• Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of proteins called collectin. (wikipedia.org)
  • Surfactant proteins SP-A and SP-D: structure, function and receptors. (ox.ac.uk)
  • Surfactant proteins, SP-A and SP-D, are collagen-containing C-type (calcium dependent) lectins called collectins, which contribute significantly to surfactant homeostasis and pulmonary immunity. (ox.ac.uk)
  • Collectins are surfactant proteins that are present in serum, lung secretions, and mucosal surfaces. (brmi.online)
  • It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
  • In contrast, the intestinal SALSA was more enriched with the scavenger receptor cysteine-rich domains. (researchgate.net)
  • Purification, characterization and cDNA cloning of human lung surfactant protein D". The Biochemical Journal. (wikipedia.org)
  • These receptors are present on phagocytic cells, mast cells, and lung epithelial and smooth muscle cells. (medscape.com)
  • 2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J. Immunol. (wikipedia.org)
  • Studies involving gene knock-out mice, murine models of lung hypersensitivity and infection, and functional characterization of cell surface receptors have revealed the diverse roles of SP-A and SP-D in the control of lung inflammation. (ox.ac.uk)
  • Surfactant development - allows lung inflation and decreases the work of breathing and also related to immunology of the lungs. (edu.au)
  • Evidence suggests that C1q binds a receptor present on phagocytic cells, termed C1qRP. (medscape.com)
  • C1qRP binds to MBL and surfactants. (medscape.com)
  • The C3a receptor binds C3a and C4a. (medscape.com)
  • Molecular structure of pulmonary surfactant protein D (SP-D)". The Journal of Biological Chemistry. (wikipedia.org)
  • Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type l. (targetmol.com)
  • Surfactants and MBL play an important role in innate immunity. (medscape.com)
  • The immune surfactant or collectin surfactant protein D (SP-D) is a crucial multifunctional innate immune receptor. (cdc.gov)
  • Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. (ersjournals.com)
  • Weight discount plan Modifies Pioglitazone's Have an impact on on Hepatic PPAR γ-Regulated Mitochondrial Gene Expression Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose outcomes end end result predominantly from its modulation of the transcriptional practice of peroxisome proliferator-activated-receptor-gamma (PPARγ). (scalegen.com)
  • Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116. (cdc.gov)
  • The trimeric CRDs can recognize carbohydrate or charge patterns on microbes, allergens and dying cells, while the collagen region can interact with receptor molecules present on a variety of immune cells in order to initiate clearance mechanisms. (ox.ac.uk)
  • Glycosylation of classical death receptors fine-tunes cell death programs. (nature.com)
  • events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Toll Like Receptor 9 (TLR9) in Tissue homogenates, cell lysates and other biological fluids. (2sars.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rabbit Toll Like Receptor 9 (TLR9) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
  • Description: A sandwich ELISA kit for detection of Toll Like Receptor 9 from Rabbit in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
  • ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
  • whether a distinct receptor for C4a is present is unclear (see Table 1). (medscape.com)
  • Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
  • Volatile anesthetics act primarily through upregulating the activity of γ-aminobutyric acid type A (GABA A ) receptors. (asahq.org)
  • A recently proposed model based on studies with the calreticulin-CD91 complex as a receptor for SP-A and SP-D has suggested an anti-inflammatory role for SP-A and SP-D in naïve lungs which would help minimise the potential damage that continual low level exposure to pathogens, allergens and apoptosis can cause. (ox.ac.uk)
  • Little work to date has examined the effect of such collectins in response to organic dusts. (cdc.gov)
  • The complement system exerts many of its effects through complement receptors (CRs). (medscape.com)
  • Please see: Gallos G, Emala CW: Anesthetic effects on γ-aminobutyric acid A receptors: Not just on your nerves. (asahq.org)
  • We also try to put in perspective the controversial subject of the candidate receptor molecules for SP-A and SP-D. (ox.ac.uk)
  • Examination of the SP-D regulatory receptor GPR116 showed that its mRNA expression was increased in response to dust and inhibited by blocking PKCa, implicating it as a means of inhibiting SP-D in the lungs in response to organic dusts. (cdc.gov)
  • The majority of surfactant is synthesized and secreted by alveolar type II cells. (biomedcentral.com)
  • The collectins mannan-binding lectin (MBL) and lung surfactant protein D (SP-D) play a significant role in innate immunity. (nih.gov)
  • Purification, characterization and cDNA cloning of human lung surfactant protein D". The Biochemical Journal. (wikipedia.org)
  • 12. Human surfactant protein D alters oxidative stress and HMGA1 expression to induce p53 apoptotic pathway in eosinophil leukemic cell line. (nih.gov)
  • Examination of the SP-D regulatory receptor GPR116 showed that its mRNA expression was increased in response to dust and inhibited by blocking PKCa, implicating it as a means of inhibiting SP-D in the lungs in response to organic dusts. (cdc.gov)
  • Immunohistochemistry and in situ hybridization studies demonstrated that surfactant protein and mRNA expression are not restricted to alveolar type II cells. (biomedcentral.com)
  • 2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J. Immunol. (wikipedia.org)
  • Serum IKBα, p-IKBα, surfactant protein-A (SP-A) and toll-like receptor 4 (TLR4) levels were examined using enzyme-linked immunosorbent assay (ELISA). (silverchair.com)
  • While the role of surfactant in the alveolar compartment has been intensively elucidated both in health and disease states, the possible role of surfactant in the airways requires further research. (biomedcentral.com)
  • During expiration, alveolar surfactant becomes extruded into the adjacent conducting airways. (biomedcentral.com)
  • Surfactant protein D (SP-D) is a collectin protein synthesized by alveolar type II cells in the lungs. (bvsalud.org)
  • 6. Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages. (nih.gov)
  • 20. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. (nih.gov)
  • This review summarizes the current knowledge on surfactant functions regarding the airway compartment and highlights the impact of various surfactant components on allergic inflammation in asthma. (biomedcentral.com)
  • In the past decade, direct and indirect evidence has emerged for surfactant as a factor in the regulation of airway calibers and a modulator of allergic inflammation. (biomedcentral.com)
  • The immune surfactant or collectin surfactant protein D (SP-D) is a crucial multifunctional innate immune receptor. (cdc.gov)
  • 4. Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation. (nih.gov)
  • 19. Surfactant protein D interacts with alpha2-macroglobulin and increases its innate immune potential. (nih.gov)
  • The complement system exerts many of its effects through complement receptors (CRs). (medscape.com)
  • Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1. (medscape.com)
  • Proline hydroxylation is crucial for collagen and extracellular matrix assembly as well as for assembly of other protein molecules that have collagen-like domains, including surfactants and complement. (nih.gov)
  • Electron microscopy has revealed that surfactant material forming monolayers and multilayers can be found at the air-liquid interface of the airway lumen. (biomedcentral.com)
  • Collectins form trimers that may assemble into larger oligomers. (nih.gov)
  • 18. Surfactant protein D delays Fas- and TRAIL-mediated extrinsic pathway of apoptosis in T cells. (nih.gov)
  • Endogenous molecules, and abundant receptors for ifn- or vita- tions may include fever, rash. (stonecottagegardens.com)
  • While surfactant was initially thought to be a key player in the biophysical behavior of the lung, today its immunomodulatory properties make surfactant a fascinating compound in innate and adaptive immunity of the lung. (biomedcentral.com)
  • The mucus lining your nose and throat contains a powerful virus killing compound called surfactant protein. (coronanlm.com)
  • In addition to learning about how the virus infects lung cells, this PA specifically encourages in vitro research on the role of lung collectins and other extracellular lung host factors. (nih.gov)
  • Surfactants and MBL play an important role in innate immunity. (medscape.com)
  • 6] These receptors play a role in C3a-mediated and C5a-mediated anaphylactic reactions. (medscape.com)
  • The following sections review the potential role of surfactant in asthma. (biomedcentral.com)
  • 15. Linking surfactant protein SP-D and IL-13: implications in asthma and allergy. (nih.gov)
  • 5] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)
  • At time of the ICU admission, 45% (14/31) of the patients had HAI antibody titers80 in the first serum (S1), most (13/14) exhibited narrowly-focused HAI and/or anti-HA-head binding antibodies targeting single epitopes in or around the receptor binding site. (cdc.gov)
  • Binding of collectins to microorganisms results in their agglutination and enhanced clearance. (nih.gov)
  • Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region. (nih.gov)
  • This increases expression of ACE2 receptors, which serve to heal damaged cells but also creates a "doorway" for how the Coronavirus can enter body cells. (coronanlm.com)
  • 13. Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells. (nih.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adrenergic Receptor Beta 1 (ADRb1) in Tissue homogenates, cell lysates and other biological fluids. (resourcerecovery.be)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Adrenergic Receptor Beta 1 (ADRb1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (resourcerecovery.be)
  • Description: Quantitativesandwich ELISA kit for measuring Human Beta-1 adrenergic receptor (ADRB1) in samples from serum, plasma, tissue homogenates, cell lysates. (resourcerecovery.be)
  • Description: A sandwich ELISA kit for detection of Adrenergic Receptor Beta 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (resourcerecovery.be)
  • 10. Surfactant protein SP-D modulates activity of immune cells: proteomic profiling of its interaction with eosinophilic cells. (nih.gov)
  • All membrane-bound splice variants showed receptor activity toward fluorescent AcLDL when expressed transiently in COS-1 cells ( 10 ). (frontiersin.org)
  • Surfactant protein D has been shown to interact with DMBT1, and hemagglutinin of influenza A virus. (wikipedia.org)
  • Whitsett and coworkers [ 5 ] have shown that during lung development, the hydrophobic surfactant protein (SP)-B and SP-C mRNAs are first expressed in bronchi and bronchioles. (biomedcentral.com)
  • Little work to date has examined the effect of such collectins in response to organic dusts. (cdc.gov)
  • These receptors are present on phagocytic cells, mast cells, and lung epithelial and smooth muscle cells. (medscape.com)
  • Description: A sandwich ELISA kit for detection of Lectin Like Oxidized Low Density Lipoprotein Receptor 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)