ProteinsGranulocyte macropCytokineSpecificityAntibodiesAssayHumanMacrophage activaSpeciesAntibodyColiPulmonary fibrosisCytokinesAntigenYeastBindsActimmuneImmuneReactivityReceptorMurineSupernatantsDilutionsPathwayFusionConcentrationCellsChemokineViralPatientsExpressionAffinityClinicalLymphocytesSignificantlyTypeProducts
Proteins6
- Recombinant human interferon proteins are not just limited to the process of discharging of reactive oxygen species. (clickpress.com)
- Recombinant human interferon protein is one of the recombinant proteins available currently, the only difference is that it is sourced from CHO-cell line. (clickpress.com)
- Though the effectiveness of recombinant human interferon proteins is still debatable with other species induced, recombinant proteins are being used in general applications. (clickpress.com)
- This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. (acrobiosystems.com)
- The secretion of recombinant proteins into the extracellular space by Escherichia coli presents advantages like easier purification and protection from proteolytic degradation. (uni-bielefeld.de)
- In this study, we have developed a biolayer interferometry (BLI)-based assay to determine dominant binding epitopes of the HA1 in antibody response to influenza vaccines using a panel of recombinant HA1 proteins of A(H1N1)pdm09 virus with each carrying a single amino acid substitution. (cdc.gov)
Granulocyte macrop2
- The effects of recombinant interleukins-1 beta,2,3,interferon-gamma, and granulocyte macrophage colony stimulating factor were tested in the same system. (bmj.com)
- Recombinant granulocyte macrophage colony stimulating factor was a weak stimulus to epithelial DNA synthesis, interleukin-1 beta was weakly inhibitory but other cytokines tested did not have any effect. (bmj.com)
Cytokine6
- This gene encodes a soluble cytokine that is a member of the type II interferon class. (origene.com)
- Human interferon gamma (hIFNγ) is a cytokine belonging to a diverse group of interferons which have a crucial immunological function against mycobacteria and a wide variety of viral infections. (edu.au)
- Native rabbit interferon gamma is a 167 amino acid cytokine with potent activating, anti-viral and anti-proliferative properties. (bio-rad-antibodies.com)
- Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. (wikipedia.org)
- IFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. (wikipedia.org)
- This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. (origene.com)
Specificity1
- This assay has high sensitivity and excellent specificity for detection of Interferon Gamma (IFNg). (uscnk.com)
Antibodies3
- Recombinant Human Novel Coronavirus Spike glycoprotein(S) (D614G), partial (Active) referenced in "Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries", Cell discovery , 2021. (cusabio.com)
- No. IFN-BS138) captured on CM5 chip via anti-mouse antibodies surface can bind Human IFN-gamma, premium grade (Cat. (acrobiosystems.com)
- To minimize the problems due to use of pure mouse antibody, researchers have used recombinant DNA techniques to create monoclonal antibodies that are part human and part mouse. (msdmanuals.com)
Assay4
- Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interferon Gamma (IFNg) were tested 20 times on one plate, respectively. (uscnk.com)
- Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interferon Gamma (IFNg) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
- Gamma Assay Laboratories manufactures the interferon gamma release assay (igra) reagents distributed by Genprice. (ifn-a.com)
- The Interferon Gamma Release Assay (Igra) reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (ifn-a.com)
Human24
- The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. (wikipedia.org)
- Actions of recombinant human gamma-interferon and tumor necrosis factor alpha on the proliferation and osteoblastic characteristics of human trabecular bone cells in vitro. (ox.ac.uk)
- Using cultured human osteoblast-like cells, we studied the effects of tumor necrosis factor (TNF) and recombinant human gamma-interferon (gamma-IFN) on osteoblast growth and function, and demonstrated that TNF stimulated bone cell proliferation and prostaglandin production while inhibiting 1,25-(OH)2D3-stimulated alkaline phosphatase activity and osteocalcin release. (ox.ac.uk)
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Nucleocapsid Protein (NP) Antibody is a chimaeric recombinant Monoclonal Antibody against SARS-CoV-2/COVID-19 NP, containing Mouse variable region and Human IgG1 constant region. (proteomecommons.org)
- Recombinant Human C-C chemokine receptor type 8(CCR8) referenced in "The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis", Immunity , 2021. (cusabio.com)
- Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial (Active) referenced in "Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile", Science Advances , 2021. (cusabio.com)
- Recombinant human interferon protein (IFN-y) is a bioactive protein primarily used for cell culture applications in many diagnostic laboratories. (clickpress.com)
- The status of recombinant human interferon protein is strictly regulated as it require strict temperature control, which is around -70°C or below for retaining full action activity. (clickpress.com)
- Recombinant human interferon protein is mostly available in beta and alpha form, though other forms have started emerging in the market. (clickpress.com)
- Recombinant human interferon protein is principally studied on the protein production, it is probably going to strike the intensive research and development sector. (clickpress.com)
- The adoption of recombinant human interferon protein started with the advancement in the field of molecular biology. (clickpress.com)
- Tentatively, the global recombinant human interferon protein market can be segmented on the basis of type, end user and geography. (clickpress.com)
- The global market for recombinant human interferon protein is expected to witness steady growth over the forecast period due to rise of molecular biology in most of the disease applications. (clickpress.com)
- Geographically, the global recombinant human interferon protein market is segmented into North America, Latin America, Europe, CIS & Russia, Asia-Pacific excluding Japan (APEJ), Japan and the Middle East and Africa (MEA). (clickpress.com)
- North America is expected to be the dominant regional market for recombinant human interferon protein owing to increasing number of research activities in the region. (clickpress.com)
- The recombinant human interferon protein market in Asia Pacific excluding Japan is expected to grow at a significant CAGR due to product development and expansion by key players. (clickpress.com)
- Europe is expected to hold a large share in the global recombinant human interferon protein market throughout the forecast period due to its quality healthcare facilities and modern outlook for recombinant human Interferon protein. (clickpress.com)
- The global market for recombinant human interferon protein is highly fragmented. (clickpress.com)
- Examples of some of the key players operating in the global recombinant human interferon protein market are Merck KGaA, Abcam plc, R&D Systems, Thermo Fisher Scientific, BioLegend, Invitrogen, OriGene, and Biorbyt, among others. (clickpress.com)
- Human IFN-gamma, premium grade (IFG-H4211) stimulates proliferation of HT-29 cells. (acrobiosystems.com)
- The specific activity of Human IFN-gamma, premium grade is＞2.0*10^7 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586) (QC tested). (acrobiosystems.com)
- Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
- Production of Functional Recombinant Human Interferon-gamma by RTX CPD-fusion Technology. (bas.bg)
- Results for the test samples are reported in International Units (IU) relative to a standard curve prepared by testing dilutions of a recombinant human IFN-γ standard. (cdc.gov)
Macrophage activa1
- Recombinant Rabbit interferon gamma , (IFNγ), known previously as macrophage activating factor, belongs to the type II interferon family and is produced by T lymphocytes and NK cells. (bio-rad-antibodies.com)
Species1
- a yeast once reported as a methane-oxidizing yeast, for growth on cheap C1 carbon sources (methane and methanol) to evaluate the species potential for lowering production costs of recombinant immuno-therapeutics. (edu.au)
Antibody3
- The microtiter plate provided in this kit has been pre-coated with an antibody specific to Interferon Gamma (IFNg). (uscnk.com)
- Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Interferon Gamma (IFNg). (uscnk.com)
- After TMB substrate solution is added, only those wells that contain Interferon Gamma (IFNg), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (uscnk.com)
Coli3
- In the current study, the strain E. coli JM109 harboring plasmid p582 was shown to stably express and secrete recombinant beta-glucanase in continuous culture using a minimal medium. (uni-bielefeld.de)
- The plasmid stability in a continuously cultivated E. coli fermentation, in the absence of antibiotics, with extracellular secretion of recombinant protein provides an interesting model for further improvements. (uni-bielefeld.de)
- R.S.V. Selvamani, K. Friehs, and E. Flaschel, "Extracellular recombinant protein production under continuous culture conditions with Escherichia coli using an alternative plasmid selection mechanism", Bioprocess and Biosystems Engineering , vol. 37, 2014, pp. 401-413. (uni-bielefeld.de)
Pulmonary fibrosis2
- In a double-blind, multinational trial, we randomly assigned 330 patients with idiopathic pulmonary fibrosis that was unresponsive to corticosteroid therapy to receive subcutaneous interferon gamma-1b or placebo. (nih.gov)
- In a well-defined population of patients with idiopathic pulmonary fibrosis, interferon gamma-1b did not affect progression-free survival, pulmonary function, or the quality of life. (nih.gov)
Cytokines2
- Type II IFN expression is upregulated by the production of interleukin cytokines, such as IL-12, IL-15, IL-18, as well as type I interferons (IFN-α and IFN-β). (wikipedia.org)
- GSE5091: Cell line stimulated with recombinant cytokines interleukin-1b and interferon gamma. (elsevierpure.com)
Antigen1
- Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. (acrobiosystems.com)
Yeast1
- This thesis aimed to 1) lower the cost of production by using cheap C1 carbon sources (e.g. methane) from agricultural activities (e.g. intensive dairy, piggeries, etc.) for the cultivation of transformed yeast and 2) to assess the therapeutic efficacy of recombinant hIFNγ in its glycosylated and non-glycosylated form from different expression systems against ovarian cancer cells. (edu.au)
Binds2
- The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (origene.com)
- Type II IFN is serologically different from interferon type 1, binds to different receptors, and is encoded by a separate chromosomal locus. (wikipedia.org)
Actimmune1
- Number 5 on the list is interferon gamma 1-b ( Actimmune , Horizon Pharma), approved to decrease the number and severity of infections in patients with chronic granulomatous disease and to delay the progression of severe, malignant osteopetrosis. (medscape.com)
Immune2
- Candidemia is associated with a suppressed immune status and research has provided evidence that patients with candidemia might benefit from recombinant interferon gamma (rIFN-γ) immunotherapy. (sepsis.gr)
- Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. (acrobiosystems.com)
Reactivity1
- No significant cross-reactivity or interference between Interferon Gamma (IFNg) and analogues was observed. (uscnk.com)
Receptor1
- Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of Interferon gamma receptor 1 (IFNGR1) and Interferon gamma receptor 2 (IFNGR2). (wikipedia.org)
Murine1
- Recombinant murine CXCL9 contains 105 amino acids which is a single non-glycosylated polypeptide chain. (watson-int.cn)
Supernatants1
- It was notable that macrophages from AIDS patients showed normal killing with recombinant gamma interferon, but that the supernatants from AIDS patients had reduced activity with normal macrophages. (uwl.ac.uk)
Dilutions1
- The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Interferon Gamma (IFNg) and their serial dilutions. (uscnk.com)
Pathway1
- Activation of the JAK-STAT pathway induces upregulation of interferon-stimulated genes (ISGs), including MHC II. (wikipedia.org)
Fusion1
- 7. Coagulation factor IX recombinant Fc fusion protein ( Alprolix , Bioverativ), the first long-acting hemophilia B drug approved by the FDA for use in children and adults with hemophilia B. It has a list price of about $503,800 per year. (medscape.com)
Concentration1
- The concentration of Interferon Gamma (IFNg) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (uscnk.com)
Cells2
- In contrast, gamma-IFN inhibited proliferation and stimulated alkaline phosphatase activity of the cells, while inhibiting 1,25-(OH)2D3-stimulated osteocalcin production and having variable effects on the release of prostaglandins, depending on the presence of other factors. (ox.ac.uk)
- Our results suggest that TNF and gamma-IFN can act directly on bone-forming cells to affect both their proliferation and their differentiated function, and that changes in the ability of cells to produce these factors in disease states may contribute to alterations in the integrity of connective tissue matrices. (ox.ac.uk)
Chemokine1
- CXCL9 belongs to the CXC chemokine family and also known as Monokine induced by gamma interferon (MIG). (watson-int.cn)
Viral1
- Specifically, recombinant hIFNγ has been shown to be an effective biopharmaceutical, against a wide range of viral, immuno-suppressive diseases with promising prospects in cancer immunotherapy resulting in a strong increase in demand and price. (edu.au)
Patients2
- Ten percent of patients in the interferon gamma-1b group died, as compared with 17 percent of patients in the placebo group (P=0.08). (nih.gov)
- More pneumonias were reported among patients in the interferon gamma-1b group, but the incidence of severe or life-threatening respiratory tract infections was similar in the two groups. (nih.gov)
Expression1
- Chapter 1 of the thesis gives a comprehensive review of expression and production of recombinant hIFNγ leading to the aims of the research. (edu.au)
Affinity1
- Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)
Clinical1
- IFN-gamma has been used in a wide variety of clinical indications. (acrobiosystems.com)
Lymphocytes1
- IFN Gamma is the major interferon produced by mitogenically or antigenically stimulated lymphocytes. (iwai-chem.net)
Significantly2
- Over a median of 58 weeks, interferon gamma-1b therapy did not significantly affect the primary end point of progression-free survival, defined as the time to disease progression or death, and no significant treatment effect was observed on measures of lung function, gas exchange, or the quality of life. (nih.gov)
- Significantly, it showed a stable maintenance of the recombinant plasmid in the absence of any antibiotics. (uni-bielefeld.de)
Type1
- It is structurally different from type I interferon and its major activity is immunoregulation. (iwai-chem.net)
Products2
- High-quality interferon products and biomarker testing services you can trust. (pblassaysci.com)
- Other Interferon products are available in stock. (ifn-a.com)