• binds
  • This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. (cancerindex.org)
  • When the protein binds to that cell, it is taken in through endocytosis, and the toxin kills the cell. (wikipedia.org)
  • antigens
  • Immune responses of two recombinant adenoviruses expressing VP1 antigens of FMDV fused with porcine granulocyte macrophage colony-stimulating factor," Vaccine , vol. 25, no. 49, pp. 8209-8219, 2007. (hindawi.com)
  • Likewise, the relative immunodominance of individual antigens in the fusion molecule is altered by the choice of delivery system. (mendeley.com)
  • antibodies
  • Anti-CD22 immunotoxins, being tested in hairy cell leukemia Antibody-drug conjugates, most, if not all, are immunotoxins but use whole antibodies and non-protein drugs Immunopharmacology and Immunotoxicology (medical journal) Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ (2007). (wikipedia.org)
  • gene
  • Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. (abcam.com)
  • What does this gene/protein do? (cancerindex.org)
  • Plasminogen-related protein B is a protein that in humans is encoded by the PLGLB2 gene. (wikipedia.org)
  • In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17. (wikipedia.org)
  • vivo
  • This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)
  • It also makes it relatively non-toxic in vivo as the recognized sequence scarcely occurs in proteins. (wikipedia.org)
  • novel
  • Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1," Veterinary Research , vol. 45, no. 1, article 62, 2014. (hindawi.com)
  • First, ProINS-Tf is a novel fusion protein and the first proprotein within the Tf-based fusion protein family. (usc.edu)
  • coli
  • Modeling and Simulation of Production of Metallothionein and Red Fluorescent Fusion Protein by Recombinant Escherichia Coli Using Graphical Programming, Modeling, Programming and Simulations Using LabVIEW™ Software Riccardo De Asmundis, IntechOpen, DOI: 10.5772/14091. (intechopen.com)
  • citation needed] They are now made using recombinant DNA techniques, are produced in bacteria like E. coli or yeast like P. pastoris and are called recombinant immunotoxins. (wikipedia.org)
  • mediates
  • We also found that cAMP-GEFII mediates cAMP-dependent, protein kinase A (PKA)-independent insulin secretion, and that this requires interaction with both Rim2 and Piccolo ( 16 - 18 ). (diabetesjournals.org)
  • viral
  • Pneumoviruses replicate entirely in the cytoplasm, and this process begins with adsorption of the virus to the cellular receptor on the host cell, directed by the viral attachment protein, variously called G, H (hemagglutinin) or HN (hemagglutinin-neuraminidase). (wikipedia.org)
  • tumor
  • We can used specific TAAs, tumor lysates,created DC-cancer cell fusions, electroporation/transfection of DCs with total cancer cell-mRNA or tumor derived exosomes (TDEs) by the stimulation.There is also possibility of aditonal co-stimulating with cytokine "cocktails" to assure strong maturation. (wikipedia.org)
  • Interactions
  • HMPV is thought to attach to the target cell via the glycoprotein (G) protein interactions with heparan sulfate and other glycosaminoglycans. (wikipedia.org)
  • activation
  • Radioimmunoassays clearly demonstrate a TfR-mediated conversion and activation of ProINS-Tf to an immunoreactive insulin-transferrin fusion protein during the 24 h incubation with hepatoma cells. (usc.edu)
  • It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. (abcam.com)
  • cells
  • Cells in which regulated exocytosis occurs share several molecules that constitute the exocytotic machinery, including SNARE proteins (VAMP/synaptobrevin, SNAP, and syntaxin), synaptotagmins, and Rab proteins ( 2 , 3 ). (diabetesjournals.org)
  • The result revealed that the fusion protein His-TAT-p53 accumulated in the nucleus and inhibited the growth of the Saos-2 cells. (biomedsearch.com)
  • The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells - B-lymphocyte stimulator (BLyS) and A proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. (wikipedia.org)
  • citation needed] These patients were treated with the recombinant immunotoxin, BL22, which targets the CD22 cell surface receptor, which is highly expressed on these leukemic cells. (wikipedia.org)
  • It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. (wikipedia.org)
  • cell
  • In the present study, an 11-amino acid domain of TAT protein which has been demonstrated to be able to transduce across cell membranes was fused with p53. (biomedsearch.com)
  • active
  • Catalytically active tetramer-dimer (in equilibrium) forms of the fusion protein were separated from inactive, aggregated forms by size-exclusion h.p.l.c. (biochemj.org)
  • site
  • CAZ ( c ytoskeletal matrix associated with the a ctive z one) proteins have been suggested to organize the site of neurotransmitter release. (diabetesjournals.org)