AnesthesiaSodiumPropofolAnestheticIntracranial hypertensionDuration of actionInductionPharmacokineticsMidazolamFentanylHemodynamicsDoseSedationIntravenouslyInduceDifferencesNeuromuscularReduceParametersLevelsTimeImportantRoomSodiumInjectionMethohexitalAnaesthesiaFentanylAnestheticsSpontaneous recoveryContinuing infusionDosageSymptomWidelyModerateRespiratoryInduction and recoveryBolusEffectsGeneralTreatmentOccursDurationPatientsPeriodTableStageMentalFunction
Anesthesia17
- Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. (nih.gov)
- Premedicants are used to reduce anxiety, provide pre-emptive pain relief, reduce the amount of anesthetic induction and maintenance anesthesia required, produce some muscle relaxation, and help provide "smooth" inductions and recoveries. (rrcus.org)
- The rapid, smooth recovery from anesthesia is probably Propofol's most important attribute. (rrcus.org)
- The pharmacokinetics 9,10 and effects 11,12 of R- and S- thiopental differ quantitatively after anesthesia induction doses. (silverchair.com)
- The purpose of this study was to investigate whether pyridostigmine affects the level of the BIS during recovery from sevoflurane anesthesia. (ewha.ac.kr)
- Anesthesia was induced with thiopental 4 mg/kg and rocuronium 0.6 mg/kg. (ewha.ac.kr)
- Conclusions: The finding that pyridostigmine increases TOF and BIS suggests that pyridostigmine may enhance recovery during recovery from sevoflurane anesthesia. (ewha.ac.kr)
- It proved superior to thiopental because fewer adjuvant anesthetics are required to maintain an acceptable depth of anesthesia. (anesthesiageneral.com)
- After use for maintenance of anesthesia, recovery is longer (1-2.5 times) from midazolam than from thiopental. (anesthesiageneral.com)
- Rapid-sequence induction and intubation with cricoid pressure using thiopental-succinylcholine have been the standard for cesarean section under general anesthesia for a long time. (anesth-pain-med.org)
- Thiopental is often used as an induction agent to rapidly induce anesthesia in patients undergoing neurosurgical procedure s. (neurosurgery.directory)
- This allows for precise control of anesthesia depth and a quick recovery once the drug is discontinued. (neurosurgery.directory)
- Chemically, propofol is not related to barbiturates and has largely replaced sodium thiopental (Pentothal) for induction of anesthesia because recovery from propofol is more rapid and "clear" when compared with thiopental. (neurosurgery.directory)
- This presentation focused on research being conducted in our laboratory to understand the genetics of three conditions that afflict Scottish Deerhounds-slow anesthesia recovery, perianesthetic stress hyperthermia, and delayed post-operative bleeding. (deerhoundhealth.org)
- GKM-OS anesthesia may be useful for prolonged equine surgery because of its minimal cardiovascular effect and good recovery. (lookformedical.com)
- Thiopental is an extremely short-lasting barbiturate that makes anesthesia pleasant and smooth for the patient. (bijog.com)
- Intervention 1: Intervention group 1: In this group, after lying on the bed and monitoring connection, patients received 5 mg/kg Sodium Thiopental from Jaber Ibn Hayyan company and 0.3 mg/kg Succinylcholine made by Caspian company for anesthesia and then under Electroconvulsive therapy with energy. (who.int)
Sodium3
- Twelve bulls ranging from 341 to 545 kilograms in body mass were successfully anesthetized for either vasectomy or prosthetic vas deferens implantation with a combination of thiopental sodium, glyceryl guaiacolate, nitrous oxide, halothane and oxygen. (lookformedical.com)
- An array of routine and emergency drugs, including Dantrolene sodium (the specific treatment for malignant hyperthermia), airway management equipment, a cardiac defibrillator, and a recovery room staffed by properly trained individuals completes the picture. (medscape.com)
- Thiopental,5-ethyl-5-(1-methylbutyl)2-thiobarbituric acid, is synthesized by the alkylation of ethylmalonic ester with 2-bromopentane in the presence of sodium ethoxide. (bijog.com)
Propofol1
- Delayed recovery after injectable anesthetics, especially barbiturates like thiopental and propofol (to a lesser extent), has been well documented in greyhounds and is thought to occur in other sighthound breeds. (deerhoundhealth.org)
Anesthetic4
- Side Effect s: Like all anesthetic drugs, thiopental can have side effects, including respiratory depression, hypotension (low blood pressure), and a risk of allergic reactions. (neurosurgery.directory)
- That's because recovery from these anesthetics normally occurs as the anesthetic agent rapidly diffuses out of the blood and into body fat, where it prefers to be. (deerhoundhealth.org)
- In that situation, recovery occurs only when the anesthetic left in the blood is broken down (metabolized) by the liver, a process that can take many hours. (deerhoundhealth.org)
- Our laboratory has evidence that another factor contributing to slow anesthetic recovery in sighthound breeds may be that their livers metabolize anesthetics more slowly. (deerhoundhealth.org)
Intracranial hypertension2
- PROLONGED high-dose thiopental therapy is used to reduce intracranial hypertension and protect the brain against ischemic injury in acute neurologic and neurosurgical emergencies. (silverchair.com)
- In some cases of severe traumatic brain injury or refractory intracranial hypertension , thiopental has been used to induce a controlled barbiturate coma. (neurosurgery.directory)
Duration of action3
- The onset of action (T95), duration of action (T25) and recovery time (T25-75) of neuromuscular blockade were recorded. (selcukmedj.org)
- Thiopental: highly lipophilic-use higher absolute dose-expect longer duration of action. (medicine-handbook.com)
- One of the advantages of thiopental is its short duration of action. (neurosurgery.directory)
Induction2
- Anaesthesia induction was realized by 2mg/kg alfentanil + 5 mg/kg thiopental. (selcukmedj.org)
- Why is Thiopental chosen for induction in neurosurgery? (neurosurgery.directory)
Pharmacokinetics5
- During conditions of prolonged high-dose therapy, the pharmacokinetics of thiopental may become nonlinear, but whether this derives from one or both enantiomers has not been evaluated. (silverchair.com)
- The authors determined the pharmacokinetics of R- and S-thiopental and serum concentrations of R- and S-pentobarbital from prolonged high-dose infusion of thiopental for neuroprotection. (silverchair.com)
- The pharmacokinetics of R- and S-thiopental became nonlinear at these doses. (silverchair.com)
- It is well-established that thiopental shows nonlinear Michaelis-Menten pharmacokinetics at high doses. (silverchair.com)
- However, it is not known whether the nonlinearity of high-dose thiopental pharmacokinetics is an artifact of data analysis because of two drugs being combined or whether the component enantiomers each undergo nonlinear pharmacokinetics. (silverchair.com)
Midazolam1
- One hour after surgery, patients are equally alert with either midazolam or thiopental. (anesthesiageneral.com)
Fentanyl1
- was achieved by thiopental (3.5 mg/kg/hr) and fentanyl (15 mg/kg/hr). (nopainhanna.com)
Hemodynamics2
- There were no differences betvveen the two groups with respect to hemodynamics parameters, recovery time, quality of intubation and demografic datas (p>0,05). (selcukmedj.org)
- 1991. Effect of massive intraoperative thiopental loading on cardiovascular hemodynamics and myocardial performance. . (cornell.edu)
Dose4
- BIS is used as an adjunct to monitoring under anaesthesia - its use has been shown to reduce overall dose of anaesthetic agent used and therefore may improve recovery time from anaesthesia. (wikipedia.org)
- Twenty patients received a mean thiopental dose of 41.2 g over a mean duration of 95 h. (silverchair.com)
- Furthermore, the significance of any pharmacodynamic differences between R- and S- thiopental enantiomers, during conditions of prolonged high-dose therapy is unknown. (silverchair.com)
- Atracurium: dose/total wt-recovery time is unaffected. (medicine-handbook.com)
Sedation2
- Thiopental induces a state of sedation, amnesia, and unconsciousness, which is important for ensuring that patients do not experience pain or awareness during surgery. (neurosurgery.directory)
- Despite various advantages of sevoflurane sedation, including rapid onset, quick recovery, reduced airway irritation, and greater hemodynamic stability, emergence agitation (EA) induced by sevoflurane is a major concern to pediatric anesthesiologists. (anesth-pain-med.org)
Intravenously1
- Thiopental is administered intravenously, typically as a rapid bolus injection. (neurosurgery.directory)
Induce1
- In what situations might Thiopental be used to induce a controlled barbiturate coma? (neurosurgery.directory)
Differences1
- The pharmacokinetic differences between R- and S-thiopental, although small, were statistically significant and were influenced by the higher f(u) of R-thiopental. (silverchair.com)
Neuromuscular1
- 1999. The nature of spontaneous recovery from mivacurium-induced neuromuscular block. . (cornell.edu)
Reduce1
- Dexamethasone can reduce post-op swelling and make recovery faster in cases where the dog's throat is irritated from the ET tube, when the dog's palate is very long, or following palate surgery. (maximefrenchbulldogs.com)
Parameters1
- In both studies, the changes in intracellular Cl - were reversible, and there was complete recovery of electrophysiological parameters measured during reoxygenation. (jneurosci.org)
Levels1
- 10 minutes) and blood thiopental levels of 10-30 mcg/ml. (neurosurgery.directory)
Time2
- R- and S-thiopental enantiomer serum concentration-time data from 18 patients were fitted with two models: a linear one-compartment model with first-order output, and a nonlinear one-compartment model with Michaelis-Menten output. (silverchair.com)
- Timepoint: From the time of extubation to the end of recovery. (who.int)
Important2
- Thiopental can temporarily lower intracranial pressure (ICP), which can be important in neurosurgical procedures involving brain tumors or traumatic brain injury. (neurosurgery.directory)
- Thiopental and decompressive craniectomy are important integrated last-tier treatment options in aneurysmal subarachnoid hemorrhage , but careful patient selection is needed due to the risk of saving many patients a state of suffering 6) . (neurosurgery.directory)
Room1
- Many obstetric units now use a combined labor, delivery, recovery, and postpartum (LDRP) room, so that the woman, support person, and neonate remain in the same room throughout their stay. (msdmanuals.com)
Sodium5
- Phenytoin slows the rate of recovery of voltage-activated sodium channels in the inactivated state, preventing rapid repetitive firing of neurons. (medscape.com)
- If an adequate anesthesia depth was accomplished with 5 mg/kg thiopental sodium, administration of higher dosage would not be advisable. (medscape.com)
- The hemodynamic effects of etomidate have in most cases been qualitatively similar to those of thiopental sodium, except that the heart rate tended to increase by a moderate amount following administration of thiopental under conditions where there was little or no change in heart rate following administration of etomidate. (nih.gov)
- Intervention 1: Intervention group 1: In this group, after lying on the bed and monitoring connection, patients received 5 mg/kg Sodium Thiopental from Jaber Ibn Hayyan company and 0.3 mg/kg Succinylcholine made by Caspian company for anesthesia and then under Electroconvulsive therapy with energy. (who.int)
- group III (n=19) - operated under conditions of intravenous anesthesia based on thiopental sodium combined with fentanyl. (uran.ua)
Injection2
- Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. (nih.gov)
- Methohexital has a shorter elimination half-time than thiopental due to its larger plasma clearance (Table 25-2), leading to a faster and more complete recovery after bolus injection. (brainkart.com)
Methohexital4
- Compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. (nih.gov)
- Thus, cumulative effects are fewer and recovery is more rapid with methohexital than with thiobarbiturates. (nih.gov)
- Thiopental and methohexital undergo hepatic metabolism, mostly by oxidation but also by N -dealkylation, desulfuration, and destruction of the barbituric acid ring structure. (brainkart.com)
- Barbiturates are respiratory depressants, and a usual induction dose of thiopental or methohexital typically produces transient apnea, which will be more pronounced if other respiratory depressants are also administered. (brainkart.com)
Anaesthesia2
- BIS is used as an adjunct to monitoring under anaesthesia - its use has been shown to reduce overall dose of anaesthetic agent used and therefore may improve recovery time from anaesthesia. (wikipedia.org)
- Conclusions: Results indicate that TT 4 values may significantly decrease for at least 24 hours post recovery from anaesthesia irrelevant of the anaesthetic agent used. (thieme-connect.de)
Fentanyl2
- These same data revealed that the immediate recovery period will usually be shortened in adult patients by the intravenous administration of approximately 0.1 mg of intravenous fentanyl, one or two minutes before induction of anesthesia, probably because less etomidate is generally required under these circumstances (consult the package insert for fentanyl before using). (nih.gov)
- General anesthesia was induced with thiopental (425 mg), fentanyl (0.1 mg), and rocuronium (50 mg). (asahq.org)
Anesthetics1
- Two patients arrive simultaneously in the recovery room following general endotracheal anesthetics. (theanesthesiaconsultant.com)
Spontaneous recovery2
- Herein, we report a case of residual neuromuscular paralysis in which 4 mg/kg sugammadex was inadequate to antagonize rocuronium-induced blockade after spontaneous recovery to the appearance of 20 twitches in response to PTC stimulation. (biomedcentral.com)
- Administration of anticholinesterase agents (neostigmine, pyridostigmine) may be used to antagonize the action of neuromuscular blocking agents once the patient has demonstrated some spontaneous recovery from neuromuscular block. (unboundmedicine.com)
Continuing infusion1
- The intracranial pressure was reduced, in each case, by 185 to 500 mg (median: 250 mg) thiopental given over 15 min, and in eight cases continuing infusion achieved stable normal intracranial pressure and cerebral perfusion pressure. (nih.gov)
Dosage1
- The dosage of thiopental was adjusted incrementally until intracranial pressure, measured by extradural transducers, fell to within normal limits or adverse hemodynamic changes occurred. (nih.gov)
Symptom1
- Vice versa , others with good symptom recovery without stigmata are unable to function in a hostile work place, and are unable to integrate with society and lead meaningful lives. (pathfinderclinic.com)
Widely1
- Recovery is made possible by medications that are now widely available at a reasonable cost. (pathfinderclinic.com)
Moderate1
- The proportion of patients with a favorable outcome on the Glasgow Outcome Scale (good recovery or moderate disability) was 50.4% with progesterone, as compared with 50.5% with placebo. (neurosurgery.directory)
Respiratory1
- Observe for residual muscle weakness and respiratory distress during the recovery period. (unboundmedicine.com)
Induction and recovery1
- In addition, provision of analgesia and reduction of stress improves the quality of anaesthetic induction and recovery. (vin.com)
Bolus1
- However, if administered through repeated bolus injec-tions or continuous infusion, recovery will be markedly prolonged because elimination will depend on metabolism under these cir-cumstances (see also context-sensitive half-time, Figure 25-8). (brainkart.com)
Effects1
- When it's time to walk away from your patient in the recovery room, you'll worry less if your patient is already talking to you and has minimal residual effects of general anesthesia. (theanesthesiaconsultant.com)
General1
- After preoxygenation, general anesthesia was induced with 300 mg thiopental, 50 mg (0.7 mg·kg − 1 ) rocuronium, and 0.15 μg·kg − 1 ·min − 1 remifentanil. (biomedcentral.com)
Treatment3
- Recovery to meaningful functioning after even severe mental illness is the present standard of care in mental health treatment. (pathfinderclinic.com)
- Planning and persistence with treatment need to be ensured to achieve a quality recovery. (pathfinderclinic.com)
- With the proper diagnosis, you can begin the path to treatment and recovery. (americanaddictioncenters.org)
Occurs2
- Recovery of muscle function usually occurs in reverse order. (unboundmedicine.com)
- Maintain airway patency and ventilation until recovery of normal respirations occurs. (unboundmedicine.com)
Duration1
- Recovery duration. (who.int)
Patients3
- Based on data which suggest that barbiturates can be of value in controlling the intracranial hypertension of head injury, intravenous thiopental was assessed in 13 patients with fulminant hepatic failure. (nih.gov)
- Five of the patients made a complete recovery and there were only three deaths from intracranial hypertension. (nih.gov)
- Recovery times vary, but most patients regain consciousness shortly after the procedure and may experience grogginess and discomfort for a few hours. (mimprovement.com)
Period1
- Be sure to inquire with your doctors about their recommended wound bandages, medical tapes, or suture solutions for at home during the recovery period, with clear expectations on cleaning the wound. (chronicpainpartners.com)
Table1
- Her vital parameters in recovery are shown in Table 2. (anesthesiastudent.com)
Stage2
- Clinicians should therefore be confident in prescribing treadmill training for ambulatory stroke individuals when the primary objective of rehabilitation is to improve walking speed and distance, regardless of whether the individuals are at the subacute or chronic stage of their recovery. (ikk-signal.com)
- Which of the following is an expected assessment finding for this patient during this early stage of recovery? (studymoose.com)
Mental4
- Measures of the recovery orientation of mental health services: systematic review. (nih.gov)
- The road to recovery from mental illness has four components that together give meaning to life. (pathfinderclinic.com)
- Without medication, recovery from serious mental illness is long-drawn, stigmatising, and characterised by frequent relapses. (pathfinderclinic.com)
- Recovery from severe mental illness is a process, it does not happen overnight, but for those who stay the course it brings the meaning back to life. (pathfinderclinic.com)
Function1
- Establishing routines for these basic health tasks are essential for recovery of function. (pathfinderclinic.com)