• CD10
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • distinct
  • Furthermore, anaplastic large-cell lymphoma (ALCL) ALK−positive (ALK+) is now recognized as a distinct entity from the ALCL ALK-negative (ALK−) lymphomas, which occurs in an older population, and which bears a far worse prognosis [ 5 ]. (hindawi.com)
  • mice
  • This association could be explained by increased infections, alterations in the composition of immune complexes, modulation of T or B cell function, or deficient clearance of self-antigens in serum IgM-deficient mice. (rupress.org)
  • Splenic CD5 + B cells expressed higher levels of Fas ligand (FasL) than did CD4 + T cells or CD5 - B cells in all mice, and antigen-dependent T-cell death correlated with higher levels of CD5 + B cells in cocultures. (biomedcentral.com)
  • ligand
  • Among B cell subsets, the expression of both Fas ligand and IL-10 is highest on the CD5 + B cell population, suggesting that CD5 + B cells may have a specialized regulatory function. (springer.com)
  • development
  • These findings have led to the view that (auto)antigen drive is a promoting factor in the development and evolution of CLL and have been a pivotal in refining patient prognosis. (wikipedia.org)