AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, Agriculture
Bone RegenerationRegenerationBone and BonesGuided Tissue RegenerationBone SubstitutesOsteogenesisNerve RegenerationLiver RegenerationBone RemodelingTissue ScaffoldsX-Ray MicrotomographyCalcium PhosphatesBone Morphogenetic Protein 2SkullBone DensityBone MatrixBone DiseasesBiocompatible MaterialsTissue EngineeringParietal BoneOsteoblastsPlatelet-Rich PlasmaBone TransplantationBone Marrow CellsDurapatiteBone DevelopmentGuided Tissue Regeneration, PeriodontalAbsorbable ImplantsBone ResorptionImplants, ExperimentalBone MarrowMesenchymal Stromal CellsFracture HealingBone Morphogenetic ProteinsOsseointegrationCalcification, PhysiologicMandibleFemurBone NeoplasmsOsteogenesis, DistractionCell DifferentiationWound HealingPeriosteumPorosityAlveolar Bone LossAlkaline PhosphataseNanofibersNanocompositesCalcium SulfateBone Morphogenetic Protein 7Dental ImplantsBone CementsHematoceleMaxillary SinusCeramicsMaterials TestingSkull FracturesMandibular InjuriesPolyglycolic AcidMandibular OsteotomyMandibular FracturesBony CallusGelatinBone Marrow TransplantationFractures, BoneDental Implantation, EndosseousCore Binding Factor Alpha 1 SubunitTibiaStem CellsMicroscopy, Electron, ScanningMesenchymal Stem Cell TransplantationCell ProliferationAlveolar ProcessApatitesSilkSilicone ElastomersCells, CulturedPolyestersHydrogelsMandibular NeoplasmsTooth SocketChitosanRicinusDental ImplantationOsteocytesBiomimetic MaterialsNephroblastoma Overexpressed ProteinTime FactorsAlginatesMembranes, ArtificialPlanariansHepatectomyTitaniumFemoral FracturesModels, AnimalHydrogelOsteocalcinSiloxanesAlveolar Ridge AugmentationBone Diseases, Metabolic
Field of regenerative medicineBiomaterialsMesenchymal stemTherapiesScaffoldsClinicalMedicineApproaches2021DefectsAdvancesMusculoskeletalLimbCartilage2023GraftsPromote bone regenerationEnhance bone regenerationDentistryDamaged or diseasedExtracellular matrix componentsStem cellTherapyGraftImplantScaffoldMembranes2019DefectMarrow transplantAdiposeInduceRegenerateBiomaterialDonorInjuriesSalamandersProcessesStimulate boneTreatmentsMatricesMorphogeneticStrategiesCellsPotentialFacilitateRepairResearchMSCsOrthopedicProceduresTraumaCardiovascular
Field of regenerative medicine3
  • In this article, we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives. (techscience.com)
  • Our multidisciplinary Tissue Engineering & Innovation Technology MRes offers you the opportunity to undertake research in a rapidly evolving field of regenerative medicine with new developments in tissue engineering, biomaterials, bone substitutes, 3D printing for customised implants and prostheses, imaging, dental restoratives and drug delivery. (findamasters.com)
  • Salamanders have a unique ability to regenerate their limbs and have shown resistance to cancer in previous studies, making them a fascinating animal species for researchers in the field of regenerative medicine. (lu.se)
Biomaterials5
  • Over the past 30 years, he has explored the use of biodegradable polymeric and ceramic materials for use in bone repair, focusing on poly(ester), poly(anhydride) and poly(phosphazene) biomaterials alone or in combination with hydroxyapatite, a naturally occurring mineral, and other ceramics to form two- and three-dimensional (2D, 3D) matrices. (odtmag.com)
  • iii Studies demonstrated that unique polymer systems, which have superior lab and animal studies performance, excellent physicochemical properties and unique erosion mechanisms, representing a major paradigm shift in biomaterials design for regenerative engineering. (odtmag.com)
  • To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
  • Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
  • Her research is focused on developing biomaterials and harnessing their potential for tissue regeneration. (southampton.ac.uk)
Mesenchymal stem6
  • Thus, the strategy of functionalization of nanofibers by nanoreservoirs of BMP-2 or BMP-7 showed a great efficiency for bone regeneration and increased the differentiation of MSCs (mesenchymal stem cells), accelerating the tissue regeneration in vivo [ 9 , 10 , 13 , 14 ]. (hindawi.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
  • We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • The therapy uses mesenchymal stem cells from your own bone marrow and fat to prompt regeneration. (gaia.com)
Therapies13
  • Regenerative medicine therapies can have goals of both healing damaged tissues and forming new tissue. (plasticsurgery.org)
  • While many clinicians and scientists across all fields of medicine have been involved in regenerative medicine research and clinical advances over the last two decades, plastic surgeons have been especially instrumental in moving new therapies into the clinical arena and having a leadership role in new scientific discoveries. (plasticsurgery.org)
  • Regenerative therapies are being developed using energy-based devices, such as laser and intense pulsed light, to improve the healing of scars. (plasticsurgery.org)
  • The Center for Regenerative Biotherapeutics is developing regenerative cellular therapies for more than a dozen conditions. (mayo.edu)
  • Current approaches of regenerative therapies constitute strategies for bone tissue reparation and engineering, especially in the context of genetical diseases with skeletal defects. (hindawi.com)
  • In contrast to BMP2, the novel ability of NELL-1 to stimulate bone growth and repress the formation of fat may highlight new treatment approaches for osteoporosis and other therapies for bone loss," Soo said. (uclahealth.org)
  • When Will Dentists Be Able to Use Regenerative Therapies? (frontiersin.org)
  • In dentistry, regenerative therapies are often thought of as a future, rather than a current, modality. (frontiersin.org)
  • However, dentists have been using regenerative therapies for decades, one example being vital pulp therapy. (frontiersin.org)
  • For instance, oral surgeons, periodontists, and implantologists have used bone grafting and guided tissue regeneration (GTR) therapies, well-validated techniques that use biocompatible scaffolds to aid tissue regeneration, for many years ( 3 ). (frontiersin.org)
  • Moreover, although less well-evidenced, regenerative endodontic therapies, which aim to revitalize the damaged dental pulp, have now to some extent been clinically translated and have been used by many endodontists and pediatric dentists worldwide ( 4 ). (frontiersin.org)
  • Advances in regenerative dentistry research over recent years have seen whole tooth bioengineering and the use of dental stem cells in a wide array of promising therapies. (frontiersin.org)
  • As a PhD student you will be associated to the Berlin-Brandenburg School of Regenerative Therapies (www.bsrt.de) and benefit from the interaction with international students. (esbiomech.org)
Scaffolds7
  • These different nanofiber scaffolds with nanoreservoirs are efficient proregenerative biomimicking implants for bone regeneration. (hindawi.com)
  • Electrospun Scaffolds in Tendons Regeneration: a review. (chop.edu)
  • Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
  • To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
  • Our general aim is to study methods to induce bone regeneration following fractures and severe trauma to bone using scaffolds, cells and growth factors. (rambam.org.il)
  • A PhD position is available within the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin) on the topic of computational optimization of scaffolds to promote bone regeneration within large bone defects. (esbiomech.org)
  • The aim of this project is to investigate the potential optimization of scaffolds to promote bone regeneration within large bone defects. (esbiomech.org)
Clinical16
  • A three-stage continuum in the Center for Regenerative Biotherapeutics that represents basic science research (discovery), the movement of those laboratory findings into clinical trials and testing (translation), and their introduction into patient care (application). (mayo.edu)
  • The clinical purpose of these methods is the reparation or guided regeneration of damaged tissue, in our case, jaw bone affected by genetical diseases. (hindawi.com)
  • Clinical Applications of Bone Tissue Engineering in Orthopaedic Trauma. (chop.edu)
  • In a study just published in Inflammation and Regeneration , Japanese researchers have developed a technique for improving bone regeneration over large areas in rats-;and their findings may translate well to clinical settings. (news-medical.net)
  • The use of combinations of RNA coated in polyplex nanomicelles is potentially an effective, low-risk technique for improving bone repair in humans and has many promising clinical applications. (news-medical.net)
  • However, conflicting results indicate the clinical use of β-TCP for bone repair remains questionable in several specific experiment models. (frontiersin.org)
  • A UCLA research team has found a combination of proteins that could significantly improve clinical bone restoration. (uclahealth.org)
  • Our results suggest that deer have an application in clinical bone repair," the authors wrote in the study's conclusion. (fieldandstream.com)
  • Regenerative medicine can be regarded as a multidisciplinary field encompassing molecular biology, genetics, tissue engineering, and nanotechnology that has been successfully integrated into different clinical disciplines over the last 20 years. (frontiersin.org)
  • The Zigdon lab (Bone Regeneration Lab) is located at the Clinical Research Institute at Rambam (CRIR). (rambam.org.il)
  • Another form of cell therapy currently undergoing clinical trials involves harvesting stem and regenerative cells from adipose tissue. (axiomtek.com)
  • Aslan checked these clinical facts experimentally (5), the research showed Gerovital-H3 ® to have regenerative effects on the liver tissue, bone marrow and it shortened the time required by bone knitting after experimental fractures in rats (5). (antiaging-systems.com)
  • The pioneering technology, known as SonoHeal, was developed at Cedars-Sinai to address a clinical need for biological tissue regeneration approaches to healing. (cedars-sinai.edu)
  • The NU group led by Sam Stupp is currently seeking FDA approval to enter clinical trials using nanomaterials to assist in spinal (vertebrate) regeneration in humans. (chicagobiomedicalconsortium.org)
  • Expanded polytetrafluoroethylene (e-PTFE) membranes have been the standard materials for clinical treatment with guided bone regeneration (GBR), achieving good results when used as mechanical barriers covering sites of extraction e- PTFE is a polymer with high stability in biological systems, which provides better tissue organization, infection resistance and no induction of inflammatory reactions 1 . (bvsalud.org)
  • Despite the glimmer of hope provided by the discovery and commercialization of bone morphogenetic protein-2 (BMP-2) as a bone graft substitute, side effects related to the use of supraphysiological doses have hindered its clinical usage. (lu.se)
Medicine26
Approaches5
  • Regenerative dentistry focuses on the regeneration of soft and hard tissues by incorporating tissue engineering approaches. (frontiersin.org)
  • More recently, clinicians have used other regenerative approaches. (frontiersin.org)
  • Dr. Sarit Bhaduri is pursuing several externally funded research projects in this area, like the innovative approaches to the treatment of osteoporotic bone. (utoledo.edu)
  • The main goal of Dr. Jayasuriya's research is to develop new approaches for regeneration of damaged or diseased human bone tissues. (utoledo.edu)
  • They offer unprecedented opportunities to develop new regenerative strategies and therapeutic approaches for debilitating conditions, previously considered untreatable. (iitk.ac.in)
20211
  • Now, as 3D printing bone and other tissues becomes more commonplace, Dr. Laurencin is being honored for his work, having been named the 2021 Kappa Delta Ann Doner Vaughn Award recipient. (odtmag.com)
Defects18
  • In vivo implantation of polycaprolactone (PCL) biomembrane functionalized with BMP-2/Ibuprofen in mouse maxillary defects was followed by bone neoformation kinetics evaluation using microcomputed tomography. (hindawi.com)
  • The research showed that the use of a matrix system could facilitate bone regeneration, providing a framework which osteoblasts (cells that form new bone) may bind its extracellular matrix (ECM) and bridge bone defects. (odtmag.com)
  • Healing of large bone defects. (aofoundation.org)
  • The findings may be a big step toward developing effective therapeutic treatments for bone skeletal defects, bone loss and osteoporosis. (uclahealth.org)
  • Current treatments for bone skeletal defects utilize bone morphogenetic protein-2, or BMP2, an FDA-approved bone-healing protein. (uclahealth.org)
  • Before this study, large bone defects in patients were difficult to treat with BMP2 or other existing products available to surgeons," Ting said. (uclahealth.org)
  • The combination of NELL-1 and BMP2 may be particularly valuable for healing local bone defects in people who have osteoporosis or for those taking medications, such as steroids, that can inhibit bone growth. (uclahealth.org)
  • The researchers' findings have potential to help millions who suffer from osteoporosis and other bone defects. (uclahealth.org)
  • During her PhD, she focused on enhancing macrophage recruitment to defects and modulating the macrophage phenotype by drug delivery to accelerate the tissue regeneration process. (southampton.ac.uk)
  • Natural bovine cancellous substitute for efficient regeneration and augmentation of bone defects. (nobelbiocare.com)
  • Although bone has the fascinating ability to self-regenerate after injury, large bone defects often lead to delayed or non-unions. (esbiomech.org)
  • Because of the central location of maxillary and mandibular bones, bony defects can result in changes in physiological processes, such as breathing and mastication, and psycho-social functions, including speech and self-confidence, affected by esthetics of the face. (termedia.pl)
  • Bone regeneration is required to treat these defects, provide support for dental implants, jaw reconstruction after cystic lesion removal, cleft repair, etc. [3, 4]. (termedia.pl)
  • Several methods are widely used to treat bony defects, from filling it with bone matrices to grafting bones to induce or help skeletal defects to regenerate [5]. (termedia.pl)
  • Bone grafts are proven to be the most effective method of restoring bony jaw defects caused by a disease or invasive treatment. (termedia.pl)
  • Vascularized bone-graft are generally used to treat defects bigger than 6 cm because of their perceived benefit of lower resorption rate and higher success rate [8]. (termedia.pl)
  • Platelet-rich fibrin is a second-generation platelet concentrate, showing a substantial regenerative property with minimal to no inflammatory reactions upon application in defects [10]. (termedia.pl)
  • 11 (1988) was the first to demonstrate that bone defects created on mandibles of rats can be healed successfully using GBR procedures. (bvsalud.org)
Advances2
  • This Special Issue will focus on the new techniques and advances in guided bone regeneration. (mdpi.com)
  • thus, clinicians and researchers are required to keep abreast of advances in evidence-based regenerative materials. (frontiersin.org)
Musculoskeletal2
  • Regenerative rehabilitation of the musculoskeletal system. (chop.edu)
  • Cato T. Laurencin, M.D., Ph.D., founded the field of musculoskeletal regenerative engineering more than three decades ago. (odtmag.com)
Limb4
  • The vertebrate limb contains various tissue types including bone, skin, nerves, muscle and blood vessels. (tu-dresden.de)
  • Our main goal is to understand how individual tissues respond to an injury to further understand their interaction during axolotl limb regeneration. (tu-dresden.de)
  • Specifically, the project will focus on the potential application of SonoHeal to address a major trauma surgery challenge: extremity bone injuries so severe that they often lead to limb amputation. (cedars-sinai.edu)
  • After doing a PhD in Immunology, I felt I needed to jump headfirst into the field of regeneration and that limb regeneration was almost as interesting as antler regeneration, but I could have a lab was manipulating the system experimentally. (lu.se)
Cartilage3
  • Several therapeutic applications are developed in the field of bone and cartilage defect treatments, based on the osteoinductive and osteoconductive properties of these materials but also on the intrinsic physiological regenerative properties of bone [ 3 ]. (hindawi.com)
  • Adipose tissue is a rich source of regenerative cells that can transform into various types of cells, including muscle, bone, fat, cartilage and nerve cells. (axiomtek.com)
  • The superior osteoinductive properties of BMP-2/7 are a consequence of its direct positive effect on progenitor cell homing at the implantation site, which consequently leads to upregulation of cartilage and bone related genes and biochemical markers. (lu.se)
20231
  • According to a research paper published on February 24, 2023, the results could one day be adapted to heal bone injuries and regrow lost limbs. (fieldandstream.com)
Grafts2
  • From our very first product creos™ xenoprotect to our latest release -creos™ syntoprotect- our extensive range of bone grafts and barrier membranes for bone and soft tissue regeneration is waiting for you! (nobelbiocare.com)
  • Autogenous bone grafts are bone transplantation using bone with a donor site from the same individual, with or without vascularization [6, 7]. (termedia.pl)
Promote bone regeneration1
Enhance bone regeneration1
Dentistry2
  • Dr. Ting and his research team have made a very valuable discovery for the field of bone regeneration," said Dr. No-Hee Park, dean of the UCLA School of Dentistry. (uclahealth.org)
  • In dentistry, GBR is commonly understood as a surgical technique to improve bone defect in a particular region through new bone formation. (bvsalud.org)
Damaged or diseased1
Extracellular matrix components1
  • Further evaluation of the molecular mechanisms responsible for this increased osteoinductivity at an early stage in the regeneration process indicated that the CHA+BMP-2/7 enhanced progenitor cell homing at the implantation site, upregulated the key transcriptomic determinants of bone formation, and increased the production of bone extracellular matrix components. (lu.se)
Stem cell5
  • A type of stem cell found in organs of the body that can be used for regenerative interventions. (mayo.edu)
  • Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
  • The study showed that NELL-1 works by activating the cellular signaling pathway that regulates whether a stem cell differentiates into a bone cell or a fat cell. (uclahealth.org)
  • Once they'd isolated stem cell populations with the most potency and potential for regenerative effects, they started inserting those cells directly into the heads of their test mice. (fieldandstream.com)
  • You will explore techniques in cellular and molecular regeneration, particularly stem cell and gene delivery. (findamasters.com)
Therapy4
  • One of the most significant breakthroughs in regenerative therapy for wound healing has been the use of negative pressure devices. (plasticsurgery.org)
  • MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
  • Vital pulp therapy was first introduced in the 17th century, and it relies on the regenerative and reparative capabilities of the tooth ( 2 ). (frontiersin.org)
  • Dr. Adelson shares his own journey of recovering from injury and pain with the help of regenerative therapy, and bringing these treatments to his patients. (gaia.com)
Graft3
  • Each year, more than 2 million bone graft procedures worldwide are performed. (odtmag.com)
  • Biomimetic bone graft substitute for efficient regeneration. (nobelbiocare.com)
  • Therefore, the development of methods to improve the regenerative potential of non-vascularized bone graft (NVBG) are currently on the rise [6]. (termedia.pl)
Implant2
  • Bone regeneration using electrospun nanofibers' implant has the following objectives: bone neoformation induction with rapid healing, reduced postoperative complications, and improvement of bone tissue quality. (hindawi.com)
  • a positive immune response can lead to successful biointegration of the implant and (for orthopedic implants) bone remodeling. (medscape.com)
Scaffold4
  • For example, you may examine bone repair and replacement through techniques such as scaffold production. (findamasters.com)
  • The growth of new bone within the scaffold is influenced by many factors, such as the scaffold architecture, material properties, patient health condition, etc. (esbiomech.org)
  • You will simulate the interaction of the bone regeneration process with scaffold-support structures and develop algorithms for the computer optimization of the scaffold design to promote the bone healing process. (esbiomech.org)
  • Incorporation of hydroxyapatite (HA) in a collagen scaffold dramatically improves bone morphogenic protein (BMP) sequestration via biophysical interactions with BMP, thereby providing more controlled BMP release compared with pristine collagen. (lu.se)
Membranes1
  • e-PTFE membranes are used as mechanical barriers to protect the blood clot and allow bone cells to be selected to repopulate the bone defect, preventing the epithelial tissue to migrate into the defect 1 . (bvsalud.org)
20191
Defect3
  • In this approach, 3D open porous structures are implanted in the bone defect with the aim to support bone regeneration. (esbiomech.org)
  • The project is part of a research collaboration between several Institutes on the topic of "Personalised Bone Defect Treatment" (Funded by the BMBF). (esbiomech.org)
  • However, care should be taken during placement because exposure of the membrane during the healing of the bone defect can lead to significant a decrease in bone tissue regeneration 9 . (bvsalud.org)
Marrow transplant1
  • An example of one of these processes is a bone marrow transplant, which requires harvesting healthy red blood cells from the spongy tissue inside a donor's bones and transferring them into a patient's bloodstream. (axiomtek.com)
Adipose4
  • There are a couple benefits of using adipose tissue as a source of regenerative cells as opposed to bone marrow. (axiomtek.com)
  • Instead of receiving the cells from a bone marrow donor, Adipose-Derived Regenerative Cells (ADRCs) can be harvested from the same patient who is being treated. (axiomtek.com)
  • The adipose tissue is collected from the patient through a minimally invasive surgery and yields more regenerative cells compared to ones derived from bone marrow. (axiomtek.com)
  • These machines can be used to safely and efficiently extract and separate the regenerative cells from the adipose tissue. (axiomtek.com)
Induce4
  • But the high concentrations needed to induce human bone formation may have serious side effects, including life-threatening cervical swelling and abnormal and inconsistent bone growth. (uclahealth.org)
  • It also showed that BMP2 can induce non-bone cells to form bone, with the potential risk for ectopic bone growth - bone formation in undesirable locations. (uclahealth.org)
  • NELL-1, when given systemically, does not appear to induce ectopic bone. (uclahealth.org)
  • In contrast, because of its known capacity to induce unwanted bone, BMP2 may not be as appropriate for systemic administration. (uclahealth.org)
Regenerate4
  • Although bones have the ability to regenerate and repair themselves, they are generally unable to do so when the injury is larger than a small break or chip. (news-medical.net)
  • Recent studies from our laboratory demonstrated the efficacy of EPCs to regenerate bone in a critical-size gap in rodents and large animal models. (rambam.org.il)
  • Yin is using zebrafish to study the regeneration of heart tissue because of the amazing capacity of these common aquarium fish to regenerate the form and function of almost any body part, including heart, bone, skin and blood vessels, regardless of their age. (lifeboat.com)
  • Cedars-Sinai and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health have agreed to collaborate on testing a technology designed to help the body regenerate bone to repair severe fractures. (cedars-sinai.edu)
Biomaterial3
  • ii The matrices are biodegradable and designed so that, over time, the osteoblasts secrete ECM, allowing the biomaterial to be completely absorbed and only regenerated bone remains. (odtmag.com)
  • The study shows how the passivated nanocarbon based biomaterial assists muscle regeneration, and could be of potential use in addressing other muscle disorders including muscular dystrophy. (iitk.ac.in)
  • It is possible to find different techniques using physical barriers 2-7 and the characteristics of the biomaterial and the design of the membrane used in guided tissue regeneration play an important role in obtaining good results 8 . (bvsalud.org)
Donor1
  • Autografts are the gold standard for use in bone regeneration, but they have limitations in terms of donor site morbidity for harvesting and supply,' said Dr. Laurencin. (odtmag.com)
Injuries3
  • While in the Army, Hale recognized the need for advanced regenerative repair for extreme facial injuries. (wikipedia.org)
  • Given that large bone injuries can be difficult to repair in the clinic, the findings of this study bring new hope to patients. (news-medical.net)
  • In earlier research led by the Cedars-Sinai team, severe bone injuries in laboratory animals were successfully repaired using this technique. (cedars-sinai.edu)
Salamanders1
  • In this edition, we turn our spotlight to Nicholas Leigh, a distinguished fellow in Regenerative Immunology specializing in Salamanders, a species known for remarkable tissue regeneration capabilities and extraordinary resistance against cancer. (lu.se)
Processes4
  • The centrum and transverse processes were the first identifi-able features of all different types of bone in the vertebral column to be ossified. (ac.ir)
  • You will develop computer models to simulate the bone healing process and the interaction between mechanical signals (strains) within the healing region and biological processes (e.g. cellular migration, matrix deposition, etc.) taking place. (esbiomech.org)
  • We are focused on characterizing regeneration processes using a simple approach. (lu.se)
  • There are a lot of incredible sequencing technologies now that have let us characterize the regeneration processes at a level that we couldn't have imagined just 10 years ago. (lu.se)
Stimulate bone1
  • Used together, the two proteins stimulate bone production more dramatically than either does alone. (uclahealth.org)
Treatments1
Matrices1
  • The functionalization of these matrices enhances the bone regenerative process. (hindawi.com)
Morphogenetic1
  • Some of our work focused on the fact that we could create engineered materials that are actually inductive, that is, they can foster bone regeneration by themselves without the addition of morphogenetic factors. (odtmag.com)
Strategies2
  • The use of strategies that help body to restore bone are needed to increase the quality life of people suffering this problem. (ibecbarcelona.eu)
  • By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
Cells19
  • The main interest of the use of bone marrow derived stem cells is their osteogenic potential for neoangiogenesis. (hindawi.com)
  • When he started his laboratory at the Massachusetts Institute of Technology, growing human bone cells outside the body had only recently been discovered. (odtmag.com)
  • When I first started my laboratory at the Massachusetts Institute of Technology in 1988, bone was a primary target to study and develop as scientists had just learned how to actually grow human bone cells outside the body,' said Dr. Laurencin, the Albert and Wilda Van Dusen Distinguished Endowed Professor of Orthopaedic Surgery and CEO of the Connecticut Convergence Institute for Translation in Regenerative Engineering at the University of Connecticut. (odtmag.com)
  • Their organic phase, normally a biodegradable biopolymer, holds the mechanical stress while their inorganic phase, a glass or ceramic, provides the needed bioactivity to recruit cells and produce bone. (ibecbarcelona.eu)
  • They first demonstrated that the combination of these two RNAs led to a better regenerative response in bone cells than each RNA alone. (news-medical.net)
  • They found that the combination of the two proteins increased bone formation while inhibiting the formation of fat cells - a negative side effect of BMP2, which encourages stem cells to form both bone and fat cells. (uclahealth.org)
  • By contrast, NELL-1 encourages stem cells to form bone cells instead of fat cells. (uclahealth.org)
  • The two proteins complement each other in that BMP2 helps to turn non-bone cells into bone-forming cells, and NELL-1 then increases the bone-forming ability of bone cells. (uclahealth.org)
  • Red blood cells (RBC) are produced in the bone marrow. (ivis.org)
  • Effete red cells are phagocytized and metabolized by the macrophages of spleen, bone marrow, and liver. (ivis.org)
  • Currently our research expanded to investigate the mechanism of EPCs in bone and blood vessel formation and to analyze the phenotype and genotype of these cells. (rambam.org.il)
  • This smart device is required to be closed and automated in order to retrieve the patient's regenerative cells and safely process the tissues. (axiomtek.com)
  • Regarding the regeneration of cells, I recall Schedel's experiment with procaine injections around a wound (10). (antiaging-systems.com)
  • The histologic examination of the wound revealed the appearance of the granulation tissue after a 3-week treatment along with the accumulation of the so-called "regeneration cells" around many vessels (see figure 2 over). (antiaging-systems.com)
  • The MDI Biological Laboratory has announced new discoveries about the mechanisms underlying the regeneration of heart tissue by Assistant Professor Voot P. Yin, Ph.D., which raise hope that drugs can be identified to help the body grow muscle cells and remove scar tissue, important steps in the regeneration of heart tissue. (lifeboat.com)
  • Platelets are cells derived from the bone marrow containing or producing several biomolecules, such as platelet-derived growth factors (PDGF), interleukin 1, platelet-derived endothelial growth factors, basic fibroblast growth factor, transforming growth factors (TGF-1 and TGF-2), and vascular endothelial growth factors. (termedia.pl)
  • Therefore, the aim of GBR to exclude soft tissue with the use of barriers in such a way that only bone cells populate the region to be regenerated. (bvsalud.org)
  • First, we investigate what is going on during regeneration, mainly by looking at cells and how they are behaving. (lu.se)
  • Then we work to either remove these cells or modify their behavior and see if that affects regeneration. (lu.se)
Potential5
  • Our long-term goal is to build an understanding of regeneration, alternating between an organism with high regenerative potential and one with very limited regeneration. (tu-dresden.de)
  • These disadvantages can result in complications and the development of a bone substitute materials offers a potential alternative to overcome these shortcomings. (frontiersin.org)
  • Shark teeth were first studied in the 18th century ( 17 ), which prompted a series of studies to understand the mechanism behind their regenerative potential. (frontiersin.org)
  • Under another federal grant, awarded in 2018, the Cedars-Sinai team is investigating potential applications of SonoHeal to tissues besides bone. (cedars-sinai.edu)
  • The effect of adjunct PRF in bone grafting is currently being studied to understand its' potential. (termedia.pl)
Facilitate2
  • This will facilitate bridging our discoveries from the axolotl into viable mammalian therapeutics that can impact human regeneration. (tu-dresden.de)
  • They facilitate molecular transportation, cell repair, and regeneration and provide mechanical and structural support to the bones and skin . (organicfacts.net)
Repair4
  • Dr. Laurencin's work has led to the development and advancement of biodegradable polymeric materials in bone repair and tissue regeneration. (odtmag.com)
  • After an injury these tissues respond to a plethora of signals driving repair and, in few animal species, regeneration. (tu-dresden.de)
  • As most of us know from experience, bones can repair themselves after a minor break or fracture, leaving us as good as new. (news-medical.net)
  • Although there are many different ways to improve bone repair over larger areas in animal models, very few techniques translate well into the clinic. (news-medical.net)
Research3
  • A research team from Tokyo Medical and Dental University (TMDU) decided to tackle this challenge using vascular endothelial growth factor (VEGF), which improves regeneration of the blood circulatory system, and Runt-related transcription factor 2 (Runx2), which is important for bone regeneration. (news-medical.net)
  • The same research team has conducted other studies on bone growth, including one that utilized a protein called NELL-1, which successfully increased bone formation and stimulated key factors for bone growth in multiple preclinical models. (uclahealth.org)
  • In this paper, we review the mechanisms of the regenerative and anti-inflammatory capacity of SCs and exosomes in incurable gynecological diseases and the current progress in their application in genetic engineering to provide a foundation for further research. (bvsalud.org)
MSCs1
  • However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
Orthopedic1
  • Large bone loss as a result of trauma, tumor removal, infection, and developmental congenital disorders, often leads to delayed healing or non-union, and remains a critical challenge for orthopedic surgeons. (frontiersin.org)
Procedures3
  • With creos™ regenerative product line, Nobel Biocare offers you and your patients safe and reliable solutions for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. (nobelbiocare.com)
  • Case reports have shown significant results of adding platelet-rich fibrin to bone grafting procedures for bone regeneration in sinus augmentation, cleft reconstruction, and fistula management [11, 12]. (termedia.pl)
  • Periodontal regeneration and bone ridge restoration using physical barriers are well-established procedures in reconstructive surgery. (bvsalud.org)
Trauma1
  • Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. (frontiersin.org)
Cardiovascular2