• It catalyzes the hydrolysis of glucocerebroside to glucose and ceramide, which results in reduced spleen and liver enlargement and increased RBCs and platelets. (medscape.com)
  • It catalyzes the hydrolysis of plasma membrane sphingomyelin to generate bioactive ceramide and phosphocholine. (uwindsor.ca)
  • EC 3.5.1.1) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. (fortunepublish.com)
  • Glyoxalase II catalyzes the hydrolysis of S-lactoylglutathione, the product of the glyoxalase I reaction, to glutathione and lactate. (rndsystems.com)
  • UDGase catalyzes the hydrolysis of the N-glycosylic bond between uracil and sugar, leaving an apyrimidinic site in uracil-containing single-stranded or double-stranded DNA. (qiagen.com)
  • Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). (calixar.com)
  • Examination of transcriptome data and secreted proteins suggests that the two fungi use shared approaches in the hydrolysis of cellulose and xylan but distinct mechanisms in pectin degradation. (utwente.nl)
  • Thus, there is a big demand for high-copy-number plasmids for useful gene manipulation and overproduction of recombinant proteins in Leuconostoc . (biomedcentral.com)
  • The effectiveness of the isolated high-copy-number plasmid for the overproduction of recombinant proteins was successfully demonstrated with two protein models Glutathione-S-transferase (GST) and α-amylase. (biomedcentral.com)
  • In particular, expression plasmids are one of the most fundamental systems for genetic manipulations and protein production, especially to carry foreign DNA and to produce recombinant proteins in a host. (biomedcentral.com)
  • Here, we present general methods to generate recombinant proteins from both helicase families, as well as standard biochemical assays to investigate their activities on DNA. (indiana.edu)
  • Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins. (calixar.com)
  • More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)
  • Derived proteins or mixtures of cleavage products produced by the partial hydrolysis of a native protein either by an acid or by an enzyme. (bvsalud.org)
  • Approximately 10-15% of patients with Gaucher disease treated with imiglucerase develop antibodies to the enzyme protein, but few develop any significant allergic reactions, which are controlled with premedication with hydrocortisone, antihistamines, or both. (medscape.com)
  • This diploma thesis revolves around the preparation of biocompatible polymeric conjugates called "iBodies" that will be used to induce targeted lysosomal degradation of two model enzymes - Fibroblast activation protein α, and Glutamate carboxypeptidase II. (nusl.cz)
  • Due to the existence of this equilibrium, the GSNO metabolizing enzyme GSNO reductase (GSNOR) indirectly drives protein de-nitrosation. (uwindsor.ca)
  • Besides their traditional uses, LAB are also regarded as attractive hosts for recombinant protein production due to their generally recognized as safe (GRAS) status [ 2 , 3 ]. (biomedcentral.com)
  • Applicants can have a background from general biochemistry, protein and enzyme technology and carbohydrate analysis. (ku.dk)
  • After induction with lipopolysaccharide, the expression of tsGILT mRNA was upregulated in spleen and kidney and recombinant tsGILT protein transferred to late endosomes and lysosomes in HeLa cells. (bvsalud.org)
  • The process of immune response to bacteria challenge needs GILT to catalyze the reduction of disulfide bond and unfolding native protein antigens, promoting their hydrolysis by proteases. (bvsalud.org)
  • Protopectinases which were consisted of various different enzymes can promote the solubilization of protopectin from the plant cell and can be applied in the protein industry extraction. (springeropen.com)
  • Allergen avoidance strategies including personal protective equipment, engineering controls, protein encapsulation, and reduction of airborne enzyme concentrations are required to mitigate occupational exposure to fungal enzymes. (cdc.gov)
  • Alkaline phosphatase (ALP) is a calcium- and phosphatebinding protein and a phosphor-hydrolytic enzyme. (bvsalud.org)
  • It is shown that semichemical pulp after cooking with green liquor displays high reactivity in enzymatic hydrolysis with cellulase complex and is of clear interest as a substrate for scaling the bioengineering processes of renewable plant feedstock conversion. (slu.se)
  • Cellulolytic enzymes are hydrolases that cleave O-glycosidic bonds and are classified according to the sites on the cellulosic substrate upon which they act. (biomedcentral.com)
  • Enzymatic parameters of the recombinant PhAcP were measured using benzoyl phosphate as the substrate. (rcsb.org)
  • The four enzymes differ in substrate specificity and in the design of item formation. (bioinf.org)
  • the carboxylesterase-mediated rate of metabolism of DABE and the result of alcohol around the hydrolysis of the traditional carboxylesterase substrate (cocaine) had been analyzed to validate the in vitro model. (gasyblog.com)
  • The goal of treatment is to reduce the rate of glucocerebroside biosynthesis so that the amount is reduced to a level that allows the residual activity of the deficient glucocerebrosidase enzyme to be more effective (substrate reduction therapy). (medscape.com)
  • N1-(5'-Phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase (HisI, PR-AMP cyclohydrolase) is a central enzyme in histidine biosynthesis catalyzing the hydrolysis of the N1-C6 bond of the purine substrate, a reaction unique to this pathway. (rhea-db.org)
  • Cellulosomes are naturally occurring elaborate enzyme complexes found in many anaerobic microorganisms that can efficiently hydrolyze cellulose based on the high level of enzyme-substrate synergy [ 9 ]. (biomedcentral.com)
  • The synergistic effects are due to (1) the targeting effect of the cellulose binding module, (2) the proximity effect of the enzymes, and (3) the elimination of substrate inhibition from the quick uptake of glucose. (biomedcentral.com)
  • Isolation and characterization of an angiotensin converting enzyme substrate from vitellogenic ovaries of Neobellieria bullata. (ox.ac.uk)
  • Vitellogenic ovaries of the gray fleshfly Neobellieria bullata contain a variety of unidentified substances that interact, either as a substrate or as an inhibitor, with angiotensin converting enzyme (ACE). (ox.ac.uk)
  • MYOZYME ® (alglucosidase alfa) is a lysosomal glycogen-specific enzyme indicated for use in patients with Pompe disease (GAA deficiency). (nih.gov)
  • Hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy for type 1 Gaucher disease. (medscape.com)
  • ELELYSO is a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for the treatment of patients 4 years and older with a confirmed diagnosis of Type 1 Gaucher disease ( 1 ). (pfizermedicalinformation.com)
  • The enzyme gamma-interferon-inducible lysosomal thiol reductase (GILT) plays an important role in promoting the processing and presentation of major histocompatibility complex (MHC) class II-restricted antigens. (bvsalud.org)
  • Classically, lysosomal storage diseases encompassed only enzyme deficiencies of the lysosomal hydrolases. (medscape.com)
  • This has led to active clinical trials evaluating the safety and efficacy of intrathecal enzyme delivery in several lysosomal storage diseases (see www.ClinicalTrials.gov ). (medscape.com)
  • A capillary electrophoresis (CE) way for the characterization of recombinant NTPDases 1, 2, and 3, as well as for assaying NTPDase inhibitors continues to be developed executing the enzymatic response inside the capillary. (bioinf.org)
  • Characterization of the biomass-hydrolyzing activity of recombinant enzymes suggests that these organisms are highly efficient in biomass decomposition at both moderate and high temperatures. (utwente.nl)
  • A source of the recombinant monofunctional Methanococcus vannielii PR-AMP cyclohydrolase has been developed, and the first characterization of a purified form of the enzyme is reported. (rhea-db.org)
  • Each GH was affinity-tagged, overexpressed, and purified from recombinant C. bescii for side-by-side characterization in vitro and to examine the contribution of each of these enzymes to microcrystalline cellulose hydrolysis in vivo. (princeton.edu)
  • The cascade comprises five recombinant enzymes expressed in Escherichia coli that were purified by immobilized metal affinity chromatography. (bvsalud.org)
  • Here, a cell-free multi-enzyme cascade was developed to synthetize nucleotide-activated glycerol from the inexpensive and readily available substrates cytidine and glycerol. (bvsalud.org)
  • These enzymes belong to the phosphodiesterase family and are capable of cleaving phosphodiester internal bonds within double-stranded (ds)or single-stranded (ss) DNA and RNA substrates. (silverchair.com)
  • Cellulose is the most important component of lignocellulose, and its degradation requires three different types of enzymes to act synergistically. (biomedcentral.com)
  • Considering the demand for a synergistic action of multiple enzymes, the expression of a variety of enzymes in a single cell is likely to improve the efficiency of cellulose degradation [ 10 ]. (biomedcentral.com)
  • Cellulose is highly recalcitrant and thus requires a specialized suite of enzymes to solubilize it into fermentable sugars. (biomedcentral.com)
  • When a Δ cipA mutant C . thermocellum strain was cultured with a CipA*-expressing T . saccharolyticum strain, hydrolysis and fermentation of 10 grams per liter SigmaCell 101, a highly crystalline cellulose, were observed. (biomedcentral.com)
  • In addition, we demonstrate a high degree of hydrolysis (up to 93%) on microcrystalline cellulose. (biomedcentral.com)
  • Ideally, a recombinant microorganism, possessing the capability to utilize cellulose for simultaneous growth and ethanol production, is of great interest. (biomedcentral.com)
  • Instead, the substantial increase in ethanol production is consistent with the reported synergistic effect on cellulose hydrolysis using the displayed mini-cellulosome. (biomedcentral.com)
  • An ideal microorganism for CBP should possess the capability of efficient enzyme production and simultaneous cellulose saccharification and ethanol fermentation. (biomedcentral.com)
  • Neither the native C. bescii secretome nor cocktails of GDL GHs in vitro exceeded 25% of cellulose hydrolysis observed for wild-type C. bescii in vivo. (princeton.edu)
  • They also reinforce the importance of microbial contributions to microcrystalline cellulose hydrolysis and suggest that mass action effects from glucan fermentation shift equilibria to drive degradation. (princeton.edu)
  • C. bescii deletion strains lacking specific GDL GHs could be restored to wild-type degradation levels with the exogenous addition of either 5 µg/ml of recombinant GDL GH cocktails based on the natural secretome or mixtures optimized in vitro. (princeton.edu)
  • The influence of fly ash on hydrolysis, degradation and adsorption of methyl parathion in aqueous soil suspensions. (cdc.gov)
  • They catalyze the sequential hydrolysis from the - and -phosphate residues of nucleoside triand diphosphates, generating the related nucleoside monophosphate derivatives [2]. (bioinf.org)
  • The sequential hydrolysis of DABE in HIMs and HLS9 fractions can be proven in Fig. 3. (gasyblog.com)
  • Sequential hydrolysis of DABE (200 nM) in HIMs (A) (step one 1) and HLS9 fractions (B) (step two 2). (gasyblog.com)
  • The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. (qmul.ac.uk)
  • The type 1 cohesin domains bind with high affinity to type 1 dockerin domains present in over 70 catalytically-active enzymes [ 14 ]. (biomedcentral.com)
  • 2006). Commercial production of FOS currently rely on the enzymatic hydrolysis of inulin by endo-inulinases from various sources (Chi et al. (justia.com)
  • In Vitro Enzyme Kinetics. (gasyblog.com)
  • The enzyme kinetics email address details are proven in Desk 1 and Supplemental Shape 2. (gasyblog.com)
  • Department of Plant and Environmental Sciences, The Section for Plant Glycobiology, invites applicants for a PhD fellowship in Interfacial enzyme kinetics. (ku.dk)
  • Minor elevations of liver and angiotensin-converting enzyme levels are common. (medscape.com)
  • 1413B were used as strains that produce the chromosome- enzymes (NmcA, IMI-1, Sme-1/Sme-2) (2,4-9). (cdc.gov)
  • Among the four strains, the purified recombinant ASNase from S. thermophilus exhibited the highest specific activity of 113.0 U/mg and specificity for L-asparagine. (fortunepublish.com)
  • The available commercial preparations of ASNase in the food industry are based on enzymes from recombinant strains of Aspergillus niger or A. oryzae [12]. (fortunepublish.com)
  • Recombinant inulinases and engineered host strains have many potential industrial applications, however, efficient production processes of highly processive enzymes are required (Wang et al. (justia.com)
  • Thermostable enzymes and thermophilic cell factories may afford economic advantages in the production of many chemicals and biomass-based fuels. (utwente.nl)
  • Furthermore, we present evidence suggesting that aside from representing a potential reservoir of thermostable enzymes, thermophilic fungi are amenable to manipulation using classical and molecular genetics. (utwente.nl)
  • The enzyme is produced in a recombinant E. coli (ung-) strain that contains a modified Cod UNGgene. (sigmaaldrich.com)
  • In this study, we exploited the enzyme repertoire of E. coli K5 and the E. coli K5-specific bacteriophage ΦK5B for the controlled synthesis and depolymerization of heparosan. (bvsalud.org)
  • In contrast, enzymes from E. coli [8] and E. carotovora [9] the most effective for this purpose. (fortunepublish.com)
  • constructed a co-expression vector containing two independent expression cassettes based on six restriction enzyme sites and achieved the co-expression of egv 3 (GenBank: HG313887.1) and cbh 2 (GenBank: HG313872.1) genes each controlled by a separate promoter in Trichoderma reesei [ 11 ]. (biomedcentral.com)
  • The present paper examined the effects of three non synonymous BCHE mutations (G75R, E90D and /99M) on enzyme kinetic parameters obtained after the expression of the respective recombinant BChEs. (nebraska.edu)
  • To day four different cell surface-located isoforms from the enzyme family members have already been cloned and functionally characterized (NTPDase1, 2 and 3, and incredibly lately NTPDase8) [30C32]. (bioinf.org)
  • The authors have been investigating the metabolism of a number of agrochemicals by human liver microsomes and recombinant CYP isoforms and have recently embarked on studies of the induction of XMEs in human hepatocytes. (cdc.gov)
  • is inclusive of papers focused on stucture, function, and properties of enzymes as well as catalytic and inhibition mechanisms of enzymes, mechanisms of drug action, and related advances on enzymes. (mdpi.com)
  • The research focus is within the area "enzymes of extremophilic microorganisms", especially concerning thermostable glycoside hydrolases (including representatives from GH-family 1, 3, 10, 12 and 13). (lu.se)
  • Supported by biochemical studies and comprehensive 2D nuclear magnetic resonance, our data explain how the ribofuranosyltransferase CriT, the phosphatase CrpP, the ribitol-phosphate transferase CroT and a polymer-binding domain function as a unique multi-enzyme assembly. (bvsalud.org)
  • Although genetics, structural biology, and a variety of other techniques have been used to study these helicases, ensemble analyses of their basic biochemical activities such as DNA binding, ATP hydrolysis, and DNA unwinding have made significant contributions to our understanding of their physiological roles. (indiana.edu)
  • The studies involve biochemical structure/function-related studies of enzymes with a biotechnological potential. (lu.se)
  • The active form of β-gal is a tetramer and hydrolyses lactose into glucose and galactose. (sigmaaldrich.com)
  • NTPDase1 hydrolyzes ATP right to AMP, ADP may be the preferential item of ATP hydrolysis by NTPDase2, and NTPDase3 and NTPDase8 hydrolyze ADP created from ATP effectively to AMP. (bioinf.org)
  • 3) and α- l - arabinofuranosidases (AFs, EC 3.2.1.55), exo-type enzyme, which hydrolyze terminal nonreducing residues from arabinose-containing polysaccharides and are active on 4-nitrophenyl-α- l -arabinofuranoside. (springeropen.com)
  • Our data suggest that, while PhAcP is less efficient than other mammalian homologues at 25 degrees C, the thermophilic enzyme is fully active at the optimal growth temperature (98 degrees C) of P. horikoshii. (rcsb.org)
  • The disorder results from the deficiency of the enzyme glucocerebrosidase. (medscape.com)
  • Enzyme replacement therapy (ERT) with glucocerebrosidase purified from human placenta was FDA approved in 1991, followed by approval in 1994 of a recombinant form of the enzyme produced in cultured Chinese hamster ovary (CHO) cells, marketed as imiglucerase (Cerezyme). (medscape.com)
  • Recombinant beta-glucocerebrosidase (imiglucerase [Cerezyme]) has replaced the original tissue-derived product, alglucerase (Ceredase). (medscape.com)
  • A recombinant-derived analog of beta-glucocerebrosidase produced in mammalian cell culture and chemically modified by mannose termination of glycosylated amino acids. (medscape.com)
  • The remaining two are known potent inhibitors of the chosen model enzymes that will serve as their targeting-ligands. (nusl.cz)
  • Application of complex biocatalysts based on recombinant Penicillium verruculosum enzyme preparations in the hydrolysis of semichemical hardwood pulp. (slu.se)
  • A comparative study of the efficiency of the biocatalysts based on recombinant enzyme preparations obtained from the Penicillium verruculosum fungus in the hydrolysis of semichemical hardwood pulp is performed. (slu.se)
  • In fruit and vegetable juice processing, α- l -arabinofuranosidases in the enzyme preparations cause haze formation due to the precipitation of polymeric debranched arabinans. (springeropen.com)
  • GR has a disulfide bond in its active site, but ROS interferes with the disulfide bond and inhibits the enzyme. (adenosine-kinase.com)
  • Commercial human recombinant salivary and pancreatic amylases (AMs) will be used to engineer starch to increase its hydrolytic resistance. (ku.dk)
  • The activity of the biocatalysts with respect to different types of semichemical pulp and the dependence of the depth of exhaustive hydrolysis on its beating and drying is determined. (slu.se)
  • One Unit of endo -polygalacturonanase activity is defined as the amount of enzyme required to release one μmole of galacturonic acid from polygalacturonic acid (5 mg/mL) per min in sodium acetate buffer (100 mM), pH 5.5 at 40 o C. (megazyme.com)
  • The filter paper enzyme activity of BCE was higher than those of BG, CBH and EG, reached 2.04 IU/mg. (biomedcentral.com)
  • A few patients with Gaucher disease have developed antibodies that impair enzyme activity. (medscape.com)
  • The activity of the enzyme was significantly inhibited by Ni 2+ . (fortunepublish.com)
  • The enzyme shows no activity on RNA or oligonucleotides. (qiagen.com)
  • 1975. [Effect of methyl parathion or zineb administration on the activity of some hepatic enzymes in rats]. (cdc.gov)
  • 2016). Enzymes that are easily produced in high yields usually have low specific activity, such as the endo-imulinase gene product from Pseudomonas sp. (justia.com)
  • Recombinant AbnZ2 had optimal activity at pH 6.0 and 35°C. And, AbnZ3 had optimal activity at pH 6.0 and 30°C. However, unlike most reported endo-arabinanases, the specific activity of AbnZ3 remained 48.7% of maximum at 5°C, which meant AbnZ3 was an excellent cold-adapted enzyme. (springeropen.com)
  • This yeast has been considered one of the best producers of amylolytic enzymes among ascomycetous yeast species [ 3 ], since its capacity to perform starch hydrolysis was first reported by Wickerham et al. (biomedcentral.com)
  • The Section for Plant Glycobiology undertakes research and teaching related to plant and algal glycobiology with particular focus on starch, cell walls and carbohydrate-active enzymes targeting bio-refining, bio-materials, functional food ingredients and nutraceuticals. (ku.dk)
  • The Starch Group works with enzyme technology and crop genome editing to design healthy foods, biomaterials and bioplastics. (ku.dk)
  • Deleting amino acids 11-41 of β-gal (called the lacZΔM15 mutation) means the enzyme is unable to form a tetramer and is non-functional (Langley et al. (sigmaaldrich.com)
  • Enzymes recognizing helical parameters such as groove width and flexibility(Dnase-I) or helical distortions caused by abasic sites (exonuclease III,HAP1), and enzymes specific for such structures as flap DNA (5′nucleases of eukaryotes and phage and eubacterial DNA polymerases) and four-way junctions (T4 endonuclease VII, RuvC) have been reported (reviewed by Suck, 1997 ). (silverchair.com)
  • Enzymes that can release arabinoses are found in various bacteria and fungi. (springeropen.com)
  • In earlier studies, a number of compounds continues to be tested concerning their strength for inhibiting ecto-nucleotidases, frequently in intact cells or on cells with undefined enzyme varieties. (bioinf.org)
  • This form of recombinant enzyme is produced in cultured human cells and is marketed as velaglucerase alfa (VPRIV). (medscape.com)
  • The enzyme is believed to be important for the response of cells to stress. (rndsystems.com)
  • disruption of the salt bridge between E90 and R42 may cause the enzyme to be rapidly degraded inside the cells. (nebraska.edu)
  • The same phenomenon was observed with membranes from Sf9 cells, expressing a recombinant PLCβ 1 cascade. (jneurosci.org)
  • The amylolytic yeast Saccharomycopsis fibuligera has served as a good source of enzymes and genes involved in saccharification. (biomedcentral.com)
  • The gene inventory facilitates the discovery of new genes applicable to the production of novel valuable enzymes and chemicals. (biomedcentral.com)
  • We mapped the sfr8 mutation to MUR1 , a gene encoding the fucose biosynthetic enzyme GDP‐d‐mannose‐4,6‐dehydratase. (megazyme.com)
  • The addition of the carboxylesterase inhibitor BNPP didn't affect this technique, suggesting how the gradual hydrolysis of DABE in individual plasma was spontaneous or mediated by various other enzymes. (gasyblog.com)
  • Uracil-DNA glycosylases are DNA repair enzymes that participate in the base excision repair pathway. (sigmaaldrich.com)
  • To identify the precise enzymes in charge of DABE hydrolysis, distinct incubations using recombinant CES1 and CES2 had been conducted. (gasyblog.com)
  • Uracil DNA Glycosylase, also known as UNGor UDG, is an enzyme that hydrolyses the N-glycosylic bond between the deoxyribose sugar and the base in uracil-containing DNA leaving an abasic(apyrimidinic) site in DNA. (sigmaaldrich.com)
  • One Unit is defined as the amount of enzyme that liberates 1 nmol Uracil per hour from Uracil-labelled DNA at 37 °C in 70 mm Tris-HCI pH 8.0 (@25 °C), 10 mM NaCI, 1 mM EDTA and 0.1 mg/ml BSA. (sigmaaldrich.com)
  • One unit is defined as the amount of enzyme that catalyzes the release of 60 pmol of uracil per minute from uracil-containing dsDNA. (qiagen.com)
  • The recalcitrant nature of cellulosic materials and the high cost of enzymes required for efficient hydrolysis are the major impeding steps to their practical usage for ethanol production. (biomedcentral.com)
  • Unfortunately, the recalcitrant nature of cellulosic materials and the high cost of enzymes required for efficient hydrolysis are the major limiting steps to the more widespread exploitation of this natural resource [ 3 ]. (biomedcentral.com)
  • Find all CAZy enzyme products on our list. (megazyme.com)
  • The final hydrolysis products of this enzyme, detected by ion exchange chromatography, yielded DNA fragments ranging form 8-12 base pairs. (silverchair.com)
  • Agrochemicals and other xenobiotics are metabolized by xenobiotic-metabolizing enzymes (XMEs) to products that may be more or less toxic than the parent chemical. (cdc.gov)
  • Acylphosphatases catalyze the hydrolysis of the carboxyl-phosphate bond in acyl phosphates. (rcsb.org)
  • We are looking for candidates within the field(s) of plant biochemistry, enzyme technology and polysaccharide science and technology. (ku.dk)
  • Whereas NTPDase1 hydrolyzes ATP and ADP about similarly well, NTPDase2 includes a high choice for the hydrolysis of ATP over ADP. (bioinf.org)
  • 6]. Some of the best examples of high-molecular-weight sectors, workers are at increased risk of becoming sensitized occupational allergens are the fungal enzymes. (cdc.gov)
  • In some occupational environments, workers are at an increased risk of exposure to fungal enzymes used in industrial production. (cdc.gov)
  • Exposure-response relationships have been demonstrated, and atopic workers directly handling fungal enzymes are at an increased risk for IgE-mediated disease and occupational asthma. (cdc.gov)
  • Immunologically mediated OA accounts for approximately weight allergens in industrial settings and describe the 90% of cases [9], but the severity of disease is dependent main enzymes that have been associated with occupational on the concentration, route, agent of exposure, and the sensitization and asthma. (cdc.gov)
  • The utilization of new and emerging fungal enzymes in industrial production will present new occupational exposures. (cdc.gov)
  • In C . thermocellum , these extracellular enzymes are present as a highly active multi-component system known as the cellulosome. (biomedcentral.com)
  • The enzyme remains active when Cd(2+) is substituted for Zn(2+). (rhea-db.org)
  • In homozygous form the E90D enzyme may confer increased susceptibility to succinylcholine, but may delay cognitive impairment in aged individuals. (nebraska.edu)
  • The present invention relates in general to improved endoinulinases and their use in hydrolysis of inulin to form fructooligosaccharides. (justia.com)
  • We could demonstrate that the enzymes act in a distributive manner, producing labeled heparosan of low dispersity. (bvsalud.org)
  • Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)
  • Enzyme replacement therapy (ERT) is indicated for patients with type 1 and type 3 Gaucher disease who exhibit clinical signs and symptoms of the disease, including anemia, thrombocytopenia, skeletal disease, or visceromegaly. (medscape.com)