The key mechanisms of action in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1 Inhibitor, Tyrosine Protein Kinase JAK2 Inhibitor, Tyrosine Protein Kinase BTK Inhibitor, Interleukin 2 Receptor Agonist, Alpha 1 Antitrypsin Replacement, Cytotoxic To Cells Expressing B Lymphocyte Antigen CD20 , Interleukin 2 Receptor Subunit Beta Antagonist, Programmed Cell Death Protein 1 Agonist, Tyrosine Protein Kinase ITK/TSK Inhibitor, and CD40 Ligand Inhibitor among others. (globaldata.com)
SEAP (secreted embryonic alkaline phosphatase) has been suggested as versatile reporter protein inter alia for cell ligand interaction. (envite.org)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
Full length human recombinant protein of human CD27 (NP_001233) produced in HEK293T cell. (thermofisher.com)
Human recombinant protein fragment corresponding to amino acids 21-166 of human CD40(NP_001241) produced in E.coli. (origene.com)
Humanized monoclon2
Tonix's immunology development portfolio includes biologics to address organ transplant rejection, autoimmunity and cancer, including TNX-1500, which is a humanized monoclonal antibody targeting CD40-ligand (CD40L or CD154) being developed for the prevention of allograft rejection and for the treatment of autoimmune diseases. (itbusinessnet.com)
Tonix's immunology portfolio features biologics to handle organ transplant rejection, autoimmunity and most cancers, together with TNX-1500 which is a humanized monoclonal antibody concentrating on CD40-ligand being produced for the avoidance of allograft and xenograft rejection and for the treatment method of autoimmune ailments. (logansfamilydental.com)
CD40L3
X-linked immunodeficiency with hyper-immunoglobulin M (XHIGM or HIGM1) is a rare form of primary immunodeficiency disease caused by mutations in the gene that codes for CD40 ligand (CD40L, also known as CD154 or TNFSF5 or gp39). (medscape.com)
The secondary antibody repertoire generation is antigen and T-cell dependent and occurs in peripheral lymphoid organs, mainly through the interaction between CD40L (CD154), expressed on activated CD4 + T cells, and CD40, expressed on B cells (see image below). (medscape.com)
Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. (assaygenie.com)
Coordinately regulate the expression1
AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. (neuromics.com)
Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. (ac.ir)
In this review, we summarize the many examples of immunoadhesins in the literature, and discuss some essential structural and functional features of this expanding fanuly of recombinant proteins. (coek.info)
Monoclonal1
Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.cn)
CD275
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. (thermofisher.com)
In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. (thermofisher.com)
RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. (thermofisher.com)
We have used OVA and anti-CD40 to establish a memory CD8(+) T-cell population and report here that their secondary expansion, driven by peptide and anti-CD40, polyI:C, or LPS, requires CD27. (solent.ac.uk)
Furthermore, antigenic peptide and a soluble form of the CD27 ligand, CD70 (soluble recombinant CD70 (sCD70)), is sufficient for secondary memory CD8(+) T-cell accumulation at multiple anatomical sites, dependent on CD80/86. (solent.ac.uk)
Antibodies2
We report that the variable domains of recombinant HIV-1 Env immunogens activate a large number of B cell clones that give rise to many non-neutralizing antibodies, and that removing the variable domains from the immunogen reduces the number of activated B cell lineages and leads to the development of autologous neutralizing antibodies, a step towards bNAb-production. (plos.org)
It is unequivocal that membrane-presented ligand (delivered to target cells via cell-surface presentation by co-culture with ligand-expressing third-party cells) induces a greater extent of carcinoma cell death in vitro in comparison to non-cross-linked agonists (agonistic antibodies and/or recombinant ligands). (bio-thing.cn)
CD701
In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. (elabscience.com)
Interaction3
The interaction of TNFRSF9 and its ligand, TNFSF9, leads to the activation of cytotoxic T cells, reactivation of anergic T lymphocytes, and induces T-cell proliferation. (biolegend.com)
The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis. (neuromics.com)
Using the interaction of recombinant hCD40 ligand with HEK-Blue sensor cells expressing the CD40 receptor as example, we show that such an assay can be developed based on BCIP/NBT (5-bromo-4-chloro-3-indolyl phosphate/nitroblue tetrazolium chloride) as substrate. (envite.org)
Superfamily1
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. (assaygenie.com)
Coli1
CD40 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 196 amino acids (21-193a.a) and having a molecular mass of 21.6kDa. (neuromics.com)
Molecule1
Homo sapiens CD40 molecule (CD40), transcript variant 1, mRNA. (origene.com)
Vaccine2
TNX-801 also serves as the live virus vaccine platform or recombinant pox vaccine platform for other infectious diseases. (itbusinessnet.com)
The adjuvanted recombinant zoster vaccine (RZV, Shingrix) was shown to be well-tolerated and effective in preventing HZ in adults aged ≥ 50 years. (bvsalud.org)
Cytokine1
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (elabscience.com)
TNFSF51
Recombinant Human TNFSF5 is produced by our Mammalian expression system and the target gene encoding Met113-Leu261 is expressed. (bonopusbio.com)
Amino acid1
CD40 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. (neuromics.com)
Tumor1
Role of Fas ligand expression in promoting escape from immune rejection in a spontaneous tumor model. (southernbiotech.com)
Human7
FLT-3 ligand promotes long-term expansion and differentiation of human pro-B cells in the presence of IL-7 or in combination of IL-7 and IL-3. (topsan.org)
Recombinant Human soluble CD40 Ligand/TRAP (sCD40 Human), 50 ug. (jxsgjy.com)
No. 750002) is immobilized at 1 μg/mL, biotinylated recombinant human TNFRSF9-Fc chimera binds in a dose-dependent manner with EC 50 range of 0.75 - 3.0 ng/mL. (biolegend.com)
Stability Testing for Biotinylated Recombinant Human TNFRSF9-Fc Chimera. (biolegend.com)
Biotinylated recombinant human TNFRSF9-Fc chimera was aliquoted in PBS, 5% glycerol at 0.2 mg/mL. (biolegend.com)
The samples were tested in a binding assay with recombinant human TNFSF9. (biolegend.com)
Vitro1
B cells of patients with XHIGM are intrinsically normal, in that they can be induced to proliferate and undergo CSR upon in vitro activation by CD40 agonists and appropriate cytokines. (medscape.com)
Belongs1
CD40 belongs to the TNF-receptor super family. (neuromics.com)
Lineage1
Alone, flt-3 ligand supports the survival of precursors in the lineage of blood-forming cells such as CFU-GM, CFU-GEMM, and the very primitive high proliferative potential colony-forming cells, HPP-CFC. (topsan.org)
Expression5
CD40 expression correlated with bax but not with bcl -2 expression. (aacrjournals.org)
CD23 and CD40 expression seems to be prognostically favorable in DLBCL. (aacrjournals.org)
Recombinant Cynomolgus CD40 is produced by our Mammalian expression system and the target gene encoding Glu21-Arg193 is expressed with a Fc tag at the C-terminus. (assaygenie.com)
The recombinant AAV (rAAV) genome composed of a foreign expression cassette and AAV inverted terminal repeat (ITR) sequences exists in eukaryotic cells in an episomal form that is responsible for persistent transgene expression (Schnepp et al. (justia.com)
Of these, AAV1, 6, 8, and 9 recombinant vectors have been reported to result in higher transgene expression level in muscle than rAAV2 vector (Wang et al. (justia.com)
Cells2
flt-3 ligand only has marginal effects on progenitors for erythroid cells and megakaryocytes. (topsan.org)
CD40 ligand trimer enhances the response of CD8 + T cells to Mycobacterium tuberculosis. (southernbiotech.com)
Cell3
CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. (neuromics.com)
In 2015, the International Union of Immunology Societies (IUIS) Phenotypic Classification for Primary Immundeficiencies named it CD40 ligand deficiency and classified XHIGM under combined immunodeficiency without T cell lymphopenia. (medscape.com)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
Functional1
Generation of recombinant fragments of CD11b expressing the functional β-glucan-binding lectin site of CR3 (CD11b/CD18). (southernbiotech.com)
Shown1
By Cox regression analysis, positivity for CD40 was shown to be a prognostic factor for OS, independent of International Prognostic Index. (aacrjournals.org)