Receptors virus. Medical search. Frequent questions

Furthermore, the team showed that an antibody, which binds to the receptor protein, is able to block infection by both viruses. (biologynews.net)
The structure shows how the virus binds to its cellular receptor, the Anthrax toxin receptor. (oist.jp)
Recombinant human angiotensin-converting enzyme 2 (ACE2) extracellular domain (18-615) was expressed in HEK293 cells using a C-terminal sheep Fc-tag and purified to SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the host cell ACE2 receptor to facilitate viral entry into the cell. (thenativeantigencompany.com)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
SARS-CoV-2 , the coronavirus that causes COVID-19, binds to a receptor called ACE2, which plays a number of roles in regulating blood pressure, blood volume, and inflammation. (scitechdaily.com)
Although ACE2 binds to SARS-CoV-2, it is not optimized for that purpose, which means that subtle mutations to the receptor could make it bind more strongly. (scitechdaily.com)
Furthermore, they found that the decoy receptor not only binds to the virus in live tissue cultures, it effectively neutralizes it, preventing cells from becoming infected. (scitechdaily.com)
We demonstrate that CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. (ox.ac.uk)
The thrombopoietin receptor is turned on (activated) when a protein called thrombopoietin attaches (binds) to it. (medlineplus.gov)

Glycan array results for selected (non) fucosylated glycans for the complete set of wild-type and mutant H5 proteins of influenza viruses. (cdc.gov)
Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity. (cdc.gov)
Seneca Valley Virus capsid proteins are shown in blue, green, and red, and the ANTXR1 receptor is shown in magenta. (oist.jp)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
The Hill analysis result is supported by the detection of two affinity purified putative receptor proteins (M.W. 97,000 & 70,000 daltons) from BMP cells. (mun.ca)
Chromatofocusing studies on these proteins confirmed that the putative virus receptor contains Neu5Ac. (mun.ca)
Both heart cells and lung cells are covered with surface proteins known as angiotensin-converting enzyme 2 (ACE2) - these molecules serve as "doorways" for the virus to enter cells. (sott.net)
When tissues in the body are damaged - either by an invading virus such as SARS-CoV-2 or by other means, the body's natural healing response involves releasing inflammatory molecules, such as small proteins called cytokines , into the bloodstream. (sott.net)
when the virus latches onto ACE2 proteins, these proteins get knocked out of commission, possibly reducing the anti-inflammatory protection that they give. (sott.net)
It's really hard to tease out whether having more ACE2 is helpful or harmful, as these proteins are how the virus enters the cells, but also known to protect the cells against injury , Michos said. (sott.net)
Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
Since the genomic sequence of HCV was determined, progress has been made towards understanding the functions of the HCV-encoded proteins and identifying the cellular receptor(s) responsible for adsorption and penetration of the virus particle into the target cells. (biomedcentral.com)
Scavenger receptors are cell membrane proteins that bind chemically modified lipoproteins, such as acetylated and oxidized LDLs. (biomedcentral.com)
Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. (aspetjournals.org)
Adherence was not affected by pretreatment of the cells with virus particles or viral proteins. (lu.se)

Unlike HIV-1, infection with either M-tropic or T-tropic strains of simian immunodeficiency virus (SIV) can be mediated by CCR5, but not CXCR4. (nih.gov)
Usage of these new receptors following experimental infection of non-human primates with SIV strains may provide important insight into viral transmission and the mechanisms of SIV- and HIV-induced acquired immune-deficiency syndrome. (nih.gov)
That's important because if you can identify and understand the first step in infection - how the virus enters cells - then perhaps you can prevent the infection by nipping it in the bud. (biologynews.net)
Finally, work performed by Robert Davey, Ph.D., in a BSL-4 lab (the highest level of biocontainment) at University of Texas Medical Branch verified that the ARD5 antibody blocks infection by infectious Zaire Ebola Virus in cells that express the TIM-1 protein. (biologynews.net)
Epstein-Barr virus (EBV) infection of B lymphocytes is near universal in humans and stimulates high levels of EBV-specific helper and cytotoxic T cells, which persist indefinitely. (nih.gov)
Das D, Sarkar N, Sengupta I, Pal A, Saha D, Bandopadhyay M, Das C, Narayan J, Singh SP, Chakravarty R. Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study. (wjgnet.com)
Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. (nature.com)
Objective: The recent availability of novel antiviral drugs has raised new hope for a more effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. (uninsubria.it)
In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
Severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG antibody levels after AZD1222 vaccination and/or SARS-CoV-2 infection. (ajtmh.org)
Monoclonal antibodies raised against the putative receptor blocked EMC-D virus infection of BMP cells and virus binding to β-cells from SJL/J mice. (mun.ca)
To study the adsorption, penetration and replication of the virus, a major obstacle has been the lack of an efficient and reproducible in vitro infection system. (biomedcentral.com)
et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
Hepatitis C virus (HCV) infection has impaired cellular immune response and circulating NK cells, NK subsets (in- the ability to establish chronic infection virus persistence [8]. (who.int)
The virus-infected cells were harvested at various times after infection and analyzed for the ability to bind strains of Haemophilus influenzae and Streptococcus pneumoniae. (lu.se)
This suggested that adenovirus infection upregulated receptors for S. pneumoniae. (lu.se)
The increased attachment may be one mechanism by which viruses precondition the respiratory mucosa for bacterial infection. (lu.se)
2018]. Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection. (bvsalud.org)

We find that the human H7 virus has significantly higher affinity for α-2,6-linked sialic acid analogues ('human receptor') than avian H7 while retaining the strong binding to α-2,3-linked sialic acid analogues ('avian receptor') characteristic of avian viruses. (flutrackers.com)
Pretreatment of the cells with protease, neuraminidases, or with lectins, showed that the receptor is a protein and that sialic acids are required for virus binding to BMP cells. (mun.ca)
Influenza A Virus Agnostic Receptor Tropism Revealed Using a Novel Biological System with Terminal Sialic Acid Knockout Cells. (bvsalud.org)
Avian or human influenza A viruses bind preferentially to avian- or human -type sialic acid receptors, respectively, indicating that receptor tropism is an important factor for determining the viral host range . (bvsalud.org)
In this study, we established a novel system using MDCK cells with avian- or human -type sialic acid receptors and with both sialic acid receptors knocked out (KO). (bvsalud.org)
When we examined the replication of human and avian influenza viruses in these KO cells , we observed unique viral receptor tropism that could not be detected using a conventional solid-phase sialylglycan binding assay, which directly assesses physical binding between the virus and sialic acids . (bvsalud.org)
These data indicate that a panel of sialic acid receptor KO cells could be a useful tool for determining the biological receptor tropism of influenza A viruses . (bvsalud.org)
In this study, we established a novel system using a set of genetically engineered MDCK cells with knocked out sialic acid receptors to biologically evaluate the receptor tropism for influenza A viruses . (bvsalud.org)
In contrast to FMDV, which uses integrins as cellular receptors, the receptor for ERAV has been reported to involve the sugar moiety sialic acid. (ox.ac.uk)
This study confirmed the importance of sialic acid for cell entry by ERAV and reports the crystal structure of ERAV particles complexed with the receptor analogue 3′-sialyllactose. (ox.ac.uk)
The receptor is attached to the rim of a capsid pit adjacent to the major immunogenic site and distinct from the sialic acid binding site used by a related picornavirus, the cardiovirus Theiler's murine encephalitis virus. (ox.ac.uk)

FACS analyses of virus binding and anti-EMC virus anti-idiotypic antibody binding to β-cells, showed that cells from SJL/J and C57BL/6J mice contain about the same number of EMC-D virus receptors. (mun.ca)
Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)
The structure of the major antigenic determinant of the virus, previously identified from antibody escape mutations, is also described as the EF loop of VP1, which forms a hairpin stretching across the capsid surface close to the icosahedral fivefold axis, neighbouring the receptor-binding site, and spanning two protomeric units. (ox.ac.uk)

Here, we found that proliferation of white spot syndrome virus (WSSV) was decreased after knockdown of mTor (mechanistic target of rapamycin) or injection inhibitor of mTORC1, rapamycin, in Marsupenaeus japonicus, which suggests that mTORC1 is utilized by WSSV for its replication in shrimp. (genscript.com)
Virus titers show diminished replication of ZIKV over 7 days compared to controls. (uky.edu)
Additionally, an ephemeral form of double-stranded RNA exists as a replicative intermediate during virus replication. (wikipedia.org)
The virus is engulfed by endocytosis and the viral and cell membranes fuse, releasing the viral RNA (yellow string) which directs the production of new virus particles (viral replication) and so completes the viral life cycle. (rkm.com.au)
Studies sug- terized by flow cytometry using anti between the immune response and the gest that HCV inhibits receptor genes in CD3, CD56 and CD16 monoclonal virus replication rate [5] and play a cru- the activation of NK cells [20], and the antibodies. (who.int)
Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)
Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
Certain single-strand, (+) sense RNA viruses termed retroviruses use a very different method of replication. (msdmanuals.com)
Replication of examinations such as patient's mental state, the virus in lymphoid cells may cause extra- build, pulse rate, respiratory rate, body tem- hepatic manifestations. (who.int)

Several members of the chemokine-receptor family serve, in conjunction with CD4, as receptors for the entry of human immunodeficiency virus type I (HIV-1) into cells. (nih.gov)
SIV strains will also infect CD4+ cells that lack CCR5, which suggests that these strains use as yet unidentified receptors. (nih.gov)
Subsequent experiments proved that both Ebola and Marburg viruses use TIM-1 is a receptor for infecting cells. (biologynews.net)
A further collaboration with Paul Rennert, Ph.D., at Biogen Idec, a biotech company based in Cambridge, Mass., provided the team with antibodies targeted to TIM-1 and the team found that one of these antibodies, ARD5, very effectively blocks Ebola and Marburg virus entry into cells. (biologynews.net)
It's clear that there are other receptors for Ebola because while TIM-1 is found on a number of epithelial cells in the body, it is not found on some important cell types that are infected by Ebola," Maury said. (biologynews.net)
Ultimately, epithelial cells are not as important a target for the virus as some other cell types, but they may be the first entry point for Ebola, so they may provide a conduit that allows Ebola access to those other cells within the body. (biologynews.net)
Primary T cells expressing chimeric receptors specific for tumor or viral antigens have considerable therapeutic potential. (nih.gov)
Unfortunately, their clinical value is limited by their rapid loss of function and failure to expand in vivo, presumably due to the lack of costimulator molecules on tumor cells and the inherent limitations of signaling exclusively through the chimeric receptor. (nih.gov)
We now report that EBV-specific (but not primary) T cells transduced with tumor-specific chimeric receptor genes can be expanded and maintained long-term in the presence of EBV-infected B cells. (nih.gov)
EBV-specific T cells expressing chimeric antitumor receptors may represent a new source of effector cells that would persist and function long-term after their transfer to cancer patients. (nih.gov)
If you have a virus that targets cancer cells and nothing else, that's the ultimate cancer fighting tool," said Prof. Matthias Wolf, principal investigator of the Molecular Cryo-Electron Microscopy Unit at OIST and co-senior author of the study. (oist.jp)
Type 1 of this receptor is selectively expressed in up to 60% of human cancer cells and allows the virus to infect and destroy them while not affecting healthy cells. (oist.jp)
Anticancer viruses tend to target tumors while sparing the healthy cells around them, and many already exist in nature. (oist.jp)
Seneca Valley Virus stands out as a potential virotherapy for one key reason: it selectively targets a receptor found coating tumor cells in over 60 percent of human cancers. (oist.jp)
Seneca Valley Virus doesn't bind with the similar receptor on healthy cells -- it only shows strong affinity for ANTXR1. (oist.jp)
You want the virus to evade the immune system, continue to replicate and kill the cancer cells. (oist.jp)
Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one being that between the viral E2 envelope glycoprotein and the CD81 receptor. (gla.ac.uk)
Configuration and expression of the T cell receptor beta chain gene in human T-lymphotrophic virus I-infected cells. (rupress.org)
We studied the configuration and expression of the gene encoding the beta chain of the T cell receptor (TCR beta) in cell lines and primary tumor cells infected by the human T cell leukemia/lymphoma (lymphotrophic) virus type I (HTLV-I). Most of the cell lines and all the primary tumor cells showed rearrangement of the TCR beta gene, and in each case the rearrangement was distinct. (rupress.org)
By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)
Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
To this end we have used chimeric antigen receptors (CARs), a very promising approach recently used in several clinical trials to redirect primary human T cells against different tumours. (uninsubria.it)
Their role is to detect virus-infected cells and destroy them. (tum.de)
The graphic shows the distribution of the Ly49H-receptor on the surface of different natural killer cells (NK). (tum.de)
Depending on the amount of receptors, single cells expand stronger or weaker. (tum.de)
Together with T cells, natural killer cells (NKs) effectively keep the virus in check, although it can cause serious illnesses in people with a weakened immune system. (tum.de)
NKs possess surface molecules that identify CMV-infected cells, such as the receptor Ly49H in mice. (tum.de)
It is known that NKs equipped with this receptor (Ly49H-NKs) are particularly effective at destroying CMV-infected cells. (tum.de)
Nevertheless, if the PCSK9 molecule is normally obstructed, LDL receptors are recycled, came back to the top of cells, and remove even more LDL contaminants from flow. (researchensemble.com)
Simple Western™ analysis of lysates (0.75 mg/mL) from Mouse Brain cells using AMPA Receptor 4 (GluA 4) (D41A11) XP ® Rabbit mAb #8070. (cellsignal.com)
Western blot analysis of extracts from mouse brain, NIH/3T3 cells, rat brain, and C6 cells using AMPA Receptor 4 (GluA 4) (D41A11) XP ® Rabbit mAb. (cellsignal.com)
Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes in cultured human retinal pigmented epithelial (RPE) cells and impairs lysosomal function. (sens.org)
The diabetogenic variant of EMC virus, EMC-D, can infect mouse pancreatic β-cells and may induce a type 1 diabetes-like syndrome in SJL/J mice, but not in C57BL/6J mice. (mun.ca)
Yet a great deal more is known about EMC-D virus, than about the receptor structures that allow its entry into β-cells. (mun.ca)
The aim of this project was to characterize the virus receptor on BMP cells and to see if the receptor plays a role in EMC-D virus-induced diabetes in SJL/J mice. (mun.ca)
The nature of the EMC-D virus receptor was investigated by in vitro attachment of ³H-labelled EMC-D virus to BMP cells. (mun.ca)
4 X l0⁵ sites/cell) binding site, Hill analysis of the saturation binding data strongly suggested that EMC-D virus has more than one binding site on BMP cells. (mun.ca)
Pretreating cells with phospholipases C and D or with enzymes specific for N-linked carbohydrates had no significant effect on virus binding. (mun.ca)
It is concluded that the receptor for EMC-D virus on BMP cells is a sialylated glycoprotein, and virus binding involves Neu5Ac, and possibly Neu5Gc, but not N-linked sugars. (mun.ca)
It is concluded that the inability of EMC-D virus to cause IDDM in C57BL/6J may not be due to lack of, or a reduction in the number of virus receptors on β-cells from C57BL/6J mice. (mun.ca)
So the virus may be acting as a double-whammy by damaging cells directly and preventing the body from protecting tissues from inflammatory damage. (sott.net)
Procko examined more than 2,000 ACE2 mutations and created cells with the mutant receptors on their surfaces. (scitechdaily.com)
Detached from cells, the soluble receptor is suspended in solution and free to interact with the virus as a decoy receptor. (scitechdaily.com)
This article reviews the cellular receptors for HCV and suggests a general model for HCV entry into cells, in which lipoproteins play a crucial role. (biomedcentral.com)
Thus, the identification of the HCV receptor on the surface of susceptible cells, especially hepatocytes, remains a major challenge for the development of both in vitro cell culture systems, and for the design of successful therapies [ 3 , 4 ]. (biomedcentral.com)
Moreover, the PB2KO virus experimental system could help to safely and efficiently identify the mutations required for avian influenza viruses to adapt to human cells that could trigger a new influenza pandemic . (bvsalud.org)
In order to study the possible role over Ficoll-Hypaque (density 1.077 production, and are the key players in that NK cells might play in the patho- g/L) (Amersham Biosciences) and immune responses to viruses [7]. (who.int)
The MPL gene provides instructions for making the thrombopoietin receptor protein, which promotes the growth and division (proliferation) of cells. (medlineplus.gov)
This receptor is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting. (medlineplus.gov)
Research suggests that the thrombopoietin receptor may also play a role in the maintenance of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, and platelets. (medlineplus.gov)
The activated thrombopoietin receptor stimulates a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus and is important for controlling the production of blood cells. (medlineplus.gov)
Viruses depend completely on cells (bacterial, plant, or animal) to reproduce. (msdmanuals.com)

Examples of retroviruses are the human immunodeficiency viruses and the human T-cell leukemia viruses. (msdmanuals.com)

These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)

ACE2 molecule acts as a gateway for the virus to enter the cell and replicate, but on the other hand, it normally serves a "protective" function , Michos said. (sott.net)
Animation of a coronavirus (COVID-19) particle (virion) attaching to ACE2 receptors (purplish tree-like clumps) on the surface (green) of a human cell. (rkm.com.au)

Both receptors are closely related to the chemokine-receptor family and are expressed in lymphoid tissues. (nih.gov)
C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. (harvard.edu)

Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
It is speculated that anti-idiotypic antibodies may play a role in the initiation of β-cell destruction in virus-infected SJL/J mice, possibly by molecular mimicry. (mun.ca)
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins. (harvard.edu)
Researchers there, along with the lab of Illinois biochemistry professor David Kranz, verified the strong affinity between the virus and the decoy receptor, rivaling the best antibodies identified to date, Procko said. (scitechdaily.com)

Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. (novusbio.com)
We are testing whether the decoy receptor is safe and stable in mice, and if successful, we then hope to show treatment of disease in animals. (scitechdaily.com)

Ebola and Marburg viruses cause hemorrhagic fever in humans and other primates. (biologynews.net)
Receptor binding by an H7N9 influenza virus from humans. (flutrackers.com)
We conclude that the human H7 virus has acquired some of the receptor-binding characteristics that are typical of pandemic viruses, but its retained preference for avian receptor may restrict its further evolution towards a virus that could transmit efficiently between humans, perhaps by binding to avian-receptor-rich mucins in the human respiratory tract rather than to cellular receptors. (flutrackers.com)
This virus was highly pathogenic in chickens and humans and posed a significant threat to public health. (nature.com)
The receptors are widely expressed in humans. (medscape.com)
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. (wikipedia.org)
He also is exploring how the decoy receptor bonds to other coronaviruses with the potential to become future pandemics if they cross from bats to humans. (scitechdaily.com)
IMPORTANCE The acquisition of mutations that allow avian influenza A virus hemagglutinins to recognize human -type receptors is mandatory for the transmission of avian viruses to humans , which could lead to a pandemic . (bvsalud.org)

TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. (wikipedia.org)

Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. (nature.com)
Thyroid Hormone Receptor alpha is encoded by this gene is a nuclear hormone receptor for triiodothyronine. (novusbio.com)
MPL gene mutations associated with essential thrombocythemia change a single protein building block (amino acid) in the thrombopoietin receptor protein. (medlineplus.gov)
The MPL gene mutations involved in CAMT lead to a reduced functioning or nonfunctioning thrombopoietin receptor protein. (medlineplus.gov)

The human H7 virus does not, therefore, have the preference for human versus avian receptors characteristic of pandemic viruses. (flutrackers.com)
X-ray crystallography of the receptor-binding protein, haemagglutinin (HA), in complex with receptor analogues indicates that both human and avian receptors adopt different conformations when bound to human H7 HA than they do when bound to avian H7 HA. (flutrackers.com)
Human receptor bound to human H7 HA exits the binding site in a different direction to that seen in complexes formed by HAs from pandemic viruses and from an aerosol-transmissible H5 mutant. (flutrackers.com)
The human-receptor-binding properties of human H7 probably arise from the introduction of two bulky hydrophobic residues by the substitutions Gln226Leu and Gly186Val. (flutrackers.com)
As of 31 March 2015, H5N1 virus caused at least 826 laboratory-confirmed human infections, including 440 deaths across 16 countries 2 . (nature.com)
Orthologous to human TLR3 (toll like receptor 3). (nih.gov)
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. (harvard.edu)
Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound. (harvard.edu)
Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment. (harvard.edu)
Many human cancer-associated viruses also express constitutively active viral GPCRs. (nature.com)
To infect a human cell, a virus must first bind to a receptor protein on the surface of the cell. (scitechdaily.com)
Synthetic peptide within Human Scavenging Receptor SR-BI aa 50-150 (N terminal). (abcam.com)
The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. (ox.ac.uk)
The Flavivirus genus is composed of more than 70 arthropod-transmitted viruses, of which 30 are known to cause human disease. (medscape.com)

By analyzing how these interacted with the coronavirus, he found a combination of three mutations that made a receptor that bound to the virus 50 times more strongly, making it a much more attractive target for the virus. (scitechdaily.com)
These mutations lead to a constitutively activated thrombopoietin receptor protein, which results in the overproduction of abnormal megakaryocytes. (medlineplus.gov)

abstract = "Zika virus (ZIKV) is an arbovirus belonging to the flaviviridae family with a risk assessment that has been increasing in recent years and was labeled a global health emergency by the World Health Organization in 2016. (uky.edu)
ABSTRACT Natural kil er (NK) cel s are key players in the immune response to viruses. (who.int)

The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release. (ox.ac.uk)

Both mutant viruses were significantly less dependent on SR-BI, and its lipid-transfer activity, for virus entry. (gla.ac.uk)
Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. (sens.org)
The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
Several cellular receptors for HCV have been proposed, all of which are associated with lipid and lipoprotein metabolism. (biomedcentral.com)

They recognize EBV-infected targets through their conventional T-cell receptor and tumor targets through their chimeric receptors. (nih.gov)

The differences between the two receptors are subtle, but nonetheless, these subtle differences make one bind the virus with high affinity while the other doesn't," said Wolf. (oist.jp)
Greater than 95% purity and shown to bind to Chikungunya Virus-like particles. (thenativeantigencompany.com)
Therefore, the virus cannot easily adapt to escape neutralization without simultaneously losing its ability to bind to its natural receptor. (scitechdaily.com)

Mammalian expressed recombinant MXRA8 protein, the cell surface receptor for alphaviruses. (thenativeantigencompany.com)
The receptor is normally avoided by This technique from time for the cell surface area, where in fact the receptor could remove even more LDL particles. (researchensemble.com)
BMP cell surface receptor regeneration after protease treatment took about 6 h, and was inhibited by cycloheximide, but not by tunicamycin. (mun.ca)

Here we use an expression-cloning strategy to identify SIV receptors and have isolated genes encoding two members of the seven-transmembrane G-protein-coupled receptor family that are used not only by SIVs, but also by strains of HIV-2 and M-tropic HIV-1. (nih.gov)

We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)

Double-stranded RNA is also recognised by the cytoplasmic receptors RIG-I and MDA-5. (wikipedia.org)

Further analyses of mutants with hydrophobic residues (F or Y) found that interactions with receptors SR-BI as well as CD81 were modulated which in-turn determined the viral uptake route. (gla.ac.uk)
We analyzed the effect of changing this residue in the virus and confirmed that this region is important for binding to the CD81 receptor. (gla.ac.uk)
Instead, these authors proposed that CD81 may be an attachment receptor with poor capacity to mediate the viral entry, and that reducing environments may not not favor CD81-HCV interaction. (biomedcentral.com)

When electron microscopy was used, there was no evidence that virus particles bound directly to bacteria. (lu.se)

Now, scientists at the Okinawa Institute of Science and Technology (OIST) and the University of Otago have described exactly how the virus interacts with tumors -- and why it leaves healthy tissues alone. (oist.jp)
The receptor, known as ANTXR1, is only expressed on tumors, but it has a cousin that only appears on healthy tissues, called ANTXR2. (oist.jp)

This study contributes to elucidation of the relationship between the physical binding of virus and receptor and viral infectivity. (bvsalud.org)

The former is shared with the 1957 H2 and 1968 H3 pandemic viruses and with the aerosol-transmissible H5 mutant. (flutrackers.com)

Amino acid changes at position 505 or 515 result in a thrombopoietin receptor protein that is constantly turned on (constitutively activated), which, in essential thrombocythemia, leads to the overproduction of abnormal megakaryocytes and an increased number of platelets. (medlineplus.gov)
Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)

The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). (nature.com)

Procko then made a soluble version of the engineered receptor. (scitechdaily.com)

The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)

In this report, DAX-1, a nuclear receptor family member with corepressor properties, was identified as a potent CAR regulator. (aspetjournals.org)

The principal receptor for entry of macrophage-tropic (M-tropic) HIV-1 strains is CCR5, whereas that for T-cell-line-tropic (T-tropic) strains is CXCR4. (nih.gov)
Using this system, we observed unique receptor tropism in several virus strains that was undetectable using conventional solid-phase binding assays that measure physical binding between the virus and artificially synthesized sialylglycans. (bvsalud.org)

Viruses are thought to facilitate bacterial infections of the respiratory tract, but the mechanisms are poorly understood. (lu.se)

Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer's disease in APP/PS1 mouse. (nih.gov)
TLR3 is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. (wikipedia.org)

Here we describe a model system, SELective Expression and Controlled Transduction In Vivo (SELECTIV), that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre-inducible overexpression of the multi-serotype AAV receptor, AAVR. (nature.com)
Our approach exploits the absolute dependence of AAV transduction on the expression of its receptor 22 , AAVR (also named KIAA0319L). (nature.com)

But there's one problem: the body builds up immunity to the virus within three weeks and squashes the bug before its work is done. (oist.jp)
The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)

Small ruminant lentiviruses (SRLV) are members of the Retrovirus family comprising the closely related Visna/Maedi Virus (VMV) and the Caprine Arthritis-Encephalitis Virus (CAEV), which infect sheep and goats. (mdpi.com)
A benefit of a decoy receptor is that it closely resembles the natural receptor. (scitechdaily.com)

Anatomy12

Organisms124

Diseases24

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

Health Care3

Binds9

Proteins18

Infection18

Sialic11

Antibody3

Replication9

Cells54

Immunodeficiency viruses1

Protein-Coupled Receptors1

ACE22

Chemokine-receptor3

Antibodies4

Mice2

Humans8

Innate immune1

Gene4

Human14

Mutations2

Abstract2

Cytokine1

Lipid4

Chimeric1

Bind3

Cell surface3

Genes1

Single nucleotide p1

Cytoplasmic1

CD813

Particles1

Tissues2

Infectivity1

Mutant1

Amino Acid2

Influenza virus1

Soluble1

Density1

Nuclear1

Strains2

Respiratory tract1

Activation2

Expression2

Immunity2

Closely2