• protein
  • HAP40-associated mitochondrial dysfunction is associated with reduction of adhesion regulating molecule 1 (ADRM1) protein. (ijbs.com)
  • In previous papers, it has been shown that K-ras transformed mouse cells are much more sensitive as compared with normal cells to glucose withdrawal (undergoing apoptosis) and present a high glycolytic rate and a strong reduction of mitochondrial complex I. Recent observations suggest that transformed cells have a derangement in the cyclic adenosine monophosphate/cAMP-dependent protein kinase (cAMP/PKA) pathway, which is known to regulate several mitochondrial functions. (uniba.it)
  • Here, we performed comparative polysome and associated transcriptional profiling analyses to study the dynamics and functional implications of endoplasmic reticulum (ER)-associated protein synthesis in the mouse liver under conditions of obesity and nutrient deprivation. (harvard.edu)
  • We discovered that ER from livers of obese mice exhibits a general reduction in protein synthesis, and comprehensive analysis of polysome-bound transcripts revealed extensive down-regulation of protein synthesis machinery, mitochondrial components, and bile acid metabolism in the obese translatome. (harvard.edu)
  • This electron flow changes the redox state of the protein, inducing conformational changes of the protein which alters the pK values of ionizable side chain, and causes four hydrogen ions to be pumped out of the mitochondrial matrix. (wikipedia.org)
  • The high reduction potential of the N2 cluster and the relative proximity of the other clusters in the chain enable efficient electron transfer over long distance in the protein (with transfer rates from NADH to N2 iron-sulfur cluster of about 100 μs). (wikipedia.org)
  • ROS generated via pharmacologic activation of the mitochondrial potassium-sensitive ATP channel (mitoK(ATP)) and the endogenous G-protein coupled receptor ligand, apelin. (wikipedia.org)
  • It forms a heterodimeric complex with its cellular target protein (HBX interacting protein: HBXIP), and this interaction dysregulates centrosome dynamics and mitotic spindle formation. (wikipedia.org)
  • membranes
  • Some derivatives that were designed to penetrate mitochondrial cell membranes (SkQ1 (plastoquinonyl-decyl-triphenylphosphonium), SkQR1 (the rhodamine-containing analog of SkQ1), SkQ3) have anti-oxidant and protonophore activity. (wikipedia.org)
  • sparrows
  • 1994). Survival and growth of nestling Vesper Sparrows exposed to experimental food reductions. (wikipedia.org)
  • The chromosomes of Italian sparrows are distinct from those of the house sparrow, but mitochondrial DNA suggest a close relation to the house sparrow. (wikipedia.org)
  • cellular
  • We thus examined markers for macroautophagy, chaperone-mediated autophagy (CMA), mitochondrial quality control, as well as cellular metabolites in skeletal and cardiac muscle from young (5 months old) and aged (27 months old) mice. (readbyqxmd.com)
  • INSL3 causes a reduction in cellular proliferation, increases cellular motility in FTC-133 and downregulates transcripts for the inhibitory transcription factor Id-2H. (uni-halle.de)
  • Short-time treatment with compounds favoring mitochondrial fusion strongly decreased the cellular ROS levels especially in transformed cells. (uniba.it)
  • They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. (wikipedia.org)
  • apoptosis
  • These findings support the notion that glucose shortage-induced apoptosis, specific of K-ras-transformed cells, is associated to a derangement of PKA signaling that leads to mitochondrial complex I decrease, reduction of ATP formation, prevalence of mitochondrial fission over fusion, and thereby opening new approaches for development of anticancer drugs. (uniba.it)
  • mtDNA
  • Originally believed to be a rare phenomenon, heteroplasmy - the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual - is emerging as an important component of eukaryotic genetic diversity. (biomedcentral.com)
  • Genomic DNA was extracted from frozen muscle specimens, and the mitochondrial DNA (mtDNA) content was quantified by real-time PCR. (bmj.com)
  • vivo
  • In vivo, a reduction in insulin gene expression due to reduced Pdx-1 binding has been observed in rats perifused with glucose and intralipids ( 11 , 12 ). (diabetesjournals.org)
  • neuronal
  • Whereas reductions in Sod2 would be expected to trigger or exacerbate neuronal and vascular pathology in AD, increasing Sod2 activity might be of therapeutic benefit. (jneurosci.org)
  • oxidation
  • In step 6 of the citric acid cycle, SQR catalyzes the oxidation of succinate to fumarate with the reduction of ubiquinone to ubiquinol. (wikipedia.org)
  • antioxidant
  • SkQ1 has been proposed as an anti-aging treatment, with the possible reduction of age-related vision issues due to its antioxidant ability. (wikipedia.org)
  • pathway
  • Herein, the derangement of the cAMP/PKA pathway and its impact on transformation-linked changes of mitochondrial functions is investigated. (uniba.it)
  • actin
  • Proteomic and mass spectrometry analysis reveales an increase of cofilin, a molecule participating in actin filament dynamics. (uni-halle.de)
  • cardiac
  • Here we show that mitochondrial size and number in cardiomyocytes is significantly reduced, and this condition associates with a low mitochondrial fusion marker in the cardiac tissue of non-responders with idiopathic dilated cardiomyopathy (IDCM). (ahajournals.org)
  • It has been demonstrated that altering the dynamics of the RACK2 and RACK1 interaction with PKCε can influence cardiac muscle phenotypes. (wikipedia.org)
  • Assembly
  • Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Mitochondrial Assembly and Dynamics in Health, Disease and Aging. (bio-medicine.org)
  • The 2013 Conference on Mitochondrial Assembly and Dynamics in Health, Disease and Aging is a timely and unique scientific conference, where diverse aspects of mitochondrial biology and dysfunction are explored through formal talks, poster sessions, and intensive scientific discussion. (bio-medicine.org)
  • cell
  • In fact, there has been shown to be a correlation between mitochondrial activities and programmed cell death (PCD) during somatic embryo development. (wikipedia.org)