• agonist
  • The D 2 Lh form may function as a classical post-synaptic receptor, i.e., transmit information (in either an excitatory or an inhibitory fashion) unless blocked by a receptor antagonist or a synthetic partial agonist . (wikipedia.org)
  • The receptor was first named the "quisqualate receptor" by Watkins and colleagues after a naturally occurring agonist quisqualate and was only later given the label "AMPA receptor" after the selective agonist developed by Tage Honore and colleagues at the Royal Danish School of Pharmacy in Copenhagen. (wikipedia.org)
  • An optical section of the fluorescent receptors is obtained by epifluorescence confocal microscopy from insulin‐treated (a), untreated (b) and β‐adrenergic agonist‐treated (c) cells. (els.net)
  • Hadcock JR and Malbon CC (1988) Down‐regulation of beta‐adrenergic receptors: agonist‐induced reduction in receptor mRNA levels. (els.net)
  • Kallal L, Gagnon AW, Penn RB and Benovic JL (1998) Visualization of agonist‐induced sequestration and down‐regulation of a green fluorescent protein‐tagged beta2‐adrenergic receptor. (els.net)
  • 2004) Characterization of agonist stimulation of cAMP‐dependent protein kinase and G protein‐coupled receptor kinase phosphorylation of the beta2‐adrenergic receptor using phosphoserine‐specific antibodies. (els.net)
  • Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. (wikipedia.org)
  • 1988
  • 1988) Molecular cloning and expression of the cDNA for the hamster alpha 1‐adrenergic receptor. (els.net)
  • Dutar P and Nicoll RA (1988) A physiological role for GABAB receptors in the central nervous system. (els.net)
  • 1997
  • 1997) Pharmacologically distinct GABAB receptors that mediate inhibition of GABA and glutamate release in human neocortex. (els.net)
  • 1997) Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors. (els.net)
  • Slesinger PA, Stoffel M, Jan YN and Jan LY (1997) Defective γ‐amino butyric acid type B receptor‐activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and GIRK2 null mutant mice. (els.net)
  • Bowery NG, Kerr DIB and Ong J (1997) GABAB receptors: role and therapeutic implications in CNS disorders. (els.net)
  • 6-Hydroxymelatonin Agomelatine GR-196,429 Melatonin N-Acetylserotonin Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Afobazole Luzindole Prazosin Discovery and development of melatonin receptor agonists Reppert SM (1997). (wikipedia.org)
  • similarity
  • This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including CCL19, CCL21 and CCL25) and its structural similarity to chemokine receptors. (wikipedia.org)
  • However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature. (wikipedia.org)
  • mRNA
  • D1 receptor agonism and D2 receptor blockade also increases mRNA translation by phosphorylating ribosomal protein s6 , resulting in activation of mTOR. (wikipedia.org)
  • MT2 receptor mRNA has not been detected by in situ hybridization in the rat suprachiasmatic nucleus or pars tuberalis. (wikipedia.org)
  • Chemokines
  • In Chemokine Receptors, leading investigators attempt to distill the large body of literature ranging from basic molecular and cellular mechanism of chemokine receptors, to physiological and pathological roles of chemokines. (springer.com)
  • CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including CCL11, CCL26, CCL7, CCL13, CCL15, CCL24 and CCL5 that attract eosinophils, and CCL28 that attracts B and T lymphocytes to mucosal tissues. (wikipedia.org)
  • The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor. (wikipedia.org)
  • CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. (wikipedia.org)
  • physiological
  • Their authoritative contributions cover the major aspects of these receptors, describing the relationships between the physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. (springer.com)
  • chemokine receptor
  • To date, ten true members of the CC chemokine receptor subfamily have been described. (wikipedia.org)
  • There is some suggestion that this chemokine receptor is restricted to memory T-cells within the lymphocyte pool. (wikipedia.org)
  • To note, the chemokine binding protein D6 had previously been named CCR9, but this molecule is a scavenger receptor not a true (signaling) chemokine receptor. (wikipedia.org)
  • The chemokine receptor CXCR5 is expressed on B cells and CD4+ Tfh cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. (wikipedia.org)
  • regulate
  • Neurons and glia, including immune cells, integrate a functional network that uses several serotonin receptors to regulate their roles in this particular part of the limbic system. (hindawi.com)
  • Shumay E, Gavi S, Wang HY and Malbon CC (2004) Trafficking of beta2‐adrenergic receptors: insulin and beta‐agonists regulate internalisation by distinct cytoskeletal pathways. (els.net)
  • In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes. (wikipedia.org)
  • structures
  • It stores a manual annotation of all GPCR crystal structures, the largest collections of receptor mutants and reference sequence alignments. (wikipedia.org)
  • It crosslinks to GuideToPharmacology database and has adopted the official NC-IUPHAR receptor naming nomenclature, has exchange with GPCR servers, and has also recently become part of the GPCR Consortium set out to generate an unprecedented number of crystal structures. (wikipedia.org)
  • The 3D crystallographic structures of the seven transmembrane helical domain (7TM) and the extracellular domain (ECD) and an electron microscopy (EM) map of full length glucagon receptor have been determined. (wikipedia.org)
  • regulation
  • Shenoy SK, McDonal PH, Kohout TA and Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta2‐adrenergic receptor and beta‐arrestin. (els.net)
  • 2007). "Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver. (wikipedia.org)
  • CCK-B receptors possess a complex regulation of dopamine activity in the brain. (wikipedia.org)
  • humans
  • In humans, this receptor can be found on peripheral blood lymphocytes and monocytes. (wikipedia.org)
  • Inactivating mutation of glucagon receptor in humans causes resistance to glucagon and is associated with pancreatic alpha cell hyperplasia, nesidioblastosis, hyperglucagonemia, and pancreatic neuroendocrine tumors. (wikipedia.org)
  • expression
  • At a global level, D 1 receptors have widespread expression throughout the brain. (wikipedia.org)
  • Maximum expression of dopamine D 3 receptors is noted in the islands of Calleja and nucleus accumbens . (wikipedia.org)
  • This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types (e.g. neutrophils, monocytes, T and B cells, dendritic cells, Langerhans cells and macrophages). (wikipedia.org)
  • However, there is considerable variation in the density and location of MT receptor expression between species. (wikipedia.org)
  • peptide
  • In addition, stretching of atrial receptors increases secretion of atrial natriuretic peptide (ANP), which promotes increased water and sodium excretion through the urine. (wikipedia.org)
  • novel
  • Chemokine Receptors targets the pharmaceutical industry, provides an authoritative perspective on the future direction of this field, and insights into areas of active development of novel therapeutics. (springer.com)
  • signals
  • When such chemical signals bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. (wikipedia.org)
  • functional
  • Binding of growth hormone to the receptor leads to receptor dimerization (the receptor may however also exist as a pre-assembled non-functional dimer ) and the activation of an intra- and intercellular signal transduction pathway leading to growth. (wikipedia.org)
  • subtype
  • The critical survey and synthesis offered by The P2 Nucleotide Receptors lays a strong foundation for future work on P2 receptors-some no doubt yet to be cloned-as well as for establishing conclusively the identity of the cloned P2 receptor subtype(s) involved in the varied physiologic effects of extracellular nucleotides. (springer.com)
  • Decoy
  • A decoy receptor is a receptor that is able to recognize and bind specific growth factors or cytokines efficiently, but is not structurally able to signal or activate the intended receptor complex. (wikipedia.org)
  • Decoy receptors participate in a common methods of signal inhibition and are also abundant in malignant tissues, making up a significant topic in cancer research. (wikipedia.org)
  • IL1R2 was one of the first identified decoy receptors. (wikipedia.org)
  • It acts as a decoy receptor for TNF cytokine members: FasL, LIGHT, and TL1A, inhibiting the ability of the cytokines to signal for cell death or apoptosis. (wikipedia.org)
  • Decoy receptors are being designed that bind to Gas6 and prevent Axl activation. (wikipedia.org)
  • ACE-031 is an engineered decoy receptor used in attempts to treat children with Duchenne Muscular Dystrophy (DMD). (wikipedia.org)