Reduction ventricular function left. Medical search. Frequent questions

The pathophysiological mechanisms underlying preserved left ventricular (LV) ejection fraction (EF) in patients with heart failure and preserved ejection fraction (HFpEF) remain incompletely understood. (frontiersin.org)
Among patients hospitalized for an HF incident, 47% had HF with preserved ejection fraction (HFpEF) or systolic function, which is the focus of this paper. (frontiersin.org)
They also showed significant improvement in left ventricular ejection fraction, diastolic function and exercise capacity. (trustedhealthproducts.com)
The reconstructed SPECT images were analyzed to calculate global MPS defect size and regional defect size for 3 coronary artery territories-left anterior descending, left circumflex, and right-as well as left ventricular (LV) volume and ejection fraction. (snmjournals.org)
For patients with normal MPS results, there were no differences in defect size, LV volume, or ejection fraction, regardless of whether 50% or 75% reduction was used. (snmjournals.org)
The LV end-diastolic and end-systolic volumes and LV ejection fraction were not significantly different, regardless of whether 50% or 75% dose reduction was used. (snmjournals.org)
one can speak equally of the left ventricular ejection fraction (LVEF) and the right ventricular ejection fraction (RVEF). (wikidoc.org)
Without a qualifier, the term ejection fraction refers specifically to that of the left ventricle. (wikidoc.org)
Right ventricular volumes being roughly equal to those of the left ventricle, the ejection fraction of the right ventricle is normally equal to that of the left ventricle within narrow limits. (wikidoc.org)
This reduction in the ejection fraction can manifest itself clinically as heart failure . (wikidoc.org)
WS 1442 is safe in patients with more severe congestive heart failure and left ventricular ejection fraction lower than 35 percent," said Dr. Holubarsch of Median Kliniken Hospitals in Bad Krozingen, Germany, and lead study author. (sciencedaily.com)
The results of these trials suggest that AF ablation has beneficial effects on all-cause mortality, hospitalisation for heart failure, improvement of left ventricular ejection fraction, quality of life, and functional capacity. (touchcardio.com)
For purposes of this measure, LVSD is defined as chart documentation of a left ventricular ejection fraction (LVEF) less than 40% or a narrative description of left ventricular systolic (LVS) function consistent with moderate or severe systolic dysfunction. (jointcommission.org)
Beta-blocker therapy has been recommended for the treatment of patients with heart failure and reduced left ventricular ejection fraction (LVEF) since the 1970 s (HFSA, 2010). (jointcommission.org)

Late arrhythmia in adults with the Mustard procedure for transposition of great arteries: a surrogate marker for right ventricular dysfunction? (bmj.com)
Surgical repair of pulmonary outflow obstruction often involves patching the right ventricular outflow tract and resecting the obstructing right ventricular muscle. (medscape.com)
Frequently, the conus branch of the RCA is large and supplies a significant portion of the right ventricular infundibular muscle. (medscape.com)
Right ventricular failure and its complications are late-stage sequelae. (cdc.gov)

The computational results simulating the effects of transmural alterations in the ventricular tissue replicate the phenotypic patterns of LV dysfunction observed in clinical practice. (frontiersin.org)
Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial fibrosis, which corresponds to the failure of cardiac tissue remodeling. (nature.com)
Left ventricular remodeling after acute myocardial infarction (MI) is a complex pathological process producing alterations in topography of both the infarcted and non-infarcted regions of the ventricle leading to progressive dilatation and systolic dysfunction (2). (escardio.org)
Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. (biomedcentral.com)
Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes. (biomedcentral.com)
Heart failure (HF) is a syndrome of ventricular dysfunction. (msdmanuals.com)
Mitral regurgitation is related to posterior papillary muscle dysfunction.Additionally, the sudden onset of cardiac symptoms accompanied by deterioration of left ventricular function in young DMD patients already on treatment with a prednisone derivate, that postpones the development of DMD cardiomyopathy, should raise the suspicion of possible myocarditis (3). (escardio.org)
IR has been associated with increased cardiac mass, fibrosis, and mitochondrial dysfunction which attenuate diastolic function. (thoracickey.com)
Conclusions-Early and long-term nonselective β-blockade was associated with adverse left ventricular remodeling, systolic dysfunction, and a reduction in survival in the experimental rat model of organic MR. (elsevierpure.com)
The severity of symptomatic exercise limitation varies between patients with CHF and appears to be unrelated to the extent of left ventricular systolic dysfunction at rest. (biomedcentral.com)
The reason for fatigue in CHF has been more readily attributed to persistent vasoconstrictor drive, endothelial dysfunction, and a wide range of structural and functional abnormalities of skeletal muscle than to ventricular dysfunction per se [ 1 ]. (biomedcentral.com)
This review focuses on the evidence for training as a therapeutic option in patients with stable symptomatic CHF and refers specifically to studies on post-infarct left ventricular dysfunction or selective muscle training where necessary. (biomedcentral.com)

[ 1 ] In this report, Muller and Danimann described palliation by the "creation of pulmonary stenosis" in a 5-month-old infant who had a large ventricular septal defect (VSD) and pulmonary overcirculation. (medscape.com)
[ 12 ] Consider placing an IABP in patients with cardiogenic shock who have acute mitral regurgitation or a ventricular septal defect, as well as select patients with severe cardiogenic shock when other MCS devices are unavailable. (medscape.com)
Ostium secundum atrial septal defect of 1.1 cm with left to right shunt, great vessels side to side, the pulmonary artery located to the right and aorta to the left. (scirp.org)

Urine albumin/creatinine ratio and echocardiographic left ventricular structure and function in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. (nih.gov)
The urine albumin/creatinine ratio (UACR) and echocardiographic measures of LV structure and function were obtained in 833 patients with stage I to III hypertension and LV hypertrophy determined by electrocardiogram (ECG) (Cornell voltage-duration or Sokolow-Lyon voltage criteria) after 14 days of placebo treatment. (nih.gov)
In a normal heart that is exposed to long term increased cardiac output requirements, for example, that of an athlete, there is an adaptive process of slight ventricular dilation and muscle myocyte hypertrophy. (justia.com)
In a normal heart, the adaptation of muscle hypertrophy (thickening) and ventricular dilatation maintain a fairly constant wall tension for systolic contraction. (justia.com)
In particular, statins reduce ischemic heart disease, improve endothelial function, reduce pro-inflammatory cytokines, reduce left ventricular hypertrophy and adverse remodeling, and slow/arrest atherosclerotic process. (eurekaselect.com)
Additional autopsy findings included coronary artery disease, cardiomegaly (enlarged heart), and left ventricular hypertrophy (LVH). (cdc.gov)

Acceleration of ventricular rate and/or ventricular fibrillation has been reported in patients with atrial flutter or atrial fibrillation and a coexisting accessory AV pathway following administration of verapamil. (drugs.com)
Other procedures discussed in this review are the percutaneous left atrial appendage closure as a non-pharmacologic therapy to prevent strokes, and renal denervation for resistant hypertension. (bmj.com)
Other important developments are the percutaneous treatment options for mitral regurgitation (MR) (MitraClip), non-pharmacologic therapy to prevent cerebral embolisation in patients with atrial fibrillation (AF) such as left atrial appendage (LAA) closure and closure of the patent foramen ovale, and renal denervation to treat resistant hypertension. (bmj.com)
The post-transplantation estimated glomerular filtration rate (eGFR) was directly correlated with left ventricular (LV) systolic function and inversely correlated with LV dimensions, LV wall thickness, left atrial diameter, and estimated systolic pulmonary arterial pressure. (ima.org.il)
Atrial fibrillation, flutter and ventricular premature complexes can also be found. (escardio.org)
To understand why, we will compare the function of individual human right atrial and left ventricular cardiac cells (cardiomyocytes) from coronary bypass patients who have diabetes and those who do not. (otago.ac.nz)
While complex fractionated atrial electrograms and linear lesions have been abandoned as a consequence of the STAR AF II (Substrate and Trigger Ablation for Reduction of Atrial Fibrillation Trial-Part II) results, 4 the ablation of fibrotic areas, posterior wall isolation, and the ablation of non-pulmonary vein triggers show more promising results. (touchcardio.com)

We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-γ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)

2 Echocardiography is recommended for the subset of patients at high risk for the development of serious ventricular arrhythmias or SCD, such as those with dilated, hypertrophic, or RV cardiomyopathies, AMI survivors, or relatives of patients with inherited disorders associated with SCD. (wikidoc.org)
These carefully selected patients could exercise without serious ventricular arrhythmias and had no other medical condition that limited their exercise tolerance. (biomedcentral.com)

The terminal event is often a cardiac arrhythmia, either ventricular tachycardia deteriorating to ventricular fibrillation or extreme bradycardic arrest. (medscape.com)

Pigs that developed ventricular fibrillation had shorter QT intervals than survivors of either group. (diabetesjournals.org)
Acute treatment with troglitazone increases susceptibility to ventricular fibrillation during myocardial ischemia and reperfusion. (diabetesjournals.org)

Dipyridamole is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease Dipyridamole has been shown to lower pulmonary hypertension without significant drop of systemic blood pressure It inhibits formation of pro-inflammatory cytokines (MCP-1, MMP-9) in vitro and results in reduction of hsCRP[clarification needed] in patients. (wikipedia.org)
This technique was widely used in the past as an initial surgical intervention for infants born with cardiac defects characterized by left-to-right shunting and pulmonary overcirculation. (medscape.com)
Congenital heart defects with left-to-right shunting and unrestricted pulmonary blood flow (PBF) due to a drop in pulmonary vascular resistance result in pulmonary overcirculation. (medscape.com)
Although not necessary for the diagnosis of cardiogenic shock, invasive monitoring with a pulmonary artery catheter may be helpful in guiding fluid resuscitation in situations in which left ventricular (LV) preload is difficult to determine. (medscape.com)
In contrast, in patients with preserved kidney function, there was a significant reduction in both LV diameter and arterial pulmonary systolic pressure. (ima.org.il)
A reduction in the anteroposterior chest dimensions is usually responsible for a systolic impulse displaced to the left sternal border, a grade 1-3/6 short mid-systolic murmur in the second left interspace and a loud pulmonary component of the second heart sound. (escardio.org)
We present a rare case of an adult woman with L-TGA associated with Ebstein's anomaly, left superior vena cava and pulmonary hypertension diagnosed by non-invasive imaging and computed tomography. (scirp.org)
The flow in this vessel, which has its distribution over the left ventricular myocardium, is retrograde to the main pulmonary artery. (medscape.com)
The most common anomaly (4% of patients) is the origin of the left anterior descending (LAD) coronary artery from the right coronary artery (RCA), which then courses across the pulmonary outflow tract. (medscape.com)
Patients with beryllium disease who have abnormal or deteriorating pulmonary functions are usually treated with prednisone. (cdc.gov)
1999). Before initiating corticosteroid therapy, a baseline chest radiograph, high resolution CT, complete pulmonary function tests (including lung volumes, spirometry, and diffusing capacity), and exercise testing, with arterial blood gas measurements, should be performed. (cdc.gov)

Preload represents the degree of end-diastolic fiber stretch and end-diastolic volume, which is influenced by ventricular diastolic pressure and the composition of the myocardial wall. (msdmanuals.com)
Typically, left ventricular (LV) end-diastolic pressure, especially if higher than normal, is a reasonable measure of preload. (msdmanuals.com)
Clinically, preload is defined in several ways including left ventricular end diastolic pressure (LVEDP), or left ventricular end diastolic volume (LVEDV). (justia.com)

More recently, PAB has played a role in the preparation and "training" of the left ventricle (LV) in patients with dextro-transposition of the great arteries (d-TGA) who are evaluated for a delayed arterial switch procedure. (medscape.com)
A reduction of PBF also decreases the total blood volume returning to the LV (or the systemic ventricle) and often improves ventricular function. (medscape.com)
We are using cardiac ultrasound during exercise to determine whether high intensity interval training exercise can improve the function of the diabetic left ventricle and 'normalise' the response of the diabetic heart to vigorous exercise. (otago.ac.nz)
Similarly, the volume of blood left in a ventricle at the end of contraction is end-systolic volume . (wikidoc.org)
A MUGA scan involves the injection of a radioisotope into the blood and detecting its flow through the left ventricle. (wikidoc.org)
The basic problem with a large dilated left ventricle is that there is a significant increase in wall tension and/or stress both during diastolic filling and during systolic contraction. (justia.com)

Before ischemia, acute troglitazone treatment had no effect on LV function, electrocardiogram, or substrate utilization. (diabetesjournals.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
Although adults acquire coronary artery disease (CAD) from lifelong deposition of atheroma and plaque, which causes coronary artery spasm and thrombosis, children usually have either an acute inflammatory condition of the coronary arteries or an anomalous origin of the left coronary artery (LCA). (medscape.com)

However, results showed reductions of around 20% for the heart failure composite endpoint and for all-cause mortality, with confidence intervals that did not cross 1.0, and directionally consistent effects were observed for all supportive secondary endpoints. (medscape.com)
Therefore, we tested the hypothesis that CFR assessed by transthoracic echocardiography is associated with LV diastolic function in patients with type 2 diabetes without a history of heart failure. (biomedcentral.com)
These changes in heart function occur early on in the progression of diabetes, putting patients with diabetes at increased risk of cardiovascular disease and heart failure. (otago.ac.nz)
A total of 2,681 patients with markedly impaired left ventricular function -- indicating advanced congestive heart failure -- were randomized to WS®1442 or placebo for a duration of two years. (sciencedaily.com)
Heart failure may be considered to be the condition in which an abnormality of cardiac function is responsible for the inability of the heart to pump blood at a rate commensurate with the requirements of the metabolizing tissues, or can do so only at an abnormally elevated filling pressure. (justia.com)
There are many specific disease processes that can lead to heart failure with a resulting difference in pathophysiology of the failing heart, such as the dilatation of the left ventricular chamber. (justia.com)
Nitrates, arteriolar vasodilators, angiotensin converting enzyme inhibitors have been used to treat heart failure through the reduction of cardiac workload through the reduction of afterload. (justia.com)

Transthoracic Doppler echocardiography was performed that included pulsed tissue Doppler of the mitral annulus and CFR of the left anterior descending artery (induced by adenosine 0.14 mg/kg/min). (biomedcentral.com)
The ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/e′) was used as a surrogate marker of diastolic function. (biomedcentral.com)

It has been shown to increase myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy. (wikipedia.org)
6 min) is feasible using a hybrid CZT SPECT/CT camera without compromising image quality or significantly altering quantification of myocardial perfusion or LV function. (snmjournals.org)
SPECT with 99m Tc-labeled radiotracers has been widely used for the detection of abnormalities of myocardial perfusion and left ventricular (LV) function ( 1 - 9 ). (snmjournals.org)
3 Exercise testing with an imaging modality (echocardiography or nuclear perfusion [single-photon emission computed tomography (SPECT)]) is recommended to detect silent ischemia in patients with ventricular arrhythmias who have an intermediate probability of having CHD by age, symptoms, and gender and in whom ECG assessment is less reliable because of digoxin use, LVH, greater than 1-mm ST-segment depression at rest, WPW syndrome, or LBBB. (wikidoc.org)
4 Pharmacological stress testing with an imaging modality (echocardiography or myocardial perfusion SPECT) is recommended to detect silent ischemia in patients with ventricular arrhythmias who have an intermediate probability of having CHD by age, symptoms, and gender and are physically unable to perform a symptomlimited exercise test. (wikidoc.org)

Albuminuria, reflecting systemic microvascular damage, and left ventricular (LV) geometric abnormalities have both been shown to predict increased cardiovascular morbidity and mortality. (nih.gov)

Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function. (ucsf.edu)
This result suggests a possible link between coronary microvascular disease and LV diastolic function in these subjects. (biomedcentral.com)
For patients with abnormal MPS results, at a 50% reduction there was a significant difference in global defect size but not in regional defect size in the left anterior descending, left circumflex, and right coronary artery territories, whereas at a 75% reduction the difference was statistically significant in all territories, including the difference in global defect size. (snmjournals.org)
The computed tomography corroborated these findings and additionally showed a left superior vena cava and an abnormal origin of the coronary arteries. (scirp.org)

Several large-scale clinical trials have provided unequivocal evidence of important reductions in both morbidity and mortality. (jointcommission.org)

The patients were evaluated in terms of aortic elastic parameters, right and left ventricular systolic and diastolic function using conventional, pulsed Doppler and tissue Doppler imaging (TDI) echocardiographic parameters.Results:Fifteen infants were in the LPC group, 16 in the IVA group, and 20 in the control group. (bvsalud.org)

Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)

The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. (nih.gov)
The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. (nih.gov)

There was no detectable deterioration in left ventricular function in patients included in these studies. (biomedcentral.com)

Airflow obstruction has profound effects on cardiac function and gas exchange with systemic consequences. (ersjournals.com)

In patients with cardiac defects that produce left-to-right shunting, this restriction of PBF reduces the shunt volume and consequently improves both systemic pressure and cardiac output. (medscape.com)

Inotropes like digoxin are cardiac glycosides and function to increase cardiac output by increasing the force and speed of cardiac muscle contraction. (justia.com)

Injection of myoblasts into infarcted myocardium has been shown to augment systolic and diastolic functions in experimental animal studies (7). (escardio.org)
The process of ventricular dilatation is generally the result of chronic volume overload or specific damage to the myocardium. (justia.com)

The earliest sign of obesity cardiomyopathy is impaired left ventricular (LV) diastolic function, which may be evident in obese children and adolescents. (thoracickey.com)

In conclusion, OW youth with IR and inflammation are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature cardiovascular disease in adulthood. (thoracickey.com)
The adverse effects of IR and obesity are further supported by the improvements in diastolic function observed after reductions in weight and IR through lifestyle interventions. (thoracickey.com)
If use is unavoidable, closely monitor for adverse reactions and consider dose reduction of BCRP substrate drug (refer BCRP substrate prescribing information). (medscape.com)

The 'pump function' (a.k.a. contractility) of the diabetic heart is reduced. (otago.ac.nz)

The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and obese (OW) youth and to assess the relative individual contributions of adiposity, IR, and inflammation to alterations in cardiac structure and function. (thoracickey.com)

Our results show that in kidney transplant recipients, allograft function significantly affects cardiac structure and function. (ima.org.il)

The dystophin protein provides a structural link between myocyte cytoskeleton and extracellular matrix functioning to link contractile proteins to the cell membrane. (escardio.org)

The aim of our study was to determine whether obese adolescents had reduced diastolic function and cardiovascular remodeling and whether IR, inflammation, and adipokines were associated with these cardiac changes. (thoracickey.com)

To investigate the relationship between post-transplant kidney function and echocardiographic measures in patients with normal/preserved pre-transplant cardiac structure and function. (ima.org.il)

Studies in obese adolescents and children have shown a relative reduction in diastolic function and altered cardiac geometry. (thoracickey.com)

however, data on cardiac adaptation and its relation to kidney allograft function remain sparse. (ima.org.il)
The patients were evaluated by echocardiography before and after transplantation, and the relation between allograft function and echocardiographic changes was evaluated. (ima.org.il)

All participants said they would recommend the program to other veterans but more importantly - participants with elevated depression scores before the yoga program had a significant reduction in depression symptoms after the eight weeks. (trustedhealthproducts.com)
γ-cameras with solid-state cadmium-zinc-telluride (CZT) detectors have better count sensitivity and spatial resolution than conventional sodium iodine detectors, allowing for significant reductions in radiotracer dose or acquisition time. (snmjournals.org)
Ablation's effect on outcomes was associated, perhaps causally, with significant gains in left ventricular (LV) function and more than triple the reduction in AF burden seen in the control group, noted Dr. Sohns, from the Heart and Diabetes Center North-Rhine Westphalia, Bad Oeynhausen, Germany. (mdedge.com)
Participation in an exercise program was historically considered to be ill-advised for patients with significant left ventricular impairment. (biomedcentral.com)
All HCs induced a reversible reduction of amplitude of electrically induced Ca+2 without significant effects on diastolic Ca+2. (cdc.gov)

We quantified alterations in myocardial function in a mathematical model of the human LV that is based on the finite element method. (frontiersin.org)

Beyond improvement of symptoms and quality of life, several recent studies have demonstrated the prognostic benefit of catheter ablation for certain patient groups including reduced mortality and a reduction in hospitalisation. (touchcardio.com)

Final results of the SELECT trial have shown that the anti-obesity drug semaglutide (Wegovy) produced a consistent reduction of around 20% vs placebo across major cardiovascular event endpoints over the approximately 3-year follow-up in patients with overweight or obesity and cardiovascular disease but not diabetes. (medscape.com)
In diabetes, where it is already established that there is a cardiovascular risk reduction, it is easier to get these drugs reimbursed, he noted. (medscape.com)

Anatomy17

Organisms5

Diseases61

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment101

Phenomena and Processes39

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Health Care27

Ejection14

Right ventricular4

Dysfunction12

Septal defect3

Hypertrophy6

Atrial7

Causing arrhythmias1

Serious ventricular arrhythmias2

Tachycardia1

Fibrillation2

Pulmonary11

Diastolic pressure3

Ventricle6

Acute3

Heart failure7

Mitral2

Perfusion5

Abnormalities1

Coronary4

Morbidity1

Aortic1

Cardiomyocytes2

Peripheral2

Deterioration1

Obstruction1

Systemic1

Contraction1

Myocardium2

Cardiomyopathy1

Adverse3

Contractility1

Doppler1

Significantly1

Myocyte1

Remodeling1

Cardiac structure and function1

Geometry1

Relation2

Significant5

Alterations1

Mortality1

Cardiovascular2