord stem cells, amniotic fluid stem cells, and embryonic live cell therapy. (asu.edu)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)

Mesenchymal stem cells (MSCs) are highly abundant in the amniotic fluid and several techniques have been described for their isolation. (wikipedia.org)
Originally it was proposed that the MSCs were discarded from the embryo at the end of their life cycle but since the cells remained viable in the amniotic fluid and were able to proliferate in culture this hypothesis was overturned. (wikipedia.org)
Comparison of amniotic fluid-derived MSCs to bone-marrow-derived ones showed that the former has a higher expansion potential in culture. (wikipedia.org)
The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
Further investigations are required to overcome the current limitations to allow the clinical translation of MSCs in regenerative medicine. (springer.com)
These procedures have been augmented with MSCs to enhance their regenerative potential. (springer.com)
Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
In conclusion, MSCs in musculoskeletal system, mediated by the interaction between MSC paracrine and Mφs, have therapeutic potential in musculoskeletal diseases. (frontiersin.org)
In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)
The chorionic villi are a rich source of mesenchymal stromal cells (MSCs) and these cells are being used to push the boundaries of conventional medicine. (parentsguidecordblood.org)
Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and the feasibility to generate functionally enhanced EVs by modifications to parental MSCs. (frontiersin.org)
Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)
The clinical application of MSCs to tissue engineering has been introduced due to their numerous advantages including high expansion potential and extensive differentiation potential [ 6 , 7 ]. (hindawi.com)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
Moreover, replicative senescence of MSCs exhibits reduced functionality, and cellular senescence might impair the regenerative potential of MSCs [ 10 ]. (hindawi.com)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)

hAMSCs have been proposed to exert their anti-inflammatory and healing potential via secreted factors, both free and conveyed within extracellular vesicles (EVs). (mdpi.com)
show that mitochondria can be expelled from cells via extracellular vesicles as a route of quality control that is an alternative to lysosomal degradation. (nature.com)
Extracellular vesicles (EVs) are nanoscale membrane-bound vesicles released by cells into bio-fluids. (rsc.org)
Also known as extracellular vesicles (particles that release naturally from a cell that cannot replicate), they are responsible for cell-to-cell communication. (enhancetexas.com)
Extracellular vesicles derived from target cells were shown to carry cell-specific cargos of proteins, lipids, and genetic materials and can be selectively taken up by neighboring or distant cells far from their release, reprogramming the recipient cells upon their bioactive compounds. (enhancetexas.com)
Background: An increasing number of studies on stem cells suggests that the therapeutic effect they exert is primarily mediated by a paracrine regulation through extracellular vesicles (EVs) giving solid grounds for stem cell EVs to be exploited as agents for treating diseases or for restoring damaged tissues and organs. (123dok.org)
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. (nature.com)
In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. (nature.com)
Figure 1: Biogenesis of extracellular vesicles and their interactions with recipient cells. (nature.com)
Extracellular vesicles play a crucial role in intercellular communication by transmitting biological materials from donor cells to recipient cells. (biomedcentral.com)
How do cells within these mechanically active tissues interpret external loads imposed on their extracellular environment, and, how are cell–substrate interactions converted into biochemical signals? (ncsu.edu)
The extracellular matrix (ECM) provides structural and biochemical support to the surrounding cells, and it has been used as a coating substrate for cell culture. (hindawi.com)
The vesicles can either fuse with the cell membrane and disgorge their contents into the space between cells, or they can pass through the cell membrane into the extracellular space. (thrivewellcenter.com)
During my thesis, we evaluated whether cell-derived strategies, in this case, extracellular vesicles (EVs) could be a potential new therapy to repair salivary gland injury and restore function following radiotherapy or in autoimmune diseases. (lu.se)

A multitasking plasma membrane protein coordinates cell division and energy metabolism in healthy-and perhaps also cancerous- Drosophila cells. (the-scientist.com)

There is some debate whether c-Kit is a suitable marker to distinguish amniotic stem cells from other cell types because cells lacking c-Kit also display differentiation potential. (wikipedia.org)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
Mesenchymal stem cells have anti-inflammatory, immunomodulatory, and multipotent differentiation potential, but disappear from the body relatively quickly after intravenous administration. (nii.ac.jp)
We speculate that this novel pattern of pluripotent stem cell metabolism may also regulate hPSC differentiation potential and also possibly provide a barrier to limit reprogramming efficiency to hiPSCs. (ca.gov)
A number of clinical studies have used AM for applications in regenerative medicine, but it has yet to be elucidated whether the different areas of the AM have the same plasticity and differentiation potential. (fupress.net)
Specific properties, such as proliferative and differentiation potential, are slightly different among DSCs. (bvsalud.org)

Human amniotic membrane and amniotic membrane-derived mesenchymal stromal cells (hAMSCs) have produced promising results in regenerative medicine, especially for the treatment of inflammatory-based diseases and for different injuries including those in the orthopedic field such as tendon disorders. (mdpi.com)
Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application. (biocellcenter.it)

however, cell-based therapy has its risks. (techscience.com)
Light-responsive biomaterials have a strong potential for developing the next generation of noninvasive, precise, and controllable medical devices for a range of biomedical applications, including drug delivery, cancer therapy, regenerative medicine, and 3D printing," Gaharwar says. (futurity.org)
An ultimate goal of stem cell research is to turn on the regenerative potential of one's own stem cells for tissue and organ repair and disease therapy," said Kang Zhang, MD, PhD, chief of Ophthalmic Genetics, founding director of the Institute for Genomic Medicine and co-director of Biomaterials and Tissue Engineering at the Institute of Engineering in Medicine, both at UC San Diego School of Medicine. (sciencedaily.com)
In cell therapy, in vivo kinetic control of the therapeutic cells, such as accumulation of the cells at the target site of therapy and enhancement of their interaction with the target cells, may lead to improved therapeutic efficacy. (nii.ac.jp)
Find out what potential options you have with stem cell therapy. (stemedix.com)
It is best known for the development of TotiCyte, a method for processing cord blood that gives an uplift in the number of stem cells retained at the point of therapy. (parentsguidecordblood.org)
When an experimental therapy goes through clinical trials and is approved or patented by regulatory authorities, the approval requires the manufacturer of the product to consistently use the same cell source and same procedures that were in the request for approval. (parentsguidecordblood.org)
Parents that are seeking an alternative cell therapy for the same condition could turn to a different tissue source. (parentsguidecordblood.org)
What are the advantages of utilizing stem cell therapy? (dallasvitality360.com)
When should I expect to see results from the non-surgical stem cell therapy procedure? (dallasvitality360.com)
Neil Riordan, PA PhD, is also renowned for providing autism therapy using cord tissue cells and he will share results from his clinic in Panama. (parentsguidecordblood.org)
The rapid advances in theﬁeld of regenerative medicine have identiﬁed novel sources of stem cells with potential for therapy. (123dok.org)
Knee Replacements will be Unnecessary in the Next Five Years Cell therapy makes up over 60% of the regenerative medicine market, most of which is in the area of stem cell therapy. (forbes.com)
Stem cell therapy, when combined with immune and gene therapy, shows even greater potential to cure diseases. (forbes.com)
For example, in the future, knee replacements may no longer be needed with regenerative cell therapy. (forbes.com)
The 2014 FDA guidelines indicate it will be necessary for clinics to offer stem cell therapy in order to have an approved Biological License Application (BLA). (forbes.com)
Lai, R. C., Chen, T. S. & Lim, S. K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. (nature.com)
After more than a decade of being promised curative stem cell therapy, many people have been unwilling to wait for American doctors to provide stem cell treatments. (asu.edu)
Some people have opted not to wait or rely on other treatments, and have chosen to receive stem cell therapy from international institutions. (asu.edu)
The society established a task force of doctors, researchers, ethicists, and regulatory officials from thirteen countries to establish guidelines for stem cell therapy, hoping to target clinics that might take advantage of patients by using experimental procedures without transparency, patient protections, or proper oversight. (asu.edu)
These models have historically played an important role in the development of new clinical interventions, such as fluid therapy and the use of supportive mechanical ventilation (MV). However, failures in recent clinical trials have highlighted the potential inadequacy of small animal models due to major anatomical and physiological differences, as well as technical challenges associated with the use of clinical co-interventions [e.g. (lu.se)

Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
Our research injects an exosome gel into the vaginal tissues of a preclinical model of mesh exposure," says Cassandra Kisby, M.D., female pelvic medicine and reconstructive surgery fellow. (mayoclinic.org)
Both of these tissues have powerful regenerative properties. (parentsguidecordblood.org)
Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
This field is nearly two decades old, and amazingly, it appears to offer the potential to restore injured tissues, improve healing and at some future point, repair whole organs. (dallasvitality360.com)
Regenerative medicine is an interdisciplinary field that applies engineering and life science principles to promote regeneration that can potentially restore diseased and injured tissues and whole organs. (dallasvitality360.com)
In addition, very recent data indicate that the structural contribution of stem cells (SCs) to regenerated tissues seems to be limited, and that rather the stimulation of local healing processes plays an important role in regeneration [6]. (123dok.org)
New regenerative medicine is changing this by engineering, growing, and regenerating tissues and organs using biological processes similar to those normally used in humans. (forbes.com)
Regenerative medicine is a promising therapeutic strategy for the repair and replacement of diseased or injured tissues and organs. (ncsu.edu)
Once properly differentiated, the cell growth is expected to replace damaged tissues and restore impaired functions. (asu.edu)
As of 2009, no American research was able to ensure that tumors would never form when hESCs were injected into damaged tissues, or even that the cells would differentiate into healthy cells of the correct type. (asu.edu)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)

Greyledge is an industry leader in isolating and concentrating a patient's own cells (autologous cells) from blood or bone marrow to create the highest quality implantable therapeutics available to ensure safety and maximize potential for successful treatment. (dallasvitality360.com)

However, it remains unclear whether the cells originate from the fetus itself, the placenta or possibly the inner cell mass of the blastocyst. (wikipedia.org)
Characterization and expansion of mesenchymal progenitor cells from first-trimester chorionic villi of human placenta. (biocellcenter.it)
Launched at the beginning of 2020, Cells4Life has become the first company in Britain to offer parents-to-be the chance to bank cells from their placenta. (parentsguidecordblood.org)
Cells4Life is the first private stem cell bank to store both of these tissue types selectively, rather than providing a generic placenta banking service. (parentsguidecordblood.org)
Speaking about the benefits of placenta banking, Lesley-Ann Martin, Chief Scientific Officer at Cells4Life, said "Research is moving rapidly, and placental banking opens up further potential therapeutic possibilities for parents looking to protect their child's long-term health. (parentsguidecordblood.org)
Studies suggest stem cells from different tissue sources such as cord blood, umbilical cord tissue and of course placenta will have different potential therapeutic applications. (parentsguidecordblood.org)
The placenta has two key components which are rich in different regenerative cell types: the chorionic villi and the amniotic membrane. (parentsguidecordblood.org)
The amniotic membrane is the innermost skin of the placenta and forms a sac around the baby holding amniotic fluid. (parentsguidecordblood.org)
Ornella Parolini, PhD , founder of the International Placenta Stem Cell Society and director of the E. Menni Research Center in Italy, will share her expert knowledge on the immunomodulation of amniotic cells. (parentsguidecordblood.org)
Women who have had a cesarean section can opt to have their fresh placenta delivered to the CSCC, where clinicians remove portions of the amniotic membrane and mix it with a growth factor solution. (asu.edu)

The results of this study are expected not only to increase the tissue-selective anti-inflammatory effects of mesenchymal stem cells, but also to lead to tissue regenerative medicine in the future. (nii.ac.jp)
Human Amniotic Membrane (AM) has been attributed anti-inflammatory, anti-angiogenic, anti-fibrotic and anti-microbial effects (1-2). (fupress.net)

Here, we show that adding sFRP1 or sFRP2, but not sFRP3 or sFRP4, to culture medium containing Wnt3a or Wnt5a increases re-secretion of exosome-loaded Wnt proteins from cells. (bvsalud.org)
PREx™ utilizes advanced patent-pending stem cell processing technology as part of our cohesive production process involving carefully controlled stem cell culture to produce stem cell derived factors that are featured in our topical exosome products. (iposcoop.com)
Our proprietary PREx™ biotechnology process yields exosome lots from human umbilical cord-derived mesenchymal stem cells ("hUMSC") for our specialty physician-dispensed skincare products. (iposcoop.com)
Mayo Clinic researchers are studying a new regenerative option, called purified exosome product (PEP) to treat a complication of the use of mesh in gynecologic surgery. (mayoclinic.org)
OurÂ proprietary PRExâ„˘ biotechnology processÂ yields exosome lots from human umbilical cord-derived mesenchymal stem cells (â€śhUMSCâ€ť) for ourÂ specialty physician-dispensed skincare products. (dakotafinancialnews.com)
Exosome/microvesicle-mediated epigenetic reprogramming of cells. (nature.com)
They are taken inside the nearby cell, "unwrapped," and the contents of the exosome can then be used by the recipient cell. (thrivewellcenter.com)

Although many breakthroughs have been reported and hailed in scientific journals over the years, the number of regenerative medicine treatments in medical use today is still limited and the efficacy is variable and transient because more comprehensive investigation is required for understanding the biology of tissue-repair and regeneration and the cellular mechanism of stem cell niche. (techscience.com)
Given the developmental aspects of the cell, the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the cell. (techscience.com)
In quick succession, the preimplantational mouse embryo undergoes a series of cellular divisions involving two critical cell fate decisions. (zeiss.com)
To determine which cells are expressing specific cellular markers and how these cells are organized relative to each other requires volumetric imaging of the pre-implantation embryos by confocal microscopy. (zeiss.com)
Due to the high-surface area of nanosheets, they can stick to the outer membrane of cells and transmit a cellular signal to the nucleus, thereby controlling their behavior. (futurity.org)
Some of the nanosheets are also eaten by the cells and can influence cellular functions from inside. (futurity.org)
In collaboration with Irtisha Singh, assistant professor in the department of molecular and cellular medicine at the Texas A&M Health Science Center, Gaharwar's team used a next-generation sequencing technique to decipher the effect of light and/or nanosheets on the gene regulation of cells. (futurity.org)
Global gene expression profiles of cells reveal that light stimulation of the nanosheet can have a significant influence on cellular migration and wound healing. (futurity.org)
They contain various types of biomolecules such as proteins, lipids, and nucleic acids, which can be transferred between cells and may modulate and support these natural cellular processes. (iposcoop.com)
Microfluidics provides the unique ability to control the cellular microenvironment with high spatiotemporal precision and to present cells with mechanical and biochemical signals in a more physiologically relevant context . (fluigent.com)
By then it was known that Listeria infects cells such as macrophages-motile human immune cells that engulf pathogens and cellular debris-by being taken up into vacuoles and breaking out of those vacuoles into the cytoplasm. (the-scientist.com)
This attention to detail pioneers our future into cellular and acellular products, relying on decades of biologics leadership with ongoing participation in the allogeneic stem cell Investigational New Drug (IND) studies. (dallasvitality360.com)
Although these liposomes have high concentrations of fusogenic lipids, which are needed to cross cellular membrane barriers, these lipids lead to toxicity when tested in vivo. (uh.edu)
Nanowerk News ) Using a suspended nanowire, a University of Massachusetts research team has, for the first time, created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue, work promising for cardiac disease studies, drug testing and regenerative medicine. (nanowerk.com)
Electrical and computer engineering (ECE) Ph.D. student Hongyan Gao, first author of the paper published by the journal Science Advances ( 'Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses' ), describes the invention as "a new tool for improved cardiac studies that has the potential for leading-edge applications in cardiac-disease experiments. (nanowerk.com)
With its size much smaller than a single cell, the nanowire can tightly patch onto the cell membrane and "listen to" cellular activities very closely. (nanowerk.com)
Mechanobiology aims to discover how the mechanical environment affects the biological activity of cells and how cells’ ability to sense these mechanical cues is converted into elicited cellular responses. (ncsu.edu)
Cellular senescence, which is morphologically characterized by an enlarged and flattened cell shape, was first described by Hayflick [ 9 ]. (hindawi.com)
Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)
These are the "power plants" of the cell and are responsible for making energy for cellular activities. (thrivewellcenter.com)
This cellular energy is adenosine triphosphate, or ATP, and is required by cells to function. (thrivewellcenter.com)
These are part of the cellular "housekeeping" system that help keep the cell free from debris. (thrivewellcenter.com)

These integrin proteins are important in normal cell functioning by providing information to cells about its surroundings. (futurity.org)
If these proteins are covered by nanosheets, they cannot tell the cells to move around, effectively stopping the cells for an indefinite time. (futurity.org)
These molecular cargoes comprise inherited constituents such as nucleic acids and proteins, as well as surface modifications and membrane-associated molecules, which can serve as biomarkers for minimally-invasive disease detection. (rsc.org)
This process is thought to play a role in intercellular communication and is being investigated as a potential mechanism for the transfer of various molecules, including proteins, RNA, and DNA, between target cells. (enhancetexas.com)
It was the early 2000s, and Mukherjee was working in Dennis Shields's lab at Albert Einstein College of Medicine, studying how cells organize the internal transport of proteins and other cargo. (the-scientist.com)
Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
Mesenchymal stem cells contain specialized proteins, which are thought to reduce inflammation and promote healing, including growth factors which support cell and tissue regeneration. (dallasvitality360.com)
Majd, on the Cullen College of Engineering faculty, wants to develop a way to deliver macromolecules, like peptides and proteins, to cells because macromolecules have tremendous potential as a therapeutic for diseases. (uh.edu)
Genetic materials or proteins conveyed by EVs functionally change the recipient cells [ 13 ], and therefore visualization and tracking of EVs currently receive great attention as a way to reveal their physiology. (biomedcentral.com)

Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
hUMSCs can be isolated from the Wharton's Jelly portion of the umbilical cord and have shown therapeutic potential in various diseases such as osteoarthritis, myocardial infarction, and neurodegenerative diseases. (iposcoop.com)
Doug Schmid, PhD , of Predictive Biotech will review the use of Wharton's Jelly in regenerative medicine. (parentsguidecordblood.org)

The focus of this special issue is to capture the current advances in cell membrane repair and stem cell regenerative biology. (techscience.com)
A s a grad student in cell biology, Shaeri Mukherjee was always on the lookout for new ways to fiddle with cells' internal structures. (the-scientist.com)
For Mukherjee, the paper was a revelation: not only did it identify the fastest way yet to target Golgi biology, it suggested that scientists could use intracellular bacteria "as a lens to understand basic processes inside the cell. (the-scientist.com)
A current paradigm in biology is that basal cells present in the epithelial lining of some organs never come into contact with the inner (luminal) side of the organ. (nih.gov)
Because the cell is a basic functional element in biology, its mechanical and electrical behaviors are two key properties that indicate cell state and consequently are important for health monitoring, disease diagnosis and tissue repair. (nanowerk.com)

Potential Use in Tissue Engineering Applications. (researchandmarkets.com)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
Human adipose-derived stem cells (hASCs) are an abundant cell source capable of osteogenic differentiation, and have been investigated as an autologous stem cell source for bone tissue engineering applications. (ncsu.edu)
The sheath–core composite fibers significantly increased calcium accretion of hASCs, indicating that collagen–PCL sheath–core bicomponent structures have potential for bone tissue engineering applications using hASCs. (ncsu.edu)
Fiber-reinforced scaffolds for tissue engineering and regenerative medicine: use of traditional textile substrates to nanofibrous arrays. (ncsu.edu)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)

In 2007, it was confirmed that the amniotic fluid contains a heterogeneous mixture of multipotent cells after it was demonstrated that they were able to differentiate into cells from all three germ layers but they could not form teratomas following implantation into immunodeficient mice. (wikipedia.org)
Although those cells which expressed the markers were able to differentiate into muscle, adipogenic, osteogenic, nephrogenic, neural and endothelial cells, this did not necessarily occur from a homogenous population of undifferentiated cells. (wikipedia.org)
Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
hUMSC are adult stem cells that can differentiate into various cell types. (iposcoop.com)
Descemet's Membrane Biomimetic Microtopography Differentiate. (lww.com)
Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
Those cells show high plasticity and the capacity to differentiate into the three types of germ layer cells, making them ideal for ap-plications in regenerative medicine[4], eventually banked and used for treatments. (123dok.org)
Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)

The revival of amniotic membrane use in various treatments, including wound management, has occurred following the introduction of advanced techniques. (researchandmarkets.com)
At CIRM, we never forget that we were created by the people of California to accelerate stem cell treatments to patients with unmet medical needs, and act with a sense of urgency to succeed in that mission. (ca.gov)
The thin layer of cells in the amnion have been used for over a century in a range of treatments for burns, ulcers, and wounds. (parentsguidecordblood.org)
Ultimately, development of this macromolecule cell delivery method could make way for better cancer treatments and regenerative medicine. (uh.edu)
Regenerative medicine represents a new paradigm in human health because the vast majority of treatments for chronic and life-threatening diseases focus on treating the symptoms, not curing the disease. (forbes.com)
Treatments at EmCell involve administering stem cells intravenously or subcutaneously, after which the cells are said to migrate to the correct site, engraft and multiply, and eventually undergo correct specialization, or differentiation. (asu.edu)
The clinic conducts stem cell treatments as well as phase I, II, and III clinical studies, and encourages clinicians to perform studies at the clinic. (asu.edu)
The company's website does not explain how its treatments are administered, nor is there any discussion of potential risks or negative side effects. (asu.edu)
The International Society for Stem Cell Research believes that clinics such as EmCell and the Cancun Stem Cell Clinic are "exploiting patients' hopes," since the treatments are costly (over $20,000) and unproven. (asu.edu)

The fusion of these two topics reflects the hope and potential that advance can advance regenerative medicine for translational application to treat human diseases. (techscience.com)
The study is published in the journal Science Translational Medicine . (ca.gov)

These cells were then placed on a synthetic scaffold that was designed to mimic Bruch's membrane, a key structure at the back of the retina that regulates the flow of oxygen to the eye and removes waste products. (ca.gov)
The scaffold containing the cells - called the California Project to Cure Blindness-Retinal Pigment Epithelium 1 (CPCB-RPE1) - was then surgically placed in the eye. (ca.gov)
The main approach for this method is the fabrication and use of scaffold materials to act as a surrogate framework and promote cell-seeded populations to develop into a mature and functional tissue. (ncsu.edu)
Scaffold based strategies for regenerative medicine have focused on the use of three dimensional, biocompatible, biodegradable structures to provide an adequate template for ex vivo cell expansion and maturation, native tissue ingrowth, and restoration of the original tissue qualities with respect to the tissue's biochemical constituents, morphology, form, and function. (ncsu.edu)

The vesicles are usually surrounded by a lipid (fat) membrane to allow them to pass through the cell membrane. (thrivewellcenter.com)
EVs are membrane-bound lipid bilayer vesicles secreted by cells or body liquids, with a strong capacity to deliver essential information between cells. (lu.se)

Amniotic stem cells are the mixture of stem cells that can be obtained from the amniotic fluid as well as the amniotic membrane. (wikipedia.org)
The use of amniotic fluid stem cells is therefore generally considered to lack the ethical problems associated with the use of cells from embryos. (wikipedia.org)
In 2009, the first US amniotic stem cell bank was opened in Medford, MA, by Biocell Center, an international company specializing in the cryopreservation and private banking of amniotic fluid stem cells. (wikipedia.org)
Haematopoietic progenitor cells were first reported to be present in the amniotic fluid in 1993, specifically up to the 12th week of pregnancy. (wikipedia.org)
In 1996, a study indicated that non-haematopoietic progenitor cells were also present in the amniotic fluid. (wikipedia.org)
The majority of stem cells present in the amniotic fluid share many characteristics, which suggests they may have a common origin. (wikipedia.org)
However, foetal stem cells attained from the amniotic fluid are more stable and more plastic than their adult counterparts making it easier for them to be reprogrammed to a pluripotent state. (wikipedia.org)
They usually involve the removal of amniotic fluid by amniocentesis and their distinction from other cells may be based on their morphology or other characteristics. (wikipedia.org)
Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. (biocellcenter.it)
Cryopreservation does not alter karyotype, multipotency, or NANOG/SOX2 gene expression of amniotic fluid mesenchymal stem cells. (biocellcenter.it)

Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Bioprocess considerations covering the cell isolation step starting from different tissue sources (i.e., stem/progenitor cells vs. more committed precursors), as well as the need for robust and cost-effective protocols featuring easy scalability envisioning clinical applications, which are approached herein. (mdpi.com)
this released a flood of progenitor cells, or cells which eventually create new cartilage. (forbes.com)
After 22 days of differentiation, the cells show visible and spectroscopic indications of completed adipogenesis yet still share spectral features common to the progenitor stem cells. (ncsu.edu)

A hypothesis formed: if the membrane can successfully initiate the regeneration process, perhaps there are unknown factors in the synovial fluid that may interfere with the healing process. (forbes.com)
first collected synovial fluid from osteoarthritis patients, and then separated the cells from the fluid. (forbes.com)

More attention has been paid to the importance of the cell membrane with the research of Bruce Lipton , developmental biologist. (thrivewellcenter.com)

Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
However, the effective clinical translation of AFCs based ap-proaches requires in vitro culture expansion to achieve a sufﬁcient number of cells and strict characterization of the cultures, two factors that may severely hamper their clinical use[5]. (123dok.org)

The cells also have potential medical applications, especially in organ regeneration. (wikipedia.org)
Regenerative medicine is an interdisciplinary field that applies engineering and life science principles to promote regeneration and healing. (dallasvitality360.com)
Stem cells find the damaged tissue and have the potential to initiate repair or regeneration. (dallasvitality360.com)
Thisﬁnding represents an initial but crucial evidence for considering AFCs derived EVs as new potential sources for tissue regeneration. (123dok.org)
These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)

The development of a 2D nanosheet 1,000 times smaller than a strand of hair could advance cancer treatment and regenerative medicine, say researchers. (futurity.org)
The researchers demonstrated that cancer cells treated with a nanosheet and light are not able to move freely, which is good news. (futurity.org)
Researchers have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses. (sciencedaily.com)
Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses. (sciencedaily.com)
After confirming the regenerative potential of LECs in animal models, the researchers developed a novel minimally invasive surgery method that preserves the integrity of the lens capsule -- a membrane that helps give the lens its required shape to function -- and a way to stimulate LECs to grow and form a new lens with vision. (sciencedaily.com)
It meets the needs of beginners in organ-on-chip cell culture research and advanced organ-on-chip researchers looking for automation and reproducibility. (fluigent.com)
By delivering a high dose of purified exomes, researchers can recruit numerous cells and pathways to help heal the tissue back to its original state. (mayoclinic.org)
The latest synthetic and chemical reagents offer researchers more flexibility, stability, and consistency when working with their cells. (the-scientist.com)

In addition, elamipretide may also have therapeutic potential when it comes to preventing damage resulting from the oxidative stress and neuroinflammation known to contribute to PND. (stemedix.com)
Despite the high expectation of therapeutic potential, the lack of knowledge of in vivo behavior of EVs is a major drawback. (biomedcentral.com)

Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
For stem cells, that would mean determining what kind of cell they will be, such as muscle, bone, etc. (futurity.org)

Amniotic membrane transplantation has emerged as a key component of ocular surface reconstructions. (researchandmarkets.com)

Hematopoietic stem cells from cord blood: limited replicative capacity. (biocellcenter.it)
These are the amniotic membrane and the chorionic villi, which can now be banked in addition to cord blood and cord tissue. (parentsguidecordblood.org)
We are very excited to present Susana Cantero Peral, MD PhD, from the Mayo Clinic, who will give a lecture titled "Cord Blood Derived Mononuclear Cells for the Treatment of Hypoplastic Left Heart Syndrome. (parentsguidecordblood.org)

Scientific papers published between 2000 and 2016 were selected through PUBMED (Public Medicine) and LILACS (Latin American and Caribbean Health Sciences) databases. (bvsalud.org)

Wu, Y. and Zhao, R.C. (2012) The Role of Chemokines in Mesenchymal Stem Cell Homing to the Myocardium. (scirp.org)
Fehrer, C. and Lepperdinger, G. (2005) Mesenchymal Stem Cell Aging. (scirp.org)
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. (nature.com)
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (nature.com)

At around the same time, it was determined that stem cells from the amniotic membrane also have multipotent potential. (wikipedia.org)
In addition to fully differentiated cells, precursors and multipotent stem like cells have been described within AF[3]. (123dok.org)

Their effects were elicited by modulating inflammation, angiogenesis, cell proliferation and matrix synthesis. (bvsalud.org)
In fact, when mitochondrial inhibitory factor-1 (IF1), a natural inhibitor of ATP hydrolysis, is ectopically expressed in hPSCs, stem cell proliferation is slowed and viability compromised. (ca.gov)
Confocal microscopy and hASC proliferation data confirmed the presence of viable cells after 2 weeks in culture on all scaffolds. (ncsu.edu)

discuss the choice between initiation of either process, and how mitochondrial DNA packaging into nucleoids controls its accessibility and function in human cells. (nature.com)
Responsible for generating the energy required for cells to complete their normal and required functions, large scale or systematic mitochondrial dysfunction, when left untreated often results in low energy, cell damage, and eventually cell death. (stemedix.com)
Protected the hippocampus against LPS-induced mitochondrial dysfunction by maintaining appropriate levels of mitochondrial membrane potential (MMP) and adenosine triphosphate assay (ATP). (stemedix.com)
Our data shows that the mitochondrial electron transport chain complexes are assembled and functional and show that they are quantitatively equivalent in amount and functional potential to normal human dermal fibroblasts (NHDFs). (ca.gov)
To maintain viability through support of the mitochondrial membrane potential, hPSCs, unlike NHDFs, hydrolyze glycolytic ATP in the mitochondrial electron transport chain complex V, also called the F1F0 ATP synthase. (ca.gov)

Thus, understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human applications. (techscience.com)
Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
The effects of quantum dots (QD) on cell viability have gained increasing interest due to many recent developments utilizing QD for pharmaceutical and biomedical applications. (ncsu.edu)
Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)

Microfluidic chips can now use geometries and structures to permit the use of physiological length scales, concentration gradients, and the mechanical forces generated by fluid flow to mimic the in vivo microenvironment experienced by cells. (fluigent.com)
2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
The responding samples to H4, displayed increased expression of myeloid markers, a clear decrease in the nuclear-cytoplasmic ratio and the potential of re-activation of the monocytic transcriptional program reducing leukemia propagation in vivo. (lu.se)

As a trade-off, they have had to come up with ways to bypass a cell's internal immune system, navigate the complicated, busy environment of the cell cytoplasm, and ultimately escape that environment to infect other cells-becoming tiny maestros of manipulation in the process. (the-scientist.com)

Regenerative medicine brings promise to redefine medical treatment of acute organ injuries and degenerative human diseases. (techscience.com)
The miRNAs are transported to the recipient cells and regulate the signaling pathways of the recipient cells, thus playing a regulatory role in the progression of diseases. (bvsalud.org)
Regenerative medicine is one of the fastest growing biomedical industries in the world because patients are being cured of diseases that were once incurable. (forbes.com)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)

Results: there are five main sources of stem cells of dental origin: stem cells from dental pulp of permanent teeth and deciduous teeth, apical papilla, periodontal ligament and dental follicle. (bvsalud.org)

This report uses 40-nm colloidal gold nanoparticles to create volumes of surface-enhanced Raman scattering (SERS) within living human-adipose-derived adult stem cells enabling molecular information to be monitored. (ncsu.edu)

Other molecules enter/exit the cell by using channels and pumps. (thrivewellcenter.com)
By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)

Collagen-PCL Sheath-Core Bicomponent Electrospun Scaffolds Increase Osteogenic Differentiation and Calcium Accretion of Human Adipose-Derived Stem Cells. (ncsu.edu)
In Situ Monitoring of Adipogenesis with Human-Adipose-Derived Stem Cells Using Surface-Enhanced Raman Spectroscopy. (ncsu.edu)
We exploit this method to spectroscopically observe chemical changes that occur during the adipogenic differentiation of human-adipose-derived stem cells over a period of 22 days. (ncsu.edu)

She was particularly interested in the Golgi apparatus, a cluster of membrane-bound compartments that help coordinate this trafficking, and spent much of her time manipulating the organelle's activity to try to better understand how it works. (the-scientist.com)

In this chapter, we first describe the biogenesis of EVs, through which molecular information can be passed onto EVs, thereby enabling EVs as disease biomarkers, as well as elaborate on the potential use of EV biomarkers for disease diagnosis. (rsc.org)
Quaini and Olshankii's mathematical and computational expertise at UH's College of Natural Sciences and Mathematics will pair with Majd's research of molecular processes across biological membranes. (uh.edu)
A molecular signature makes it possible to trace the details of hair cell replacement in the mammalian inner ear. (the-scientist.com)

In addition, in vitro cultured AECs derived from the reflected area demonstrate the highest clonogenic capacity, whereas those from the intermediate area show the highest osteogenic potential, when induced to osteogenic differentiation. (fupress.net)

Abstract Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined function. (techscience.com)

Anatomy51

Organisms11

Diseases1

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes59

Disciplines and Occupations20

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture16

Humanities4

Information Science3

Health Care1

Therapies15

Exosomes34

Embryonic15

MSCs19

Extracellular14

Plasma membrane1

Differentiation potential6

Stromal cells2

Therapy21

Tissues14

Therapeutics1

Placenta10

Anti-inflammatory2

Exosome7

Cellular22

Proteins9

Wharton's Jelly3

Biology5

Tissue Engineering6

Differentiate8

Treatments9

Translational2

Scaffold4

Lipid2

Amniotic fluid10

Progenitor6

Synovial fluid2

Developmental1

Clinical Translation2

Regeneration5

Researchers8

Therapeutic potential2

Bone2

Transplantation1

Cord blood3

20161

Mesenchymal stem4

Multipotent2

Proliferation3

Mitochondrial5

Applications4

Vivo3

Cell's1

Diseases4

Dental pulp1

Adult stem1

Molecules2

Adipose-Derived Stem Cells3

Compartments1

Molecular3

Osteogenic differentiation1

Abstract1