• HMG coenzyme-A reductase inhibitors. (medlineplus.gov)
  • The chemical structure of these HMG-CoA reductase inhibitors is shown in Fig. 1 . (aspetjournals.org)
  • Preparation of the HMG-CoA Reductase Inhibitors. (aspetjournals.org)
  • Dosing solutions (5 mg/ml) were prepared immediately before administration of the HMG-CoA reductase inhibitors to the rats. (aspetjournals.org)
  • Pravastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). (safemedication.com)
  • The present study was designed to investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (atorvastatin, pravastatin, simvastatin) on the pharmacokinetics of losartan and its active metabolite EXP-3174 in rats. (karger.com)
  • Pharmacokinetic parameters of losartan and EXP-3174 in rats were determined after oral and intravenous administration of losartan (9 mg/kg) without and with HMG-CoA reductase inhibitors (1 mg/kg). (karger.com)
  • The effect of HMG-CoA reductase inhibitors on P-gp and cytochrome (CYP) 3A4 activity were also evaluated. (karger.com)
  • Recent clinical evidence indicates a potential for skeletal muscle toxicity after therapy with HMG-CoA reductase inhibitors (HMGRIs) in man. (aspetjournals.org)
  • Because HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol , Pitavastatin may cause fetal harm when administered to pregnant women. (wikidoc.org)
  • Since HMG-CoA reductase inhibitors have the potential to cause serious adverse reactions in nursing infants, Pitavastatin, like other HMG-CoA reductase inhibitors, is contraindicated in pregnant or nursing mothers. (wikidoc.org)
  • Candidate drugs included two types of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, simvastatin and pravastatin, because of their importance at reducing the health expenditure for hyperlipidemia. (bvsalud.org)
  • Drug substrates of OATP1B1 and OATP1B3 include antibiotics and HMG-CoA reductase inhibitors (statins). (aspetjournals.org)
  • Zocor 40 mg belongs to a family of drugs called HMG CoA reductase inhibitors or statins. (onlinegenericmed.com)
  • 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) effectively reduce cholesterol levels and decrease the incidence of cardiovascular and cerebrovascular events (4). (cdc.gov)
  • Merck and Co, Inc) to warn of drug interactions with 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA) inhibitors. (medscape.com)
  • The aim of this study was to investigate, and compare with pravastatin and simvastatin, the tissue-specific distribution of rosuvastatin. (aspetjournals.org)
  • Bolus intravenous doses (5 mg/kg) of radiolabeled rosuvastatin, pravastatin, and simvastatin were administered to rats, and initial uptake clearance (CL uptake ) in various tissues was calculated. (aspetjournals.org)
  • The results of this study indicated that rosuvastatin was taken up by hepatic cells more selectively and more efficiently than pravastatin and simvastatin. (aspetjournals.org)
  • 14 C]Rosuvastatin (1.15 MBq/mg), [ 14 C]pravastatin (1.17 MBq/mg), and [ 14 C]simvastatin (1.85 MBq/mg) were synthesized at Shionogi and Co., Ltd. (Osaka, Japan). (aspetjournals.org)
  • Atorvastatin, pravastatin and simvastatin inhibited CYP3A4 activities with IC 50 values of 48.0, 14.1 and 3.10 µmol/l, respectively. (karger.com)
  • Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. (nih.gov)
  • Synthetically prepared HMG-CoA reductase inhibitor with some similarities to lovastatin, simvastatin, and pravastatin. (medscape.com)
  • In the Sprague-Dawley rat, very high, pharmacologically comparable dosages (150-1200 mg/kg/day) of structurally similar HMGRIs (lovastatin, simvastatin, pravastatin and L-647, 318) produced dose-related increases in the incidence and severity of skeletal muscle degeneration. (aspetjournals.org)
  • A total of 118 patients in the simvastatin study and 43 patients in the pravastatin study were candidates for the present study. (bvsalud.org)
  • The aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) both in vivo and in vitro with simvastatin. (nature.com)
  • Q. Is simvastatin the same as Lipitor (atorvastatin) or Crestor (rosuvastatin) or pravastatin? (kauverymeds.com)
  • Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia. (csnpharm.com)
  • Concomitant use of indinavir with lovastatin or simvastatin is not recommended by the FDA, and interactions with pravastatin and fluvastatin have not been studied. (medscape.com)
  • Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite. (csnpharm.com)
  • Scholars@Duke publication: The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. (duke.edu)
  • The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin has been reported to have a beneficial effect on reducing the new onset of diabetes as well as lowering plasma lipids. (duke.edu)
  • Rosuvastatin is a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. (aspetjournals.org)
  • Rosuvastatin (Crestor), calcium bis[(+)-(3 R ,5 S ,6 E )-7-[4-( p -fluorophenyl)-6-isopropyl-2-( N -methylmethanesulfonamido)-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoate], is a new and highly effective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA 1 ) reductase (the rate-limiting enzyme in cholesterol biosynthesis). (aspetjournals.org)
  • As a reversible competitive inhibitor, pravastatin sterically hinders the action of HMG-CoA reductase by occupying the active site of the enzyme. (wikipedia.org)
  • HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies. (aspetjournals.org)
  • Pitavastatin is a HMG-CoA reductase inhibitor that is FDA approved for the treatment of primary hyperlipidemia and mixed dyslipidemia . (wikidoc.org)
  • Has the patient ever had an allergic reaction to Pravachol, pravastatin, or another HMG-CoA reductase inhibitor medication? (pushhealth.com)
  • Pravastatin (brand name Pravachol) is an HMG-CoA reductase inhibitor. (clincalc.com)
  • Pitavastatin Calcium is a potent and competitive inhibitor of HMG-CoA reductase with Ki value of 1.7nM, which can block cholesterol synthesis. (csnpharm.com)
  • Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. (csnpharm.com)
  • Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. (csnpharm.com)
  • Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. (csnpharm.com)
  • Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. (wikipedia.org)
  • Pravastatin has been shown to have a similar effectiveness at lowering low-density lipoprotein cholesterol as other statin medications such as fluvastatin but may low level evidence indicates that pravastatin may not be as effective as some other statin medications that are available. (wikipedia.org)
  • As the precise mechanisms of the effect of pravastatin on glucose metabolism and diabetes have not been clarified, we examined the roles of the organic anion transporter family on pravastatin-treated islet and adipocyte functions. (duke.edu)
  • The beneficial effect of pravastatin is dependent on the dose and the potential for side effects or unwanted effects from this medication are not clear from clinical trials. (wikipedia.org)
  • These highlights do not include all the information needed to use PRAVASTATIN SODIUM TABLETS safely and effectively. (nih.gov)
  • See full prescribing information for PRAVASTATIN SODIUM TABLETS. (nih.gov)
  • For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving pravastatin sodium tablets 80 mg daily, prescribe alternative LDL-C-lowering treatment ( 2.1 ). (nih.gov)
  • Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating pravastatin sodium tablets, and adjust the dosage if necessary ( 2.1 ). (nih.gov)
  • Recommended maximum pravastatin sodium tablets dosage is 40 mg once daily. (nih.gov)
  • medical citation needed] The combination of fenofibrate with pravastatin is approved for use in the European Union. (wikipedia.org)
  • Discontinue pravastatin if markedly elevated CK levels occur or myopathy is diagnosed or suspected. (nih.gov)
  • Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing pravastatin dosage. (nih.gov)
  • Pravastatin uptake into INS-1e cells was detected and this transport was inhibited by sulfobromophthalein and rifampicin, both of which are known to inhibit oatp family-mediated uptake. (duke.edu)
  • Of interest, pravastatin uptake was stimulated by these NSAIDs, and for ibuprofen we determined activation constants (EC 50 values) of 64.0 and 93.1 μM for OATP1B1- and OATP1B3-mediated uptake, respectively. (aspetjournals.org)
  • There are two major P450 classes in terms of the native RP systems, namely, the prokaryotic Class I P450 consisting of three stand-alone components (redoxin reductase/redoxin/P450) that are all cytosolically soluble proteins and the two-component eukaryotic Class II P450 comprised of P450 and cytochrome P450 reductase (CPR), both of which are membrane-bound proteins. (nature.com)
  • Pravastatin comes as a tablet to take by mouth. (safemedication.com)
  • Each pink-to-peach-coloured, rounded, rectangular, biconvex, uncoated tablet, debossed with 'P10' on one side and 'I' on the other side, contains 10 mg of pravastatin sodium. (pharmachoice.com)
  • Each rounded, rectangular, pink-to-peach, biconvex tablet, engraved 'PRA' over '10' on one side and 'APO' on the other, contains 10 mg of pravastatin. (mediresource.com)
  • Each rounded, rectangular, yellow, biconvex tablet, engraved 'PRA' over '20' on one side and 'APO' on the other, contains 20 mg of pravastatin. (mediresource.com)
  • Do not use it if you have had an allergic reaction to pravastatin, or you are pregnant or breastfeeding. (optionrx.com)
  • Pravastatin also inhibits the synthesis of very-low-density lipoproteins, which are the precursor to low-density lipoproteins (LDL). (wikipedia.org)
  • Selective competitive inhibition of HMG-CoA reductase decreases cholesterol synthesis and increases cholesterol metabolism. (medscape.com)
  • Competitively inhibits HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol synthesis. (medscape.com)
  • Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)
  • Pravastatin is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. (wikipedia.org)
  • Pravastatin can be used to reduce the risk of death, heart attacks, stroke, angioplasty, and hospitalization for people with heart disease and normal to moderately high cholesterol. (medbroadcast.com)
  • Bovine adrenodoxin (Adx) and adrenodoxin reductase (AdR) are involved in steroid hormone biosynthesis in the adrenal gland mitochondria. (nature.com)
  • Pravastatin has undergone over 112,000 patient-years of double-blind, randomized trials using the 40 mg, once-daily dose and placebos. (wikipedia.org)
  • The recommended starting dose of pravastatin is 20 mg daily, taken with or without food in a single dose at bedtime. (medbroadcast.com)
  • Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher pravastatin dosage. (nih.gov)
  • In this study we investigated whether non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol interact with OATP1B1 and OATP1B3 using the standard substrate BSP and the drug substrate pravastatin. (aspetjournals.org)
  • These trials indicate pravastatin is well tolerated and displays few noncardiovascular abnormalities in patients. (wikipedia.org)
  • Temporarily discontinue pravastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. (nih.gov)
  • A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Pravastatin for at Least 4 Weeks. (druglib.com)
  • The goal of the trial was to evaluate intensive statin therapy using atorvastatin 80 mg/d compared with moderate statin therapy using pravastatin 40 mg/d among older patients with stable coronary artery disease (CAD). (acc.org)
  • Patients with stable CAD and ages 65 to 85 years were randomized in a double-blind, double-dummy manner to intensive statin therapy using atorvastatin 80 mg/d (n = 446) or moderate statin therapy using pravastatin 40 mg/d (n = 445). (acc.org)
  • Among older patients with stable CAD, treatment with intensive statin therapy using atorvastatin 80 mg/d was not associated with a different magnitude of reduction in duration of ischemia on Holter at 12 months compared with moderate statin therapy using pravastatin 40 mg/d. (acc.org)
  • Pravastatin acts as a lipoprotein-lowering drug through two pathways. (wikipedia.org)
  • The occurrence of serious adverse events was similar between groups (12.1% for atorvastatin vs. 11.9% for pravastatin), but liver function test abnormalities were more frequent in the atorvastatin group (4.3% vs. 0.2%, p (acc.org)
  • Severe renal impairment: recommended starting dosage is pravastatin sodium 10 mg once daily. (nih.gov)
  • After administration of rosuvastatin and pravastatin, silver grains were distributed selectively in the intracellular space of the liver, but more rosuvastatin (3.3 ± 1.0 × 10 5 particles/mm 2 ) than pravastatin (2.0 ± 0.3 × 10 5 particles/mm 2 ) tended to distribute to the liver. (aspetjournals.org)
  • Both intensive statin therapy with atorvastatin and moderate statin therapy with pravastatin were associated with reductions in myocardial ischemia at 12 months, but the degree of reduction did not differ between groups. (acc.org)