Reductase gene gene encodes alcohol aldehyde dehydrogenase. Medical search. Frequent questions

Alcohol dehydrogenase [NADP+] also known as aldehyde reductase or aldo-keto reductase family 1 member A1 is an enzyme that in humans is encoded by the AKR1A1 gene. (wikipedia.org)
Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. (nih.gov)
Furthermore, the dual role of LuxAB as sensor and monooxygenase, emitting bioluminescence through the oxidation of aldehydes to the corresponding carboxylates, promises implementation in artificial enzyme cascades for the synthesis of carboxylic acids. (tuni.fi)
Product Description specifical Introduction: Alcohol dehydrogenase (ADH) is an enzyme discovered in the mid-1960s in Drosophila melanogaster. (biobool.com)
One of those ions is crucial for the operation of the enzyme: it is located at the catalytic site and holds the hydroxyl group of the alcohol in place. (biobool.com)
NADPH-dependent acetoacetyl-CoA reductase (phaB) is the enzyme which plays an essential role in P(3HB) synthesis by catalyzing the conversion of the intermediates. (bvsalud.org)
Results showed that the cell age of 4 h, induction time of 12 h at 37°C were identified as the optimal conditions for the enzyme reductase expression. (bvsalud.org)
The findings provide an alternative for the synthesis of the reductase enzyme which can be used in the industrial-scale production of the biodegradable polymers. (bvsalud.org)
An enzyme encoding valencene synthase gene ( Cstps1 ) was more abundant in Temple than in Murcott. (biomedcentral.com)

It catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols and catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. (wikipedia.org)
AKR1A1 belongs to the AKR superfamily, which are predominantly monomeric, soluble, NADPH-dependent oxidoreductases involved in the reduction of aldehydes and ketones into primary and secondary alcohols. (wikipedia.org)
Whereas, microorganic synthesis of PAA is impeded by the formation of by-product phenethyl alcohol due to quick, endogenous, and superfluous conversion of aldehydes to their corresponding alcohols, which resulted in less conversation of PAA from aldehydes. (springeropen.com)
In this work, the LuxAB biosensor system from Photorhabdus luminescens was implemented in Escherichia coli to monitor the enzymatic production of aldehydes from primary alcohols and carboxylic acid substrates. (tuni.fi)
Alcohol dehydrogenases are a group of seven dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of NAD+ to NADH. (biobool.com)
Alcohol dehydrogenase is responsible for catalyzing oxidation of primary and secondary alcohols to aldehydes and ketones, respectively, and also can effect the reverse reaction. (biobool.com)
These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)

The enzymatic requirements for EtOH to inhibit RA biosynthesis were studied using inhibitors of the middle-chain alcohol dehydrogenases (ADH), 4-methylpyrazole (4MP), or the short-chain dehydrogenase/reductases, carbenoxolone (CBX) and chloral hydrate (CH). Late blastula stage embryos were treated with EtOH alone or in combination with 4MP (a,b), CH (c,d) or CBX (e,f). (xenbase.org)
FDE genes in this category are from the cytochrome (CYP) P450 family, ATP-binding cassette (ABC) transporter family, short-chain dehydrogenase/reductase (SDR) family, or cinnamyl alcohol dehydrogenase (CAD) family. (afpm.org.my)

The aldo-keto reductase superfamily. (wikipedia.org)
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)

Aldehyde dehydrogenase are a superfamily enzymes which catalyze the oxidation of a large variety of aldehydes (Jo et al. (springeropen.com)
Pharmacological inhibition of the embryonic alcohol dehydrogenase activity, prevents the oxidation of ethanol to acetaldehyde that in turn functions as a RALDH2 inhibitor. (xenbase.org)

This protein belongs to the aldehyde dehydrogenase family of proteins. (nih.gov)
kinase in candida, is an important mitosis regulatory proteins encoded on human being chromosome 20q13.2 that induces oncogenic change followed with centrosome amplification and aneuploidy when over indicated SEMA3E in rodent cells and (6-8). (arcillaresearch.com)
Genes encoding proteins involved in processing of drugs and other xenobiotics. (gsea-msigdb.org)
A combination of methods, including the isobaric tags for relative and absolute quantification (iTRAQ), quantitative real-time polymerase chain reaction, gas chromatography, and high-performance liquid chromatography, was used to identify proteins, measure gene expression levels, volatiles, sugars, organic acids and carotenoids. (biomedcentral.com)
This genome encodes 3,018 proteins, Gata3 of which 222 are annotated as encoding secretome proteins (6) (see http://www.cmbi.ru.nl/lab_secretome for detailed information for the predicted secretome). (cancer-pictures.org)
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)

The application of genetically encoded biosensors enables the detection of small molecules in living cells and has facilitated the characterization of enzymes, their directed evolution and the engineering of (natural) metabolic pathways. (tuni.fi)
We found significant dysregulation of genes encoding drug-metabolizing enzymes and stress response components of the NRF2- mediated oxidative damage pathway, potentially representing key genes in African-American esophageal squamous carcinogenesis. (biomedcentral.com)
Loss of activity of drug metabolizing enzymes would confer increased sensitivity of esophageal cells to xenobiotics, such as alcohol and tobacco smoke, and may account for the high incidence and aggressiveness of ESCC in this ethnic group. (biomedcentral.com)
An analysis of the genome and its transcriptome revealed enzymes with biotechnological potential, such as two extracellular tannases (Atan1p and Atan2p) of the tannic-acid catabolic route, and a new pathway for the assimilation of n-butanol via butyric aldehyde and butyric acid. (biomedcentral.com)

Alda1 is used in treatment for the alcohol flush reaction experienced by people with genetically deficient ALDH2. (alda1agonist.com)

LuxAB was used to screen the substrate scopes of three prokaryotic oxidoreductases: an alcohol dehydrogenase (Pseudomonas putida), a choline oxidase variant (Arthrobacter chlorophenolicus) and a carboxylic acid reductase (Mycobacterium marinum). (tuni.fi)

AKR1A1 belongs to the aldo-keto reductase (AKR) superfamily. (wikipedia.org)

The engineered strain converts glucose to ethanol via acetate and acetaldehyde, catalyzed by the host-encoded aldehyde ferredoxin oxidoreductase AOR and heterologously expressed AdhA, in an energy-conserving, redox-balanced pathway. (brenda-enzymes.info)

Alternative splicing of this gene results in two transcript variants encoding the same protein. (wikipedia.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)

of a 174-kb plasmid that bears a cluster of genes necessary for the synthesis of the polyketide toxin mycolactone. (cdc.gov)
The data includes many genes involved in cell division, cell wall synthesis, and cell differentiation. (afpm.org.my)

AKR1A1 is shown to demonstrate characteristically high specific activity towards many aromatic and aliphatic aldehydes, and preferentially catalyses the NADPH-dependent reduction of aliphatic aldehydes, aromatic aldehydes and biogenic amines. (wikipedia.org)
In this study, an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that does duty for a platform for aromatic aldehyde biosynthesis was used to prompt more PAA biosynthesis. (springeropen.com)
A simple high-throughput assay utilized the bacterial luciferase-previously reported to only accept aliphatic long-chain aldehydes-to detect structurally diverse aldehydes, including aromatic and monoterpene aldehydes. (tuni.fi)
The AOR/AdhA pathway also converts exogenously added aliphatic and aromatic carboxylic acids to the corresponding alcohol using glucose, pyruvate, and/or hydrogen as the source of reductant. (brenda-enzymes.info)

aldehyde oxidase 1 [Source:HGNC Symbol. (gsea-msigdb.org)

carbonyl reductase 1 [Source:HGNC Symb. (gsea-msigdb.org)

During general alcohol metabolism, hepatocytes generate mitochondria- and cytochrome P450 2E1 (CYP2E1)-mediated reactive oxygen species (ROS) whose accumulation elicits activation of the hepatic anti-oxidant system, including glutathione (GSH). (e-cmh.org)
In addition, we address different responses of alcohol metabolism that are specific to hepatic zones ( Fig. 1 ). (e-cmh.org)
The CcpA regulon comprises genes involved in sugar uptake, fermentation and amino acids metabolism, confirming the role of CcpA as a link between carbon and nitrogen pathways. (studyres.com)
Progress in gene isolation related to volatile production has been impeded by the lack of information concerning plant secondary metabolism, with flavor-associated volatiles [ 17 ]. (biomedcentral.com)
In the Kyoto Encyclopedia of Genes and Genomes (KEGG) and KOG analysis, the profile of the FDE transcripts suggest that JA- and LA-treated bark samples have a sufficient molecular basis for secondary laticifer differentiation, especially regarding secondary metabolites metabolism. (afpm.org.my)

Class 1 consists of A,B, and C subunits that are encoded by the genes ADH1A, ADH1B, and ADH1C. (biobool.com)

The pathogenesis in the early stages of ALD, including alcoholic steatosis, also varies with oxidative stress, alcohol metabolite-mediated toxicity, and activation of diverse inflammatory signals. (e-cmh.org)

Orthologs are sequences of genes that evolved from a common ancestor and can be traced evolutionarily through different species. (pharmaceuticalintelligence.com)

We establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine in E. coli with heterologous coexpression of aminotransferase (ARO8), keto acid decarboxylase (KDC) and aldehyde dehydrogenase H (AldH) gene. (springeropen.com)
In this study, we establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine through overexpression of an aminotransferase gene ARO8, a keto acid decarboxylase gene KDC from S. cerevisiae and an aldehyde dehydrogenase H gene aldH from E. coli in E. coli (Fig. 1 ). (springeropen.com)
However, chronic alcohol consumption decreases GSH generation through cysteine deficiency by suppressing the methionine cycle and trans-sulfuration system, whereas it turns on an alternative defense pathway, such as the xCT transporter, to compensate for GSH shortage. (e-cmh.org)
construction of a synthetic pathway for bioalcohol production at 70°C by insertion of the gene for alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. (brenda-enzymes.info)
We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)

The AKR1A1 gene lies on the chromosome location of 1p34.1 and consists of 10 exons. (wikipedia.org)
This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancerindex.org)

The purified ReBDH in the native form was found to exist as a monomer with a calculated subunit size of 37180, belonging to the family of the zinc-containing alcohol dehydrogenases. (mdpi.com)

Furthermore, the C. difficile toxin genes (tcdA and tcdB) and their regulators (tcdR and tcdC) are direct CcpA targets. (studyres.com)

A transcriptome analysis was performed of Saccharomyces cerevisiae undergoing isoamyl alcohol-induced filament formation. (rhea-db.org)

A conserved Hb heme pocket structure facilitates the dioxygenation reaction and efficient turnover is achieved through the univalent reduction of HbFe(III) by associated reductases. (pharmaceuticalintelligence.com)

alpha-ketoisovalerate decarboxylase Kivd from Lactococcus lactis combined with alcohol dehydrogenase Adh3 from Zymomonas mobilis are the optimum candidates for 3-methyl-1-butanol production in Corynebacterium glutamicum. (brenda-enzymes.info)

2016 ). However, aldehyde dehydrogenase involved in the last step to generate PAA has not yet been experimentally characterized and this knowledge gap limits the process development for producing PAA from phenylalanine. (springeropen.com)

Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. (xenbase.org)
Ethanol-dependent retinoic acid inhibition requires middle-chain alcohol dehydrogenases. (xenbase.org)
11]). The silencing effectiveness of the genes ranged between 50% to 80%, aside from ACRBP which demonstrated 40% inhibition (Shape 1A). (bioinf.org)

The GWD gene, which is known to regulate starch phosphorylation-dephosphorylation, participates in the regulation of a number of morphological traits, rather than one specific trait. (peerj.com)
By whole transcriptome analyses, we characterized glucosedependent and CcpA-dependent gene regulation in Clostridium difficile. (studyres.com)
About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. (studyres.com)

Using combination of chromatin immunoprecipitation and genome sequence analysis, we detected 55 CcpA binding sites corresponding to 140 genes directly controlled by CcpA. (studyres.com)
First, the Human Genome Project laid the foundation for modern genetic studies of disease by determining the basic sequence of the 3 billion building blocks (i.e., base pairs) that make up the human genome and by identifying the approximately 25,000 genes included in this sequence ( http://www.ornl.gov/sci/techresources/Human_Genome/home.shtml ). (nih.gov)

in yeast and many bacteria, some alcohol dehydrogenases catalyze the opposite reaction as part of fermentation. (biobool.com)
However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)

Aldo-keto reductase family 1 member B10 (AKR1B10) is an inflammatory regulator and is closely related to the prognosis of patients with GC. (portlandpress.com)

Recent genome-wide association studies, gene expression profiling, DNA methylation and proteomic studies conducted in Japanese and Chinese ESCCs (reviewed in [ 6 ]) have identified multiple risk variants and gene signatures associated with ESCC. (biomedcentral.com)
more recently, however, modern advances in genotyping have resulted in widespread use of genome-wide association studies for alcohol dependence. (nih.gov)
Genome-wide association studies now offer a host of emerging opportunities, as well as challenges, for discovering the genetic etiology of alcohol dependence and for unveiling new treatment strategies. (nih.gov)

Alternative splicing results in multiple transcript variants encoding distinct isoforms. (nih.gov)
Three transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)

The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)

As a broad host range pathogen, M. phaseolina possesses a large number of pathogen-host interaction genes including those for adhesion, signal transduction, cell wall breakdown, purine biosynthesis, and potent mycotoxin patulin. (biomedcentral.com)
Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. (xenbase.org)

Alcohol dehydrogenase is also involved in the toxicity of other types of alcohol: for instance, it oxidizes methanol to produce formaldehyde and ethylene glycol to ultimately yield glycolic and oxalic acids. (biobool.com)

Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)

There are five classes (I-V) of alcohol dehydrogenase, but the hepatic form that is primarily used in 3 humans is class 1. (biobool.com)

It is well-documented that (bio)chemical reaction capacity of raw potato starch depends on crystallinity, morphology and other chemical and physical properties of starch granules, and these properties are closely related to gene functions. (peerj.com)

The gene encoding a (2 R ,3 R )-2,3-butanediol dehydrogenase from Rhodococcus erythropolis WZ010 (ReBDH) was over-expressed in Escherichia coli and the resulting recombinant ReBDH was successfully purified by Ni-affinity chromatography. (mdpi.com)

To overcome the host plant defense response, M. phaseolina encodes a significant number of P450s, MFS type membrane transporters, glycosidases, transposases, and secondary metabolites in comparison to all sequenced ascomycete species. (biomedcentral.com)
Subfamily I HKT genes ( HKT1s ) encode Na + -selective transporters, which are mostly located at the plasma membrane in xylem parenchyma cells. (springeropen.com)
Therefore, when plants are exposed to salt, the phytohormone ABA, TFs, and transporters act as key components that integrate cellular signal transduction and stress-responsive gene expression to confer salt tolerance. (springeropen.com)

A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. (rhea-db.org)

Knockdown Assay Knockdown of applicant genes was performed using commercially-available pLKO.1 plasmids expressing shRNA (Country wide RNAi Core Service, Academia Sinica, Taipei, Taiwan) as referred to before [9]. (bioinf.org)

In 2018, the World Health Organization reported that 3 million people per year die as a result of the abuse of alcohol [ 1 - 3 ]. (e-cmh.org)

Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. (nih.gov)
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)

Chronic alcohol consumption induces the development of alcoholic steatosis in the liver, which is one of the most widespread liver diseases worldwide. (e-cmh.org)

Using the Basic Local Alignment Search Tool (BLAST) as part of annotation and functional prediction, several characterised as well as uncharacterized transcription factors and genes were found in the dataset. (afpm.org.my)

We suggest that, while a known link from gene mutation to increased production of bisretinoids (as in ABCA4- and RDH12-associated diseases) causes primary elevation in fundus autofluorescence, a secondary autofluorescence elevation also exists, where an impairment and degeneration of photoreceptor cells by various causes leads to an increase in bisretinoid levels in RPE cells. (bvsalud.org)
This study provides a platform for the further characterization and identification of the key genes involved in secondary laticifer differentiation. (afpm.org.my)

In the embryo , RA production by RALDH2 (ALDH1A2), the main retinaldehyde dehydrogenase expressed at that stage, is inhibited by ethanol exposure. (xenbase.org)
deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. (brenda-enzymes.info)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting]. (nih.gov)

AKR1A1 gene is found highly expressed in kidney and liver, and moderately expressed in cerebrum, small intestine and testis. (wikipedia.org)
Chronic alcohol intake leads to a broad spectrum of alcoholic liver disease (ALD) such as simple steatosis, steatohepatitis, hepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma [ 2 , 4 ]. (e-cmh.org)
Most individuals consuming over 40 g of alcohol per day are known to develop alcoholic steatosis, or alcoholic fatty liver, but only a subgroup of them progresses to more advanced ALD [ 3 ]. (e-cmh.org)

moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer. (nih.gov)

These results indicate a previously unsuspected and novel role for the GRE2 gene product as a suppressor of filamentation by virtue of encoding isovaleraldehyde reductase activity. (rhea-db.org)

The bHLH TF OsbHLH035 is a salt-induced gene that is primarily expressed in germinating seeds and seedlings. (springeropen.com)

furthermore, compared with that in wild-type (WT) seedlings, the salt-induced expression of OsABA8ox1 , an ABA catabolic gene, in germinating Osbhlh035 mutant seeds is downregulated. (springeropen.com)

Anatomy9

Organisms9

Diseases9

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology4

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Named Groups1

Health Care3

Enzyme9

Alcohols7

Short-chain dehydro2

Aldo-keto reductase superfamily2

Oxidation2

Proteins6

Enzymes4

ALDH21

Oxidoreductases1

Superfamily1

Ferredoxin1

Protein4

Synthesis2

Aromatic4

Oxidase1

Carbonyl1

Metabolism5

ADH1B1

Oxidative1

Sequences1

Pathway5

Chromosome2

Subunit1

Toxin genes1

Saccharomyces1

Reduction1

Decarboxylase1

20161

Inhibition3

Regulation3

Sequence2

Catalyze2

Family1

Genome-wide as3

Variants2

Amino1

Biosynthesis2

Formaldehyde1

Differentially1

Hepatic1

Reaction1

Escherichia1

Transporters3

Transcriptome1

Assay1

20181

Isoforms2

Induces1

Transcription1

Secondary2

Ethanol2

Datasets1

Genetic1

Liver3

Esophageal cancer1

Suppressor1

Primarily1

Catabolic1