Metastatic castration-resistant prostateChemical castrationProstateSymbolicallyPenisPsychoanalysisAnxietyTesticlesAndrogen deprivationPatientsResistantMalesPsychoanalyticCanineDisavowalOne'sTherapyTreatmentsThreatSurgicalTestosteronePerson'sMaleEmasculationInfectionGenderRequireTermLeadWomanSurgeryOperationLifeResultHouseKindIdeaHumanSexual desireBack
Metastatic castration-resistant prostate11
- The results from a phase II trial of sipuleucel-T with or without radium-223 in patients with metastatic castration-resistant prostate cancer were recently published with intriguing findings. (nature.com)
- Randomized phase II trial of sipuleucel-T with or without radium-223 in men with bone-metastatic castration-resistant prostate cancer. (nature.com)
- Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. (nature.com)
- Final analysis of the ipilimumab versus placebo following radiotherapy phase III trial in postdocetaxel metastatic castration-resistant prostate cancer identifies an excess of long-term survivors. (nature.com)
- A systematic review of the emerging role of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: will combination strategies improve efficacy? (nature.com)
- NEW YORK, November 13, 2023 - Pfizer Inc. (NYSE: PFE) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion for TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide), for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated. (pfizer.com)
- ERLEADA ® has shown a statistically significant improvement in OS with a consistent safety profile in both approved indications of mCSPC (TITAN) and non-metastatic castration-resistant prostate cancer or nmCRPC (SPARTAN). (jnj.com)
- Patients with non-metastatic castration-resistant prostate cancer (CRPC) who were treated with enzalutamide plus androgen deprivation therapy (ADT) had significantly improved metastasis-free survival compared with those treated with ADT only according to final results from a multinational, randomized Phase III clinical trial. (northwestern.edu)
- Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
- In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
- Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). (cdc.gov)
Chemical castration5
- Carlson also lied that trans youth are undergoing "genital mutilation and chemical castration. (mediamatters.org)
- He also repeatedly and falsely referred to such treatments as "chemical castration," a popular myth pushed by right-wing and anti-LGBTQ media. (mediamatters.org)
- Campaigners use this term to lump together outdated and harmful practices - like electro-shock and aversive therapies, chemical castration and even 'corrective rape' - with conversational therapies. (christianconcern.com)
- The other more likely option, however, is chemical castration: injecting synthetic LH-RH agonists (blocks an action) or antagonists (stimulates an action) into the body every three months to suppress the natural production of testosterone. (bcm.edu)
- Poland on Friday approved a law making chemical castration mandatory for pedophiles in some cases, sparking criticism from human rights groups. (blogspot.com)
Prostate15
- Cancers that develop resistance to androgen deprivation therapy are referred to as castration-resistant prostate cancer (CRPC). (medicalnewstoday.com)
- Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. (nature.com)
- Sipuleucel-T immunotherapy for castration-resistant prostate cancer. (nature.com)
- RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
- Castration-resistant prostate cancer (CRPC) refers to the subset of men whose prostate cancer progresses despite hormone therapy. (northwestern.edu)
- Referred to as complete androgen blockade, or CAB, this treatment choice combines an orchiectomy or LH-RH antagonist with anti-androgens, drugs that block the effects of adrenal gland hormones by influencing a receptor in the nucleus of the prostate cancer cell. (bcm.edu)
- The global castration-resistant Prostate Cancer market is expected to register a robust revenue CAGR over the forecasted period due to increased burden of prostate cancer. (reportsanddata.com)
- An advanced form of prostate cancer that no longer responds to hormone therapy is referred to as castrate-resistant prostate cancer. (reportsanddata.com)
- Castration-resistant prostate cancer no longer responds to hormone therapy. (reportsanddata.com)
- Expansion of the castration-sensitive prostate cancer market in the upcoming years will be influenced by a number of variables, including increased R&D initiatives and surge in research into prostate cancer treatment options. (reportsanddata.com)
- Additionally, the market for castration-sensitive prostate cancer will be directly driven by medication innovation, advances in genetics and proteomics , label extension within prostate cancer, and other factors. (reportsanddata.com)
- Moreover, rise in awareness for this illness will a major factor in expansion of the castration-sensitive prostate cancer market. (reportsanddata.com)
- Patients' resistance to expensive treatments, clinical trial failure rates, high proportion of treatment-related side effects, prolonged treatment duration, and lack of awareness in developing nations are all factors that are predicted to restrain growth of the castration-resistant prostate cancer market. (reportsanddata.com)
- Growing focus on "patient-centric" care is anticipated to foster innovation regarding efficient drugs and therapies, rise in pharmaceutical spending by emerging markets, and technological breakthroughs creating a plethora of opportunities, revolutionize technological advancements in research & development, and increase in clinical studies contribute to growth of the global castration-resistant prostate cancer market over the forecast period. (reportsanddata.com)
- Furthermore, the market for castration-resistant prostate cancer experienced quickest growth over the projected period due to rising demand for novel treatments, favorable reimbursement policies, and rising per capita disposable income. (reportsanddata.com)
Symbolically2
- Castration anxiety can also refer to being castrated symbolically. (wikipedia.org)
- According to some dreambooks, castration symbolically warns of loss of respect or reflects the fear of impotence. (checkmydream.com)
Penis7
- Castration anxiety is an overwhelming fear of damage to, or loss of, the penis-a derivative of Sigmund Freud's theory of the castration complex, one of his earliest psychoanalytic theories. (wikipedia.org)
- In Freud's theory, it is the child's perception of anatomical difference (the possession of a penis) that induces castration anxiety as a result of an assumed paternal threat made in response to their sexual proclivities. (wikipedia.org)
- A man who pleads for castration and amputation of his penis may arouse, on an unconscious level, significant anxiety in male psychiatrists. (health.am)
- Canine priapism refers to continuous canine penis erection. (dog-health-guide.org)
- Canine balantis refers to inflammation of the dog penis head. (dog-health-guide.org)
- This condition refers to inflammation of the canine penis head and the internal layer of the prepuce (canine foreskin). (dog-health-guide.org)
- He seems to imply it means a human born with a penis, but there is a broad spectrum of genitalia that could be subjected to castration. (stackexchange.com)
Psychoanalysis4
- In Freudian psychoanalysis, castration anxiety (Kastrationsangst) refers to an unconscious fear of penile loss that originates during the phallic stage of psychosexual development and continues into adulthood. (wikipedia.org)
- According to Freudian psychoanalysis, castration anxiety can be completely overwhelming to the individual, often breaching other aspects of his or her life. (wikipedia.org)
- There are no female fetishists, either for Freud or Lacan, for to speak of female fetishism would involve displacing the basic precepts of psychoanalysis -- namely the scene of castration leading to phallic fetishism. (cis-india.org)
- Freud is best known for his theories of the unconscious mind and the defense mechanism of repression, and for creating the clinical practice of psychoanalysis for treating psychopathology through dialogue between a patient, technically referred to as an "analysand", and a psychoanalyst. (crystalinks.com)
Anxiety10
- Freud regarded castration anxiety as a universal human experience. (wikipedia.org)
- Although typically associated with males, castration anxiety is thought to be experienced, in differing ways, by both sexes. (wikipedia.org)
- In the literal sense, castration anxiety refers to a child's fear of having their genitalia disfigured or removed as punishment for Oedipal desire. (wikipedia.org)
- Symbolic castration anxiety refers to the fear of being degraded, dominated or made insignificant, usually an irrational fear where the person will go to extreme lengths to save their pride and/or perceives trivial things as being degrading making their anxiety restrictive and sometimes damaging. (wikipedia.org)
- This can also tie in with literal castration anxiety in fearing the loss of virility or sexual dominance. (wikipedia.org)
- citation needed] A link has been found between castration anxiety and fear of death. (wikipedia.org)
- Essentially, castration anxiety can lead to a fear of death, and a feeling of loss of control over one's life. (wikipedia.org)
- This will lead to the fear associated with bodily injury in castration anxiety, which can then lead to the fear of dying or being killed. (wikipedia.org)
- Themes central to castration anxiety that feature prominently in circumcision include pain, fear, loss of control (with the child's forced restraint, and in the psychological effects of the event, which may include sensation seeking, and lower emotional stability) and the perception that the event is a form of punishment. (wikipedia.org)
- Also McClintock points to racist, nationalistic and patriotic fetishes -- such as flags, crowns, maps, swastikas (or for instance chaddis) -- that can't be simply rendered equivalent to the disavowal of male castration anxiety. (cis-india.org)
Testicles2
- Castration is referred to as "neutering" because the reproductive organs (testicles) are removed. (speakingforspot.com)
- So, it makes sense that castration (removal of both testicles) reduces testosterone production to almost nil. (speakingforspot.com)
Androgen deprivation1
- Androgen deprivation is usually achieved by either surgery or medication, in what is commonly referred to as monotherapy, because one method is used. (bcm.edu)
Patients2
- The author has not had any cases of requests for reversal, suicidality after SRS, or postoperative psychosis in any patients referred over a 20-year span. (health.am)
- Based on these data, ADT alone should no longer be considered sufficient for patients with advanced, castration-sensitive disease. (jnj.com)
Resistant1
- Furthermore, after a mean time of 13-19 months, some men become castration resistant and no longer respond to ADT. (gla.ac.uk)
Males2
- For example, the claim is ' Biological males that were castrated at birth and raised as females often still identify and act like males ' , which clearly refers to the ' biological males ' as being ' raised as females ' after castration, not being females after castration. (stackexchange.com)
- Still, you seem to think that he's defining males as people with penises, even though he's clearly referring to males who don't have penises. (stackexchange.com)
Psychoanalytic1
- Psychoanalytic theory often refers to one's "highly prized sexual organs" (Brenner 1974) and the cathexis of libidinal energy. (health.am)
Canine2
- and, as we learn more and more about the impacts of traditional canine neutering (castration), vasectomy surgery is becoming increasingly popular. (speakingforspot.com)
- Dog posthitis refers to inflammation of the prepuce (canine foreskin inflammation). (dog-health-guide.org)
Disavowal1
- the other one, whose paradigm is fetishism, refers to a specific sintomatology which is produced by the disavowal of castration. (bvsalud.org)
One's1
- In a broad sense, castration analogues include fears of losing something, for example, a thing that is seen as a phallic symbol, a fear of sharing one's ideas. (checkmydream.com)
Therapy2
- The trial was double-blinded, meaning participants and doctors don't know which therapy is received until the trial is over, creating less bias, and placebo-controlled, which refers to a group of participants receiving a treatment that has no active properties. (wkrn.com)
- Core Issues is accused by LGBT activists of practising 'conversion therapy' - a misleading term referring to attempts to change sexual orientation. (christianconcern.com)
Treatments1
- ADT refers to the treatments that aim to reduce the effects of testosterone and other androgens by surgically or chemically preventing their production. (gla.ac.uk)
Threat1
- Soon, Brittany took her story - "I think that children should not be allowed to make these life-changing decisions at such a young age," she said - to Tucker Carlson's Fox News show, where the right-wing host invoked the threat of unchecked castration and called Morris a "lunatic" and a "country music person who I hope leaves country music immediately. (latimes.com)
Surgical1
- Dreams in which the surgical removal of any part of our body takes place reflect our fears about puberty and castration. (checkmydream.com)
Testosterone1
- If ever you become unhappy with the role testosterone is playing in your vasectomized dog's life (he's humping everything in sight, he's jumping the fence to be with the neighbor's dog who is in heat), you can always opt for castration at a later date. (speakingforspot.com)
Person's2
- However, in that decade certain sexologists decided to use the term "gender" to refer to the inner experience of a person's sexual identity. (hli.org)
- It also refers to a person's sense of personal and social identity based on those attractions, related behaviors, and membership in a community of others with similar attractions and behaviors. (msdmanuals.com)
Male5
- Indeed, shortly after the SfW rally in Brighton, the same force made a spectacle of itself by referring to a trans-identified male paedophile as a woman on social media. (spiked-online.com)
- As for Psychoanalytical dreambook , it gives the following explanations of dreams about castration: it can mean conflict between male and female personalities. (checkmydream.com)
- Each novel's concern with the theme of white male authorship appears intentionalist, since both Adichie and Jones employ self-reflexivity, referring to their own writing, vis-à-vis the central white author character in the formulation of a final statement about authorial rights. (lu.se)
- sex refers especially to the physical and biologic traits that are physically evident at birth and is often captured in the phrases "assigned male at birth" (AMAB) and "assigned female at birth" (AFAB). (msdmanuals.com)
- Infection with HIV is the effects of male castration on longevi- men, which is similar to patterns of strongest known risk factor for dis- ty (3). (cdc.gov)
Emasculation2
- The term refers to the fear of emasculation in both a literal and metaphorical sense. (wikipedia.org)
- All it takes is some joke about castration, or some kind of emasculation, and I find it really hard to not masturbate over these concepts, and destroy all the owrk I've put in thinking about normal images. (agony-aunt.com)
Infection1
- This condition refers to a dog yeast infection. (dog-health-guide.org)
Gender2
- Up to the 1950's, the term "gender" was used in the European languages to refer to things, not to persons. (hli.org)
- Some refer to themselves as nonbinary with respect to their gender identity and/or role. (msdmanuals.com)
Require2
- The bad news is that it will require castration. (basicjokes.com)
- As these procedures usually require general anesthesia, please refer to our anesthesia service for more information. (vcahospitals.com)
Term2
- It is rather a term that has been invented to refer to the sexual identity a person claims he or she experiences interiorly, independently of his or her biological sex. (hli.org)
- [13] In addition to referring to sky and heaven and to Anu, the same sign could also be read as dingir or ilu , the generic term "god" in, respectively, Sumerian and Akkadian. (wikipedia.org)
Lead1
- But the political neutrality Bach invokes must not lead to self-castration. (playthegame.org)
Woman3
- James Pennington conducted the home castration on a transgender woman in Denver, Colorado. (ibtimes.co.uk)
- As recently as 1998, one psychiatrist discussed her countertransference difficulties in using the proper pronouns to refer to a patient with GID who had already undergone "vaginoplasty as a young man and had since been living as a woman" (Quinodoz 1998, p. 95) . (health.am)
- Neutering in a dream can also indicate fear of responsibility, fear of confrontation with real life, fear of being defeated by others, especially in competition for a woman, and, ultimately, fear of castration refers to impotence in old age. (checkmydream.com)
Surgery2
- Castration tends to be a "bigger deal" surgery in that the incisions are larger and there is more overall tissue trauma. (speakingforspot.com)
- It referred to the sex-reassignment surgery that Green's 16-year-old son underwent in Thailand as a castration. (spiked-online.com)
Operation1
- A dream in which you observe a castration operation in men portends love affairs in search of a man who could fully satisfy you sexually. (checkmydream.com)
Life1
- Dreams about castration can also be indicative of other kinds of power struggles in your life. (checkmydream.com)
Result1
- An obsession with castration could be the result of shame and guilt and a conviction that what you are doing is sinful or dangerous. (agony-aunt.com)
House2
- We refer to "la casa" ("the house") as feminine or to "el lápiz" ("the pencil") as masculine. (hli.org)
- Did CNN perform your castration in house or did they refer you to a specialist? (twitchy.com)
Kind1
- Therefore I don't think protection of human rights should refer to these kind of events," Tusk also said. (blogspot.com)
Idea1
- Transgenderism refers to the idea that there are persons whose inner experience of their own sexual identity does not coincide with their biological sex. (hli.org)
Human1
- After singer and "The Voice" winner Cassadee Pope condemned Brittany's statement on Twitter, Morris replied to Pope, referring to Brittany as "Insurrection Barbie" and writing, "It's so easy to, like, not be a scumbag human? (latimes.com)
Sexual desire1
- I can only think about one thing- the possibility of castration- and that's the only object of my sexual desire. (agony-aunt.com)
Back2
- Resolution 14 -New Policy on Sheep and Goat Castration This resolution was referred back to Board of Directors for further consideration by the Animal Welfare Committee. (wsvma.org)
- Washington voted in favor of referring this back to the Animal Welfare Committee. (wsvma.org)