• cytokine
  • Interleukin-7 (IL-7) is an antiapoptotic common γ-chain cytokine that is essential for lymphocyte proliferation and survival. (jci.org)
  • Since its inception in 1999, Cytheris has had a close relationship with IL-7 investigators at the US National Institutes of Health, a connection that has played a pivotal role in bringing the potential of this cytokine to the attention of the medical community," said Michel Morre, DVM, President and CEO of Cytheris. (technologynetworks.com)
  • 20 , 21 Unlike the homodimeric Kit and Epo-R, γc heterodimerizes with ligand-specific type I cytokine receptor subunits to form receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. (bloodjournal.org)
  • citation needed] IL-7 is a cytokine important for B and T cell development. (wikipedia.org)
  • A human study of IL-7 in patients with cancer demonstrated that administration of this cytokine can transiently disrupt the homeostasis of both CD8+ and CD4+ T cells with a commensurate decrease in the percentage of CD4+CD25+Foxp3+ T regulatory cells. (wikipedia.org)
  • No objective cancer regression was observed, however a dose limiting toxicity (DLT) was not reached in this study due to the development of neutralizing antibodies against the recombinant cytokine. (wikipedia.org)
  • proteins
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • 1993
  • Plum, J., De Smedt, M., and Leclercq, G. (1993) Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+i-precursor cells and blocks the differentiation pathway of TCR-a13 cells in fetal thymus organ culture. (springer.com)
  • thymic
  • Among the cytokines binding to γc-containing receptors, IL-7 is the most important one for thymic development since loss of IL-7 signaling causes a severe reduction in thymic cellularity comparable with that caused by the loss of γc. (bloodjournal.org)
  • Administration of IL-7 to mice results in an increase in recent thymic emigrants, increases in B and T cells, and increased recovery of T cells after cyclophosphamide administration or after bone marrow transplantation. (wikipedia.org)
  • gene
  • The IL-7 responsive B-lineage cells were clearly defined in vitro using sorted B-cell precursor populations and shown to express B220, CD43 heat stable antigen (HSA), and to carry heavy-chain gene rearrangements (3) . (springer.com)
  • IL-7 responsiveness is lost following light-chain gene rearrangement and acquisition of the pre-B-cell phenotype (4) . (springer.com)
  • cytokines
  • Therapies currently in clinical trials in the transplant setting include keratinocyte growth factor, cytokines (IL-7 and IL-22), and hormonal modulation including sex steroid inhibition and growth hormone administration. (jimmunol.org)
  • therapy
  • IL-7 represents a promising investigative therapy which has shown in pre-clinical and Phase I studies in oncology and in HIV-infected patients to be well tolerated in repeated dose trials, with long-lasting increases in both CD4 and CD8 T cells. (technologynetworks.com)
  • Subjects will either get tetanus, diphtheria, polio, and pneumonia vaccines before IL-7 therapy (Sequence 1) or hepatitis A and hepatitis B vaccines before IL-7 therapy (Sequence 2). (clinicaltrials.gov)
  • This will be followed by IL-7 therapy, then administration of the other group of vaccines. (clinicaltrials.gov)
  • Therefore, subjects on both arms will receive the same set of vaccines, just at different times with respect to IL-7 therapy. (clinicaltrials.gov)
  • These results suggest that IL-7 therapy can possibly improve the quality of life of those patients. (wikipedia.org)
  • clinical
  • We are very pleased that NIH has again recognized the value of the IL-7 program and has chosen to provide financial support as well as the participation of NIAID investigators in this clinical development program focused on ICL. (technologynetworks.com)
  • Recombinant IL-7 has been safely administered to patients in several phase I and II clinical trials. (wikipedia.org)
  • Others including IL-2, IL-7, IL-12, various chemokines, synthetic cytosine phosphate-guanosine (CpG) oligodeoxynucleotides and glucans are involved in clinical and preclinical studies. (wikipedia.org)
  • IL7R
  • The three-dimensional structure of IL-7 in complex with the ectodomain of IL7R has been determined using X-ray diffraction. (wikipedia.org)
  • Vaccines
  • One group will be people who have received vaccines before IL-7. (clinicaltrials.gov)
  • The other group will be people who have received Vaccines after IL-7. (clinicaltrials.gov)
  • We will compare the responses of people in Sequence 1 who will receive vaccines before IL-7 with the responses of people in Sequence 2 who received the same vaccines after IL-7. (clinicaltrials.gov)
  • promotes
  • IL-7 promotes hematological malignancies (acute lymphoblastic leukemia, T cell lymphoma). (wikipedia.org)
  • inflammatory
  • These data indicate that rhIL-7 administration can expand gut T lymphocyte numbers, predominantly central memory CD4+ T cells, and warrant an exploration of the effects of IL-7 on gut mucosal barrier function and the inflammatory and coagulation pathways. (natap.org)
  • The TNFs affect cells In different ways, some of which resemble the functional modes of other inflammatory mediators, like interleukin-1 (IL-1) and interleukin-6 (IL-6). (google.com)
  • cells
  • IL-7 may improve HIV-specific immune responses by increasing the number of CD4 cells and boosting immune response. (clinicaltrials.gov)
  • 3. A method according to claim 2 wherein the cDNA is introduced into an expression vector and is cotransfected with a recombinant vector containing the dihydrofolate reductase (DHFR) cDNA into DHFR-deficient chinese hamster ovary (CHO) cells. (google.com)
  • mice
  • In vivo analyses of thymopoiesis in mice defective in signaling through Kit and γc or Kit and IL-7Rα demonstrate synergy and partial complementation of γc or IL-7-mediated signaling by the Kit signaling pathway. (bloodjournal.org)
  • cell
  • They are also the central mediators of graft-versus-host disease (GVHD), borne out in the reduction of this complication through use of T cell-depleted grafts ( 7 ). (jimmunol.org)
  • IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant. (wikipedia.org)