AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
GlucagonReceptors, GlucagonImmune Reconstitution Inflammatory SyndromeGlucagon-Secreting CellsInsulinLiverSomatostatinBlood GlucoseIslets of LangerhansKineticsGlucoseProglucagonHypoglycemiaProteolipidsGluconeogenesisGlucagon-Like PeptidesPancreasPancreatic HormonesPancreatic PolypeptideLiposomesRats, Inbred StrainsGlucagon-Like Peptide 1EpinephrineAdenylate CyclaseCyclic AMPLiver GlycogenBone Marrow TransplantationCell MembraneReceptors, Gastrointestinal HormoneMolecular Sequence DataDogsHematopoietic Stem Cell TransplantationFastingEscherichia coliRecombinant ProteinsTime FactorsSevere Combined ImmunodeficiencyHormonesAmino Acid SequenceCells, CulturedC-PeptideDetergentsMice, Inbred C57BLSecretinLactatesHematopoietic Stem CellsElectrophoresis, Polyacrylamide GelAdenoma, Islet CellHyperglycemiaBucladesineArginineThymus GlandTransplantation, HomologousAmino AcidsCalciumProtein BindingT-LymphocytesSomatostatin-Secreting CellsCattleEnzyme ActivationHematopoiesisGlucagonomaMacromolecular SubstancesSolubilityMembrane ProteinsCell LineOxyntomodulinFatty Acids, NonesterifiedPeptidesGastrointestinal HormonesApoenzymesPerfusionAdenosine TriphosphateGastric Inhibitory Polypeptide3-Hydroxybutyric AcidAntiretroviral Therapy, Highly ActiveSecretory RateCell-Free SystemKetone BodiesMolecular WeightMice, KnockoutCarrier ProteinsMitochondria, LiverApoproteinsBiological TransportBase SequencePhosphorylasesPeptide FragmentsChromatography, GelDose-Response Relationship, DrugVasopressinsGlycerolPhospholipidsDiabetes Mellitus, ExperimentalGlycogenolysisAlanineHydroxybutyratesRadioimmunoassayHydrocortisoneInsulin-Secreting Cells
InsulinPeptide 1 receptorVialSecretionReceptorsInjectionSyringeHormonesFreezeFormulationsPeptidesInjectablePancreaticIncretinConcentrationAntibioticHypoglycemiaEmergency KitAntibodyMoleculeFacilitatesFormulationInjectionsStableRefillBlood-sugarBottleHumanHANDLINGSolutionRegulatoryDoseWaterTreatmentMonthsMultipleAdditionLevelsAdministrationActivationWeeksRelease
Insulin8
Peptide 1 receptor1
  • Interchanging a glucagon-like peptide-1 receptor agonist (GLP-1 RA) for another in the class may be necessary or desirable. (powerpak.com)
Vial6
  • Rescue has been simplified by the development of the glucagon hypoglycemia rescue kit, consisting of: biosynthetic human glucagon, in a freeze dried form within a vial, a sturdy syringe, pre-filled with a sterile diluting solution, and a conspicuous red or orange colored plastic storage box, which includes instructions. (wikipedia.org)
  • Glucagon Emergency Kit for Low Blood Sugar contains: 1 mg single dose vial of Glucagon for Injection with 1 mL single dose syringe of Sterile Water for Injection, USP for reconstitution. (fresenius-kabi.us)
  • The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. (rndsystems.com)
  • The Practi-Powder White 2 mL for clinical training, are the only simulated practice for small vial handling multiple dosage reconstitution Each 2 mL vial contains a white powder that dissolves in. (anatomywarehouse.com)
  • The Practi-Glucagon Powder Vial Refill 1mg/1 mL, for clinical training, simulates glucagon powder for injection and prepares students for patients with severe hypoglycemia or low blood sugar Each 1. (anatomywarehouse.com)
  • Easy to use Practi-Vancomycin is a white powder in a 10 mL vial that emulates 500 mg of the antibiotic vancomycin (Vancocin) for reconstitution practice. (anatomywarehouse.com)
Secretion1
  • At the same time, Liraglutide lowered inappropriately high glucagon secretion in the body. (purerawz.co)
Receptors2
Injection3
  • Glucagon rescue is the emergency injection of glucagon in case of severe diabetic hypoglycemia. (wikipedia.org)
  • The glucagon rescue kit facilitates rapid rescue by a simple injection, which does not require medical expertise, and can be done quickly and easily outside of a medical facility. (wikipedia.org)
  • User information for 'GlucaGen HypoKit' from Novo Nordisk[dead link] User information for 'Glucagon Emergency Kit' from Eli Lilly and Company 'GlucaGen Hypo Kit' elearning course Archived 13 February 2013 at archive.today "Glucagon for Injection, rDNA formulation" (PDF). (wikipedia.org)
Syringe3
  • Glucagon must be reconstituted using a multi-step process that requires the administrator to use a prepared syringe containing an inactive compound and a sealed dosage bottle of glucagon. (wikipedia.org)
  • After the contents of the syringe are injected into the glucagon bottle, the administrator must determine if the reconstitution appears appropriate: clear with a water-like consistency. (wikipedia.org)
  • Immediately after reconstitution, using the same syringe, withdraw the correct dose of GlucaGen. (guidelinecentral.com)
Hormones2
  • Hormones of the glucagon family have a common evolutionary origin that is reflected in high homology among their primary sequences in all vertebrate species 17 (Fig. 1b and Supplementary Fig. 1 ). (nature.com)
  • Glucagon-like peptide-1 (GLP-1) is a member of the glucagon family of hormones. (sysy.com)
Freeze2
  • Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. (sigmaaldrich.com)
  • Once reconstituted, the antibody should be stable for a few days at -4°C. For storage up to a few months, prepare small aliquots after reconstitution and freeze at -20°C or -80°C. Repeated freeze thaw cycles should be strictly avoided. (phoenixbiotech.net)
Formulations4
  • Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas. (wikipedia.org)
  • New York, NY, June 20, 2013 -JDRF announced today partnerships with both Xeris Pharmaceuticals, Inc., and LATITUDE Pharmaceuticals, Inc. (LPI), to support the development of soluble glucagon formulations-an important step toward the advancement of future generation, fully automated and multi-hormonal artificial pancreas systems for people with type 1 diabetes (T1D). (jdrf.org)
  • Said Dr. Dutta: "We are excited to explore whether the novel glucagon formulations by Xeris and LATITUDE could prove effective for use in an infusion pump, thereby bringing us closer to the future of closed loop artificial pancreas systems by 'resetting' the missing hormonal balance in people with type 1 diabetes. (jdrf.org)
  • More recently, formulations of the sugar-regulating peptide hormone, glucagon, have been approved for marketing using dimethyl sulfoxide (DMSO) as the solvent. (ondrugdelivery.com)
Peptides2
  • Here, we identify an evolutionarily conserved hexapeptide sequence as the major aggregation-prone region (APR) of gastrointestinal peptides of the glucagon family: xFxxWL. (nature.com)
  • We determine nine polymorphic crystal structures of the APR segments of glucagon-like peptides 1 and 2, and exendin and its derivatives. (nature.com)
Injectable2
  • Xeris-a specialty pharmaceutical company based in Austin, TX, focused on developing injectable therapeutics-will study its stable, room-temperature, and non-aqueous injectable glucagon (G-Pump™ Glucagon) to treat hypoglycemia. (jdrf.org)
  • Only two uses in 21 years, but with the advent of GLP-1 injectable therapies for weight loss, most recently Ozempic and now Mounjaro, I have needed glucagon at least three times at the beginning of therapy because juice was not raising my sugar. (t1dexchange.org)
Pancreatic2
  • Glucagon-like peptide 1 (1-37) (human, rat) is a pancreatic hormone synthesized by post-translational processing of proglucagon. (tocris.com)
  • The process involves the reversion of delta cells (which produce somatostatin, another pancreatic hormone) to a precursor-like cell state, with proliferation and later reconstitution of the populations of beta and delta cells. (cancerlive.net)
Incretin1
  • It mimics the action of human incretin glucagon-like peptide-1 (GLP-1). (muscleandbrawn.com)
Concentration1
  • Antibody concentration after reconstitution 1 mg/ml. (alomone.com)
Antibiotic1
  • Ideal for use with larger Practi-Vials (containing distilled water) for antibiotic reconstitution practice. (anatomywarehouse.com)
Hypoglycemia2
  • Mini-Dose Glucagon Rescue for Hypoglycemia in Children With Type 1 Diabetes - Haymond and Schreiner. (wikipedia.org)
  • Glucagon is a naturally occurring hormone that raises blood-sugar levels to prevent hypoglycemia (low blood sugar), but its regulation is impaired in people with T1D, for whom hypoglycemia can be dangerous. (jdrf.org)
Emergency Kit1
  • Novo Nordisk manufactures the GlucaGen HypoKit and Eli Lilly and Company manufactures the Glucagon emergency kit. (wikipedia.org)
Antibody2
  • Storage before reconstitution The antibody ships as a lyophilized powder at room temperature. (alomone.com)
  • For optimal results, use the antibody as soon as possible after reconstitution. (phoenixbiotech.net)
Molecule2
  • within hours of reconstitution, the molecule will degrade into amyloid fibrils. (wikipedia.org)
  • LPI-a drug formulation development company based in San Diego, CA-will use a unique, proprietary, solvent-free, glucagon nanoemulsion (Nano-G) to solubilize and stabilize the molecule, such that it is not vulnerable to degradation and remains biologically active. (jdrf.org)
Facilitates1
  • These experiments indicate that the glucagon receptor facilitates activation of N by: (i) decreasing the apparent Km of N for Mg2+, and (ii) increasing the extent of activation that can be elicited by saturating concentrations of guanine nucleotide. (nih.gov)
Formulation1
  • This partnership will accelerate LATITUDE's stable, soluble glucagon formulation and its potential for new medical applications. (jdrf.org)
Injections3
  • My sweet mom revived me with glucagon injections ~4 times/year in those days when I didn't wake up in the morning. (t1dexchange.org)
  • I required only 1-2 glucagon injections in my the 20 years since, over 7 years ago. (t1dexchange.org)
  • Tirzepatide injections are a class of medications called glucagon-like-peptide-1 (GLP-1) agonists, although Tirzepatide has enhanced effects as a glucose-dependent insulinotropic polypeptide (GIP) agonist that produce more drastic weight loss results. (1bmflabz.com)
Stable1
  • To become fully automated, closed loop systems, new technologies and drugs-including stable, pumpable glucagon-will be required in order to more closely and accurately mimic the functions of a healthy pancreas. (jdrf.org)
Refill1
  • Most recent refill btw is an auto-injector prefilled pen rather than the reconstitution kit. (t1dexchange.org)
Blood-sugar1
  • It's a compound known as GLP-1 (Glucagon Like Peptide 1) which can help you lower blood sugar levels and reduce the risk of high blood pressure, a heart attack, and best of all, it's FDA Approved. (muscleandbrawn.com)
Bottle1
  • 1 x 20ml Bottle of Bac Water: The kit contains a 20ml bottle of bacteriostatic water (bac water) for peptide reconstitution, providing a sterile and safe solution. (purerawz.co)
Human5
HANDLING1
  • A downside is that lyophilised drugs require reconstitution prior to administration, which presents additional handling requirements, a potential risk of contamination and can easily result in over- or under-dilution. (ondrugdelivery.com)
Solution5
  • Both Xeris and LPI are using approaches distinct from the ongoing JDRF-supported research program led by W. Kenneth Ward , M.D. at OHSU, which is utilizing a liquid solution of glucagon at a high pH in order to stabilize the drug. (jdrf.org)
  • The reconstituted solution is 1 mg per mL glucagon. (guidelinecentral.com)
  • This was because my stomach was full, and or with n/v, and glucagon became the only quick solution. (t1dexchange.org)
  • Storage after reconstitution The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. (alomone.com)
  • For reconstitution add 50 µl H 2 O to get a 1mg/ml solution in PBS. (sysy.com)
Regulatory1
  • N-Ethylmaleimide treatment of rat liver plasma membranes results in an adenylyl cyclase (EC 4.6.1.1) system that shows no measurable cyclizing activity but retains both an active glucagon receptor and a receptor-sensitive regulatory component N as assessed by reconstitution into cyclase-negative (cyc-) membranes from S49 murine lymphoma. (nih.gov)
Dose1
  • The purpose of the off-label 'mini-dose' is to avoid an emergency condition that may require glucagon rescue. (wikipedia.org)
Water1
  • Reconstitution 15 μl or 50 µl double distilled water (DDW), depending on the sample size. (alomone.com)
Treatment1
  • We also present that PTCy treatment promotes speedy reconstitution of donor-derived tTregs without impacting their epigenetic profile or efficiency. (informationalwebs.com)
Months1
Multiple1
  • RRPs make use of microfluidics to perform optimal on-spot reconstitution and delivery of multiple AIs. (gearjumptech.com)
Addition1
  • Addition of glucagon during the activation results in a lowering of the Mg2+ requirement for full activation from 25 mM to around 10 muM and in concomitant increases in both the rate and the extent of N activation. (nih.gov)
Levels1
  • Short-term fasting lowers glucagon levels under euglycemic and hypoglycemic conditions in healthy humans. (uc.edu)
Administration1
  • Some U.S. union teacher contracts stipulate they shall not be allowed to deliver glucagon or even be trained in administration of glucagon. (wikipedia.org)
Activation1
  • In contrast to its dramatic effect on Mg2+ requirement, glucagon has little (less than 2-fold) effect on the GTP[gamma S] requirement of N activation. (nih.gov)
Weeks1
  • Mice were injected each and every three days beginning at week 4 following bone marrow reconstitution, and analyzed six weeks just after reconstitution. (glucagon-receptor.com)
Release1