• CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)
  • Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation. (exbio.cz)
  • Extracellular matrix proteins Collagens IVI Fibronectin Laminin Tenascin Vitronectin (S-protein) 8. (forextipsnow.com)
  • Due to its high transfectability and ability to produce large amounts of recombinant proteins and viral vectors, the 293T cell line is a useful tool in vaccine development. (cytion.com)
  • Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone. (wikipedia.org)
  • Vitronectin contains an RGD (45-47) sequence, which is a binding site for membrane-bound integrins, e.g., the vitronectin receptor, which serve to anchor cells to the extracellular matrix. (wikipedia.org)
  • The normal attachment, growth and development of multiple cell types are dependent on attachment factors and extracellular matrix (ECM) components. (cellseco.com)
  • MMP-2 has shown specificity to breakdown collagen types I, II, and III as well as the extracellular matrix component aggrecan. (southernbiotech.com)
  • Endocytosis is involved in a wide variety of cellular processes, including uptake and internalization of solutes and components of the extracellular matrix (ECM), regulation of signaling induced by extracellular ligands, trafficking of cell surface receptors, such as integrins, and rearrangement of the actin cytoskeleton. (ldbiopharma.com)
  • The somatomedin B domain of vitronectin binds to plasminogen activator inhibitor-1 (PAI-1), and stabilizes it. (wikipedia.org)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • On occasion, the protein is cleaved after arginine 379, to produce two-chain vitronectin, where the two parts are linked by a disulfide bond. (wikipedia.org)
  • Recombinant lyophilized protein for the attachment of human pluripotent stem cells. (cellseco.com)
  • Synthetic peptides or recombinant fragments containing bio- logically active motifs have been shown to partially mimic the effects of native laminin in various cellular functions, such as cell adhesion, spreading, migration, neurite outgrowth, and tumor metastasis [6-10], suggesting that laminin-derived-short peptide- modified biomaterials may have therapeutic potential in tissue regeneration applications. (mirnamimic.com)
  • In addition to IL-4, `biologicals' such as humanized anti-TGF-β antibodies and recombinant human interferons are, accordingly, being tested as a treatment for fibrotic diseases. (biomedcentral.com)
  • Catalog #100-0096/27147) are required for use with Vitronectin XF™ and are available for purchase separately. (stemcell.com)
  • In addition, the regulator of the terminal pathway of complement activation, vitronectin, is hijacked by both bacteria. (bvsalud.org)
  • C5 complement component 5: C5a is a critical mediator in human blood during C. albicans infection. (polygenicpathways.co.uk)
  • Based on the widely cited Essential 8 Medium, Gibco CTS Essential 8 Medium is the first globally available human pluripotent stem cell (hPSC) culture medium with components not directly derived from animals. (thermofisher.com)
  • Support the growth and differentiation of human pluripotent stem cells by using Vitronectin XF™, a defined and xeno-free cell culture matrix. (stemcell.com)
  • Use Vitronectin XF™ with mTeSR™1 , mTeSR™ Plus , TeSR™-E8™ , or TeSR™-AOF medium to provide a defined culture system for the maintenance of human embryonic stem (ES) cells and human induced pluripotent stem (iPS) cells under feeder-free conditions. (stemcell.com)
  • Vitronectin is a 54 kDa glycoprotein, consisting of 478 amino acid residues. (wikipedia.org)
  • While some cells are able to synthesize these components, others require an exogenous source, this is particularly true when the cells are grown in serum-free culture system. (cellseco.com)
  • We work both on purified and reconstituted components and in cultured cells. (au.dk)
  • MEFs used as feeder cells may also secrete certain components into the media that support SSC proliferation. (molcells.org)
  • Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. (exbio.cz)
  • What organism was used to produce Tropoelastin in the recombinant manufacturing process? (advancedbiomatrix.com)
  • Exercise of the rights to these additional components attracts further fees. (bioinformant.com)
  • Vitronectin contains an RGD (45-47) sequence, which is a binding site for membrane-bound integrins, e.g., the vitronectin receptor, which serve to anchor cells to the extracellular matrix. (wikipedia.org)
  • PAI-1 inhibited microglial engulfment of zymosan particles in a vitronectin- and Toll-like receptor 2/6-dependent manner. (biomedcentral.com)
  • PAI-1 plays a dual role in the regulation of cell migration through differential interactions with its binding partners such as uPA, tPA, vitronectin, and low-density lipoprotein receptor-related protein (LRP)1. (biomedcentral.com)
  • Bone 6: 179-185, 1985) and vitronectin receptor (Davies et al. (justia.com)
  • Abciximab also binds to the vitronectin (α v β 3 ) receptor found on platelets and vessel wall endothelial and smooth muscle cells. (nih.gov)
  • Abciximab binds with similar affinity to the vitronectin receptor, also known as the α v β 3 integrin. (nih.gov)
  • The vitronectin receptor mediates the procoagulant properties of platelets and the proliferative properties of vascular endothelial and smooth muscle cells. (nih.gov)
  • Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M: The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. (exbio.cz)
  • Background: The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51. (m-entrepreneurship.com)
  • The basic function of the integrin molecule alpha-vb 3 is to bind vitronectin and other matrix components that are overexpressed in angiogenically stimulated blood vessels. (medscape.com)
  • Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. (wikipedia.org)
  • The PAI-vitronectin complex binds to the Arg-Gly-Asp motif of αv integrins and inhibits the integrin-mediated cell migration [ 28 - 33 ]. (biomedcentral.com)
  • One example is, to HGF Proteins Accession market synergistic signaling among integrins and growth factor receptors, a multifunctional recombinant fragment of fibronectin was engineered to comprise a fibrin-binding sequence, the key integrin-binding domain of fibronectin, and one of the growth factor-binding domains of fibronectin. (gsk-3inhibitor.com)
  • In direct ELISAs, no cross-reactivity with recombinant human Integrin alpha 5, alpha 8, alpha V, beta 3, beta 5, beta 6, recombinant mouse Integrin beta 2b or beta 3 is observed. (rndsystems.com)
  • Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. (rndsystems.com)
  • Finally, the ability of rGAPDH to bind different ECM components was demonstrated, including fibronectin, laminin, collagen type IV and vitronectin. (biomedcentral.com)
  • The objective of the proposed studies is to examine the developmentally regulated interaction of trophoblast cells with components of the uterine extracellular matrix (ECM), focusing on fibronectin which is a major component of the endometrial ECM that is infiltrated by differentiated trophoblasts early during interstitial implantation. (grantome.com)
  • Experiments will also be conducted, using similar methods, to determine whether specific receptors for fibronectin or various other adhesion-promoting ECM components (laminin, vitronectin, hyaluronic acid) are ligand-induced or constitutively expressed by trophoblast cells. (grantome.com)
  • A) The biological activity of Human Recombinant FGF-acidic, ACF was tested by its ability to promote proliferation of NR6R-3T3 cells in the presence of 10 μg/mL heparin. (stemcell.com)
  • Vitronectin is a secreted glycoprotein which is synthesized in the liver. (reliatech.de)
  • Vitronectin is a 54 kDa glycoprotein, consisting of 478 amino acid residues. (wikipedia.org)
  • Recombinant GAPDH (rGAPDH) was found to be able to bind porcine-derived PK-15 and human-derived NCI-H292 cells. (biomedcentral.com)
  • The multifunction of GAPDH to bind both plasminogen and ECM components is believed to increase the targeting of proteolysis and facilitate the dissemination of M. hyorhinis . (biomedcentral.com)
  • Recombinant human Vitronectin promotes attachment of hESC and iPSC in serum-free, feeder conditions at 5μg/ml. (reliatech.de)
  • Studies show that schizophrenia has genetic components, but cannot be isolated to one gene. (aabioetica.org)
  • Therefore, our focus is on the development of approaches for multi-component systems where several different macromolecular components interact to allow association and dissociation of different co-existing complexes in different states. (nih.gov)
  • The components of these multistep processes are illustrated as follows: enzymes (pink circles), inhibitors (blue circles), zymogens (green boxes), or complexes (cream ovals). (hindawi.com)
  • Factor IX and factor X are converted to the serine proteases factor IXa and factor Xa, which are the enzymatic components of the intrinsic factor Xase and the prothrombinase complexes, respectively. (hindawi.com)
  • It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. (hindawi.com)
  • During later years recombinant factor VIII has been approved for therapeutic use, which minimizes the risk of viral transmission. (diapharma.com)
  • Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. (rndsystems.com)
  • Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. (exbio.cz)
  • Animal models of DVT have provided many insights into the molecular and cellular mechanisms involved in the formation, propagation, and resolution of venous thrombi as well as the roles of key components of the fibrinolytic system in these processes. (frontiersin.org)
  • The BIONET User community is divided into different classes, representing different levels of use of the computer system and staff resources, as follows: e Class I. Class I users represent the Service component of the scientific community. (nih.gov)
  • Class II users represent the Collaborative component of the user community. (nih.gov)
  • This product is animal component-free. (stemcell.com)
  • The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). (rndsystems.com)
  • 4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. (rndsystems.com)