• Management of locally recurrent nasopharyngeal carcinoma. (nih.gov)
  • Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study. (nih.gov)
  • A Phase 2 Trial of Rivoceranib, an Oral Vascular Endothelial Growth Factor Receptor 2 Inhibitor, for Recurrent or Metastatic Adenoid Cystic Carcinoma. (ucsf.edu)
  • Clinical Trial Development in TP53-Mutated Locally Advanced and Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma. (ucsf.edu)
  • Latent Epstein-Barr virus (EBV) infection is associated with a heterogeneous group of malignancies, including Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma, and lymphoproliferative disease (LPD). (nih.gov)
  • The US Food and Drug Administration (FDA) has approved toripalimab-tpzi (Loqtorz, Coherus BioSciences) in combination with cisplatin and gemcitabine for the first-line treatment of adults with metastatic or recurrent locally advanced nasopharyngeal carcinoma. (medscape.com)
  • The FDA also approved toripalimab , a programmed death receptor 1-blocking antibody, as a single agent for recurrent unresectable or metastatic nasopharyngeal carcinoma with disease progression on or after a platinum-containing chemotherapy. (medscape.com)
  • Efficacy of toripalimab as a single agent was evaluated in the POLARIS-02 study in 172 patients with unresectable or metastatic nasopharyngeal carcinoma who had received prior platinum-based chemotherapy or had progressed within 6 months of its completion in the neoadjuvant, adjuvant, or definitive chemoradiation setting. (medscape.com)
  • The recommended dose as a single agent for previously treated nasopharyngeal carcinoma is 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity. (medscape.com)
  • Cite this: FDA Approves Toripalimab for Nasopharyngeal Carcinoma - Medscape - Oct 30, 2023. (medscape.com)
  • epstein-barr virus (ebv) is a human γ-herpesvirus associated with cancer, including burkitt lymphoma, nasopharyngeal, and gastric carcinoma. (liverpool.ac.uk)
  • whole-body (18)f-fdg pet/ct for m staging in the patient with newly diagnosed nasopharyngeal carcinoma: who needs? (liverpool.ac.uk)
  • although whole-body fluorine-18 fluorodeoxyglucose ((18)f-fdg) positron emission tomography (pet)/computed tomography (ct) ((18)f-fdg pet/ct) is commonly used for m staging of newly diagnosed nasopharyngeal carcinoma (npc), some patients may not benefit from this procedure. (liverpool.ac.uk)
  • Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. (intechopen.com)
  • Nasopharyngeal carcinoma (NPC) is a rare disease and one of the most common types of malignancies that appear in the nasopharynx, which is the narrow tube passage behind the nasal cavity and one of the malignancies associated with the Epstein-Barr virus (EBV) and is considered one of the malignant and rare tumors in most parts of the world and is distinguished by distribution geographical and ethnic [ 1 ]. (intechopen.com)
  • According to the Singapore Cancer Registry, the most common head and neck cancer is nasopharyngeal carcinoma (NPC), which features as the eighth most common cancer amongst Singaporeans. (healthxchange.sg)
  • Patients with squamous cell carcinoma, lymphoma, thyroid cancer, salivary gland cancer, nasopharyngeal carcinoma, metastatic lesion with primary tumor outside the head and neck, and metastasis from unknown primary squamous cell carcinoma or adenocarcinoma were excluded, as were patients not assessed by FDG PET prior to treatment or during follow-up and patients with inadequate follow-up information. (e-ceo.org)
  • Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. (elsevierpure.com)
  • The purpose of this clinical report is to present our surgery approach combined to the preoperative embolization and the follow-up management of a patient with a Juvenile Nasopharyngeal Angiofibroma (JNA). (embj.org)
  • Objective: This is a retrospective study to assess treatment outcomes according to stage and surgical approach in advanced juvenile nasopharyngeal angiofibroma (JNA). (elsevierpure.com)
  • Concurrent chemotherapy with radiotherapy is the standard treatment for locoregionally advanced nasopharyngeal cancer. (cambridge.org)
  • Recurrent episodes of epistaxis, even if self-limited, should raise suspicion for significant nasal pathology. (medscape.com)
  • In the context of recurrent severe epistaxis and high cardiac output (due to hepatic AVM) in the third trimester, a multidisciplinary decision was made to plan an elective caesarean section at 35 4/7 weeks combined with nasal packing under GA. This report discusses the implications of HHT, the multidisciplinary planning of the caesarean section, intraoperative anaesthetic management and patient follow-up. (bvsalud.org)
  • Macromorphology of excised recurrent nasal polyp from a 24-year-old Black woman with rhinosporidiosis, South Africa. (cdc.gov)
  • We present a case of a nineteen-year-old patient with severe and recurrent episodes of epistaxis in the last months. (embj.org)
  • Nonsquamous cell cancers, including minor salivary gland cancers, sarcomas, and melanomas, account for the other half (see the histologic distribution of hard palate malignant neoplasms and the histologic types and frequencies of minor salivary gland neoplasms of the palate, below). (medscape.com)
  • [ 4 ] With the abundance of cats and dogs in US households and the commensal nature of the bacteria, the risk of acquiring Pasteurella infections is increasing, particularly in patients who have predisposing factors such as prosthetic joints, malignant neoplasms, and immunosuppression. (medscape.com)
  • Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
  • With few exceptions, only patients with recurrent Hodgkin's disease have been treated with autologous EBV-specific CTL, and although the results have been promising, they do not include cures. (nih.gov)
  • It is usually associated with radiation therapy (in advanced disease) and chemotherapy (in recurrent disease and / or metastatic disease). (health-alphabet.com)
  • The first-line approval was based on the JUPITER-02 trial in 289 patients who had not received previous systemic chemotherapy for recurrent or metastatic disease. (medscape.com)
  • At 1-year postoperative follow-up, the patient was found to be free of symptoms and had no recurrent disease. (jmedscindmc.com)
  • She was hospitalised several times during the second and third trimester for serious recurrent epistaxis, leading to severe anaemia. (bvsalud.org)
  • Niraparib in combination with dostarlimab is in clinical development for patients with recurrent or primary-advanced endometrial cancer. (nihr.ac.uk)
  • With the goal of centralizing data and long-term follow-up, this comprehensive guide is invaluable for all otolaryngologists, head and neck surgeons, oncologists, neurosurgeons, and maxillofacial and plastic surgeons who treat patients with challenging sinonasal, skull base, and nasopharyngeal neoplasms. (thieme.com)
  • Patients with locoregional recurrent pancreatic cancer after surgery treated with SBRT in our institution were retrospectively investigated from January 2010 to January 2020. (frontiersin.org)
  • Due to the higher glycolytic rates of many neoplasms relative to normal tissue, the glucose analog 18 F-fluorodeoxyglucose (FDG) can be used to detect tumors, and positron emission tomography (PET) using FDG has been utilized in patients with HNCs for initial staging, management of recurrent cancers, and therapeutic monitoring ( 2 - 5 ). (e-ceo.org)
  • All patients with previously untreated or recurrent rare HNCs were assessed by biopsy, CT and whole body FDG PET before treatment for previously untreated or recurrent rare HNCs. (e-ceo.org)
  • We aimed to study LVC patients to identify treatment patterns for primary and recurrent diseases. (researchgate.net)
  • JNA is a relatively uncommon vascular benign neoplasm that affects almost exclusively adolescent males and represents 0.05% of all head and neck tumors with an incidence of 1:150,000. (embj.org)
  • Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors. (viictr.org)
  • incidence rates were highest for leukemia (46.6), central nervous system (CNS) neoplasms (30.8), and lymphoma (27.3). (cdc.gov)
  • This study aimed to analyze the efficacy and toxicity of stereotactic body radiotherapy (SBRT) for locoregional recurrent pancreatic cancer after radical resection. (frontiersin.org)
  • The reemergence of a malignant head and neck neoplasm after a period of remission. (nih.gov)
  • However, one of the worst-prognostic neoplasms not only of the throat, but also of the head and neck, is laryngeal cancer. (health-alphabet.com)
  • Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck. (elsevierpure.com)
  • In the clinical situation of a recurrent astrocytoma (postradiation therapy), radiation necrosis presents a diagnostic dilemma. (medscape.com)
  • Glioblastoma multiforme's hallmark histology of pseudopalisading necrosis makes it difficult to differentiate radiation necrosis from recurrent astrocytoma using MRI. (medscape.com)
  • Niraparib as maintenance therapy for treating recurrent or primary-advanced endometrial cancer after chemotherapy in combination with dostarlimab. (nihr.ac.uk)
  • Baranov E‡, Davis JL , Winsnes K, Church A, Breen M, Janeway KA, Dubois S, Al-Ibraheemi A. Histologic characterization of targeted therapy-treated pediatric mesenchymal neoplasms with kinase alterations. (iu.edu)
  • There is a need to develop new treatments and combinations that can produce longer-lasting positive outcomes for women with advanced/recurrent endometrial cancer. (nihr.ac.uk)
  • The authors insufficiency, hypercalcaemia, anaemia and concluded that "the reasons underlying the recurrent infection [ 3,4 ]. (who.int)
  • recurrent cancer means the cancer has come back after treatment. (nihr.ac.uk)
  • It can be a common cause of recurrent otitis media. (cdc.gov)
  • Transmission occurs through direct contact with respiratory droplets from a nasopharyngeal carrier or case patient. (cdc.gov)
  • We evaluated whether DNA repair gene polymorphisms had an effect on clinical outcomes in metastatic/recurrent nasopharyngeal carcinoma (NPC) patients treated with cisplatin-based chemotherapy. (nih.gov)
  • To determine the efficacy and safety of single-agent sorafenib in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) and nasopharyngeal carcinoma (NPC). (nih.gov)
  • 11. A rare case of intracytoplasmic mucin-rich nasopharyngeal carcinoma. (nih.gov)
  • Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. (cdc.gov)
  • Functional polymorphisms in antioxidant genes in Hurthle cell thyroid neoplasm - an association of GPX1 polymorphism and recurrent Hurthle cell thyroid carcinoma. (cdc.gov)
  • Squamous cell carcinoma of tongue and papillary thyroid carcinoma occurred as metachronous cancers in a patient with primary nasopharyngeal carcinoma. (biomedcentral.com)
  • A 60 year old Saudi female patient presented in March 2011 with locally advanced nasopharyngeal carcinoma. (biomedcentral.com)
  • After completion of concurrent chemoradiation in June 2011, she developed two new primaries i-e thyroid cancer and tongue cancer in May 2012 along with recurrent nasopharyngeal carcinoma. (biomedcentral.com)
  • Here-in we report a 60 year old lady having three primary head and neck malignancies, i.e. nasopharyngeal, tongue and papillary thyroid carcinoma. (biomedcentral.com)
  • Nasendoscopy showed left sided nasopharyngeal mass, biopsy of which showed undifferentiated carcinoma on March 20th, 2011 Figure 1 . (biomedcentral.com)
  • Among the modalities for managing recurrent nasopharyngeal carcinoma, surgical treatment has attracted increased attention. (sdu.edu.cn)
  • With the continuous improvement in surgical techniques, especially the development of endoscopic nasopharyngoscopy, the standard treatment for recurrent nasopharyngeal carcinoma has gradually changed from re-radiotherapy to surgery. (sdu.edu.cn)
  • Status of surgical treatment for recurrent nasopharyngeal carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 12-16. (sdu.edu.cn)
  • How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? (sdu.edu.cn)
  • The impact of dosimetric inadequacy on treatment outcome of nasopharyngeal carcinoma with IMRT[J]. Oral Oncol, 2014, 50 (5): 506- 512. (sdu.edu.cn)
  • Current treatment options for local residual nasopharyngeal carcinoma[J]. Curr Treat Options Oncol, 2013, 14 (4): 475- 491. (sdu.edu.cn)
  • Nasopharyngectomy for recurrent nasopharyngeal carcinoma: an innovative transnasal approach through a mid-face deglove incision with stereotactic navigation guidance[J]. Br J Oral Maxillofac Surg, 2001, 39 (1): 55- 62. (sdu.edu.cn)
  • Current understanding and management of nasopharyngeal carcinoma[J]. Auris Nasus Larynx, 2012, 39 (2): 137- 144. (sdu.edu.cn)
  • Outcome of Patients Undergoing Salvage Surgery for Recurrent Nasopharyngeal Carcinoma: a Meta-analysis[J]. Ann Surg Oncol, 2014, 21 (9): 3056- 3062. (sdu.edu.cn)
  • Salvage endoscopic nasopharyngectomy is superior to intensity-modulated radiation therapy for local recurrence of selected T1-T3 nasopharyngeal carcinoma-A case-matched comparison[J]. Radiother Oncol, 2015, 115 (3): 399- 406. (sdu.edu.cn)
  • A retrospective study of salvage surgery for recurrent nasopharyngeal carcinoma[J]. Int J Clin Oncol, 2012, 17 (3): 212- 217. (sdu.edu.cn)
  • 1. To determine the prognostic implication of plasma Epstein-Bar Virus (EBV) DNA concentrations, as measured by quantitative polymerase chain reaction (PCR) in patients with nasopharyngeal carcinoma (NPC). (stanford.edu)
  • Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population-based study. (uchicago.edu)
  • Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. (uchicago.edu)
  • Renal cell carcinoma (RCC) forms 85% of all primary renal neoplasms. (manuscriptscientific.com)
  • Renal cell carcinoma (RCC) is a heterogeneous group of cancers arising from renal tubular epithelial cells that encompasses 85% of all primary renal neoplasms. (manuscriptscientific.com)
  • To our knowledge this is the first reported case of an isolated vesicocutaneous fistula related to previous radiation therapy for recurrent vulvar cancer. (annals.edu.sg)
  • Current status of surgical trenment for nasopharyngeal cancer[J]. Chinese Journal of Cancer Prevention and Treatment, 2006, 13 (6): 401- 402. (sdu.edu.cn)
  • Specifically, compared with nonvaccinated patients, vaccinated patients with advanced nasopharyngeal cancer showed higher objective response rates and disease control rates after anti-PD-1 therapy and similar rates of severe immune-related adverse events. (medscape.com)
  • Overall, the study suggests that "the efficacy of combination of anti-PD-1 treatment and chemotherapy was significantly improved for vaccinated nasopharyngeal cancer patients," the authors write. (medscape.com)
  • Given the promising outcomes associated with COVID-19 vaccination in patients receiving anti-PD-1 therapy, this study may be "valuable to clinicians and other people who are dealing with nasopharyngeal cancer," Li added. (medscape.com)
  • But the authors also expressed caution about the findings, even entitling the article: "Potentially improved response of COVID-19 vaccinated nasopharyngeal cancer patients to combination therapy with anti-PD-1 blockade and chemotherapy. (medscape.com)
  • Experts have raised concerns about whether anti-PD-1 treatment might interfere with COVID-19 vaccination in patients with nasopharyngeal cancer, given that both COVID-19 and nasopharyngeal cancer affect the upper respiratory tract. (medscape.com)
  • Li and colleagues have previously found that patients with metastatic lung, liver, or intestinal tract cancers receiving PD-1 inhibitors had no significant differences in outcomes after COVID-19 vaccination, and wanted to extend their research to patients being treated for nasopharyngeal cancer. (medscape.com)
  • The authors evaluated 1537 patients with nasopharyngeal cancer who were enrolled at 23 hospitals in China from January 2021 and followed through to June 2022. (medscape.com)
  • All patients - who were mostly men with a median age of 45 years - had a recurrent metastatic stage of cancer, and most were receiving concomitant anti-PD-1 therapy along with chemotherapy. (medscape.com)
  • Although the potential association between COVID-19 vaccination and increased efficacy of anti-PD-1 therapy in recurrent metastatic nasopharyngeal cancer is "interesting," the finding "needs to be validated in a larger cohort study," Li and colleagues conclude. (medscape.com)
  • Selon le registre du cancer, le Niger compte en moyenne 426 cas de cancer par an. (bvsalud.org)
  • Cette étude a pour objectif : - d'établir le profil épidémiologique du cancer, - analyser les paramètres pouvant influencer l'accès des malades aux médicaments anticancéreux au Niger, - proposer les solutions pour améliorer la prise en charge. (bvsalud.org)
  • Cancer neoplasms constituted 40% of malignant ASBOT. (ozhurnal.com)
  • Recurrent Ovarian Cancer: When to Treat and How to Assess -- 3. (nshealth.ca)
  • Most benign cases (84%) were juvenile nasopharyngeal angiofibroma, meningioma or osteoma. (ozhurnal.com)
  • Twelve retrospective studies published between 2000 and 2020 that analysed the effect of radiotherapy on salivary gland neoplasms and ACCs of salivary glands and met the inclusion criteria were included in the review. (bvsalud.org)
  • 10. Clear Cell Neoplasms of Salivary Gl and s: A Diagnostic Challenge. (nih.gov)
  • 15. SalvGl and Dx - a comprehensive salivary gl and neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets. (nih.gov)
  • 17. Molecular Pathology of Salivary Gl and Neoplasms: Diagnostic, Prognostic, and Predictive Perspective. (nih.gov)
  • Background: Recurrent cancers of the head and neck are associated with poor survival outcome. (researchgate.net)
  • Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically. (nih.gov)
  • The incidence of distant metastases is influenced by location of the primary tumor, initial T and N stage of the neoplasm, and the presence or absence of regional control above the clavicle. (keyopinionleaders.com)
  • Transmission occurs through direct contact with respiratory droplets from a nasopharyngeal carrier or case patient. (cdc.gov)
  • Accurate diagnosis and classification of craniopharyngeal canals are valuable to characterize lesions requiring surgery, identify patients with potential pituitary dysfunction, and avoid iatrogenic hypopituitarism or CSF leak during surgical resection of nasopharyngeal masses. (ajnr.org)
  • The most common complications include renal insufficiency, hypercalcaemia, anaemia and recurrent infection [3,4]. (who.int)
  • Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. (uchicago.edu)
  • 2 , 4 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 13 CPC is a rare but important entity to recognize in the evaluation of nasopharyngeal or midline skull base lesions. (ajnr.org)
  • The most often reported are: intra- and extracavernous or metastatic neoplasms, intra-cavernous carotid artery aneurysms, carotid-cavernous fistulas (see image below), infections, thrombosis, and Tolosa-Hunt syndrome. (medscape.com)
  • The craniopharyngeal canal is a rare, well-corticated defect through the midline of the sphenoid bone from the sellar floor to the anterosuperior nasopharyngeal roof. (ajnr.org)