• antigen
  • IMP321 is a 200 kDA soluble dimeric recombinant fusion protein of the extracellular portion of LAG3 with immunoglobulin, designed to activate antigen presenting cells. (wikipedia.org)
  • had successfully produced a soluble fusion protein of LAG3 and immunoglobulin around 1995 and had initially envisaged its use as an immunosuppressant after evidence that its interaction with MHC class II molecules leads to the down-regulation of CD4+ antigen-specific T cell clone proliferation and cytokine secretion, and that it inhibited the alloresponses of naive peripheral blood lymphocytes. (wikipedia.org)
  • The investigators for this work used influenza matrix protein antigen and the tumor antigens Melan-A/MART-1 and survivin when seeking this CD8+ T cell response. (wikipedia.org)
  • The toxin is usually a cytotoxic protein derived from a bacterial or plant protein, from which the natural binding domain has been removed so that the Fv directs the toxin to the antigen on the target cell. (wikipedia.org)
  • The cells are incubated ex vivo in the presence of a recombinant fusion protein PA2024 containing a prostate antigen, prostate acid phosphatase and GM-CSF, an immune-cell activator. (wikipedia.org)
  • glycoprotein
  • HMPV is thought to attach to the target cell via the glycoprotein (G) protein interactions with heparan sulfate and other glycosaminoglycans. (wikipedia.org)
  • subunit
  • Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. (abcam.com)
  • G saL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. (abcam.com)
  • mediates
  • We also found that cAMP-GEFII mediates cAMP-dependent, protein kinase A (PKA)-independent insulin secretion, and that this requires interaction with both Rim2 and Piccolo ( 16 - 18 ). (diabetesjournals.org)
  • viral
  • Pneumoviruses replicate entirely in the cytoplasm, and this process begins with adsorption of the virus to the cellular receptor on the host cell, directed by the viral attachment protein, variously called G, H (hemagglutinin) or HN (hemagglutinin-neuraminidase). (wikipedia.org)
  • tumor
  • We can used specific TAAs, tumor lysates,created DC-cancer cell fusions, electroporation/transfection of DCs with total cancer cell-mRNA or tumor derived exosomes (TDEs) by the stimulation.There is also possibility of aditonal co-stimulating with cytokine "cocktails" to assure strong maturation. (wikipedia.org)
  • Antibodies
  • Anti-CD22 immunotoxins, being tested in hairy cell leukemia Antibody-drug conjugates, most, if not all, are immunotoxins but use whole antibodies and non-protein drugs Immunopharmacology and Immunotoxicology (medical journal) Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ (2007). (wikipedia.org)
  • active
  • Catalytically active tetramer-dimer (in equilibrium) forms of the fusion protein were separated from inactive, aggregated forms by size-exclusion h.p.l.c. (biochemj.org)
  • The purified hbFGF proteins, both with and without the fusion tags, were biologically active, which was confirmed by their ability to stimulate proliferation of NIH3T3 cells. (figshare.com)
  • cells
  • Cells in which regulated exocytosis occurs share several molecules that constitute the exocytotic machinery, including SNARE proteins (VAMP/synaptobrevin, SNAP, and syntaxin), synaptotagmins, and Rab proteins ( 2 , 3 ). (diabetesjournals.org)
  • The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells - B-lymphocyte stimulator (BLyS) and A proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. (wikipedia.org)
  • citation needed] These patients were treated with the recombinant immunotoxin, BL22, which targets the CD22 cell surface receptor, which is highly expressed on these leukemic cells. (wikipedia.org)
  • It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. (wikipedia.org)
  • site
  • CAZ ( c ytoskeletal matrix associated with the a ctive z one) proteins have been suggested to organize the site of neurotransmitter release. (diabetesjournals.org)
  • activation
  • It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. (abcam.com)
  • beta
  • The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. (abcam.com)