AntagonistMember of the interleukinCytokinesSolublePeroxisome proliferaProteinCytokine receptorsGenePolymorphismMonoclonal AntibodyKinaseExpressionInduces2021IL1RL1Nuclear receptorsLigandInflammationCellsHistamineAffinityFamilialGenesHistone2001AlphaClosely relatedSerumTissueMolecularGlucoseAssociationsImmuneGeneticsInhibitorsTypeActivationClinicalFamily
Antagonist12
- Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
- The secreted form of the interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein intervening in the counterregulation of inflammatory processes. (diabetesjournals.org)
- The interleukin-1 receptor antagonist (IL-1Ra) is a member of the interleukin (IL)-1 family that binds to IL-1 receptors without inducing a cellular response, thereby antagonizing the effects of IL-1α and -1β ( 1 ). (diabetesjournals.org)
- Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. (ox.ac.uk)
- The epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor. (balimedicaljournal.org)
- Interleukin 1 receptor antagonist. (balimedicaljournal.org)
- Type I IL-1 Receptor Mediates IL-1 and Intracellular IL-1 Receptor Antagonist Effects in Skin Inflammation. (balimedicaljournal.org)
- Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1 alpha and IL-1 receptor antagonist. (balimedicaljournal.org)
- Study of interleukin-1 receptor antagonist (IL-1Ra) gene polymorphism in healthy individuals from Northern India. (balimedicaljournal.org)
- the effect was inhibited by the H1 receptor antagonist diphenhyramine, suggesting that BEAS cells retain functioning histamine receptors. (epa.gov)
- Here, we asked if cell-based delivery of the interleukin-1 receptor antagonist (IL-1Ra), a known neuroprotectant in stroke, can promote neuroprotection, by modulating the detrimental inflammatory response in the tissue at risk. (lu.se)
- The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)
Member of the interleukin2
- Interleukin-1 receptor-like 1 (Il1rl1 or ST2), a member of the Interleukin-1 Receptor family, has pleiotropic roles including tissue homeostasis, inflammation, immune polarization, and disease resistance in mammals. (usda.gov)
- A new member of the interleukin 1 family. (balimedicaljournal.org)
Cytokines6
- Levels of IL12RB1 mRNA are dynamically regulated by various cytokines, including interferon-γ (IFN-γ) and IL-15. (elsevierpure.com)
- In the present study, we investigated the effect of LPS on the releasing function of afferent terminals as measured by calcitonin gene-related peptide (CGRP) release in ex vivo perfused rat trachea, and examined the possible role of the cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) as intermediaries in this effect. (jneurosci.org)
- Cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can be generated by inflammatory and nonimmune cells in response to inflammation, tissue injury, microbial invasion, and immunological reactions ( Dinarello, 1994 ). (jneurosci.org)
- Other cytokines including tumour necrosis factor alpha, transforming growth factor beta 1, interleukin 1 and interleukin 6 have no inhibitory effect. (microbiologyresearch.org)
- Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
- This webinar will discuss the critical biological roles and therapeutic applications of γc cytokines and receptors. (news-medical.net)
Soluble3
- We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP). (nih.gov)
- We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. (nih.gov)
- Another theory is that interactions between Fas (a cell-surface receptor that induces apoptosis) and its ligand, particularly a soluble form of Fas ligand released from mononuclear cells, lead to cell death and blister formation. (msdmanuals.com)
Peroxisome prolifera2
- However, metabolic dysregulated factors such as peroxisome proliferator-activated receptors and sirtuins may serve as therapeutic targets to control this response by mitigating both Toll-like receptors and inflammasome signaling. (hindawi.com)
- Peroxisome proliferator-activated receptor-γ (PPARγ) is one of the isotypes of peroxisome proliferator-activated receptors, which are a group of closely related nuclear receptors. (jci.org)
Protein4
- Consistently, IL-15, as a histone deacetylase inhibitor, synergistically enhanced IL12RB1 gene expression and promoter activation by IFN-γ through increased protein binding to ETS/PU.1 and IRE/ISRE sites. (elsevierpure.com)
- The protein encoded by this gene is a subunit of the receptor for IL-23 . (wikidoc.org)
- This protein pairs with the receptor molecule IL-12Rβ1 ( IL12RB1 ), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. (wikidoc.org)
- Expression of ALK in malignant T cells is typically due to the t(2;5) translocation resulting in formation of the fusion gene which encodes a 80-kDa hybrid protein that contains portion of the nuclear protein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK. (upenn.edu)
Cytokine receptors1
- Under this project my lab investigates the role of signals mediated through receptor for interleukin-2 (IL-2R) and functionally related cytokine receptors in malignant transformation of T lymphocytes. (upenn.edu)
Gene4
- Promoter analyses in a mouse macrophage cell line, RAW264.7, revealed that the 2508-bp region upstream of the transcriptional start Site is sufficient for the full transcriptional activation of the IL12RB1 gene by IFN-γ or IL-15. (elsevierpure.com)
- Thus, IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-γ through the recruitment of PU.1 and IRF3. (elsevierpure.com)
- Analysis of transcript abundance in 15 tissues obtained from healthy adult rainbow trout by RNA-seq indicates constitutive expression of all three genes with the highest relative expression of gene-1 in oocyte tissue and highest expression of gene-2 and -3 in gill tissue. (usda.gov)
- inflammatory bowel disease: …mutation of a gene called TNFSF15 (tumour necrosis factor ligand superfamily member 15), which is involved in suppressing inflammation, has been identified as an ethnic-specific IBD susceptibility gene. (britannica.com)
Polymorphism3
- We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
- rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia. (cdc.gov)
- ABSTRACT Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. (who.int)
Monoclonal Antibody2
- Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC) is a Mouse Monoclonal Antibody conjugated to APC against Interleukin 2 Receptor Alpha (IL2Ra) for use in flow cytometry. (markelab.com)
- Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) is a Mouse Monoclonal Antibody conjugated to FITC against Interleuk. (markelab.com)
Kinase2
- IRAK: a kinase associated with the interleukin-1 receptor. (microbiologyresearch.org)
- Using multiwalled carbon nanotube s (MWCNT) via pulmonary delivery in mice, we observed acute deficits in blood brain barrier, activation of astrocytes, and induction of cortical CCL5 and interleukin-6 (IL6) mRNA that were abrogated by coadministration of a rho kinase inhibitor that improves endothelial barrier integrity. (cdc.gov)
Expression2
- Our cancer studies have expanded to include oesophageal cancer with emphasis on oestrogen receptor expression and function in this malignancy. (nottingham.ac.uk)
- [ 16 ] Expression of protease-activated receptor 1 and 2 occurs in orofacial granulomatosis. (medscape.com)
Induces1
- Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. (diabetesjournals.org)
20211
- 2021 Apr 15. (yale.edu)
IL1RL12
- As part of an effort to determine the mechanisms behind rainbow trout resistance to BCWD, we have identified for the first time, three interleukin-1 receptor like-1 (il1rl1) genes within a genetic locus associated with disease resistance. (usda.gov)
- Unrooted phylogenetic trees grouped the il1rl1 genes apart from other genes of the interleukin 1 receptor family and genomic comparisons identify preserved synteny between mammals, birds and salmonids albeit a pseudogene is present in both Atlantic salmon and Coho salmon. (usda.gov)
Nuclear receptors1
- We found previously that nuclear receptors (NRs) compete for heterodimerization with their common partner, retinoid X receptor (RXR), in a ligand-dependent manner. (bvsalud.org)
Ligand1
- Th17 cell proliferation is promoted by tumor necrosis factor (TNF)-like ligand 1A (TL1A), which binds to death receptor 3 (DR3) expressed on Th17 cells. (nih.gov)
Inflammation5
- BACKGROUND: To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. (ox.ac.uk)
- Cardiac Toll-like receptors and inflammasome complexes may be key inducers for inflammation probably through NF- B activation and ROS overproduction. (hindawi.com)
- We and others have reported that myocardial inflammation develops in human patients and experimental models of type 1 (T1DM) and type 2 (T2DM) diabetes mellitus [ 8 , 14 , 15 ]. (hindawi.com)
- Activation of Toll-like receptors (TLRs) and the inflammasome complex has recently been proposed to be central in cardiac inflammation and likely in the pathogenesis of DCM. (hindawi.com)
- Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
Cells12
- In vitro, long-term exposure to high glucose and the peptide hormone leptin secreted by adipose tissue induce β-cell apoptosis and production of the proinflammatory cytokine interleukin (IL)-1 in β-cells and pancreatic islets, respectively ( 7 , 8 ). (diabetesjournals.org)
- Interleukin-12 receptor β1 (IL12RB1) is expressed on a variety of immune cells, including T and natural killer (NK) cells and macrophages, and is involved in innate and adaptive immune responses. (elsevierpure.com)
- Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (ox.ac.uk)
- SCF in combination with interleukin-7 (IL-7) can also stimulate the combined myeloid and B-cell differentiation of uncommitted hematopoietic progenitor cells as well as the growth of early B-cell progenitor cells, although the involvement of c-kit in early B lymphopoiesis remains controversial. (ox.ac.uk)
- The identification of Th17 cells, which produce interleukins (ILs) - 17A, IL-17F, IL-21, IL-22, granulocyte-macrophage colony-stimulating factor (GM-CSF), and many other factors shed a light on the previously observed CMI in the absence of IFN-)γ. (medscape.com)
- These small chemicals are believed to act as haptens or activate T cells by directly binding to T cell Ag receptor (TCRs)/major histocompatibility complex (MHC). (medscape.com)
- Little eicosanoid production was induced by histamine, either in the apical or the basolateral direction, although BEAS cells constitutively produced small amounts of prostaglandin E2 and 15-HETE. (epa.gov)
- We found that cutaneous T-cell lymphoma cells display activation of the interleukin-2 receptor/cytokine common chain-associated Jak/STAT signal transduction pathway that is transient in the early stage of the lymphoma and constitutive in the late stage of the disease progression. (upenn.edu)
- In contrast to T cells, which did not exhibit a significant difference, B cells from PPARγ +/- showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. (jci.org)
- A closer examination of SBA-15-hypericin uptake by fluorescence lifetime imaging showed that aggregated hypericin molecules, characterized by a short fluorescence lifetime (â ¼4 ns), were still present in the SBA-15 particles upon uptake by cells. (bvsalud.org)
- To investigate potential competition in their DNA binding, we monitored the mobility of retinoic acid receptor (RAR) and vitamin D receptor (VDR) in live cells by fluorescence correlation spectroscopy. (bvsalud.org)
- Here, we studied the effects of Dox on the chromatin binding of the architectural proteins high mobility group B1 (HMGB1) and the linker histone H1, and the transcription factor retinoic acid receptor (RARα) by fluorescence recovery after photobleaching (FRAP) and fluorescence correlation spectroscopy (FCS) in live cells. (bvsalud.org)
Histamine1
- Monolayers exposed to histamine for 30 min released interleukin-6 and fibronectin in the apical direction, in a dose-dependent manner. (epa.gov)
Affinity1
- A low affinity interleukin-15 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-15. (childrensmercy.org)
Familial1
- We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. (cdc.gov)
Genes1
- SCID results from mutations in any of more than 15 known genes. (medscape.com)
Histone1
- Notably, chromatin immunoprecipitation (ChIP) assays revealed IL-15 rapidly induced histone H3 acetylation at the IL12RB1 promoter. (elsevierpure.com)
20011
- Elevated IL-6 concentrations have been reported in numerous clinical disorders (Jones S. A. et al, 2001, The FASEB J. 15:43-58 ), where they appear to orchestrate a variety of inflammatory responses. (sbhsciences.com)
Alpha6
- It consists of an interleukin 15 receptor, alpha subunit and shares common beta and gamma subunits with the IL-2 receptor. (wikipedia.org)
- Interleukin-15 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- This graph shows the total number of publications written about "Interleukin-15 Receptor alpha Subunit" by people in this website by year, and whether "Interleukin-15 Receptor alpha Subunit" was a major or minor topic of these publications. (childrensmercy.org)
- Below are the most recent publications written about "Interleukin-15 Receptor alpha Subunit" by people in Profiles. (childrensmercy.org)
- IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
- Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
Closely related1
- This study integrated liver function data and ILs data in patients with COVID-19 and found that liver injury and two ILs, interleukin-2 receptor (IL-2R) and interleukin-6 (IL-6), were closely related to the prognosis of patients with COVID-19. (frontiersin.org)
Serum3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
- Description: A sandwich ELISA kit for detection of Interleukin 8 Receptor Beta from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
Tissue1
- C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
Molecular1
- Molecular vision 2009 15 609-18. (cdc.gov)
Glucose1
- Peroxisome proliferator-activated receptor-γ (PPARγ) controls adipogenesis and glucose metabolism. (jci.org)
Associations1
- RÉSUMÉ Les associations observées entre le polymorphisme du récepteur de la vitamine D et le diabète de type 1 varie en fonction des groupes ethniques. (who.int)
Immune2
- These findings further the understanding of interleukin receptor family evolution and their contribution to teleost immune function. (usda.gov)
- They work as pattern recognition receptors (PRRs) implicated in tailoring innate immune signaling [ 22 ]. (hindawi.com)
Genetics1
- Interleukin 1 Genetics Consortium None. (ox.ac.uk)
Inhibitors1
- Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can reduce hypertension and may also contribute to reducing proteinuria. (medscape.com)
Type2
- Interleukin-15 receptor is a type I cytokine receptor, binding interleukin-15. (wikipedia.org)
- Un groupe de 69 patients atteints de diabète de type 1 et 45 témoins en bonne santé sans lien entre eux ont été recrutés pour cette étude. (who.int)
Activation1
- The Ag presentation and subsequent T-cell activation via CD3 and T-cell Ag receptor (TCR)(CD3/TCR) complex elicit an influx of macrophages, monocyte, and lymphocytes at the site of Ag exposure. (medscape.com)
Clinical1
- Data on gender were obtained from the clinical records of patients with Lyme borreliosis aged $15 years who had been evaluated at the University Medical Center Ljubljana, Ljubljana, Slovenia. (cdc.gov)
Family2
- Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 comprise a cytokine family based on sharing a receptor component, the common cytokine receptor γ chain (γc). (news-medical.net)
- We conducted a family history-wide association study to systematically assess the association of a first-degree family history of 15 ODHBs in AoU. (cdc.gov)