• 1996
  • Mutant IL-15 Protein exerting antagonistic effects on IL-15 triggered cell proliferation", Journal of the American Society of Nephrology, 7(9): 1654 (1996). (patentgenius.com)
  • 1998
  • 1998 Jun 15;91(12):4701-7. (nih.gov)
  • 1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. (wikipedia.org)
  • expression
  • This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. (wikipedia.org)
  • The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface. (nih.gov)
  • Proliferation response to interleukin-2 and Jak/Stat activation of T cells immortalized by human T-cell lymphotropic virus type 1 is independent of open reading frame I expression. (nih.gov)
  • The proliferation observed in cells stimulated with IL-2 primarily occurred in a subset of the CD70 + CD8 + T cells that up-regulated IL-2 receptor expression but did not occur in CD70 − CD8 + T cells. (jimmunol.org)
  • however, expression of CD27 is down-regulated in late effector stage T cells ( 14 , 15 , 16 , 17 ). (jimmunol.org)
  • variants
  • The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. (patentgenius.com)
  • The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. (patentgenius.com)
  • signals
  • Proper T cell function relies on the integration of signals delivered by Ag, cytokine, and costimulatory receptors. (jimmunol.org)
  • Without important developmental signals from IL-7 and IL-15, T-cell and NK cell populations respectively fail to develop. (wikipedia.org)
  • neutrophils
  • These receptors are generally found on human neutrophils, a type of white blood cell of the myeloid lineage, with approximately 65,000 receptors per neutrophil. (wikipedia.org)
  • The reported size of the translated protein is approximately 40kD, differing from the native purified receptors from the surface of neutrophils by 20kD. (wikipedia.org)
  • antigen
  • The adaptive immune system has evolved antigen receptor diversity to cope with a large variety of pathogens and non-self antigens. (frontiersin.org)
  • Broadly, ILCs are defined by their lymphoid lineage and their lack of RAG-mediated recombined antigen receptors. (frontiersin.org)